A Cooperative Strategy for 21st Century Seapower

A Cooperative Strategy for 21st Century Seapower” represents an historical first. Never before have the maritime forces of the United States—the Navy, Marine Corps, and Coast Guard—come together to create a unified maritime strategy. This strategy stresses an approach that integrates seapower with other elements of national power, as well as those of our friends and allies. It describes how seapower will be applied around the world to protect our way of life, as we join with other like-minded nations to protect and sustain the global, inter-connected system through which we prosper

Creating a center for global health at the University of Wisconsin-Madison.

Globalization, migration, and widespread health disparities call for interdisciplinary approaches to improve health care at home and abroad. Health professions students are pursuing study abroad in increasing numbers, and universities are responding with programs to address these needs. The University of Wisconsin (UW)-Madison schools of medicine and public health, nursing, pharmacy, veterinary medicine, and the division of international studies have created an interdisciplinary center for global health (CGH). The CGH provides health professions and graduate students with courses, field experiences, and a new Certificate in Global Health. Educational programs have catalyzed a network of enthusiastic UW global health scholars. Partnerships with colleagues in less economically developed countries provide the foundation for education, research, and service programs. Participants have collaborated to improve the education of health professionals and nutrition in Uganda; explore the interplay between culture, community development, and health in Ecuador; improve animal health and address domestic violence in Mexico; and examine successful public health efforts in Thailand. These programs supply students with opportunities to understand the complex determinants of health and structure of health systems, develop adaptability and cross-cultural communication skills, experience learning and working in interdisciplinary teams, and promote equity and reduce health disparities at home and abroad. Based on the principles of equity, sustainability, and reciprocity, the CGH provides a strong foundation to address global health challenges through networking and collaboration among students, staff, and faculty within the UW and beyond

Segregation and linkage analysis for longitudinal measurements of a quantitative trait

We present a method for using slopes and intercepts from a linear regression of a quantitative trait as outcomes in segregation and linkage analyses. We apply the method to the analysis of longitudinal systolic blood pressure (SBP) data from the Framingham Heart Study. A first-stage linear model was fit to each subject's SBP measurements to estimate both their slope over time and an intercept, the latter scaled to represent the mean SBP at the average observed age (53.7 years). The subject-specific intercepts and slopes were then analyzed using segregation and linkage analysis. We describe a method for using the standard errors of the first-stage intercepts and slopes as weights in the genetic analyses. For the intercepts, we found significant evidence of a Mendelian gene in segregation analysis and suggestive linkage results (with LOD scores ≥ 1.5) for specific markers on chromosomes 1, 3, 5, 9, 10, and 17. For the slopes, however, the data did not support a Mendelian model, and thus no formal linkage analyses were conducted

