2,435 research outputs found
AAOmega spectroscopy of 29 351 stars in fields centered on ten Galactic globular clusters
Galactic globular clusters have been pivotal in our understanding of many
astrophysical phenomena. Here we publish the extracted stellar parameters from
a recent large spectroscopic survey of ten globular clusters. A brief review of
the project is also presented. Stellar parameters have been extracted from
individual stellar spectra using both a modified version of the Radial Velocity
Experiment (RAVE) pipeline and a pipeline based on the parameter estimation
method of RAVE. We publish here all parameters extracted from both pipelines.
We calibrate the metallicity and convert this to [Fe/H] for each star and,
furthermore, we compare the velocities and velocity dispersions of the Galactic
stars in each field to the Besan\c{c}on Galaxy model. We find that the model
does not correspond well with the data, indicating that the model is probably
of little use for comparisons with pencil beam survey data such as this.Comment: 6 pages, 5 figures, 4 tables. Accepted for publication in A&A. Data
described in tables will be available on CDS (at
http://cdsweb.u-strasbg.fr/cgi-bin/qcat?J/A+A/530/A31) once publishe
Physical Activity in Rural African School-Aged Children and Adolescents
In industrialized countries, reduced levels of physical
activity (PA) associated with increased prevalence of the
so-called âhypokinetic diseasesâ stimulates the interest in
research in PA and its correlate
A Perfect Script? Manchester United's Class of â92
The Class of â92 is a documentary film featuring six Manchester United F.C. players who recount their time during a pivotal period for the club, English football and English society. The documentary claims to offer a commentary on Britain in the 1990s, but appears, without acknowledging the fact, to be a promotional vehicle to establish the six men as a brand labeled the Class of â92 (CO92). Creating this brand necessarily involved presenting a selective account of their time and places with the film being little more than an advertisement, masquerading as an observational documentary. The film draws freely upon the symbolic capital held by the club and the city of Manchester and uses the Busby Babes/Munich chapter and the more recent âMadchester sceneâ to forge the Class of â92 brand by editing out those elements that did not accord with this project. The article argues that a more complete representation of â90s Britain, while disrupting the intended narrative, would acknowledge the significant structural and commercial changes experienced by the club, the sport, and the city in the last decade of the 20th century. We suggest that the Class of â92 invites the viewer to consider how the documentary film genre can contribute to brand development and promotion
Major Substructure in the M31 Outer Halo: the South-West Cloud
We undertake the first detailed analysis of the stellar population and
spatial properties of a diffuse substructure in the outer halo of M31. The
South-West Cloud lies at a projected distance of ~100 kpc from the centre of
M31, and extends for at least ~50 kpc in projection. We use Pan-Andromeda
Archaeological Survey photometry of red giant branch stars to determine a
distance to the South-West Cloud of 793 +/- 45 kpc. The metallicity of the
cloud is found to be [Fe/H] = -1.3 +/- 0.1. This is consistent with the
coincident globular clusters PAndAS-7 and PAndAS-8, which have metallicities
determined using an independent technique of [Fe/H] = -1.35 +/- 0.15. We
measure a brightness for the Cloud of M_V = -12.1 mag; this is ~75 per cent of
the luminosity implied by the luminosity-metallicity relation. Under the
assumption that the South-West Cloud is the visible remnant of an accreted
dwarf satellite, this suggests that the progenitor object was amongst M31's
brightest dwarf galaxies prior to disruption.Comment: 13 pages, 9 figures, accepted for publication in MNRA
Therapeutic Rescue of Misfolded Mutants: Validation of Primary High Throughput Screens for Identification of Pharmacoperone Drugs
Functional rescue of misfolded mutant receptors by small non-peptide molecules has been demonstrated. These small, target-specific molecules (pharmacological chaperones or "pharmacoperones") serve as molecular templates, promote correct folding and allow otherwise misfolded mutants to pass the scrutiny of the cellular quality control system (QCS) and be expressed at the plasma membrane (PM) where they function similarly to wild type (WT) proteins. In the case of the gonadotropin releasing hormone receptor (GnRHR), drugs that rescue one mutant typically rescue many mutants, even if the mutations are located at distant sites (extracellular loops, intracellular loops, transmembrane helices). This increases the value of these drugs. These drugs are typically identified, post hoc, from "hits" in screens designed to detect antagonists or agonists. The therapeutic utility of pharmacoperones has been limited due to the absence of screens that enable identification of pharmacoperones per se.We describe a generalizable primary screening approach for pharmacoperone drugs based on measurement of gain of activity in stable HeLa cells stably expressing the mutants of two different model G-protein coupled receptors (GPCRs) (hGnRHR[E(90)K] or hV2R[L(83)Q]). These cells turn off expression of the receptor mutant gene of interest in the presence of tetracycline and its analogs, which provides a convenient means to identify false positives.The methods described and characterized here provide the basis of novel primary screens for pharmacoperones that detect drugs that rescue GPCR mutants of specific receptors. This approach will identify structures that would have been missed in screens that were designed to select only agonists or antagonists. Non-antagonistic pharmacoperones have a therapeutic advantage since they will not compete for endogenous agonists and may not have to be washed out once rescue has occurred and before activation by endogenous or exogenous agonists
Osteonectin, bone proteoglycan, and phosphophoryn defects in a form of bovine osteogenesis imperfecta.
