Systems Integration and Test of the Lunar Flashlight Spacecraft

Lunar Flashlight is a 6U CubeSat launching in late 2022 or early 2023 that will search for surface water ice content in permanently shadowed regions at the south pole of the Moon using infrared relative reflectance spectroscopy. The mission will act as a technology demonstration of an Advanced Spacecraft Energetic NonToxic (ASCENT) green propulsion system and active laser spectroscopy within the CubeSat form-factor. This paper provides an overview of the entire Systems Integration and Test campaign which took place at the Jet Propulsion Laboratory and the Georgia Institute of Technology. From initial testing of the isolated avionics and payload subsystems to the final tests with a fully integrated spacecraft, the project’s integration and test campaign is reviewed, with a focus on lessons learned

Finishing the euchromatic sequence of the human genome

The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead

Parasite-Mediated Disruptive Selection in a Natural \u3ci\u3eDaphnia\u3c/i\u3e Population

Background: A mismatch has emerged between models and data of host-parasite evolution. Theory readily predicts that parasites can promote host diversity through mechanisms such as disruptive selection. Yet, despite these predictions, empirical evidence for parasite-mediated increases in host diversity remains surprisingly scant. Results: Here, we document parasite-mediated disruptive selection on a natural Daphnia population during a parasite epidemic. The mean susceptibility of clones collected from the population before and after the epidemic did not differ, but clonal variance and broad-sense heritability of post-epidemic clones were significantly greater, indicating disruptive selection and rapid evolution. A maximum likelihood method that we developed for detecting selection on natural populations also suggests disruptive selection during the epidemic: the distribution of susceptibilities in the population shifted from unimodal prior to the epidemic to bimodal after the epidemic. Interestingly, this same bimodal distribution was retained after a generation of sexual reproduction. Conclusion: These results provide rare empirical support for parasite-driven increases in host genetic diversity, and suggest that this increase can occur rapidly

An Observation of Racial and Gender Disparities in Congestive Heart Failure Admissions Using the National Inpatient Sample

Background Congestive heart failure (CHF) is a frequent cause of inpatient admissions in the United States. The purpose of this study was to analyze the racial and gender disparities that occur in CHF admissions and determine the impact of these disparities on medical expenditure. Methods We analyzed the National Inpatient Sample (NIS) database from 2009 to 2014 for patients with a primary discharge diagnosis of CHF, and further stratified the cohort on the basis of race and sex. Multivariate analysis was performed to identify the association between CHF and total charges along with other variables such as mortality, length of stay (LOS), and number of procedures. Results There were a total of 5,491,050 admissions with a primary diagnosis of CHF from 977,850 in 2009 to 901,425 in 2014. Females accounted for 49.7%. Total charges for CHF admission were highest in Asians at an average cost of $59,668. African Americans had the lowest mortality rate at 1.75$42,920 and $36,744 for females (p<0.05). Males also had more procedures at 1.16 vs 0.98 for females (p<0.05). Elixhauser mortality score was higher in males than females at 5.95 vs 5.42 (p<0.05). Conclusion Healthcare disparities exist in CHF admissions in both contexts of race and gender. Further studies are required to pinpoint the source of these differences not only to address mortality but also expenditure costs.Open access journalThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at [email protected]

Parasite-mediated disruptive selection in a natural Daphnia population

© 2008 Duffy et al; licensee BioMed Central Ltd. The electronic version of this article is the complete one and can be found online at: http://www.biomedcentral.com/1471-2148/8/80DOI: 10.1186/1471-2148-8-80Background. A mismatch has emerged between models and data of host-parasite evolution. Theory readily predicts that parasites can promote host diversity through mechanisms such as disruptive selection. Yet, despite these predictions, empirical evidence for parasite-mediated increases in host diversity remains surprisingly scant. Results. Here, we document parasite-mediated disruptive selection on a natural Daphnia population during a parasite epidemic. The mean susceptibility of clones collected from the population before and after the epidemic did not differ, but clonal variance and broad-sense heritability of post-epidemic clones were significantly greater, indicating disruptive selection and rapid evolution. A maximum likelihood method that we developed for detecting selection on natural populations also suggests disruptive selection during the epidemic: the distribution of susceptibilities in the population shifted from unimodal prior to the epidemic to bimodal after the epidemic. Interestingly, this same bimodal distribution was retained after a generation of sexual reproduction. Conclusion. These results provide rare empirical support for parasite-driven increases in host genetic diversity, and suggest that this increase can occur rapidly

Laser Interstitial Thermal Therapy Case Series: Choosing the Correct Number of Fibers Depending on Lesion Size

BACKGROUND: Laser interstitial thermal therapy (LITT) is being used for the treatment of recurrent glioblastoma multiforme (GBM). Lesions can be treated using 1 or multiple LITT fibers depending on the preference of surgeons. Usually, more fibers are needed for coverage of larger tumors. OBJECTIVE: To investigate and analyze how tumor size affected the number of LITT fibers used. METHODS: This is a retrospective review of patients undergoing treatment of recurrent GBM. Patients were treated with up to 4 LITT fibers for adequate tumor coverage. Patient demographics, tumor characteristics, length of stay, complications, and biopsy results were recorded. RESULTS: A total of 43 cases were treated using LITT, and of these cases, 31 consisted of contiguous lesions. We used more fibers to treat larger tumor volumes. On average, for each 5 cc of tumor volume, a fiber was added for proper coverage (P=.554). Complications and length of stay were similar across the groups (P=.378, P=.941). CONCLUSION: LITT can be used for the treatment of recurrent GBM. For each 5 cc of tumor volume, a LITT fiber can be added to the treatment plan

Influence analyses for pooled effects on primary and secondary outcomes.

<p>Removal of any single trial does not significantly influence the pooled effect of endovascular therapy on (A) the primary outcome of a beneficial shift in mRS score distributions, (B) the secondary outcome of mortality or (C) the secondary outcome of symptomatic intra-cerebral hemorrhage.</p