Some sources of variation in the assessment when introducing unaccounted mortality due to discarding practices. The case of Southern Four spot megrim stock.

Four spot megrim (Lepidorhombus boscii) is widely distributed in Atlantic waters form Iceland to Cape Bojador. In ICES Divisions VIIIc and IXa, Portuguese and Spanish ships captured this species as by-catch mainly in mixed bottom trawl fisheries. Only one exploitation unit of this species is assessed (from Divisions VIIIc and IXa) in the ICES Working Group of Hake, Monk and Megrim. Discard data are not used in the assessment of this species, though they are considered significantly high for younger ages. Discards data are available for Spanish trawlers for 1993, 1994, 1997, and the period from 1999 to 2001. A simulation using discard data was made to avoid the underestimation of mortality and recruitment. Due to the change in January 1990 in the minimum legal size for this species in this area, it was decided not to use historical information previous to this year, as it is supposed that this change could substantially affect the fleet discard pattern. Different options were considered as the way of raising: by effort (number of trips, hour of trawling) or by landings (in weight or in number). Reasons for the final choices are explained for all options considered. The way to introduce discards data in the VPA procedure for assessment was through the catch at age matrix since we considered that no fish of this species survive after being discarded. Differences in yield of Short-term and Mediumterm projections were observed

High Levels of Academic Procrastination do not Influence the Academic Performance of Nursing Students during Internship

Introducción: La procrastinación académica (AP) es un fenómeno global que afecta significativamente a los estudiantes universitarios, influyendo potencialmente en su rendimiento académico y bienestar mental. Objetivo: Investigar la relación entre los niveles de procrastinación académica y el rendimiento académico de estudiantes de enfermería durante su pasantía en el Perú. Métodos: Se realizó un estudio transversal, involucrando a 112 pasantes de enfermería, de 18 años y más, matriculados en el semestre 2019-I. Los participantes completaron la Escala de Procrastinación Académica (EPA), una escala tipo Likert que consta de 12 ítems, que midió dos dimensiones: autorregulación académica (9 ítems) y procrastinación de actividades (3 ítems). Se utilizó una puntuación umbral de 36 puntos para identificar altos niveles de procrastinación académica. El rendimiento académico se evaluó en una escala de 0 a 10 (reprobado), 11 a 14 (aprobado), 15 a 17 (notable) y 18 a 20 (sobresaliente). Resultados: La edad media de los participantes fue de 29 años, siendo el 88,4% mujeres. El estudio encontró que el 72,3% de los estudiantes de enfermería exhibieron niveles más altos de AP, particularmente entre las mujeres (62,5%) y los estudiantes más jóvenes (59,8%). A escala global, el 70,3% de los estudiantes obtuvo una calificación notable, y el 51,8% de estos estudiantes también exhibió un alto nivel de AP. Sin embargo, no se encontraron diferencias significativas en el rendimiento académico según el nivel de AP (p=0,918). Conclusión: Aunque los estudiantes de enfermería mostraron un mayor nivel de AP, este estudio no encontró una asociación significativa entre la procrastinación académica y el rendimiento académico durante el período de prácticas. Sin embargo, es crucial monitorear la AP en estudiantes de enfermería a lo largo de sus estudios para identificar factores potenciales que puedan contribuir a su impacto y desarrollar estrategias para mitigar sus efectos

On the general one-dimensional XY Model: positive and zero temperature, selection and non-selection

We consider $(M,d)$ a connected and compact manifold and we denote by $\mathcal{B}_i$ the Bernoulli space $M^{\Z}$ of sequences represented by $$x=(... x_{-3},x_{-2},x_{-1},x_0,x_1,x_2,x_3,...),$$ where $x_i$ belongs to the space (alphabet) $M$. The case where $M=\mathbb{S}^1$, the unit circle, is of particular interest here. The analogous problem in the one-dimensional lattice $\mathbb{N}$ is also considered. %In this case we consider the potential $A: {\cal B}=M^\mathbb{N} \to \mathbb{R}.$ Let A: \mathcal{B}_i \rar \R be an {\it observable} or {\it potential} defined in the Bernoulli space $\mathcal{B}_i$. The potential $A$ describes an interaction between sites in the one-dimensional lattice $M^\mathbb{Z}$. Given a temperature $T$, we analyze the main properties of the Gibbs state $\hat{\mu}_{\frac{1}{T} A}$ which is a certain probability measure over ${\cal B}_i$. We denote this setting "the general XY model". In order to do our analysis we consider the Ruelle operator associated to $\frac{1}{T} A$, and, we get in this procedure the main eigenfunction $\psi_{\frac{1}{T} A}$. Later, we analyze selection problems when temperature goes to zero: a) existence, or not, of the limit (on the uniform convergence) $$V:=\lim_{T\to 0} T\, \log(\psi_{\frac{1}{T} A}),\,\,\,\,\text{a question about selection of subaction},$$ and, b) existence, or not, of the limit (on the weak$^*$ sense) $$\tilde{\mu}:=\lim_{T\to 0} \hat{\mu}_{\frac{1}{T}\, A},\,\,\,\,\text{a question about selection of measure}.$$ The existence of subactions and other properties of Ergodic Optimization are also considered

