Book Review: Oxford Bibliographies: Hinduism and Christianity

Christopher R. Conway\u27s review of Oxford Bibliographies: Hinduism and Christianity, edited by Chad Bauman, Arun Jones, Brian Pennington, Joseph Prabhakar Dayam, and Michelle Voss Roberts

Psychometric Network Analysis of the Hungarian WAIS

The positive manifold—the finding that cognitive ability measures demonstrate positive correlations with one another—has led to models of intelligence that include a general cognitive ability or general intelligence (g). This view has been reinforced using factor analysis and reflective, higher-order latent variable models. However, a new theory of intelligence, Process Overlap Theory (POT), posits that g is not a psychological attribute but an index of cognitive abilities that results from an interconnected network of cognitive processes. These competing theories of intelligence are compared using two different statistical modeling techniques: (a) latent variable modeling and (b) psychometric network analysis. Network models display partial correlations between pairs of observed variables that demonstrate direct relationships among observations. Secondary data analysis was conducted using the Hungarian Wechsler Adult Intelligence Scale Fourth Edition (H-WAIS-IV). The underlying structure of the H-WAIS-IV was first assessed using confirmatory factor analysis assuming a reflective, higher-order model and then reanalyzed using psychometric network analysis. The compatibility (or lack thereof) of these theoretical accounts of intelligence with the data are discussed

PGC-1 alpha induced mitochondrial biogenesis in stromal cells underpins mitochondrial transfer to melanoma

INTRODUCTION: Progress in the knowledge of metabolic interactions between cancer and its microenvironment is ongoing and may lead to novel therapeutic approaches. Until recently, melanoma was considered a glycolytic tumour due to mutations in mitochondrial-DNA, however, these malignant cells can regain OXPHOS capacity via the transfer of mitochondrial-DNA, a process that supports their proliferation in-vitro and in-vivo. Here we study how melanoma cells acquire mitochondria and how this process is facilitated from the tumour microenvironment. METHODS: Primary melanoma cells, and MSCs derived from patients were obtained. Genes’ expression and DNA quantification was analysed using Real-time PCR. MSC migration, melanoma proliferation and tumour volume, in a xenograft subcutaneous mouse model, were monitored through bioluminescent live animal imaging. RESULTS: Human melanoma cells attract bone marrow-derived stromal cells (MSCs) to the primary tumour site where they stimulate mitochondrial biogenesis in the MSCs through upregulation of PGC1a. Mitochondria are transferred to the melanoma cells via direct contact with the MSCs. Moreover, inhibition of MSC-derived PGC1a was able to prevent mitochondrial transfer and improve NSG melanoma mouse tumour burden. CONCLUSION: MSC mitochondrial biogenesis stimulated by melanoma cells is prerequisite for mitochondrial transfer and subsequent tumour growth, where targeting this pathway may provide an effective novel therapeutic approach in melanoma

Geology of the Derain quadrangle (H10), Mercury

We present the results of geological mapping of Mercury’s Derain (H10) quadrangle (0°-72°E and 22.5°N-22.5°S) using data from the MESSENGER spacecraft. The map is presented on a scale of 1:3,000,000, for which linework was drawn at 1:300,000. We distinguish three major morphological plains units: Smooth, Intermediate, and Intercrater Plains. We produced two versions of the map, with craters classified according to a 3- and 5-class degradation system. This allows compatibility with other MESSENGER-era maps and Mariner 10-era maps. This map will help provide science context for the ESA-JAXA BepiColombo mission to Mercury

Supporting self-management for patients with Interstitial Lung Diseases:Utility and acceptability of digital devices

INTRODUCTION: Patients diagnosed with Interstitial Lung Diseases (ILD) use devices to self-monitor their health and well-being. Little is known about the range of devices, selection, frequency and terms of use and overall utility. We sought to quantify patients' usage and experiences with home digital devices, and further evaluate their perceived utility and barriers to adaptation.METHODS: A team of expert clinicians and patient partners interested in self-management approaches designed a 48-question cross-sectional electronic survey; specifically targeted at individuals diagnosed with ILD. The survey was critically appraised by the interdisciplinary self-management group at Royal Devon University Hospitals NHS Foundation Trust during a 6-month validation process. The survey was open for participation between September 2021 and December 2022, and responses were collected anonymously. Data were analysed descriptively for quantitative aspects and through thematic analysis for qualitative input.RESULTS: 104 patients accessed the survey and 89/104 (86%) reported a diagnosis of lung fibrosis, including 46/89 (52%) idiopathic pulmonary fibrosis (IPF) with 57/89 (64%) of participants diagnosed &gt;3 years and 59/89 (66%) female. 52/65(80%) were in the UK; 33/65 (51%) reported severe breathlessness medical research council MRC grade 3-4 and 32/65 (49%) disclosed co-morbid arthritis or joint problems. Of these, 18/83 (22%) used a hand- held spirometer, with only 6/17 (35%) advised on how to interpret the readings. Pulse oximetry devices were the most frequently used device by 35/71 (49%) and 20/64 (31%) measured their saturations more than once daily. 29/63 (46%) of respondents reported home-monitoring brought reassurance; of these, for 25/63 (40%) a feeling of control. 10/57 (18%) felt it had a negative effect, citing fluctuating readings as causing stress and 'paranoia'. The most likely help-seeking triggers were worsening breathlessness 53/65 (82%) and low oxygen saturation 43/65 (66%). Nurse specialists were the most frequent source of help 24/63 (38%). Conclusion: Patients can learn appropriate technical skills, yet perceptions of home-monitoring are variable; targeted assessment and tailored support is likely to be beneficial.</p

Intravital FRAP imaging using an E-cadherin-GFP mouse reveals disease- and drug-dependent dynamic regulation of cell-cell junctions in live tissue

