Experiencia de innovación en el aula desde la autorregulación y los estilos de aprendizaje

El presente documento tiene como propósito aportar las conclusiones obtenidas, por el profesorado del Centro Universitario Escuni, sobre las relaciones entre la autorregulación y los estilos de aprendizaje en estudiantes del Grado de Educación Infantil y Educación Primaria. Dichas conclusiones han sido extraídas después de años de investigación sobre la teoría de los estilos de aprendizaje y con la implementación de un modelo metodológico centrado en la autorregulación del aprendizaje. El referente teórico a partir del cual se basa este estudio, se orienta, por un lado en el planteamiento de Kolb (1984) sobre los estilos de aprendizaje, y por otro lado, el modelo de Pintrich (2000) sobre el aprendizaje autorregulado. Las conclusiones obtenidas inciden en la orientación por parte del profesor de los procesos autorregulatorios del aprendizaje desde el conocimiento de los estilos de aprendizaje de los alumnos e, igualmente, desde un ejercicio de autoconocimiento y autoconciencia del alumno, para adquirir mayores competencias académicas y formativasThe purpose of this document is to contribute the conclusions obtained by the teachers of Centro Universitario Escuni, on the relations between self - regulation and learning styles in students of the Kinder and Primary Education. These conclusions have been drawn after years of research on the theory of learning styles and with the implementation of a methodological model focused on self-regulation learning. The theoretical reference of this study is based in Kolb's (1984) approach to learning styles and, on the other hand, Pintrich's (2000) model of self-regulation learning. The findings obtained indicate the teacher's orientation of the self-regulating processes of learning from the knowledge of the learning styles of the students and, also, from an exercise of self-knowledge and self-awareness of the student, to acquire greater academic and formative competence

Utilización de derivados de quinazolinas para enfermedades neurodegenerativas

Peer reviewedConsejo Superior de Investigaciones CientíficasT3 Traducción de patente europe

Las actitudes del alumnado universitario frente a las personas con trastorno mental

La enfermedad mental es un problema de salud a nivel mundial que afecta a una de cada cuatro personas. A pesar de su elevada incidencia, existe una fuerte discriminación social sobre estos enfermos (OMS, 2004). Diversos profesionales se encuentran en su desempeño diario situaciones de interacción con estos pacientes pudiendo actuar como perpetuadores del estigma si muestran actitudes negativas de miedo y hostilidad (Roos y Goldner, 2009). Asimismo, el contacto con estos enfermos mentales condicionará las actitudes hacia la propia enfermedad. El objetivo de este estudio es conocer las actitudes hacia los enfermos mentales de los futuros profesionales de Ciencias de la Salud, en comparación con el alumnado de otras ramas de conocimiento, y explorar si mantener contacto con estos enfermos puede modificar dicha actitud. Se administró el cuestionario “Opiniones sobre la enfermedad mental” (Ozamiz, 1980) a 820 estudiantes (70,37% mujeres y 29,63% hombres) de diferentes titulaciones de Ciencias de la Salud y Ciencias Sociales y Jurídicas. Esta escala informa sobre la Actitud general y 5 subdimensiones (Negativismo, Etiología social, Autoritarismo, Restrictividad y Prejuicio), obteniendo una fiabilidad superior a .7 en Negativismo y Etiología Social. Los resultados indican que los estudiantes de Ciencias de la Salud muestran menores niveles de Negativismo hacia el enfermo mental que el alumnado de Ciencias Sociales y Jurídicas, independientemente del contacto mantenido. Además, los estudiantes que manifiestan haber tenido contacto con estos enfermos presentan menores niveles de Negativismo, no diferenciándose de forma estadísticamente significativa ni en la Actitud general, ni en Etiología social, con independencia de la titulación cursada. Estos resultados parecen indicar que una actitud negativa hacia el enfermo mental es menor entre el alumnado de Ciencias de la Salud en comparación con las Ciencia Sociales y Jurídicas, y entre los que han mantenido contactos con enfermos mentales.Mental illness is a global health problem that affects one in four people around the world. Despite its high incidence, there is strong social discrimination towards this population (WHO, 2004). Different professionals encounter, in their daily performance, situations of interaction with these patients and may act as stigma perpetuators if they display negative attitudes of fear and hostility (Roos and Goldner, 2009). Likewise, contact with these mental ill patients will condition their attitudes toward the disease. The aim of this study was to examine the attitudes of future professionals of Health Sciences toward mental ill patients, compared with students of other knowledge fields, and to explore if maintaining contact with these patients can modify these attitudes. The questionnaire “Opinions concerning mental illness” (Ozamiz, 1980) was administered to 820 students (70.37% women and 29.63% men) from different degrees of Health Sciences, and Social and Legal Sciences. This scale assessed global Attitude and five subscales (Negativism, Social Etiology, Authoritarianism, Restrictivism, and Prejudice), obtaining a reliability higher than .7 in Negativism and Social Etiology. Results indicated that Health Sciences students show lower levels of Negativism towards mental ill patients than students in Social and Legal Sciences degrees, regardless of the contact maintained. In addition, students who report contact with these patients have lower levels of Negativism, not differing in a statistically significant way neither in the general Attitude, nor in social Etiology, and regardless of the university degree. These results seem to indicate that negative attitudes toward mental ill patients is lower among Health Sciences students and among students who have contact with this population compared with Social and Legal Science ones

