The Hybrid Hanger: A lightweight, portable hang-on tree stand with high durability and ease of use.

The Hybrid Hanger is a fully carbon fiber-epoxy composite hang-on tree stand. This 12-pound tree stand design allows a hunter to carry the stand further without fatiguing, which is perfect for public land hunters. In order to support the weight of a person and the harshness of hunting environments, the Hybrid Hanger will need to be strong and weather resistant. It has been tested to 600 pounds and the carbon fiber is an improvement upon the current metal stands of today’s market. Other qualities of the Hybrid Hanger that improve upon current tree stands in the market include: noise reduction, corrosion 41 resistance, and the compact and sleek design. The Hybrid Hanger will also be foldable with backpack straps to easily carry on a hunter’s back as they walk to their hunting location.https://openriver.winona.edu/urc2019/1021/thumbnail.jp

Leptin fails to blunt the lipopolysaccharide-induced activation of the hypothalamic-pituitary-adrenal axis in rats

Copyright @ 2013 The authors. This work is licensed under a Creative Commons Attribution 3.0 Unported License.Obesity is a risk factor for sepsis morbidity and mortality, whereas the hypothalamic-pituitary-adrenal (HPA) axis plays a protective role in the body's defence against sepsis. Sepsis induces a profound systemic immune response and cytokines serve as excellent markers for sepsis as they act as mediators of the immune response. Evidence suggests that the adipokine leptin may play a pathogenic role in sepsis. Mouse endotoxaemic models present with elevated leptin levels and exogenously added leptin increased mortality whereas human septic patients have elevated circulating levels of the soluble leptin receptor (Ob-Re). Evidence suggests that leptin can inhibit the regulation of the HPA axis. Thus, leptin may suppress the HPA axis, impairing its protective role in sepsis.We hypothesised that leptin would attenuate the HPA axis response to sepsis.We investigated the direct effects of an i.p. injection of 2 mg/kg leptin on the HPA axis response to intraperitoneally injected 25 μg/kg lipopolysaccharide (LPS) in the male Wistar rat. We found that LPS potently activated the HPA axis, as shown by significantly increased plasma stress hormones, ACTH and corticosterone, and increased plasma interleukin 1β (IL1β) levels, 2 h after administration. Pre-treatment with leptin, 2 h before LPS administration, did not influence the HPA axis response to LPS. In turn, LPS did not affect plasma leptin levels. Our findings suggest that leptin does not influence HPA function or IL1b secretion in a rat model of LPS-induced sepsis, and thus that leptin is unlikely to be involved in the acute-phase endocrine response to bacterial infection in rats.The section is funded by grants from the MRC, BBSRC, NIHR and an Integrative Mammalian Biology (IMB) Capacity Building Award, and by a FP7-HEALTH-2009-241592 EuroCHIP grant and is supported by the NIHR Imperial Biomedical Research Centre Funding Scheme. This work is supported by a BBSRC Doctoral Training-Strategic Skills Award grant (BB/F017340/1)

Exquisite sensitivity of the ligand field to solvation and donor polarisability in coordinatively saturated lanthanide complexes

Crystallographic, emission and NMR studies of a series of C3-symmetric, nine-coordinate substituted pyridyl triazacyclononane Yb(III) and Eu(III) complexes reveal the impact of local solvation and ligand dipolar polarisability on ligand field strength, leading to dramatic variations in pseudocontact NMR shifts and emission spectral profiles, giving new guidance for responsive NMR and spectral probe design

Spectrophotometric determination of chromium as the chromium-peroxo-4-(2-pyridylazo)resorcinol complex

Der ternäre Chrom-Peroxo-PAR-Komplex weist einen scheinbaren molaren Extinktionskoeffizienten von 6280 l · mol −1 · cm −1 auf, wenn er aus 0,1 M schwefelsaurer Lösung mit Ethylacetat extrahiert wird. Das Beersche Gesetz wird bis zu 6,0 μg Cr/ml befolgt. Die Bedingungen für eine optimale Farbbildung, die Zusammensetzung des Komplexes, die Wirkung verschiedener Begleitionen und die Anwendung auf Stähle werden beschrieben. The ternary complex chromium-peroxo-PAR exhibits an apparent molar absorptivity of 6280 l mol −1 cm −1 when extracted into ethyl acetate from 0.1 M sulfuric acid solution. Beer's law is followed for solutions containing up to 6.0 μg Cr ml −1 . Conditions for optimum color formation, complex composition, effects of diverse ions, and application to the determination of chromium in steels are described.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/46457/1/216_2004_Article_BF00480608.pd

Childhood solid tumours in relation to infections in the community in Cumbria during pregnancy and around thetime of birth

In a retrospective cohort study of all 99 976 live births in Cumbria, 1975–1992, we investigated whether higher levels of community infections during the mother's pregnancy and in early life were risk factors for solid tumours (brain/spinal and other tumours), diagnosed 1975–1993 under age 15 years. Logistic regression was used to relate risk to incidence of community infections in three prenatal and two postnatal quarters. There was an increased risk of brain/spinal tumours among children exposed around or soon after birth to higher levels of community infections, in particular measles (OR for trend=2.1, 95%CI : 1.3–3.6, P=0.008) and influenza (OR for exposure=3.3, 95%CI : 1.5–7.4, P=0.005). There was some evidence of an association between exposure to infections around and soon after birth and risk of other tumours, but this may have been a chance finding. The findings are consistent with other recent epidemiological studies suggesting brain tumours may be associated with perinatal exposure to infections

Biochemical adaptations of the retina and retinal pigment epithelium support a metabolic ecosystem in the vertebrate eye

Here we report multiple lines of evidence for a comprehensive model of energy metabolism in the vertebrate eye. Metabolic flux, locations of key enzymes, and our finding that glucose enters mouse and zebrafish retinas mostly through photoreceptors support a conceptually new model for retinal metabolism. In this model, glucose from the choroidal blood passes through the retinal pigment epithelium to the retina where photoreceptors convert it to lactate. Photoreceptors then export the lactate as fuel for the retinal pigment epithelium and for neighboring Mu ̈ ller glial cells. We used human retinal epithelial cells to show that lactate can suppress consumption of glucose by the retinal pigment epithelium. Suppression of glucose consumption in the retinal pigment epithelium can increase the amount of glucose that reaches the retina. This framework for understanding metabolic relationships in the vertebrate retina provides new insights into the underlying causes of retinal disease and age-related vision loss