FIR/submm spectroscopy with Herschel: first results from the VNGS and H-ATLAS surveys

The FIR/submm window is one of the least-studied regions of the electromagnetic spectrum, yet this wavelength range is absolutely crucial for understanding the physical processes and properties of the ISM in galaxies. The advent of the Herschel Space Observatory has opened up the entire FIR/submm window for spectroscopic studies. We present the first FIR/submm spectroscopic results on both nearby and distant galaxies obtained in the frame of two Herschel key programs: the Very Nearby Galaxies Survey and the Herschel ATLAS

Divergent mutational processes distinguish hypoxic and normoxic tumours.

Many primary tumours have low levels of molecular oxygen (hypoxia), and hypoxic tumours respond poorly to therapy. Pan-cancer molecular hallmarks of tumour hypoxia remain poorly understood, with limited comprehension of its associations with specific mutational processes, non-coding driver genes and evolutionary features. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, which aggregated whole genome sequencing data from 2658 cancers across 38 tumour types, we quantify hypoxia in 1188 tumours spanning 27 cancer types. Elevated hypoxia associates with increased mutational load across cancer types, irrespective of underlying mutational class. The proportion of mutations attributed to several mutational signatures of unknown aetiology directly associates with the level of hypoxia, suggesting underlying mutational processes for these signatures. At the gene level, driver mutations in TP53, MYC and PTEN are enriched in hypoxic tumours, and mutations in PTEN interact with hypoxia to direct tumour evolutionary trajectories. Overall, hypoxia plays a critical role in shaping the genomic and evolutionary landscapes of cancer

Specifying sickle cell disease interventions: A study protocol of the Sickle Cell Disease Implementation Consortium (SCDIC)

Abstract Background Sickle cell disease (SCD) is an inherited blood disorder that results in a lifetime of anemia, severe pain, and end-organ damage that can lead to premature mortality. While the SCD field has made major medical advances, much needs to be done to improve the quality of care for people with SCD. This study capitalizes on the Sickle Cell Disease Implementation Consortium (SCDIC), a consortium of eight academic sites aiming to test implementation strategies that could lead to more accelerated application of the NHLBI guidelines for treating SCD. This report documents the process to support the consortium by specifying the interventions being developed. Methods This study consists of three steps. The Principal Investigator of each site and two site representatives who are knowledgeable of the intervention (e.g., study coordinator or the person delivering the intervention) will answer an online survey aiming to capture components of the interventions. This survey will be completed by the site representatives three times during the study: during the development of the interventions, after one year of the interventions being implemented, and at the end of this study (after 2 years). A site visit and semi-structured interview (Step 2) in the first year of the process will capture the context of the sites. Step 3 comprises of the development of a framework with the details of the multi-component SCDIC interventions at the sites. Discussion The outcome of this study, a framework of the SCDIC, will enable accurate replication and extension of published research, facilitating the translation of SCD studies to diverse populations and settings and allowing for theory testing of the effects of the intervention components across studies in different contexts and for different populations. Trial registration ClinicalTrial.Gov (#NCT03380351). Registered December 21, 2017

Contextual diversity, not word frequency, determines word-naming and lexical decision times

Word frequency is an important predictor of word-naming and lexical decision times. It is, however, confounded with contextual diversity, the number of contexts in which a word has been seen. In a study using a normative, corpus-based measure of contextual diversity, word-frequency effects were eliminated when effects of contextual diversity were taken into account (but not vice versa) across three naming and three lexical decision data sets; the same pattern of results was obtained regardless of which of three corpora was used to derive the frequency and contextual-diversity values. The results are incompatible with existing models of visual word recognition, which attribute frequency effects directly to frequency, and are particularly problematic for accounts in which frequency effects reflect learning. We argue that the results reflect the importance of likely need in memory processes, and that the continuity between reading and memory suggests using principles from memory research to inform theories of reading

Interprofessional education for first year psychology students: career plans, perceived relevance and attitudes

Undergraduate psychology students have been largely excluded from interprofessional education (IPE) initiatives. In contrast to many health professions, undergraduate psychology students do not engage in work placements as part of their degree, and many enter careers outside the health care context. However, the collaborative skills gained through an IPE experience may well be beneficial to students who work in this wider context. This research examines whether undergraduate psychology students’ views of IPE vary according to their planned career directions, and if so, whether the perceived relevance of IPE mediates the relationships. A sample of 188 Australian university undergraduate psychology students completed an online questionnaire following completion of a first-year IPE health sciences program. Path analysis indicated that psychology students’ attitudes towards IPE are associated with both professional identification and practitioner orientation, fully mediated through the perceived relevance of IPE to future career and study plans. Stronger professional identification and practitioner orientation were associated with greater perceived relevance and more positive and less negative attitudes towards IPE. Placing a stronger emphasis on the generalizability of IP skills taught may increase students’ awareness of the relevance outside of the health context, reducing disengagement of students planning alternative careers

FESTA. D6.3. FOT requirements, legal aspects planning and development

The FESTA Support Action Questionnaire to collect stakeholders' needs and indications on Field Operational Tests was a part of FESTA Task T6.1 – Analysis of the different stakeholders and their needs, relevant aspects and requirements on different level of FOT deployment. The questionnaire question sets were designed in cooperation between VTT and CRF during November-December 2007. The survey was performed by VTT through a web survey tool “SurveyMonkey”, which serves several purposes: e.g. designing surveys, collecting responses, sending invitations and reminders and downloading or analysing the results. The web survey was opened on 13th December 2007, right after the FESTA Stakeholder Workshop in Brussels. The opening of the survey was announced to the target group members by an email invitation which included an individual hyperlink to the survey. The recipient list for the invitation was mostly based on the Stakeholder Workshop attendance list that was supplemented by CRF and VTT with the other known FOT stakeholders. Two reminder email rounds were sent out to those who had received an invitation to the survey but had not responded – the first one on 21st December 2007 and the final one on 10th January 2008. The survey was closed on 24th January 2008. The results reported are synthesised from the answers given by the respondents on the questions, which are given in Appendix 1. Next to the presentation of the results, some conclusions are drawn

Euclid : Forecast constraints on consistency tests of the Lambda CDM model

Context. The standard cosmological model is based on the fundamental assumptions of a spatially homogeneous and isotropic universe on large scales. An observational detection of a violation of these assumptions at any redshift would immediately indicate the presence of new physics. Aims. We quantify the ability of the Euclid mission, together with contemporary surveys, to improve the current sensitivity of null tests of the canonical cosmological constant Lambda and the cold dark matter (Lambda CDM) model in the redshift range 0 < z < 1.8. Methods. We considered both currently available data and simulated Euclid and external data products based on a Lambda CDM fiducial model, an evolving dark energy model assuming the Chevallier-Polarski-Linder parameterization or an inhomogeneous Lemaitre-Tolman-Bondi model with a cosmological constant Lambda, and carried out two separate but complementary analyses: a machine learning reconstruction of the null tests based on genetic algorithms, and a theory-agnostic parametric approach based on Taylor expansion and binning of the data, in order to avoid assumptions about any particular model. Results. We find that in combination with external probes, Euclid can improve current constraints on null tests of the Lambda CDM by approximately a factor of three when using the machine learning approach and by a further factor of two in the case of the parametric approach. However, we also find that in certain cases, the parametric approach may be biased against or missing some features of models far from Lambda CDM Conclusions. Our analysis highlights the importance of synergies between Euclid and other surveys. These synergies are crucial for providing tighter constraints over an extended redshift range for a plethora of different consistency tests of some of the main assumptions of the current cosmological paradigm.Peer reviewe