The Analyticity of a Generalized Ruelle's Operator

In this work we propose a generalization of the concept of Ruelle operator for one dimensional lattices used in thermodynamic formalism and ergodic optimization, which we call generalized Ruelle operator, that generalizes both the Ruelle operator proposed in [BCLMS] and the Perron Frobenius operator defined in [Bowen]. We suppose the alphabet is given by a compact metric space, and consider a general a-priori measure to define the operator. We also consider the case where the set of symbols that can follow a given symbol of the alphabet depends on such symbol, which is an extension of the original concept of transition matrices from the theory of subshifts of finite type. We prove the analyticity of the Ruelle operator and present some examples

Physical activity and sex modulate obesity risk linked to 3111T/C gene variant of the CLOCK gene in an elderly population: the SUN Project

Genetic factors may interact with physical activity levels to modify obesity risk. Our aim was to explore the effect of rs1801260 SNP (3111T/C) of CLOCK gene, on obesity risk and to examine their interaction with lifestyle factors in an elderly population of the SUN Project. Subjects (n=903, aged 69±6) were recruited from the SUN (“Seguimiento Universidad de Navarra”) Project. DNA was obtained from saliva and lifestyle and dietary data were collected by validated self-reported questionnaires. Genotyping was assessed by RT-PCR plus allele discrimination. A significant interaction between the 3111T/C SNP of CLOCK gene and sex for overweight/obesity risk was observed (p for interaction [Sex*CLOCK] interaction <0.001). Our results showed that women carrying the C allele of CLOCK gene had a decreased overweight/obesity risk compared to non carrier -TT- subjects (OR 0.61, 95% CI: 0.36-1.04, p=0.069). Moreover, the protective effect of the 3111T/C gene variant may be enhanced in those women with a high physical activity practice. We found that women practicing more than 16.8 METs- h/week had a significantly lower overweight/obesity risk (OR 0.36, 95%CI: 0.17-0.79, p=0.011). A significant interaction between the 3111T/C gene variant and physical activity for overweight/obesity risk was observed in women (p for [PA x CLOCK] interaction=0.015). In conclusion, it appears that physical activity levels may act as an effect modifier for overweight/obesity risk linked to the 3111T/C SNP (rs1801260) of the CLOCK gene in an elderly population of the SUN Project

Regulación de la Expresión del Factor de Transcripción Pdx1 por Altas Concentraciones de Óxido Nítrico en Células Madre Embrionarias de Ratón

Estudios previos en nuestro laboratorio muestran que el óxido nítrico a altas concentraciones promueve la diferenciación de células madre embrionarias de ratón (mESC), e induce la expresión de genes de endodermo, entre ellos el factor de transcripción Pdx1, “Pancreas/duodenum homeobox protein 1”. Pdx1, tiene un rol importante en el desarrollo embrionario del páncreas y en la células beta madura. Con el fin de conocer los mecanismos por los que el NO incrementa la expresión de Pdx1, hemos estudiado la región promotora de este gen, encontrando que la expresión de Pdx1 se asocia con la liberación del factor de transcripción Egr1. Además, análisis epigenéticos del promotor muestran que la expresión de Pdx1 va asociada a un cambio en el patrón de metilación de su promotor y a la ocupación de marcas de histonas activadoras (H3Ac y H3K4me3) y a la desocupación de modificadores represores de histonas (HDAC) en el promotor de Pdx1

A Conformation Selective Mode of Inhibiting SRC Improves Drug Efficacy and Tolerability

43 p.-5 fig.Despite the approval of several multikinase inhibitors that target SRC and the overwhelming evidence of the role of SRC in the progression and resistance mechanisms of many solid malignancies, inhibition of its kinase activity has thus far failed to improve patient outcomes. Here we report the small molecule eCF506 locks SRC in its native inactive conformation, thereby inhibiting both enzymatic and scaffolding functions that prevent phosphorylation and complex formation with its partner FAK. This unprecedented mechanism of action resulted in highly potent and selective pathway inhibition, in culture and in vivo. Treatment with eCF506 resulted in increased antitumor efficacy and tolerability in syngeneic murine cancer models, demonstrating significant therapeutic advantages over existing SRC/ABL inhibitors. Therefore, this novel mode of inhibiting SRC could lead to improved treatment of SRC-associated disorders.C.T. thanks the CMVM of the University of Edinburgh (Principal's scholarship). D.L. acknowledges support from the Spanish Ministry of Science, Innovation and Universities for the Spanish State Research Agency Retos Grant RTI2018-099318-B-I00, cofunded by the European Regional Development Fund (FEDER). E.R.W., J.C.D. and K.G.M. are funded by CRUK. J.R.L.O. acknowledges support from the Molecular Interactions Facility funds at the CIB-CSIC. T.V. is funded by H2020-MSCA-IF-2016-749299. RCM thanks the support from the Vice Rectorate for Research of the University of Granada. X.-F.L. and B.-Z.Q. are funded by a CRUK Career Development Fellowship (C49791/A17367). B.-Z.Q. also acknowledges support from an ERC Starting Grant (716379). C.S, M.C.F. and V.G.B are funded by CRUK Programme Grant C157/A15703. N.O.C. and A.U.B are grateful to the CMVM of the University of Edinburgh and Wellcome Trust for financial support (ISSF3).Peer reviewe

