Non-critical, near extremal AdS_6 background as a holographic laboratory of four dimensional YM theory

We study certain properties of the low energy regime of a theory which resembles four dimensional YM theory in the framework of a non-critical holographic gravity dual. We use for the latter the near extremal $AdS_6$ non-critical SUGRA. We extract the glueball spectra that associates with the fluctuations of the dilaton, one form and the graviton and compare the results to those of the critical near extremal $D4$ model and lattice simulations. We show an area law behavior for the Wilson loop and screening for the 't Hooft loop. The Luscher term is found to be $-{3/24}\frac {\pi}{L}$. We derive the Regge trajectories of glueballs associated with the spinning folded string configurations.Comment: 25 pages, JHEP styl

S-matrix elements and off-shell tachyon action with non-abelian gauge symmetry

We propose that there is a unique expansion for the string theory S-matrix elements of tachyons that corresponds to non-abelian tachyon action. For those S-matrix elements which, in their expansion, there are the Feynman amplitudes resulting from the non-abelian kinetic term, we give a prescription on how to find the expansion. The gauge invariant action is an $\alpha'$ expanded action, and the tachyon mass $m$ which appears as coefficient of many different couplings, is arbitrary. We then analyze in details the S-matrix element of four tachyons and the S-matrix element of two tachyons and two gauge fields, in both bosonic and superstring theories, in favor of this proposal. In the superstring theory, the leading terms of the non-abelian gauge invariant couplings are in agreement with the symmetrised trace of the direct non-abelian generalization of the tachyonic Born-Infeld action in which the tachyon potential is consistent with $V(T)=e^{\pi\alpha' m^2T^2}$. In the bosonic theory, on the other hand, the leading terms are those appear in superstring case as well as some other gauge invariant couplings which spoils the symmetrised trace prescription. These latter terms are zero in the abelian case.Comment: Latex, 27 pages, no figures,v4:change the introduction section, add some notes to clarify the idea, add reference

Antibody decay, T cell immunity and breakthrough infections following two SARS-CoV-2 vaccine doses in inflammatory bowel disease patients treated with infliximab and vedolizumab

This is the final version. Available on open access from Nature Research via the DOI in this recordData availability: The study protocol including the statistical analysis plan is available at https://www.clarityibd.org/. Individual participant de-identified data that underlie the results reported in this article will be available immediately after publication for a period of 5 years. Due to the sensitive nature of the data, this will be made available to investigators whose proposed use of the data has been approved by an independent review committee. Analyses will be restricted to the aims in the approved proposal. Proposals should be directed to [email protected]. To gain access data requestors will need to sign a data access agreement. Data from the Virus Watch study is currently being archived on the Office of National Statistics Secure Research Service and will be available shortly. Source data are provided with this paper in the Source Data file. Source data are provided with this paper.Code availability: Statistical analyses were undertaken in R 4.1.2 (R Foundation for Statistical Computing, Vienna, Austria. Code has been made available at: https://github.com/exeteribd/clarityibd-public.Anti tumour necrosis factor (anti-TNF) drugs increase the risk of serious respiratory infection and impair protective immunity following pneumococcal and influenza vaccination. Here we report SARS-CoV-2 vaccine-induced immune responses and breakthrough infections in patients with inflammatory bowel disease, who are treated either with the anti-TNF antibody, infliximab, or with vedolizumab targeting a gut-specific anti-integrin that does not impair systemic immunity. Geometric mean [SD] anti-S RBD antibody concentrations are lower and half-lives shorter in patients treated with infliximab than vedolizumab, following two doses of BNT162b2 (566.7 U/mL [6.2] vs 4555.3 U/mL [5.4], p <0.0001; 26.8 days [95% CI 26.2 - 27.5] vs 47.6 days [45.5 - 49.8], p <0.0001); similar results are also observed with ChAdOx1 nCoV-19 vaccination (184.7 U/mL [5.0] vs 784.0 U/mL [3.5], p <0.0001; 35.9 days [34.9 - 36.8] vs 58.0 days [55.0 - 61.3], p value < 0.0001). One fifth of patients fail to mount a T cell response in both treatment groups. Breakthrough SARS-CoV-2 infections are more frequent (5.8% (201/3441) vs 3.9% (66/1682), p = 0.0039) in patients treated with infliximab than vedolizumab, and the risk of breakthrough SARS-CoV-2 infection is predicted by peak anti-S RBD antibody concentration after two vaccine doses. Irrespective of the treatments, higher, more sustained antibody levels are observed in patients with a history of SARS-CoV-2 infection prior to vaccination. Our results thus suggest that adapted vaccination schedules may be required to induce immunity in at-risk, anti-TNF-treated patients

Rapid Changes in Strength and Direction of Earth's Magnetic Field Over the Past 100,000 Years

