4,083 research outputs found
Role of Apolipoprotein E in Anxiety
Anxiety is most common among Alzheimer's disease (AD) patients with an age at onset under age 65. Apolipoprotein E4 (apoE4) is a risk factor for
developing AD at an earlier age and might contribute to this effect. In
mice, apoE plays a role in the regulation of anxiety, which might involve
histamine receptor-mediated signaling and steroidogenesis in the adrenal
gland. In addition, human apoE isoforms have differential effects on anxiety
in adult mice lacking apoE and probable AD patients. Compared to wild-type
mice, mice lacking apoE and apoE4 mice showed pathological alterations in
the central nucleus of the amygdala, which is involved in regulation of
anxiety. ApoE4, but not mice lacking apoE, or apoE3 mice showed impaired
dexamethasone suppression of plasma corticosterone. Understanding how apoE
modulates measures of anxiety might help the developments of therapeutic
targets to reduce or even prevent measures of anxiety in health and in
dementing illnesses
Laser space rendezvous and docking tradeoff
A spaceborne laser radar (LADAR) was configured to meet the requirements for rendezvous and docking with a cooperative object in synchronous orbit. The LADAR, configurated using existing pulsed CO2 laser technology and a 1980 system technology baseline, is well suited for the envisioned space tug missions. The performance of a family of candidate LADARS was analyzed. Tradeoff studies as a function of size, weight, and power consumption were carried out for maximum ranges of 50, 100, 200, and 300 nautical miles. The investigation supports the original contention that a rendezvous and docking LADAR can be constructed to offer a cost effective and reliable solution to the envisioned space missions. In fact, the CO2 ladar system offers distinct advantages over other candidate systems
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