Relative Sea-Level Change in the Northern Strait of Georgia, British Columbia

Twenty-four new radiocarbon dates from isolation basin cores, excavations and natural exposures, and an archeological site, constrain relative sea-level change since the last glaciation in the northern Strait of Georgia, British Columbia. Relative sea level fell rapidly from about 150 m elevation to 45 m elevation from 11 750 to 11 000 BP (13 750 to 13 000 cal BP), then its rate of fall slowed. The initial rapid emergence began soon after the transition from proximal to distal glaciomarine sedimentation, when the glacial front retreated from the Strait of Georgia and the Earth’s surface was unloaded. A sea-level lowstand a few metres below present-day sea level may have occurred in the early Holocene, but sea level was near its present level by 2000 BP. Sea-level change in the northern Strait of Georgia lagged the mid Strait of Georgia, 80 km to the south, by a few hundred years during initial emergence. The lowstand in the northern strait was later and probably shallower than in the mid strait. Isostatic depression inferred from the sea-level observations can be fit with two decaying exponential terms with characteristic decay times of 500 and 2600 years. The faster decay time corresponds to a shallow mantle viscosity of about 1019 Pa s, consistent with previous glacio-isostatic modelling. The present-day crustal uplift rate from the residual isostatic effects of the Cordilleran Ice Sheet is about 0.25 mm/a. Crustal uplift is not expected to significantly ameliorate projected sea-level rise in the mid and northern Strait of Georgia because present-day vertical crustal movements are inferred to be small.Vingt-quatre nouvelles dates au 14C provenant de carottes sédimentaires de bassins isolés, d’excavations, de coupes naturellement exposées et archéologiques permettent de cerner les changements du niveau marin relatif depuis la dernière glaciation dans la partie nord du détroit de Géorgie, en Colombie-Britannique. Le niveau marin relatif a rapidement passé de 150 m à 45 m d’altitude entre 11 750 et 11 000 ans BP (13 750-13 000 cal. BP), le taux d’abaissement ayant ralenti par la suite. L’émersion initiale rapide correspond à la fin de la sédimentation glaciomarine distale qui accompagnait le retrait du front glaciaire. Un bas niveau de quelques mètres sous le niveau actuel a pu s’instaurer durant l’Holocène inférieur, jusqu’en 2000 ans BP. Au début, le soulèvement isostatique a accusé un retard de quelques siècle sur celui de la zone du détroit à 80 km plus au sud. Le bas niveau de la partie nord du détroit est survenu plus tard et fut moins prononcé. Les données indiquent un enfoncement isostatique de type exponentiel avec des constantes de désintégration de 500 et de 2600 ans 14C. Le taux le plus rapide correspond à une viscosité du manteau terrestre d’environ 1019 Pa s, ce qui concorde avec les résultats de la modélisation glacio-isostatique. Le taux de soulèvement glacio-isostatique actuel résultant de l’inlandsis de la Cordillère s’établit à environ 0,25 mm/a. Ce taux ne peut contrer les effets du rehaussement du niveau marin prévu pour cette région en raison des faibles mouvements de la croûte terrestre qui y sont envisagés

Dynamic Posterior Instability Test: A New Test for Posterior Glenohumeral Instability

BACKGROUND: Recurrent posterior shoulder instability has become an increasingly recognized cause of shoulder disability, especially among athletes. The presentation can be vague and therefore its clinical diagnosis is often overlooked. Few diagnostic tests exist and these tests are difficult to perform in an anxious and apprehensive patient. Many also lack high specificity and do not effectively distinguish posterior labral tears from other shoulder pathologies. As a result, the authors worked to develop a new test, the dynamic posterior instability test (DPIT). The purpose of this study was to describe the DPIT as well as a modified DPIT test and to evaluate the accuracy of these tests in detecting posterior labral pathology. It was hypothesized that the dynamic posterior instability test (DPIT) would improve accuracy in the evaluation of posterior labral tears. METHODS: For a 9-month period, the DPIT and modified DPIT tests were performed on all patients evaluated for posterior instability of the shoulder. The records of all patients who had undergone a posterior labral repair (type VIII SLAP and posterior labral tears) were reviewed. The results of the DPIT and modified DPIT tests were compared to intra-operative findings. Anterior glenohumeral instability patients were also evaluated with these tests to serve as a control. RESULTS: Fifty-one patients had a positive and 3 patients had a negative DPIT test. Of the anterior instability patients, there was 1 positive and 19 negative test results. The sensitivity of the DPIT test was 94.4%, specificity 95%, the positive predictive value 0.98, and the negative predictive value 0.86. The results of the modified DPIT were the same as the DPIT test. CONCLUSIONS: The DPIT and modified DPIT tests provide a valuable new tool when combined with history and other physical examination findings improve the accuracy of diagnosis of posterior shoulder instability

Poultry in Texas.

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Restriction of HIV-1 Genotypes in Breast Milk Does Not Account for the Population Transmission Genetic Bottleneck That Occurs following Transmission

