274 research outputs found
Effective medium theory of elastic waves in random networks of rods
We formulate an effective medium (mean field) theory of a material consisting
of randomly distributed nodes connected by straight slender rods, hinged at the
nodes. Defining novel wavelength-dependent effective elastic moduli, we
calculate both the static moduli and the dispersion relations of ultrasonic
longitudinal and transverse elastic waves. At finite wave vector the waves
are dispersive, with phase and group velocities decreasing with increasing wave
vector. These results are directly applicable to networks with empty pore
space. They also describe the solid matrix in two-component (Biot) theories of
fluid-filled porous media. We suggest the possibility of low density materials
with higher ratios of stiffness and strength to density than those of foams,
aerogels or trabecular bone.Comment: 14 pp., 3 fig
Loop Quantum Cosmology, Boundary Proposals, and Inflation
Loop quantum cosmology of the closed isotropic model is studied with a
special emphasis on a comparison with traditional results obtained in the
Wheeler-DeWitt approach. This includes the relation of the dynamical initial
conditions with boundary conditions such as the no-boundary or the tunneling
proposal and a discussion of inflation from quantum cosmology.Comment: 20 pages, 6 figure
Period-doubling bifurcation in strongly anisotropic Bianchi I quantum cosmology
We solve the Wheeler-DeWitt equation for the minisuperspace of a cosmological
model of Bianchi type I with a minimally coupled massive scalar field as
source by generalizing the calculation of Lukash and Schmidt [1]. Contrarily to
other approaches we allow strong anisotropy. Combining analytical and numerical
methods, we apply an adiabatic approximation for , and as new feature we
find a period-doubling bifurcation. This bifurcation takes place near the
cosmological quantum boundary, i.e., the boundary of the quasiclassical region
with oscillating -function where the WKB-approximation is good. The
numerical calculations suggest that such a notion of a ``cosmological quantum
boundary'' is well-defined, because sharply beyond that boundary, the
WKB-approximation is no more applicable at all. This result confirms the
adequateness of the introduction of a cosmological quantum boundary in quantum
cosmology.Comment: Latest update of the paper at
http://www.physik.fu-berlin.de/~mbach/publics.html#
Metal-macrofauna interactions determine microbial community structure and function in copper contaminated sediments
Peer reviewedPublisher PD
Robustness in Glyoxylate Bypass Regulation
The glyoxylate bypass allows Escherichia coli to grow on carbon sources with only two carbons by bypassing the loss of carbons as CO2 in the tricarboxylic acid cycle. The flux toward this bypass is regulated by the phosphorylation of the enzyme isocitrate dehydrogenase (IDH) by a bifunctional kinase–phosphatase called IDHKP. In this system, IDH activity has been found to be remarkably robust with respect to wide variations in the total IDH protein concentration. Here, we examine possible mechanisms to explain this robustness. Explanations in which IDHKP works simultaneously as a first-order kinase and as a zero-order phosphatase with a single IDH binding site are found to be inconsistent with robustness. Instead, we suggest a robust mechanism where both substrates bind the bifunctional enzyme to form a ternary complex
Glueballs and the superfluid phase of Two-Color QCD
We present the first results on scalar glueballs in cold, dense matter using
lattice simulations of two color QCD. The simulations are carried out on a lattice and use a standard hybrid molecular dynamics algorithm for
staggered fermions for two values of quark mass. The glueball correlators are
evaluated via a multi-step smearing procedure. The amplitude of the glueball
correlator peaks in correspondence with the zero temperature chiral transition,
, and the propagators change in a significant way in the
superfluid phase, while the Polyakov loop is mearly insensitive to the
transition. Standard analysis suggest that lowest mass in the gluonic
channel decreases in the superfluid phase, but these observations need to be
confirmed on larger and more elongated lattices These results indicate that a
nonzero density induces nontrivial modifications of the gluonic medium.Comment: 26 pages, 13 figures; discussions and one figure added; to appear in
EPJ
PRegnancy Outcomes after a Maternity Intervention for Stressful EmotionS (PROMISES): study protocol for a randomised controlled trial
<p>Abstract</p> <p>Background</p> <p>There is ample evidence from observational prospective studies that maternal depression or anxiety during pregnancy is a risk factor for adverse psychosocial outcomes in the offspring. However, to date no previous study has demonstrated that treatment of depressive or anxious symptoms in pregnancy actually could prevent psychosocial problems in children. Preventing psychosocial problems in children will eventually bring down the huge public health burden of mental disease. The main objective of this study is to assess the effects of cognitive behavioural therapy in pregnant women with symptoms of anxiety or depression on the child's development as well as behavioural and emotional problems. In addition, we aim to study its effects on the child's development, maternal mental health, and neonatal outcomes, as well as the cost-effectiveness of cognitive behavioural therapy relative to usual care.</p> <p>Methods/design</p> <p>We will include 300 women with at least moderate levels of anxiety or depression at the end of the first trimester of pregnancy. By including 300 women we will be able to demonstrate effect sizes of 0.35 or over on the total problems scale of the child behavioural checklist 1.5-5 with alpha 5% and power (1-beta) 80%.</p> <p>Women in the intervention arm are offered 10-14 individual cognitive behavioural therapy sessions, 6-10 sessions during pregnancy and 4-8 sessions after delivery (once a week). Women in the control group receive care as usual.</p> <p>Primary outcome is behavioural/emotional problems at 1.5 years of age as assessed by the total problems scale of the child behaviour checklist 1.5 - 5 years.</p> <p>Secondary outcomes will be mental, psychomotor and behavioural development of the child at age 18 months according to the Bayley scales, maternal anxiety and depression during pregnancy and postpartum, and neonatal outcomes such as birth weight, gestational age and Apgar score, health care consumption and general health status (economic evaluation).</p> <p>Trial Registration</p> <p>Netherlands Trial Register (NTR): <a href="http://www.trialregister.nl/trialreg/admin/rctview.asp?TC=2242">NTR2242</a></p
Loop Quantum Cosmology
Quantum gravity is expected to be necessary in order to understand situations
where classical general relativity breaks down. In particular in cosmology one
has to deal with initial singularities, i.e. the fact that the backward
evolution of a classical space-time inevitably comes to an end after a finite
amount of proper time. This presents a breakdown of the classical picture and
requires an extended theory for a meaningful description. Since small length
scales and high curvatures are involved, quantum effects must play a role. Not
only the singularity itself but also the surrounding space-time is then
modified. One particular realization is loop quantum cosmology, an application
of loop quantum gravity to homogeneous systems, which removes classical
singularities. Its implications can be studied at different levels. Main
effects are introduced into effective classical equations which allow to avoid
interpretational problems of quantum theory. They give rise to new kinds of
early universe phenomenology with applications to inflation and cyclic models.
To resolve classical singularities and to understand the structure of geometry
around them, the quantum description is necessary. Classical evolution is then
replaced by a difference equation for a wave function which allows to extend
space-time beyond classical singularities. One main question is how these
homogeneous scenarios are related to full loop quantum gravity, which can be
dealt with at the level of distributional symmetric states. Finally, the new
structure of space-time arising in loop quantum gravity and its application to
cosmology sheds new light on more general issues such as time.Comment: 104 pages, 10 figures; online version, containing 6 movies, available
at http://relativity.livingreviews.org/Articles/lrr-2005-11
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