Statistical Significance of Precisely Repeated Intracellular Synaptic Patterns

Can neuronal networks produce patterns of activity with millisecond accuracy? It may seem unlikely, considering the probabilistic nature of synaptic transmission. However, some theories of brain function predict that such precision is feasible and can emerge from the non-linearity of the action potential generation in circuits of connected neurons. Several studies have presented evidence for and against this hypothesis. Our earlier work supported the precision hypothesis, based on results demonstrating that precise patterns of synaptic inputs could be found in intracellular recordings from neurons in brain slices and in vivo. To test this hypothesis, we devised a method for finding precise repeats of activity and compared repeats found in the data to those found in surrogate datasets made by shuffling the original data. Because more repeats were found in the original data than in the surrogate data sets, we argued that repeats were not due to chance occurrence. Mokeichev et al. (2007) challenged these conclusions, arguing that the generation of surrogate data was insufficiently rigorous. We have now reanalyzed our previous data with the methods introduced from Mokeichev et al. (2007). Our reanalysis reveals that repeats are statistically significant, thus supporting our earlier conclusions, while also supporting many conclusions that Mokeichev et al. (2007) drew from their recent in vivo recordings. Moreover, we also show that the conditions under which the membrane potential is recorded contributes significantly to the ability to detect repeats and may explain conflicting results. In conclusion, our reevaluation resolves the methodological contradictions between Ikegaya et al. (2004) and Mokeichev et al. (2007), but demonstrates the validity of our previous conclusion that spontaneous network activity is non-randomly organized

Perspectivas actuales de los sujetos de derecho

En este volumen se recogen las intervenciones del II Seminario Internacional Permanente del Departamento de Derecho Internacional, Eclesiástico y Filosofía del Derecho de la Universidad Carlos III de Madrid que se desarrolló en el curso académico 2010-2011Presentación / Rafael de Asís Roig. - Algunas reflexiones sobre el individuo en Derecho Internacional / Castor Díaz Barrado. - Sobre capacidad y derechos / Rafael de Asís Roig. - Derecho Común versus Derecho Especial : el individuo como sujeto del derecho de libertad de conciencia y religiosa en España y Portugal / Alejandro Torres Gutiérrez. - Las empresas transnacionales como actores y sujetos «potenciales» en la sociedad internacional / Romualdo Bermejo García. - Las minorías religiosas como sujetos de derechos en España : un sistema de desigualdad / José María Contreras Mazario. - Los colectivos como sujetos de Derecho / Olga Sánchez Martínez. - De «protectorado internacional» a Estado «protegido» (¿Es Kosovo un Estado?) / Cesáreo Gutiérrez Espada - Contra el Derecho Internacional : imperialismo americano y subjetividad jurídica / Cristina García Pascual. - Cooperación constitucional e internacionalidad de la Iglesia católica / Paulino Pardo Prieto. - El individuo como titular de la libertad religiosa : aproximación a un problema de filosofía jurídica / Fernando Arlettaz. - La adopción de un procedimiento de comunicaciones individuales : ¿asignatura pendiente en la consolidación de la «subjetividad internacional del niño»? / Mª del Rosario Carmona Luque. - La persona con discapacidad como sujeto de derechos : análisis desde dos modelos / Patricia Cuenca Gómez. - Los sujetos de Derecho Internacional y los desastres internacionales / Carlos R. Fernández Liesa. - Los inmigrantes como colectivo : ¿son sujeto de Derecho Internacional? / Rosana Garciandía Garmendia. - La empresa : ¿Sujeto de Derecho Internacional? : Importancia de la cuestión / Hilda Garrido Suárez. - La tolerancia étnica y religiosa en los proyectos para la independencia del Estado búlgaro de la dominación otomana, el punto de partida del concepto legal sobre la protección de los derechos fundamentales de las minorias en Bulgaria / Ángel Hristov Kolev. - El régimen jurídico del profesorado y de la asignatura de religión católica en la escuela pública. Comentario a la STC 51/2011 de 14 de abril / Andrés Murcia González. - El sujeto de derecho en Pufendorf / Antonio Pele. - ¿Puede un sujeto de Derecho Internacional juzgar a otro? Algunas consideraciones sobre la inmunidad de jurisdicción de las organizaciones internacionales / Juan Jorge Piernas Lópe