11,761 research outputs found
IP protection: Detecting Email based breaches of confidence
In this paper we discuss the ease with which email can be used to breach confidence by the propagation of corporate secrets and intelligence, and propose an intelligent filtering system for outgoing emails aimed at preventing disclosures. We report on a number of experiments undertaken with a corpus of over half a million Enron emails and the use of a variety of techniques from the field of Corpus Linguistics for reducing the number of false alarms produced by naïve keyword filtering systems, and discuss the results in detail. We also give due consideration to the danger of missing messages that should have been prevented from propagation. © 2007 IEEE
Star Formation, Radio Sources, Cooling X-ray Gas, and Galaxy Interactions in the Brightest Cluster Galaxy in 2A0335+096
We present deep emission-line imaging taken with the SOAR Optical Imaging
Camera of the brightest cluster galaxy (BCG) in the nearby (z=0.035) X-ray
cluster 2A0335+096. We analyze long-slit optical spectroscopy, archival VLA,
Chandra X-ray, and XMM UV data. 2A0335+096 is a bright, cool-core X-ray
cluster, once known as a cooling flow. Within the highly disturbed core
revealed by Chandra X-ray observations, 2A0335+096 hosts a highly structured
optical emission-line system. The redshift of the companion is within 100 km/s
of the BCG and has certainly interacted with the BCG, and is likely bound to
it. The comparison of optical and radio images shows curved filaments in
H-alpha emission surrounding the resolved radio source. The velocity structure
of the emission-line bar between the BCG nucleus and the companion galaxy
provides strong evidence for an interaction between the two in the last ~50
Myrs. The age of the radio source is similar to the interaction time, so this
interaction may have provoked an episode of radio activity. We estimate a star
formation rate of >7 solar mass/yr based on the Halpha and archival UV data, a
rate similar to, but somewhat lower than, the revised X-ray cooling rate of
10-30 solar masses/year estimated from XMM spectra by Peterson & workers. The
Halpha nebula is limited to a region of high X-ray surface brightness and cool
X-ray temperature. The detailed structures of H-alpha and X-ray gas differ. The
peak of the X-ray emission is not the peak of H-alpha emission, nor does it lie
in the BCG. The estimated age of the radio lobes and their interaction with the
optical emission-line gas, the estimated timescale for depletion and
accumulation of cold gas, and the dynamical time in the system are all similar,
suggesting a common trigger mechanism.Comment: Accepted AJ, July 2007 publication. Vol 134, p. 14-2
SU(3) breaking in hyperon transition vector form factors
We present a calculation of the SU(3)-breaking corrections to the hyperon
transition vector form factors to in heavy baryon chiral
perturbation theory with finite-range regularisation. Both octet and decuplet
degrees of freedom are included. We formulate a chiral expansion at the
kinematic point , which can be conveniently accessed
in lattice QCD. The two unknown low-energy constants at this point are
constrained by lattice QCD simulation results for the
and transition form factors. Hence we determine
lattice-informed values of at the physical point. This work constitutes
progress towards the precise determination of from hyperon
semileptonic decays
Highly conductive Sb-doped layers in strained Si
The ability to create stable, highly conductive ultrashallow doped regions is a key requirement for future silicon-based devices. It is shown that biaxial tensile strain reduces the sheet resistance of highly doped n-type layers created by Sb or As implantation. The improvement is stronger with Sb, leading to a reversal in the relative doping efficiency of these n-type impurities. For Sb, the primary effect is a strong enhancement of activation as a function of tensile strain. At low processing temperatures, 0.7% strain more than doubles Sb activation, while enabling the formation of stable, ~10-nm-deep junctions. This makes Sb an interesting alternative to As for ultrashallow junctions in strain-engineered complementary metal-oxide-semiconductor device
Global access to affordable direct oral anticoagulants
Poor control of cardiovascular disease accounts for a substantial proportion of the disease burden in developing countries, but often essential anticoagulant medicines for preventing strokes and embolisms are not widely available. In 2019, direct oral anticoagulants were added to the World Health Organization's WHO Model list of essential medicines. The aims of this paper are to summarize the benefits of direct oral anticoagulants for patients with cardiovascular disease and to discuss ways of increasing their usage internationally. Although the cost of direct oral anticoagulants has provoked debate, the affordability of introducing these drugs into clinical practice could be increased by: price negotiation; pooled procurement; competitive tendering; the use of patent pools; and expanded use of generics. In 2017, only 14 of 137 countries that had adopted national essential medicines lists included a direct oral anticoagulant on their lists. This number could increase rapidly if problems with availability and affordability can be tackled. Once the types of patient likely to benefit from direct oral anticoagulants have been clearly defined in clinical practice guidelines, coverage can be more accurately determined and associated costs can be better managed. Government action is required to ensure that direct oral anticoagulants are covered by national budgets because the absence of reimbursement remains an impediment to achieving universal coverage. Tackling cardiovascular disease with the aid of direct oral anticoagulants is an essential component of efforts to achieve the World Health Organization's target of reducing premature deaths due to noncommunicable disease by 25% by 2025