BACKGROUND. Breast milk transmission of HIV-1 remains a major route of pediatric infection. Defining the characteristics of viral variants to which breastfeeding infants are exposed is important for understanding the genetic bottleneck that occurs in the majority of mother-to-child transmissions. The blood-milk epithelial barrier markedly restricts the quantity of HIV-1 in breast milk, even in the absence of antiretroviral drugs. The basis of this restriction and the genetic relationship between breast milk and blood variants are not well established. METHODOLOGY/PRINCIPAL FINDINGS. We compared 356 HIV-1 subtype C gp160 envelope (env) gene sequences from the plasma and breast milk of 13 breastfeeding women. A trend towards lower viral population diversity and divergence in breast milk was observed, potentially indicative of clonal expansion within the breast. No differences in potential N-linked glycosylation site numbers or in gp160 variable loop amino acid lengths were identified. Genetic compartmentalization was evident in only one out of six subjects in whom contemporaneously obtained samples were studied. However, in samples that were collected 10 or more days apart, six of seven subjects were classified as having compartmentalized viral populations, highlighting the necessity of contemporaneous sampling for genetic compartmentalization studies. We found evidence of CXCR4 co-receptor using viruses in breast milk and blood in nine out of the thirteen subjects, but no evidence of preferential localization of these variants in either tissue. CONCLUSIONS/SIGNIFICANCE. Despite marked restriction of HIV-1 quantities in milk, our data indicate intermixing of virus between blood and breast milk. Thus, we found no evidence that a restriction in viral genotype diversity in breast milk accounts for the genetic bottleneck observed following transmission. In addition, our results highlight the rapidity of HIV-1 env evolution and the importance of sample timing in analyses of gene flow.National Institute of Child Health and Human Development; National Institutes of Health (R01 HD 39611, R01 HD 40777); International Maternal Pediatric Adolescent AIDS Clinical Trials Group (U01 AI068632-01); National Institutes of Health Cellular, Biochemical; Molecular Sciences Training Program Grant (T 32 067587

Comparison of genomic signatures of selection on Plasmodium falciparum between different regions of a country with high malaria endemicity.

BACKGROUND: Genome wide sequence analyses of malaria parasites from widely separated areas of the world have identified contrasting population structures and signatures of selection. To compare relatively closely situated but ecologically contrasting regions within an endemic African country, population samples of Plasmodium falciparum clinical isolates were collected in Ghana from Kintampo in the central forest-savannah area, and Navrongo in a drier savannah area ~350 km to the north with more seasonally-restricted transmission. Parasite DNA was sequenced and paired-end reads mapped to the P. falciparum reference genome. RESULTS: High coverage genome wide sequence data for 85 different clinical isolates enabled analysis of 121,712 single nucleotide polymorphisms (SNPs). The local populations had similar proportions of mixed genotype infections, similar SNP allele frequency distributions, and eleven chromosomal regions had elevated integrated haplotype scores (|iHS|) in both. A between-population Rsb metric comparing extended haplotype homozygosity indicated a stronger signal within Kintampo for one of these regions (on chromosome 14) and in Navrongo for two of these regions (on chromosomes 10 and 13). At least one gene in each of these identified regions is a potential target of locally varying selection. The candidates include genes involved in parasite development in mosquitoes, members of variant-expressed multigene families, and a leading vaccine-candidate target of immunity. CONCLUSIONS: Against a background of very similar population structure and selection signatures in the P. falciparum populations of Ghana, three narrow genomic regions showed evidence indicating local differences in historical timing or intensity of selection. Sampling of closely situated populations across heterogeneous environments has potential to refine the mapping of important loci under temporally or spatially varying selection

A Higgs Mass Shift to 125 GeV and A Multi-Jet Supersymmetry Signal: Miracle of the Flippons at the \sqrt{s} = 7 TeV LHC

We describe a model named No-Scale F-SU(5) which is simultaneously capable of explaining the dual signals emerging at the LHC of i) a 124-126 GeV Higgs boson mass m_h, and ii) tantalizing low-statistics excesses in the multi-jet data which may attributable to supersymmetry. These targets tend to be mutually exclusive in more conventional approaches. The unified mechanism responsible for both effects is the introduction of a rather unique set of vector-like multiplets at the TeV scale, dubbed flippons, which i) can elevate m_h by around 3-4 GeV via radiative loop corrections, and ii) flatten the running of the strong coupling and color-charged gaugino, resulting in a prominent collider signal from production of light gluino pairs. This well motivated theoretical framework maintains consistency with all key phenomenological constraints, and all residual parameterization freedom may in principle be fixed by a combination of the two experiments described. We project that the already collected luminosity of 5 fb^-1 may be sufficient to definitively establish the status of this model, given appropriate data selection cuts.Comment: Physics Letters B version, 10 pages, 3 figures, 2 tables. arXiv admin note: text overlap with arXiv:1105.398