835 research outputs found
Singlet vs Nonsinglet Perturbative Renormalization factors of Staggered Fermion Bilinears
In this paper we present the perturbative computation of the difference
between the renormalization factors of flavor singlet
(, : flavor index) and nonsinglet
() bilinear quark operators
(where ) on the lattice. The computation is performed to
two loops and to lowest order in the lattice spacing, using Symanzik improved
gluons and staggered fermions with twice stout-smeared links. The stout
smearing procedure is also applied to the definition of bilinear operators. A
significant part of this work is the development of a method for treating some
new peculiar divergent integrals stemming from the staggered formalism. Our
results can be combined with precise simulation results for the renormalization
factors of the nonsinglet operators, in order to obtain an estimate of the
renormalization factors for the singlet operators. The results have been
published in Physical Review D.Comment: 8 pages, 3 figures, 2 tables, Proceedings of the 35th International
Symposium on Lattice Field Theory, 18-24 June 2017, Granada, Spai
Nucleon form factors and moments of parton distributions in twisted mass lattice QCD
We present results on the electroweak form factors and on the lower moments
of parton distributions of the nucleon, within lattice QCD using two dynamical
flavors of degenerate twisted mass fermions. Results are obtained on lattices
with three different values of the lattice spacings, namely a=0.089 fm, a=0.070
fm and a=0.056 fm, allowing the investigation of cut-off effects. The volume
dependence is examined by comparing results on two lattices of spatial length
L=2.1 fm and L=2.8 fm. The simulations span pion masses in the range of 260-470
MeV. Our results are renormalized non-perturbatively and the values are given
in the MS-scheme at a scale mu=2 GeV.Comment: Talk presented in the XXIst International Europhysics Conference on
High Energy Physics, 21-27 July 2011, Grenoble, Rhones Alpes Franc
Perturbatively improving renormalization constants
Renormalization factors relate the observables obtained on the lattice to
their measured counterparts in the continuum in a suitable renormalization
scheme. They have to be computed very precisely which requires a careful
treatment of lattice artifacts. In this work we present a method to suppress
these artifacts by subtracting one-loop contributions proportional to the
square of the lattice spacing calculated in lattice perturbation theory.Comment: 7 pages, 2 figures, LATTICE 201
Renormalization of local quark-bilinear operators for Nf=3 flavors of SLiNC fermions
The renormalization factors of local quark-bilinear operators are computed
non-perturbatively for flavors of SLiNC fermions, with emphasis on the
various procedures for the chiral and continuum extrapolations. The simulations
are performed at a lattice spacing fm, and for five values of the
pion mass in the range of 290-465 MeV, allowing a safe and stable chiral
extrapolation. Emphasis is given in the subtraction of the well-known pion pole
which affects the renormalization factor of the pseudoscalar current. We also
compute the inverse propagator and the Green's functions of the local bilinears
to one loop in perturbation theory. We investigate lattice artifacts by
computing them perturbatively to second order as well as to all orders in the
lattice spacing. The renormalization conditions are defined in the RI-MOM
scheme, for both the perturbative and non-perturbative results. The
renormalization factors, obtained at different values of the renormalization
scale, are translated to the scheme and are evolved
perturbatively to 2 GeV. Any residual dependence on the initial renormalization
scale is eliminated by an extrapolation to the continuum limit. We also study
the various sources of systematic errors.
Particular care is taken in correcting the non-perturbative estimates by
subtracting lattice artifacts computed to one loop perturbation theory using
the same action. We test two different methods, by subtracting either the
contributions, or the complete (all orders in )
one-loop lattice artifacts.Comment: 33 pages, 27 figures, 6 table
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Dynamic interpersonal therapy for moderate to severe depression: A pilot randomized controlled and feasibility trial
Background: Improving Access to Psychological Therapies (IAPT) services treat most patients in England who present to primary care with major depression. Psychodynamic psychotherapy is one of the psychotherapies offered. Dynamic Interpersonal Therapy (DIT) is a psychodynamic and mentalization-based treatment for depression. 16 sessions are delivered over approximately 5 months. Neither DIT's effectiveness relative to low-intensity treatment (LIT), nor the feasibility of randomizing patients to psychodynamic or cognitive-behavioural treatments (CBT) in an IAPT setting has been demonstrated.
Methods: 147 patients were randomized in a 3:2:1 ratio to DIT (n = 73), LIT (control intervention; n = 54) or CBT (n = 20) in four IAPT treatment services in a combined superiority and feasibility design. Patients meeting criteria for major depressive disorder were assessed at baseline, mid-treatment (3 months) and post-treatment (6 months) using the Hamilton Rating Scale for Depression (HRSD-17), Beck Depression Inventory-II (BDI-II) and other self-rated questionnaire measures. Patients receiving DIT were also followed up 6 months post-completion.