Previous studies of rapid geomagnetic changes have highlighted the most extreme changes in direction and field strength found in paleomagnetic field models over the past 100 ky. Here we study distributions of rates of change in both time and space. Field models based on direct observations provide the most accurate values for rates of change, but their short duration precludes a complete description of field behavior. Broader representation is provided by time-varying paleofield models, here including GGF100k, GGFSS70, LSMOD.2, CALS10k.2, HFM.OL1.A1, pfm9k.2, and SHAWQ-iron age although variability across models and lack of temporal and spatial resolution of fine scale variations make direct comparisons difficult. For the paleofield we define rapid changes as exceeding the peak overall value of 0.4° yr−1 for directional changes and 150 nT yr−1 for intensities as established by the gufm1 model spanning 1590–1990 CE. We find that rapid directional changes are associated with low field strength and can spread across all latitudes during such episodes. Distributions of directional rates of change exhibit high skewness for models that include excursions. Rates of change in field intensity exceeding 150 nT yr−1 arise in brief intervals during the Holocene particularly associated with the strong field Levantine Iron Age Anomaly. Around the Laschamp excursion there are also rare localized occurrences of rapid intensity change. Limitations in current models make it difficult to define absolute rates for past changes, but we see that rapid changes are essential field characteristics not observed in the modern field that should nevertheless be regarded as an essential for Earth-like dynamo simulations

Green chemistry metrics and life cycle assessment for microflow continuous processing: Part 11. green metrics

In this chapter, major green metrics are described as they have been applied to microflow continuous processes (e.g., mass intensity (MI)/process mass intensity (PMI), E‐factor, atom economy, etc.). Thereafter, life cycle assessment (LCA) and life cycle costing (LCC) analysis are reviewed in the framework of their application to evaluate microflow continuous processes. Green metrics, LCA, and LCC allow an objective quantitative measurement and decision support tool to evaluate the ecological, environmental as well as the economic impact of a chemical synthesis and process. Within the approach of green chemistry, continuous microflow processing has become a major method to achieve process intensification and engineering support. Accordingly, the specific sustainability characteristics of microflow continuous processes will be described. A comparison of microscale continuous processes and conventional macroscale processes accompanied by green metrics and LCA will be conducted. This is done in a hierarchical manner, starting from single microflow reaction optimization (both with single and bundled innovation drivers) toward combined microflow reaction separation and microflow multistep reactions. The production volume under consideration is both small (pharma) and large (fine/bulk chemical). This scenario analysis allows one to draw some generic conclusions about the environmental opportunities of continuous microflow technology and, vice versa, on the suitability of these green assessment tools. Each case scenario is for a typical, mostly experimentally validated microreactor application and illustrates the pros and cons of microflow continuous processes in the fine chemical and pharmaceutical industry. The environmental analysis is completed by a snapshot of LCC analysis for these microreactor case scenarios

Model uncertainty in the ecosystem approach to fisheries

Fisheries scientists habitually consider uncertainty in parameter values, but often neglect uncertainty about model structure. The importance of this latter source of uncertainty is likely to increase with the greater emphasis on ecosystem models in the move to an ecosystem approach to fisheries (EAF). It is therefore necessary to increase awareness about pragmatic approaches with which fisheries modellers and managers can account for model uncertainty and so we review current ways of dealing with model uncertainty in fisheries and other disciplines. These all involve considering a set of alternative models representing different structural assumptions, but differ in how those models are used. The models can be used to identify bounds on possible outcomes, find management actions that will perform adequately irrespective of the true model, find management actions that best achieve one or more objectives given weights assigned to each model, or formalise hypotheses for evaluation through experimentation. Data availability is likely to limit the use of approaches that involve weighting alternative models in an ecosystem setting, and the cost of experimentation is likely to limit its use. Practical implementation of the EAF should therefore be based on management approaches that acknowledge the uncertainty inherent in model predictions and are robust to it. Model results must be presented in a way that represents the risks and trade-offs associated with alternative actions and the degree of uncertainty in predictions. This presentation should not disguise the fact that, in many cases, estimates of model uncertainty may be based on subjective criteria. The problem of model uncertainty is far from unique to fisheries, and coordination among fisheries modellers and modellers from other communities will therefore be useful

Chiral symmetry breaking and pions in nonsupersymmetric gauge/gravity duals

We study gravity duals of large N nonsupersymmetric gauge theories with matter in the fundamental representation by introducing a D7-brane probe into deformed AdS backgrounds. In particular, we consider a D7-brane probe in both the AdS Schwarzschild black hole solution and in the background found by Constable and Myers, which involves a nonconstant dilaton and S5 radius. Both these backgrounds exhibit confinement of fundamental matter and a discrete glueball and meson spectrum. We numerically compute the Psi-bar Psi condensate and meson spectrum associated with these backgrounds. In the AdS–black-hole background, a quark-bilinear condensate develops only at a nonzero quark mass. We speculate on the existence of a third order phase transition at a critical quark mass where the D7 embedding undergoes a geometric transition. In the Constable-Myers background, we find a chiral symmetry breaking condensate as well as the associated Goldstone boson in the limit of small quark mass. The existence of the condensate ensures that the D7-brane never reaches the naked singularity at the origin of the deformed AdS space. <br/

Management development: a literature review and implications for future research – Part I: Conceptualisations and Practices

Interest in management development is mushrooming. The number of articles which address different aspects of it are likewise increasing apace. This has heightened the need for a broad-based review which will pull the material together, give shape to it, evaluate it and draw out its implications. In this, the first of a two-part article, this task is commenced