Measuring Well-Being: A Review of Instruments

Interest in the study of psychological health and well-being has increased significantly in recent decades. A variety of conceptualizations of psychological health have been proposed including hedonic and eudaimonic well-being, quality-of-life, and wellness approaches. Although instruments for measuring constructs associated with each of these approaches have been developed, there has been no comprehensive review of well-being measures. The present literature review was undertaken to identify self-report instruments measuring well-being or closely related constructs (i.e., quality of life and wellness) and critically evaluate them with regard to their conceptual basis and psychometric properties. Through a literature search, we identified 42 instruments that varied significantly in length, psychometric properties, and their conceptualization and operationalization of well-being. Results suggest that there is considerable disagreement regarding how to properly understand and measure well-being. Research and clinical implications are discussed

The Unpaid Internship: Benefits, Drawbacks, and Legal Issues

This article hopes to clear up some of the confusion surrounding unpaid internships by discussing who participates in such internships, the merits and drawbacks relative to paid internships, and the relevant legal issues. This summary of existing research provides several key insights, which are of interest to potential interns as well as educators. For students, the literature suggests that unpaid internships are different from their paid counterparts in a variety of ways and pose certain risks that paid internships do not. On an institutional level, this paper documents the unique legal environment surrounding the unpaid internship and notes the unique liabilities program administrators may face if they fail to act with caution

Emigration from Two Labor Frontier Nations : A Comparison of Moroccans in Spain and Mexicans in the United States

Mexico and Morocco share many common characteristics as labor migrant pools for industrialized countries to the North. However, comparisons between migrants from each country are few, particularly with respect to economic outcomes using nationally representative data. Using recent immigrant surveys from Spain and the United States, this paper presents the first quantitative analysis to compare Moroccans and Mexicans, testing for the effects of human and social capital on employment, occupational attainment, and wages. Although the lower employment levels of Moroccans compared to Mexicans would seem to suggest greater labor market discrimination against Moroccans in Spain, closer inspection of the returns to various forms of capital and other inputs yields a more mixed picture. Both methodological and social explanations for these mixed findings are discussed.México y Marruecos comparten muchas características comunes, como la de ser países que exportan mano de obra a los vecinos países industrializados del norte. Sin embargo, los estudios comparativos entre los flujos migratorios de ambos son pocos, y menos aún lo son aquellos que utilizan a escala nacional datos representativos sobre resultados económicos. A través de la utilización de estudios recientes de España y EEUU, este artículo presenta el primer análisis cuantitativo que compara marroquíes y mexicanos, con el fin de indagar los efectos del capital social y humano en el empleo, en el logro profesional y los salarios. Aunque la ocupación en los puestos de trabajo menos cualificados de los marroquíes en España, en comparación con los mexicanos en EEUU, podría parecer sugerir una mayor discriminación en el mercado laboral de los primeros, al inspeccionar el retorno de varias formas de capital y otros inputs, se infiere una explicación algo más compleja. Tanto la explicación metodológica como la social, serán ampliamente discutidas aquí

Quantifying evolutionary constraints on B cell affinity maturation

The antibody repertoire of each individual is continuously updated by the evolutionary process of B cell receptor mutation and selection. It has recently become possible to gain detailed information concerning this process through high-throughput sequencing. Here, we develop modern statistical molecular evolution methods for the analysis of B cell sequence data, and then apply them to a very deep short-read data set of B cell receptors. We find that the substitution process is conserved across individuals but varies significantly across gene segments. We investigate selection on B cell receptors using a novel method that side-steps the difficulties encountered by previous work in differentiating between selection and motif-driven mutation; this is done through stochastic mapping and empirical Bayes estimators that compare the evolution of in-frame and out-of-frame rearrangements. We use this new method to derive a per-residue map of selection, which provides a more nuanced view of the constraints on framework and variable regions.Comment: Previously entitled "Substitution and site-specific selection driving B cell affinity maturation is consistent across individuals

Brexit... A Lifetime of Purgatory for the UK’s Environmental Laws - Or is there a Stairway to Heaven?

This paper considers the prospect that the United Kingdom’s decision to withdraw from the European Union may have a detrimental effect on its environmental protections. Brexit may provide the opportunity to pursue a more environmentally focused agenda, but it is argued that the UK’s plan to transpose EU legislation underestimates the complexity of the task and that the UK lacks the resources to replicate the system it currently enjoys. On this basis it is thought that a reordering of environmental law is more likely than a radical re writing of it

Time-bin to Polarization Conversion of Ultrafast Photonic Qubits

The encoding of quantum information in photonic time-bin qubits is apt for long distance quantum communication schemes. In practice, due to technical constraints such as detector response time, or the speed with which co-polarized time-bins can be switched, other encodings, e.g. polarization, are often preferred for operations like state detection. Here, we present the conversion of qubits between polarization and time-bin encodings using a method that is based on an ultrafast optical Kerr shutter and attain efficiencies of 97% and an average fidelity of 0.827+/-0.003 with shutter speeds near 1 ps. Our demonstration delineates an essential requirement for the development of hybrid and high-rate optical quantum networks