Long‐Wavelength Sinuosity of Linear Dunes on Earth and Titan and the Effect of Underlying Topography
AbstractOn both Earth and Titan, some linear dunefields are characterized by curvilinear patterning atypical of the regularity and straightness of typical longitudinal dunefields. We use remotely sensed imagery and an automated dune crestline detection algorithm to analyze the controls on spatial patterning. Here it is shown that topography can influence the patterning, as dune alignments bend to deflect downslope under the influence of gravity. The effect is pronounced in a terrestrial dunefield (the Great Sandy desert, Australia) where substantial topography underlies, but is absent where the dunefield is underlain by subdued relief (southwestern Kalahari). This knowledge allows the inference of subtle topographic changes underlying dunefields from dunefield patterning, where other sources of elevation data may be absent. This methodology is explored using the Belet Sand Sea of Titan, where likely areas of topographic change at resolutions finer than those currently available from radar altimetry are inferred.</jats:p
Detection of a Hard Tail in the X-ray Spectrum of the Z Source GX 349+2
We present the results of a BeppoSAX observation of the Z source GX 349+2
covering the energy range 0.1-200 keV. The presence of flares in the light
curve indicates that the source was in the flaring branch during the BeppoSAX
observation. We accumulated energy spectra separately for the non-flaring
intervals and the flares. In both cases the continuum is well described by a
soft blackbody ( keV) and a Comptonized spectrum
corresponding to an electron temperature of keV, optical depth
(for a spherical geometry), and seed photon temperature of keV. All temperatures tend to increase during the flares. In the
non-flaring emission a hard tail dominates the spectrum above 30 keV. This can
be fit by a power law with photon index , contributing of the
total source luminosity over the BeppoSAX energy range. A comparison with hard
tails detected in some soft states of black hole binaries suggests that a
similar mechanism could originate these components in black hole and neutron
star systems.Comment: 15 pages, including 8 figures, to appear in Ap
“Ah! Our very own Juliet Bravo, or is it Jill Gascoine?” Ashes to Ashes and representations of gender
Peroxisomal fission is modulated by the mitochondrial Rho-GTPases, Miro1 and Miro2
Peroxisomes are essential for a number of cellular functions, including reactive oxygen species metabolism, fatty acid β-oxidation and lipid synthesis. To ensure optimal functionality, peroxisomal size, shape and number must be dynamically maintained; however, many aspects of how this is regulated remain poorly characterised. Here, we show that the localisation of Miro1 and Miro2-outer mitochondrial membrane proteins essential for mitochondrial trafficking-to peroxisomes is not required for basal peroxisomal distribution and long-range trafficking, but rather for the maintenance of peroxisomal size and morphology through peroxisomal fission. Mechanistically, this is achieved by Miro negatively regulating Drp1-dependent fission, a function that is shared with the mitochondria. We further find that the peroxisomal localisation of Miro is regulated by its first GTPase domain and is mediated by an interaction through its transmembrane domain with the peroxisomal-membrane protein chaperone, Pex19. Our work highlights a shared regulatory role of Miro in maintaining the morphology of both peroxisomes and mitochondria, supporting a crosstalk between peroxisomal and mitochondrial biology
Drones and Digital Photogrammetry: From Classifications to Continuums for Monitoring River Habitat and Hydromorphology
Recently, we have gained the opportunity to obtain very high-resolution imagery
and topographic data of rivers using drones and novel digital photogrammetric
processing techniques. The high-resolution outputs from this method are
unprecedented, and provide the opportunity to move beyond river habitat classification
systems, and work directly with spatially explicit continuums of data.
Traditionally, classification systems have formed the backbone of physical river
habitat monitoring for their ease of use, rapidity, cost efficiency, and direct comparability.
Yet such classifications fail to characterize the detailed heterogeneity
of habitat, especially those features which are small or marginal. Drones and
digital photogrammetry now provide an alternative approach for monitoring
river habitat and hydromorphology, which we review here using two case studies.
First, we demonstrate the classification of river habitat using drone imagery
acquired in 2012 of a 120 m section of the San Pedro River in Chile, which was at
the technological limits of what could be achieved at that time. Second, we
review how continuums of data can be acquired, using drone imagery acquired
in 2016 from the River Teme in Herefordshire, England. We investigate the precision
and accuracy of these data continuums, highlight key current challenges,
and review current best practices of data collection, processing, and management.
We encourage further quantitative testing and field applications. If current
difficulties can be overcome, these continuums of geomorphic and hydraulic
information hold great potential for providing new opportunities for understanding
river systems to the benefit of both river science and management
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