Cavernous sinus thrombosis elicited by a central retinal vein venous stasis retinopathy

Background: Central retinal vein occlusion is a relatively common retinal disorder in the elderly, and those with cardiovascular or thrombophilic risk factors are at increased risk. Although still unsatisfying, some treatments for the acute and chronic phases have been established based on randomized studies. However, for rare conditions mimicking central retinal vein occlusion, treatment of the acute phase should be targeted at etiology. A rare condition mimicking central retinal vein occlusion in a 70-year-old man is presented and discussed. Methods: A 70-year-old man was admitted to the hospital for isovolemic hemodilution related to a central retinal vein occlusion of the elderly, after a sudden decrease in visual acuity to 0.1. Results: Clinical and laboratory work-up demonstrated a venous stasis retinopathy, related to an atypical cavernous sinus thrombosis of undetermined origin. The patient had experienced in the past 6 months intermittent diplopia and an irreducible conjunctival hyperemia. Hemodilution was dismissed. Soon after initiation of anticoagulation therapy, the patient's clinical signs and symptoms improved. Final visual acuity was 0.8. Conclusion: Venous stasis retinopathy secondary to cavernous sinus thrombosis is rare. However, careful clinical examination and extensive laboratory work-up is needed to exclude central retinal vein occlusion not associated with common vascular pathologies of the elderl

Parameterised Approximation of the Fixation Probability of the Dominant Mutation in the Multi-Type Moran Process

The multi-type Moran process is an evolutionary process on a connected graph $G$ in which each vertex has one of $k$ types and, in each step, a vertex $v$ is chosen to reproduce its type to one of its neighbours. The probability of a vertex $v$ being chosen for reproduction is proportional to the fitness of the type of $v$. So far, the literature was almost solely concerned with the $2$-type Moran process in which each vertex is either healthy (type $0$) or a mutant (type $1$), and the main problem of interest has been the (approximate) computation of the so-called fixation probability, i.e., the probability that eventually all vertices are mutants. In this work we initiate the study of approximating fixation probabilities in the multi-type Moran process on general graphs. Our main result is an FPTRAS (fixed-parameter tractable randomised approximation scheme) for computing the fixation probability of the dominant mutation; the parameter is the number of types and their fitnesses. In the course of our studies we also provide novel upper bounds on the expected absorption time, i.e., the time that it takes the multi-type Moran process to reach a state in which each vertex has the same type.Comment: 14 page

Radiogenic isotopes in enriched mid-ocean ridge basalts from Explorer Ridge, northeast Pacific Ocean

Extreme gradients in topography related to variations in magma supply are observed on the Southern Explorer Ridge (SER), part of the northern Juan de Fuca ridge system. We report radiogenic isotope (Pb, Sr, Nd, Hf) and geochemical data for twenty-four basalt whole-rock and glass samples collected from the length of the SER and from Explorer Deep, a rift to the north of the SER. Lavas from the SER form a north-south geochemical gradient, dominated by E-MORB at the northern axial high, and range from T-MORB to N-MORB towards the southern deepest part of the ridge. Linear relationships between incompatible element ratios and isotopic ratios in MORB along the ridge are consistent with mixing of magmas beneath the ridge to generate the geographic gradient from E- to N-MORB. The E-MORB have high Sr and Pb, and low Nd and Hf isotopic ratios, typical of enriched mantle that includes a FOZO or HIMU isotopic component. The West Valley and Endeavour segments of the northern Juan de Fuca ridge also include this isotopic component, but the proportion of the FOZO or HIMU component is more extreme in the SER basalts. The FOZO or HIMU component may be garnet-bearing peridotite, or a garnet pyroxenite embedded in peridotite. Recycled garnet pyroxenite better explains the very shallow SER axial high, high Nb/La and La/Sm, and the “enriched” isotopic compositions