Disease dynamics in wild populations: modeling and estimation: a review
Abstract Models of infectious disease dynamics focus on describing the temporal and spatial variations in disease prevalence, and on understanding the factors that affect how many cases will occur in each time period and which individuals are likely to become infected. Classical methods for selecting and fitting models, mostly motivated by human diseases, are almost always based solely on raw counts of infected and uninfected individuals. We begin by reviewing the main classical approaches to parameter estimation, and some of their applications. We then review recently developed methods which enable representation of component processes such as infection and recovery, with observation models that acknowledge the complexities of the sampling and detection processes. We demonstrate the need to account for detectability in modeling disease dynamics, and explore a number of mark-recapture and occupancy study designs for estimating disease parameters while simultaneously accounting for variation in detectability. We highlight the utility of different modeling approaches and also consider the typically strong assumptions that may actually serve to limit their utility in general application to the study of disease dynamics (e.g., assignment of individuals to discrete disease states when underlying state space is more generally continuous; transitions assumed to be simple firstorder Markov; temporal separation of hazard and transition events)
The Local Interstellar Ultraviolet Radiation Field
I have used the Hipparcos Input Catalog, together with Kurucz model stellar
atmospheres, and information on the strength of the interstellar extinction, to
create a model of the expected intensity and spectral distribution of the local
interstellar ultraviolet radiation field, under various assumptions concerning
the albedo a of the interstellar grains. (This ultraviolet radiation field is
of particular interest because of the fact that ultraviolet radiation is
capable of profoundly affecting the chemistry of the interstellar medium.) By
comparing my models with the observations, I am able to conclude that the
albedo a of the interstellar grains in the far ultraviolet is very low, perhaps
a = 0.1. I also advance arguments that my present determination of this albedo
is much more reliable than any of the many previous (and conflicting)
ultraviolet interstellar grain albedo determinations. Beyond this, I show that
the ultraviolet background radiation that is observed at high galactic
latitudes must be extragalactic in origin, as it cannot be backscatter of the
interstellar radiation field.Comment: Astrophysical Journal, in press; 9 figures + 16 text page
Sports mega-events â three sites of contemporary political contestation
This article discusses the contemporary politics of sports mega-events, involving the Olympic Games and FĂ©dĂ©ration Internationale de Football Association (FIFA) Menâs Football World Cup Finals as well as other lower âorderâ sports megas, taking two main forms: the promotional and the protest. There is a politics in, and a politics of, sports mega-events. The former focuses on the internal politics of the organizing bodies, such as the International Olympic Committee and FIFA. This form of politics has been written about elsewhere, and hence, there is no detailed discussion in this article about it. Instead this article offers a brief discussion of the range and number of sports mega-events since 2000, an assessment of the contemporary politics of sports mega-events, a focus on three main sites of political contestation â rights, legacy and labour, and finally, it offers conclusions about research into the politics of sports mega-events
- âŠ