P1_1 Resting On The Shoulders Of Giants

This paper investigates the concept of a ’World Turtle’ as imagined in Terry Pratchett’s Diskworld series. The giant astronomical elephants which stand upon the turtle’s shell support the Diskworld. By assuming that the elephants have the same anatomy as terrestrial elephants, the dimensions of these animals is found. Each of the elephants would have to be 230km tall to be able to support the mass of the disk. It was also found that the size of the elephants to support a flat Earth would be 420km tall. A relationship between the radius of a disk and the height of the elephant was also found

An attractive model: simulating fuzzy dark matter with attractive self-interactions

Fuzzy Dark Matter (FDM) comprised of ultralight ($m \sim 10^{-22}~\rm{eV}$) boson particles has received significant attention as a viable alternative to Cold Dark Matter (CDM), as it approximates CDM on large scales ($\gtrsim 1$ Mpc) while potentially resolving some of its small-scale problems via kiloparsec-scale quantum interference. However, the most basic FDM model, with one free parameter (the boson mass), is subject to a tension: small boson masses yield the desired cores of dwarf galaxies but underpredict structure in the Lyman-$\alpha$ forest, while large boson masses render FDM effectively identical to CDM. This Catch-22 problem may be alleviated by considering an axion-like particle with attractive particle self-interactions. We simulate an idealized FDM halo with self-interactions parameterized by an energy decay constant $f \sim 10^{15}~\rm{GeV}$ related to the axion symmetry-breaking conjectured to solve the strong-CP problem in particle physics. We observe solitons, a hallmark of FDM, condensing within a broader halo envelope, and find that the density profile and soliton mass depend on self-interaction strength. We propose generalized formulae to extend those from previous works to include self-interactions. We also investigate a critical mass threshold predicted for strong interactions at which the soliton collapses into a compact, unresolved state. We find that the collapse happens quickly and its effects are initially contained to the central region of the halo.Comment: 20 pages, 16 figures; to be submitted to MNRA

The importance of geometry in the corneal micropocket angiogenesis assay

The corneal micropocket angiogenesis assay is an experimental protocol for studying vessel network formation, or neovascularization, in vivo. The assay is attractive due to the ease with which the developing vessel network can be observed in the same animal over time. Measurements from the assay have been used in combination with mathematical modeling to gain insights into the mechanisms of angiogenesis. While previous modeling studies have adopted planar domains to represent the assay, the hemispherical shape of the cornea and asymmetric positioning of the angiogenic source can be seen to affect vascular patterning in experimental images. As such, we aim to better understand: i) how the geometry of the assay influences vessel network formation and ii) how to relate observations from planar domains to those in the hemispherical cornea. To do so, we develop a three-dimensional, off-lattice mathematical model of neovascularization in the cornea, using a spatially resolved representation of the assay for the first time. Relative to the detailed model, we predict that the adoption of planar geometries has a noticeable impact on vascular patterning, leading to increased vessel ‘merging’, or anastomosis, in particular when circular geometries are adopted. Significant differences in the dynamics of diffusible aniogenesis simulators are also predicted between different domains. In terms of comparing predictions across domains, the ‘distance of the vascular front to the limbus’ metric is found to have low sensitivity to domain choice, while metrics such as densities of tip cells and vessels and ‘vascularized fraction’ are sensitive to domain choice. Given the widespread adoption and attractive simplicity of planar tissue domains, both in silico and in vitro, the differences identified in the present study should prove useful in relating the results of previous and future theoretical studies of neovascularization to in vivo observations in the cornea

A Continuous, Fluorescence-based Assay of µ-Opioid Receptor Activation in AtT-20 Cells

Opioids are widely prescribed analgesics, but their use is limited due to development of tolerance and addiction, as well as high variability in individual response. The development of improved opioid analgesics requires high-throughput functional assays to assess large numbers of potential opioid ligands. In this study, we assessed the ability of a proprietary "no-wash" fluorescent membrane potential dye to act as a reporter of µ-opioid receptor (MOR) activation and desensitization via activation of G-protein-coupled inwardly rectifying potassium channels. AtT-20 cells stably expressing mouse MOR were assayed in 96-well plates using the Molecular Devices FLIPR membrane potential dye. Dye emission intensity decreased upon membrane hyperpolarization. Fluorescence decreased in a concentration-dependent manner upon application of a range of opioid ligands to the cells, with high-efficacy agonists producing a decrease of 35% to 40% in total fluorescence. The maximum effect of morphine faded in the continued presence of agonist, reflecting receptor desensitization. The effects of opioids were prevented by prior treatment with pertussis toxin and blocked by naloxone. We have demonstrated this assay to be an effective method for assessing ligand signaling at MOR, which may potentially be scaled up as an additional high-throughput screening technique for characterizing novel opioid ligands.NHMRC Grant Numbers: 1011979 & 104596