Guidance on Stimulus Materials

PACHELBEL WP4 “Stimulus Materials” uses findings from WP3 (Policy Assumptions) and from additional sources to prepare stimulus materials for the group-based process “STAVE” implemented in WP5. The output was material to inform and stimulate the group-based process. The material was of two types: a set of questionnaires common to all partners (EVOC/CAPA/SIMI questionnaires), and material that is issue-specific and individually produced for each country. EVOC/CAPA/SIMI short questionnaires serve as a comparative tool between countries, giving insight on the social construction of “sustainable consumption” across the PACHELBEL population. Partners asked participants to fill out the set individually at the first meeting of the STAVE group, results were then analyzed and data were fed back for discussion by group participants at their second meeting. A “re-test” was then conducted at the third of three group meetings. The present report details the representations revealed through this methodology – but moreover the impact of applying such a technique in STAVE groups in France, Germany, Romania, Spain, Sweden and the UK (where the methodology was slightly altered). The issue-and-country-specific material consists of an informative simulated newspaper article on the particular issue addressed in a given STAVE process, and/or other materials (for example, humorous drawings). The report details how this material was developed, and the experience of applying these stimulus materials in each country. On this basis, guidance for future STAVE processes is offered. Foremost among observations is that PACHELBEL stimulus materials serve a purpose that is distinct from that of “group exercises” as developed in WP5. The materials contributing to the formation of a group identity, a reflexive group norm, and a shared information basis. As such, stimulus materials prepare the group for a cooperative investigative process

Evidence about the policy assumptions about lay behaviour

This deliverable provides an analysis of the early fieldwork reports that have been produced as part of WP3. Its focus is on identifying the assumptions that are evident in the approaches of the policy partners to human behaviour around sustainability. The themes of this early work will form one focus of subsequent interactions with the policy partners and will be used as the basis for developing a schedule for further investigations to be deployed with policy makers in each countr

L\u27amour de l\u27or : pour voix de basse

Un Vieillard tout creusé de rides,le front courbé,l\u27oeil scintillant,plongeait ses regards avides sur un trésor richeet brilliant:oh! disait il, que mon âme est ravie! c\u27est là mon sang,c\u27est là ma vie,c\u27est mon bonheur!c\u27est plus encor c\u27est mon amour c\u27est mon amour l\u27amour de l\u27or!de l\u27or de l\u27or de l\u27or de l\u27or toujour, de l\u27or! sans richesse, sans richesse,oh! mieux vaut mieux vaut la mort de l\u27or! de l\u27or! de l\u27or!toujours de l\u27or! de l\u27or! de l\u27or! de l\u27or! jusqu\u27a la mort! Loin de moi fuyez, jeunes femmes!non, vous neme seduirez pas!vous poète aux ardentes flammes, a mon coeur vous parlez trop bas:laissez moi contempler encore ces ducats au bruit plus sonore;ce langage parle plus fort:c\u27est mon amour!l\u27amour de l\u27or! Mais bientôt le vieillard cupide,la main brulante et l\u27oeil éteint,mourant sur un grabat humide,maudissait encor le destin.oh! lui diton, quittant la terre, l\u27amour du Ciel c\u27est la prière!non, non! le Ciel c\u27est ce trésor,et mon amour et mon amour, l\u27amour de l\u27or

Nina la glaneuse

Un jour Nina pauvre enfant du village,Au champ de blé d\u27un riche moissonneur,D\u27un pas discret, se rendait à l\u27ouvragePour recueillir quelques épis en fleurs. Belle elle éteat, sa voix enchanteresse;Avec quinze ans, c\u27était la sa richesse:Aussi le fils du fermier Mathurin,En soupirant répétait ce refrain: Glanez, glanez, ma petite glanense,Avec le tems avec le tems vous serez plus heureuse!Glanez, glanez, parmi ces épis d\u27or glanez, glanez, glanez, glanez ma petite glaneuse:Pour vous pour vous ces épis d\u27or muriront encor. Chacun savait que la pauvre fillette,Au bleu regard, au sourire charmant;La nuit, le jour pour sa mère inquièteAvec ardeur travaillait constamment; Aussi le soir près de sa vieille mère,Après avoir murmuré sa prière,Il lui semblait qu\u27une voix descendaitDu haut du Ciel et tout bas lui disait: Glanez Sa mère, hélas! solitaire et rêveuse,Reçut un jour le fermier Mathurin:Je viens, dit-il, voir ma jeune glaneuse,Et pour mon fils vous demander sa main. L\u27hymen bientôt exauça leur prièreEn un palais il change a la chaumière,Et le bon père heureux de leur bonheur,Priant pour eux, les bénit sur son coeur: Et puis il dit: ma petite glaneuse,Voici le tems, voici le tems d\u27etre enfin plus heureuse!Ne glanez plus, car tous mes épis d\u27orExprès pour vous exprès pour vous ma petite glaneuse,Exprès pour vous épis d\u27ormuriront encor