Bc →bs (d) form factors from lattice QCD

We present results of the first lattice QCD calculations of $B_c \to B_s$ and $B_c \to B_d$ weak matrix elements. Form factors across the entire physical $q^2$ range are then extracted and extrapolated to the physical-continuum limit before combining with CKM matrix elements to predict the semileptonic decay rates $\Gamma(B_c^+ \to B_s^0 \overline{\ell} \nu_{\ell}) = 26.2(1.2) \times 10^9 \,\text{s}^{-1}$ and $\Gamma(B_c^+ \to B^0 \overline{\ell} \nu_{\ell}) = 1.65(10) \times 10^9 \,\text{s}^{-1}$. The lattice QCD uncertainty is comparable to the CKM uncertainty here. Results are derived from correlation functions computed on MILC Collaboration gauge configurations with a range of lattice spacings including 2+1+1 flavours of dynamical sea quarks in the Highly Improved Staggered Quark (HISQ) formalism. HISQ is also used for the propagators of the valence light, strange, and charm quarks. Two different formalisms are employed for the bottom quark: non-relativistic QCD (NRQCD) and heavy-HISQ. Checking agreement between these two approaches is an important test of our strategies for heavy quarks on the lattice. From chained fits of NRQCD and heavy-HISQ data, we obtain the differential decay rates $d\Gamma/ d q^2$ as well as integrated values for comparison to future experimental results

Artists before Columbus: A multi-method characterization of the materials and practices of Caribbean cave art

This study represents the first positive identification of plant gum binding media in pre-Columbian art, and the first dates from indigenous cave art in the Caribbean. Mona Island reveals an extensive and well-preserved pre-Columbian and early colonial subterranean cultural landscape with dense concentrations of newly-discovered cave art in up to 30 caves. A multi-method approach to the research of pigments and binding media, charcoal, and cave sediments was used to elucidate the technologies, chronologies and processes of indigenous art and artists. Analyses included on-site use of a portable X-ray fluorescence (P-XRF) device to inform sample selection, scanning electron microscopy with energy dispersive X-ray spectroscopy (SEM/EDX) on paint and charcoal samples, polarized light microscopy (PLM) for material characterizations, and gas chromatography - mass spectrometry (GC-MS) and X-ray diffraction (XRD) for detailed chemical analysis of paint structures and composition. In addition direct dates of cave art using radiocarbon (C14) and Uranium-thorium (U-Th) dating methods are discussed. Results demonstrate multiple centuries of cave use during indigenous occupation and multiple phases and techniques of mark-making in dark zone locations within extensive cave systems. Visitors set out on pre-meditated journeys underground, making rock art using pigments from the cave floors, which they mixed into complex paints with the addition of plant gums from outside. This study is the first of its kind in the Caribbean providing insight into native paint recipes, material choices, and mark-making techniques. The methods have scope for widespread application and advance the integration of cave art research in archaeology

Predictors of severe asthma attack re-attendance in Ecuadorian children: a cohort study.

Asthma is a common cause of emergency care attendance in low- and middle-income countries (LMICs). While few prospective studies of predictors for emergency care attendance have been undertaken in high-income countries, none have been performed in a LMIC.We followed a cohort of 5-15-year-old children treated for asthma attacks in emergency rooms of public health facilities in Esmeraldas City, Ecuador. We collected blood and nasal wash samples, and performed spirometry and exhaled nitric oxide fraction measurements. We explored potential predictors for recurrence of severe asthma attacks requiring emergency care over 6 months' follow-up.We recruited 283 children of whom 264 (93%) were followed-up for ≥6 months or until their next asthma attack. Almost half (46%) had a subsequent severe asthma attack requiring emergency care. Predictors of recurrence in adjusted analyses were (adjusted OR, 95% CI) younger age (0.87, 0.79-0.96 per year), previous asthma diagnosis (2.2, 1.2-3.9), number of parenteral corticosteroid courses in previous year (1.3, 1.1-1.5), food triggers (2.0, 1.1-3.6) and eczema diagnosis (4.2, 1.02-17.6). A parsimonious Cox regression model included the first three predictors plus urban residence as a protective factor (adjusted hazard ratio 0.69, 95% CI 0.50-0.95). Laboratory and lung function tests did not predict recurrence.Factors independently associated with recurrent emergency attendance for asthma attacks were identified in a low-resource LMIC setting. This study suggests that a simple risk-assessment tool could potentially be created for emergency rooms in similar settings to identify higher-risk children on whom limited resources might be better focused

