Examining consent for interventional research in potential deceased organ donors: a narrative review

In the last decade, research in transplant medicine has focused on developing interventions in the management of the deceased organ donor to improve the quality and quantity of transplantable organs. Despite the promise of interventional donor research, there remain debates about the ethics of this research, specifically regarding gaining research consent. Here, we examine the concerns and ambiguities around consent for interventional donor research, which incorporate questions about who should consent for interventional donor research and what people are being asked to consent for. We highlight the US and UK policy responses to these concerns and argue that, whereas guidance in this area has done much to clarify these ambiguities, there is little consideration of the nature, practicalities and context around consent in this area, particularly regarding organ donors and their families. We review wider studies of consent in critical care research and social science studies of consent in medical research, to gain a broader view of consent in this area as a relational and contextual process. We contend a lack of consideration has been given to: what it might mean to consent to interventional donor research; how families, patients and health professionals might experience providing and seeking this consent; who is best placed to have these discussions; and the socio‐institutional contexts affecting these processes. Further, empirical research is required to establish an ethical and sensitive model for consent in interventional donor research, ensuring the principles enshrined in research ethics are met and public trust in organ donation is maintained

TumorML: Concept and requirements of an in silico cancer modelling markup language

This paper describes the initial groundwork carried out as part of the European Commission funded Transatlantic Tumor Model Repositories project, to develop a new markup language for computational cancer modelling, TumorML. In this paper we describe the motivations for such a language, arguing that current state-of-the-art biomodelling languages are not suited to the cancer modelling domain. We go on to describe the work that needs to be done to develop TumorML, the conceptual design, and a description of what existing markup languages will be used to compose the language specification

Non-equilibrium dynamics in quantum field theory at high density: the tsunami

The dynamics of a dense relativistic quantum fluid out of thermodynamic equilibrium is studied in the framework of the Phi^4 scalar field theory in the large N limit. The time evolution of a particle distribution in momentum space (the tsunami) is computed. The effective mass felt by the particles in such a high density medium equals the tree level mass plus the expectation value of the squared field. The case of negative tree level squared mass is particularly interesting. In such case dynamical symmetry restoration as well as dynamical symmetry breaking can happen. Furthermore, the symmetry may stay broken with vanishing asymptotic squared mass showing the presence of out of equilibrium Goldstone bosons. We study these phenomena and identify the set of initial conditions that lead to each case. We compute the equation of state which turns to depend on the initial state. Although the system does not thermalize, the equation of state for asymptotically broken symmetry is of radiation type. We compute the correlation functions at equal times. The two point correlator for late times is the sum of different terms. One stems from the initial particle distribution. Another term accounts for the out of equilibrium Goldstone bosons created by spinodal unstabilities when the symmetry is asymptotically broken.Both terms are of the order of the inverse of the coupling for distances where causal signals can connect the two points. The contribution of the out of equilibrium Goldstones exhibits scaling behaviour in a generalized sense.Comment: LaTex, 49 pages, 15 .ps figure

Operation of a forced circulation, croloy 9 m, mercury loop to study corrosion product separation techniques

Forced circulation, Croloy 9M mercury loop designed to investigate corrosion product separation technique

Is unemployment and low income harmful to health? : Evidence from Britain

ACKNOWLEDGEMENTS The authors thank Ian McAvinchey for helpful comments. FUNDING This work was financially supported by the European Commission under the Fifth Framework Programme “Quality of Life and Management of Living Resources” [grant number QLRT-2001-02292].Peer reviewedPostprin

Sexual negotiation in the AIDS era: negotiated safety revisited

Objective: To test the safety of the 'negotiated safety' strategy - the strategy of dispensing with condoms within HIV-seronegative concordant regular sexual relationships under certain conditions. Method: Data from a recently recruited cohort of homosexually active men (Sydney Men and Sexual Health cohort, n = 1037) are used to revisit negotiated safety. The men were surveyed using a structured questionnaire and questions addressing their sexual relationships and practice, their own and their regular partner's serostatus, agreements entered into by the men concerning sexual practice within and outside their regular relationship, and contextual and demographic variables. Results: The findings indicate that a significant number of men used negotiated safety as an HIV prevention strategy. In the 6 months prior to interview, of the 181 men in seroconcordant HIV-negative regular relationships, 62% had engaged in unprotected anal intercourse within their relationship, and 91% (165 men) had not engaged in unprotected anal intercourse outside their relationship. Of these 165 men, 82% had negotiated agreements about sex outside their relationship. The safety of negotiation was dependent not only on seroconcordance but also on the presence of an agreement; 82% of the men who had not engaged in unprotected anal intercourse outside their regular relationship had entered into an agreement with their partner, whereas only 56% of those who had engaged in unprotected anal intercourse had an agreement. The safety of negotiation was also related to the nature of the safety agreement reached between the men and on the acceptability of condoms. Agreements between HIV-negative seroconcordant regular partners prohibiting anal intercourse with casual partners or any form of sex with a casual partner were typically complied with, and men who had such negotiated agreements were at low risk of HIV infection. Conclusions: The adoption of the strategy of negotiated safety among men in HIV-seronegative regular relationships may help such men sustain the safety of their sexual practice

Gauge Fields Out-Of-Equilibrium: A Gauge Invariant Formulation and the Coulomb Gauge

We study the abelian Higgs model out-of-equilibrium in two different approaches, a gauge invariant formulation, proposed by Boyanovsky et al. \cite{Boyanovsky:1996dc} and in the Coulomb gauge. We show that both approaches become equivalent in a consistent one loop approximation. Furthermore, we carry out a proper renormalization for the model in order to prepare the equations for a numerical implementation. The additional degrees of freedom, which arise in gauge theories, influence the behavior of the system dramatically. A comparison with results in the 't Hooft-Feynman background gauge found by us recently, shows very good agreement.Comment: 32 pages, 8 figure

The Vector Analyzing Power in Elastic Electron-Nucleus Scattering

The vector analyzing power A_n is calculated for elastic electron scattering from a variety of spin zero nuclei at energies from 14 MeV to 3 GeV. Time reversal symmetry insures that A_n vanish in first Born approximation. Therefore A_n depends on Coulomb distortions and can be large for scattering from heavy nuclei. The vector analyzing power is a potential source of systematic error for parity violation experiments. We find that A_n=-0.361 ppm for the kinematics of the Parity Radius Experiment (PREX) involving 850 MeV electrons scattering at six degrees from 208Pb. This is comparable to the parity violating asymmetry. However for HAPPEX He involving 3 GeV electrons scattering on 4He we find that A_n is very small.Comment: 6 pages, 6 figures, submitted to Phys. Rev.