Transcriptomic and Metabolomic Response to High Light in the Charophyte Alga Klebsormidium nitens

The characterization of the molecular mechanisms, such as high light irradiance resistance, that allowed plant terrestralization is a cornerstone in evolutionary studies since the conquest of land by plants played a pivotal role in life evolution on Earth. Viridiplantae or the green lineage is divided into two clades, Chlorophyta and Streptophyta, that in turn splits into Embryophyta or land plants and Charophyta. Charophyta are used in evolutionary studies on plant terrestralization since they are generally accepted as the extant algal species most closely related to current land plants. In this study, we have chosen the facultative terrestrial early charophyte alga Klebsormidium nitens to perform an integrative transcriptomic and metabolomic analysis under high light in order to unveil key mechanisms involved in the early steps of plants terrestralization. We found a fast chloroplast retrograde signaling possibly mediated by reactive oxygen species and the inositol polyphosphate 1-phosphatase (SAL1) and 3′-phosphoadenosine-5′-phosphate (PAP) pathways inducing gene expression and accumulation of specific metabolites. Systems used by both Chlorophyta and Embryophyta were activated such as the xanthophyll cycle with an accumulation of zeaxanthin and protein folding and repair mechanisms constituted by NADPH-dependent thioredoxin reductases, thioredoxin-disulfide reductases, and peroxiredoxins. Similarly, cyclic electron flow, specifically the pathway dependent on proton gradient regulation 5, was strongly activated under high light. We detected a simultaneous co-activation of the non-photochemical quenching mechanisms based on LHC-like stress related (LHCSR) protein and the photosystem II subunit S that are specific to Chlorophyta and Embryophyta, respectively. Exclusive Embryophyta systems for the synthesis, sensing, and response to the phytohormone auxin were also activated under high light in K. nitens leading to an increase in auxin content with the concomitant accumulation of amino acids such as tryptophan, histidine, and phenylalanine.España Ministerio de Ciencia e Innovación MINOTAUR (BIO2017-84066-R

New cinnamic – N-benzylpiperidine and cinnamic – N,N-dibenzyl(N-methyl)amine hybrids as Alzheimer-directed multitarget drugs with antioxidant, cholinergic, neuroprotective and neurogenic properties

