216 research outputs found

    It is Time to End Race-Based Affirmative Action

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    The Effects of Isomorphism on the American State Normal School: The Case of the Institution in Cedar Falls, Iowa from 1890 to 1915

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    This case study analyzes the transition of the American state normal school to teacher's colleges using a theoretical lens of isomorphism. This research draws upon mostly primary sources including journals, personal correspondence, published speeches, newspaper articles, and year books. Upon examination of the transition which took place at the institution located in Cedar Falls, Iowa, it becomes clear that the state normal school adopted more than simply a title change in hopes of elevating its status among other institutions of higher learning. Curricular additions, department organization, new titles for faculty and staff, and administrative transitions were among the changes which took place in Iowa. This study finds that isomorphic pressures eventually led to the state normal school emanating institutional trends at the state university in order to survive as an institution of higher learning

    Book Review: Ada English: Patriot and Psychiatrist

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    Review of Ada English: Patriot and Psychiatrist by Brendan Kelly. Irish Academic Press, 2014

    Book Review: Complex Inequality and \u27Working Mothers\u27

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    Review of Complex Inequality and ‘Working Mothers’ by Clare O’Hagan. Cork University Press, 2015

    Book Review: The Case of Rose Bird: Gender, Politics, and the California Courts

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    Review of The Case of Rose Bird: Gender, Politics, and the California Courts, by Kathleen A. Cairns. University of Nebraska Press, 2016

    Developing a Fair Share Housing Policy for Florida

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    This Article focuses on the prevalent problem of increasing concentrations of poverty in the inner city and social isolation of inner-city residents in major American cities caused by the mass exodus of middle class, working residents to the suburbs. The Article advocates the implementation of fair share housing programs to remedy these problems of socioeconomic isolation. Specifically, the Article argues that Florida has an optimal statutory scheme to easily introduce such a program. The Article gives a description of fair share programs, including federal efforts toward fair share housing and the state programs of California, New Jersey, Massachusetts, Connecticut, and Oregon. Finally, the Article closes with five alternatives for a fair share program suited specifically for Florida, utilizing the elements of other federal and state approaches to fair share housing

    Cluster J Mycobacteriophages: Intron Splicing in Capsid and Tail Genes

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    Bacteriophages isolated on Mycobacterium smegmatis mc2155 represent many distinct genomes sharing little or no DNA sequence similarity. The genomes are architecturally mosaic and are replete with genes of unknown function. A new group of genomes sharing substantial nucleotide sequences constitute Cluster J. The six mycobacteriophages forming Cluster J are morphologically members of the Siphoviridae, but have unusually long genomes ranging from 106.3 to 117 kbp. Reconstruction of the capsid by cryo-electron microscopy of mycobacteriophage BAKA reveals an icosahedral structure with a triangulation number of 13. All six phages are temperate and homoimmune, and prophage establishment involves integration into a tRNA-Leu gene not previously identified as a mycobacterial attB site for phage integration. The Cluster J genomes provide two examples of intron splicing within the virion structural genes, one in a major capsid subunit gene, and one in a tail gene. These genomes also contain numerous free-standing HNH homing endonuclease, and comparative analysis reveals how these could contribute to genome mosaicism. The unusual Cluster J genomes provide new insights into phage genome architecture, gene function, capsid structure, gene mobility, intron splicing, and evolution. © 2013 Pope et al

    Telegrams from B. D. Connerly et al. to Senator Langer Opposing Sale of Indian Land, September 1, 1955

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    These seven telegrams, dated September 1, 1955 except as noted below, from the senders listed below to United States (US) Senator William Langer express the senders\u27 opposition to a sale of Indian land to take place at New Town, North Dakota on the Forth Berthold Reservation. While the wording of the telegrams varies, all ask for this sale to be halted until further study is made. The senders include: The Reverend B. D. Connerly of Carrington, North Dakota, Marvin Kirk of Ramsey Country, North Dakota, Walter F. Jarvis of Fargo, North Dakota, The Reverend Helmuth Fitchler of Glen Ullin, North Dakota, Mrs. George Lincoln of Hunter, North Dakota, The Social Action Committee of the Congregation Christian Conference of North Dakota (dated August 31, 1955) And Mr. and Mrs. Charles Pierce of Scranton, North Dakota (dated Sepember 2, 1955). See also: Telegram from Senator Langer to B. D. Connerly Et Al. Regarding Sale of Indian Lands, September 2, 1955https://commons.und.edu/langer-papers/1795/thumbnail.jp

    Cluster J Mycobacteriophages: Intron Splicing in Capsid and Tail Genes

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    Bacteriophages isolated on Mycobacterium smegmatis mc2155 represent many distinct genomes sharing little or no DNA sequence similarity. The genomes are architecturally mosaic and are replete with genes of unknown function. A new group of genomes sharing substantial nucleotide sequences constitute Cluster J. The six mycobacteriophages forming Cluster J are morphologically members of the Siphoviridae, but have unusually long genomes ranging from 106.3 to 117 kbp. Reconstruction of the capsid by cryo-electron microscopy of mycobacteriophage BAKA reveals an icosahedral structure with a triangulation number of 13. All six phages are temperate and homoimmune, and prophage establishment involves integration into a tRNA-Leu gene not previously identified as a mycobacterial attB site for phage integration. The Cluster J genomes provide two examples of intron splicing within the virion structural genes, one in a major capsid subunit gene, and one in a tail gene. These genomes also contain numerous freestanding HNH homing endonuclease, and comparative analysis reveals how these could contribute to genome mosaicism. The unusual Cluster J genomes provide new insights into phage genome architecture, gene function, capsid structure, gene mobility, intron splicing, and evolution

    Sec16 Defines Endoplasmic Reticulum Exit Sites and is Required for Secretory Cargo Export in Mammalian Cells

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    The selective export of proteins and lipids from the endoplasmic reticulum (ER) is mediated by the coat protein complex II (COPII) that assembles onto the ER membrane. In higher eukaryotes, COPII proteins assemble at discrete sites on the membrane known as ER exit sites (ERES). Here, we identify Sec16 as the protein that defines ERES in mammalian cells. Sec16 localizes to ERES independent of Sec23/24 and Sec13/31. Overexpression, and to a lesser extent, small interfering RNA depletion of Sec16, both inhibit ER-to-Golgi transport suggesting that Sec16 is required in stoichiometric amounts. Sar1 activity is required to maintain the localization of Sec16 at discrete locations on the ER membrane, probably through preventing its dissociation. Our data suggest that Sar1-GTP-dependent assembly of Sec16 on the ER membrane forms an organized scaffold defining an ERES
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