The time-dependent expression of keratins 5 and 13 during the reepithelialization of human skin wounds

The time-dependent reepithelialization of 55 human surgical skin wounds with a wound age between 8h and more than 2 months was investigated by the immunohistochemical localization of cytokeratins 5 and 13. A complete, rebuilt epidermal layer over the wound area was first detectable in a 5-day-old wound, while all wounds of more than 18 days duration contained a completely reepithelialized wound area. Between 5 and 18 days the basal layer of keratinocytes showed — in contrast to normal skin — only some cells positive for cytokeratin 5. In some, but not all lesions with a wound age of 13 days or more, a basal cell layer completely staining for cytokeratin 5 was demonstrable. This staining pattern was found in all skin wounds with a wound age of more than 23 days. The immunohistochemical detection of cytokeratin 13 which can be observed regularly in non-cornifying squamous epithelia provides no information for the time-estimation of human skin wounds, since no significant temporary expression of this polypeptide seems to occur during the healing of human skin wounds

Understanding the Underlying Principles of the Short Film

This chapter explores the types of story possible within short films, and how often there can be confusion and uncertainty, particularly amongst student filmmakers, about what a short film really is. In order to better understand this, this chapter outlines a series of underlying principles about short film story design that, we argue, are integral to the initial stages of conceiving such films. Before script development takes place, we argue that realistic thinking about what the short film can deliver in terms of story, characters, scope and dramatic question, will result in a screen work that is not only feasible for student filmmakers to produce, but is also more likely to increase an audience’s emotional engagement with the film. Drawing on a range of multi-award-winning contemporary short films to illustrate these principles, we discuss the relationship between content and form in this genre, leading to a better understanding of the parameters within which a student filmmaker might work. While not presenting these parameters as strict and unbreakable, we argue that knowing what has worked well for others, and what audiences expect from the short film form, provides a solid basis from which to begin conceptualising a short film

Spatially and genetically distinct African trypanosome virulence variants defined by host interferon-g response

We describe 2 spatially distinct foci of human African trypansomiasis in eastern Uganda. The Tororo and Soroti foci of <i>Trypanosoma brucei rhodesiense</i> infection were genetically distinct as characterized by 6 microsatellite and 1 minisatellite polymorphic markers and were characterized by differences in disease progression and host-immune response. In particular, infections with the Tororo genotype exhibited an increased frequency of progression to and severity of the meningoencephalitic stage and higher plasma interferon (IFN)–γ concentration, compared with those with the Soroti genotype. We propose that the magnitude of the systemic IFN-γ response determines the time at which infected individuals develop central nervous system infection and that this is consistent with the recently described role of IFN-γ in facilitating blood-brain barrier transmigration of trypanosomes in an experimental model of infection. The identification of trypanosome isolates with differing disease progression phenotypes provides the first field-based genetic evidence for virulence variants in T. <i>brucei rhodesiense</i>

Clergy work-related satisfactions in parochial ministry: the influence of personality and churchmanship

The aim of this study was to test several hypotheses that clergy work-related satisfaction could be better explained by a multidimensional rather than a unidimensional model. A sample of 1071 male stipendiary parochial clergy in the Church of England completed the Clergy Role Inventory, together with the short-form Revised Eysenck Personality Questionnaire. Factor analysis of the Clergy Role Inventory identified five separate clergy roles: Religious Instruction, Administration, Statutory Duties (conducting marriages and funerals), Pastoral Care, and Role Extension (including extra-parochial activities). Respondents also provided an indication of their predispositions on the catholic-evangelical and liberal-conservative dimensions. The significant associations of the satisfactions derived from each of the roles with the demographic, personality, and churchmanship variables were numerous, varied, and, with few exceptions, small in magnitude. Separate hierarchical regressions for each of the five roles indicated that the proportion of total variance explained by churchmanship was, in general, at least as great as that explained by personality, and was greater for three roles: Religious Instruction, Statutory Duties, and Role Extension. It was concluded that clergy satisfactions derived from different roles are not uniform and that churchmanship is at least as important as personality in accounting for clergy work satisfaction