E-cadherin-mediated cell-cell junctions play a prominent role in maintaining the epithelial architecture. The disruption or deregulation of these adhesions in cancer can lead to the collapse of tumor epithelia that precedes invasion and subsequent metastasis. Here we generated an E-cadherin-GFP mouse that enables intravital photobleaching and quantification of E-cadherin mobility in live tissue without affecting normal biology. We demonstrate the broad applications of this mouse by examining E-cadherin regulation in multiple tissues, including mammary, brain, liver, and kidney tissue, while specifically monitoring E-cadherin mobility during disease progression in the pancreas. We assess E-cadherin stability in native pancreatic tissue upon genetic manipulation involving Kras and p53 or in response to anti-invasive drug treatment and gain insights into the dynamic remodeling of E-cadherin during in situ cancer progression. FRAP in the E-cadherin-GFP mouse, therefore, promises to be a valuable tool to fundamentally expand our understanding of E-cadherin-mediated events in native microenvironments

Mineralocorticoid Excess or Glucocorticoid Insufficiency:Renal and Metabolic Phenotypes in a Rat Hsd11b2 Knockout Model

Obesity and hypertension are 2 major health issues of the 21st century. The syndrome of apparent mineralocorticoid excess is caused by deficiency of 11β-hydroxysteroid dehydrogenase type 2 (Hsd11b2), which normally inactivates glucocorticoids, rendering the mineralocorticoid receptor aldosterone–specific. The metabolic consequences of Hsd11b2 knockout in the rat are investigated in parallel with electrolyte homeostasis. Hsd11b2 was knocked out, by pronuclear microinjection of targeted zinc-finger nuclease mRNAs, and 1 line was characterized for its response to renal and metabolic challenges. Plasma 11-dehydrocorticosterone was below detection thresholds, and Hsd11b2 protein was undetected by Western blot, indicating complete ablation. Homozygotes were 13% smaller than wild-type littermates, and were polydipsic and polyuric. Their kidneys, adrenals, and hearts were significantly enlarged, but mesenteric fat pads and liver were significantly smaller. On a 0.3% Na diet, mean arterial blood pressure was ≈65 mm Hg higher than controls but only 25 mm Hg higher on a 0.03% Na(+) diet. Urinary Na/K ratio of homozygotes was similar to controls on 0.3% Na(+) diet but urinary albumin and calcium were elevated. Corticosterone and aldosterone levels showed normal circadian variation on both a 0.3% and 0.03% Na(+) diet, but plasma renin was suppressed in homozygotes on both diets. Plasma glucose responses to an oral glucose challenge were reduced despite low circulating insulin, indicating much greater sensitivity to insulin in homozygotes. The rat model reveals mechanisms linking electrolyte homeostasis and metabolic control through the restriction of Hsd11b1 substrate availability

Individualism, collectivism, and emotion regulation: A cross-cultural examination among young adults from seven countries

Individualism and collectivism are dimensions of cultural variation thought to shape differences in emotion regulation tendencies, yet research to date has examined these cultural dimensions as country-level features, emphasizing variability across nations. The present study takes the approach of examining cultural differences within nations as predictors of emotion regulation strategies, shifting the perspective instead to individual differences. This present study aimed to address how individual endorsement of individualism-collectivism (i.e. prioritizing individual versus group goals) and vertical-horizontal attitudes (preference for hierarchy versus equality) are associated with use of emotion regulation strategies (i.e., reappraisal and suppression) among college students from seven countries (n=5,900; female=70.80%). Overall, we found that individual differences in individualism-collectivism and vertical-horizontal attitudes had strong connections with young adults’ emotion regulation styles. Results of our multivariate (i.e., all variables were simultaneously examined) regression model revealed: a) higher endorsement of horizontal individualism and horizontal collectivism were associated with higher use of reappraisal strategies; b) higher endorsement of horizontal individualism and vertical collectivism were associated with higher use of suppression strategies; while higher endorsement of horizontal collectivism was associated with lower use of suppression strategies. A multi-group model supported the generalizability of these associations across countries. These findings demonstrate the value of approaching cultural differences in emotion regulation from an individual differences framework, and not assuming country-level differences are representative of individuals’ affective experiences. Further work is needed examining models within-country to examine cultural variation in individualism vs collectivism compared to country-level norms.Fil: Klein, Neelamberi D.. Indiana University Bloomington; Estados UnidosFil: Bravo, Adrian J.. College Of William And Mary (w&m);Fil: Conway, Christopher C.. Fordham University; Estados UnidosFil: Keough, Matthew T.. York University; CanadáFil: Pilatti, Angelina. Universidad Nacional de Córdoba. Instituto de Investigaciones Psicológicas. - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones Psicológicas; ArgentinaFil: Mezquita, Laura. Universitat Jaume I; España. Instituto de Salud Carlos III; EspañaFil: Henson, James M.. Cross-Cultural Addictions Study Team; Estados UnidosFil: Hogarth, Lee. Cross-Cultural Addictions Study Team; Estados UnidosFil: Ibáñez, Manuel I.. Cross-Cultural Addictions Study Team; Estados UnidosFil: Kaminer, Debra. Cross-Cultural Addictions Study Team; Estados UnidosFil: Ortet, Generós. Cross-Cultural Addictions Study Team; Estados UnidosFil: Pearson, Matthew R.. Cross-Cultural Addictions Study Team; Estados UnidosFil: Prince, Mark A.. Cross-Cultural Addictions Study Team; Estados UnidosFil: Read, Jennifer. Cross-Cultural Addictions Study Team; Estados UnidosFil: Roozen, Hendrik G.. Cross-Cultural Addictions Study Team; Estados UnidosFil: Ruiz, Paul. Cross-Cultural Addictions Study Team; Estados Unido