Results: The DIT arm showed significantly lower HRSD-17 scores at the 6-month primary end-point compared with LIT (d = 0.70). Significantly more DIT patients (51%) showed clinically significant change on the HRSD-17 compared with LIT (9%). The DIT and CBT arms showed equivalence on most outcomes. Results were similar with the BDI-II. DIT showed benefit across a range of secondary outcomes.ConclusionsDIT delivered in a primary care setting is superior to LIT and can be appropriately compared with CBT in future RCTs
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On the merits of tetrapolar impedance spectroscopy for monitoring lithium concentration variations in human blood plasma
Bipolar disorder is characterized as a manic-depressive psychiatric syndrome with life-threatening risks to the patient. Diagnosed individuals undergo long-term lithium therapy which has proven to be effective for mood stabilization. Maintaining blood lithium concentration levels within a narrow therapeutic window between 0.6-1.5 mM is vital for the patient as slightly elevated concentrations of the order of 0.1 mM can be toxic. This paper aims to evaluate the merits of tetrapolar electrical impedance spectroscopy (TEIS) as an alternative method in monitoring blood Lithium levels. Measurements were performed using a custom-made tetrapolar probe in human blood plasma with Lithium concentrations covering the therapeutic range. The results indicate a limit of detection less than 0.1 mM and a response time of less than 5 s. Prediction of Lithium concentration levels using impedance values is in good agreement with conventional standard techniques to approximately 0.05 mM. This technique provides a basis for further development of instrumentation for point of care healthcare technologies
Culture and psychopathology: an attempt at reconsidering the role of social learning
This paper proposes a model for developmental psychopathology that is informed by recent research suggestive of a single model of mental health disorder (the p factor) and seeks to integrate the role of the wider social and cultural environment into our model, which has previously been more narrowly focused on the role of the immediate caregiving context. Informed by recently emerging thinking on the social and culturally driven nature of human cognitive development, the ways in which humans are primed to learn and communicate culture, and a mentalizing perspective on the highly intersubjective nature of our capacity for affect regulation and social functioning, we set out a cultural-developmental approach to psychopathology
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A Method for Rapid, Reliable, and Low-Volume Measurement of Lithium in Blood for Use in Bipolar Disorder Treatment Management
GOAL: Lithium preparations are considered the most reliable mood stabilizers for patients with Bipolar Disorder (BD), and are the most effective at reducing the risk of suicide. However, maintaining blood lithium concentration within the narrow therapeutic range of 0.4-1.2 mEq is crucial but extremely difficult. The aim of this work is to develop a personal lithium blood level analyzer using a novel method of combined optical and electrical impedance spectroscopy to test micro volumes of spiked samples of human blood. RESULTS: Impedance measurements alone showed a limit of detection of less than 0.1 mEq within the therapeutic range, whereas optical measurements could verify the presence of lithium and provide a degree of lithium content. Optical specificity to lithium was further verified in qualitative assessment of lithium spiked blood samples with varying concentrations of sodium. Moreover, analysis of multiple linear regression yielded a prediction model of R2 = 0.322716 and RMSEP =0.223602 for optical measurements only using feature wavelengths, which were found to appear at minima 560 and 605 nm. Combined with impedance measurements, prediction of lithium concentration in samples with unknown lithium content was significantly increased to R2 = 0.876438, and RMSEP = 0.513554. CONCLUSION: The combination of optical and impedance modalities for determinations of blood lithium resulted in significant improvement to the sensitivity and accuracy of measurement. SIGNIFICANCE: Results are complementary of the proposed opto-impedance method, and future work will now focus on the technical development of an integrated and miniaturized system for measurement of lithium levels in blood with a high level of accuracy and sensitivity
Nucleon scalar and tensor charges using lattice QCD simulations at the physical value of the pion mass
We present results on the light, strange and charm nucleon scalar and tensor
charges from lattice QCD, using simulations with flavors of twisted
mass Clover-improved fermions with a physical value of the pion mass. Both
connected and disconnected contributions are included, enabling us to extract
the isoscalar, strange and charm charges for the first time directly at the
physical point. Furthermore, the renormalization is computed non-perturbatively
for both isovector and isoscalar quantities. We investigate excited state
effects by analyzing several sink-source time separations and by employing a
set of methods to probe ground state dominance. Our final results for the
scalar charges are , ,
, and for the tensor charges
, ,
, in the scheme at 2~GeV. The first error is statistical, the second is the
systematic error due to the renormalization and the third the systematic
arising from possible contamination due to the excited states.Comment: 20 pages and 13 figure
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