Here we describe new families of multi-target directed ligands obtained by linking antioxidant cinnamic-related structures with N-benzylpiperidine (NBP) or N,N-dibenzyl(N-methyl)amine (DBMA) fragments. Resulting hybrids, in addition to their antioxidant and neuroprotective properties against mitochondrial oxidative stress, are active at relevant molecular targets in Alzheimer’s disease, such as cholinesterases (hAChE and hBuChE) and monoamine oxidases (hMAO-A and hMAO-B). Hybrids derived from umbellic – NBP (8), caffeic – NBP (9), and ferulic – DBMA (12) displayed balanced biological profiles, with IC50s in the low-micromolar and submicromolar range for hChEs and hMAOs, and an antioxidant potency comparable to vitamin E. Moreover, the caffeic – NBP hybrid 9 is able to improve the differentiation of adult SGZ-derived neural stem cells into a neuronal phenotype in vitro.Financial support from the Spanish Ministry of Economy and Competitiveness (MINECO, grants SAF2012-31035 and SAF2015-64948-C2-1-R to MIRF; grant SAF2014-52940-R to APC) partially financed by FEDER funds, and Consejo Superior de Investigaciones Científicas (CSIC, grant PIE-201580E109) is gratefully acknowledged. ME thanks COLCIENCIAS (Colombia) for a Ph.D. fellowship.Peer reviewe

Abnormal Alpha-1 Antitrypsin Levels and Other Risk Factors Associated with Lung Function Impairment at 6 and 12 Months after Hospitalization Due to COVID-19: A Cohort Study

Respiratory function deficits are common sequelae for COVID-19. In this study, we aimed to identify the medical conditions that may influence lung function impairment at 12 months after SARS-CoV2 infection and to analyze the role of alpha-1 antytripsin (AAT) deficiciency (AATD). A cohort study was conducted on hospitalized COVID-19 pneumonia patients in Granada (Spain) during the first infection wave who were referred to a post-COVID-19 hospital clinic. The patients were monitored with three follow-up visits from May 2020 to May 2021. Previous medical history, hospital admission data, baseline parameters and physical examination data were collected at the first visit. Pulmonary function tests were performed at 6 and 12 months together with the determination of AAT level and AATD genotype. After 12 months, 49 out of 157 patients (31.2%) continued to have lung function impairment. A multivariate analysis showed a statistically significant association of lung function impairment with: higher Charlson index; pneumonia with a central and/or mixed distribution; anemia on admission; time in intensive care; need for corticosteroid boluses; abnormal respiratory sounds at 6 months; elevated lactate dehydrogenase at 12 months; abnormal AAT; and MZ genotype. Our results suggest that these medical conditions predispose COVID-19 patients to develop long-term lung function sequelae

[18F]FDG PET/CT in Short-Term Complications of COVID-19: Metabolic Markers of Persistent Inflammation and Impaired Respiratory Function

SARS-CoV-2 virus infects organs other than the lung, such as mediastinal lymph nodes, spleen, and liver, but, to date, metabolic imaging studies obtained in short-term follow-ups of patients hospitalized with severe COVID-19 infection are rare. Our objective was to evaluate the usefulness of [18F]FDG-PET/CT in the short-term follow-up of patients admitted for COVID-19 pneumonia and to explore the association of the findings with clinical prognostic markers. The prospective study included 20 patients with COVID-19 pneumonia (November 2020–March 2021). Clinical and laboratory test findings were gathered at admission, 48–72 h post-admission, and 2–3 months post-discharge, when [18F]FDG-PET/CT and respiratory function tests were performed. Lung volumes, spirometry, lung diffusion capacity for carbon monoxide (DLCO), and respiratory muscle strength were measured. Volumetric [18F]FDG-PET/CT results were correlated with laboratory and respiratory parameters. Eleven [18F]FDG-PET/CT (55%) were positive, with hypermetabolic mediastinal lymphadenopathy in 90.9%. Mediastinal lesion’s SUVpeak was correlated with white cells’ count. Eleven (55%) patients had impaired respiratory function, including reduced DLCO (35%). SUVpeak was correlated with %predicted-DLCO. TLG was negatively correlated with %predicted- DLCO and TLC. In the short-term follow-up of patients hospitalized for COVID-19 pneumonia, [18F]FDG-PET/CT findings revealed significant detectable inflammation in lungs and mediastinal lymph nodes that correlated with pulmonary function impairment in more than half of the patients

Compuestos neurogénicos basados en melatonina y su uso en el tratamiento de enfermedades del sistema nervioso

La presente invención, que se incluye en el campo de la investigación e industria farmacéutica, se refiere a nuevas entidades químicas derivadas de melatonina con propiedades neurogénicas, moduladoras de los receptores de melatonina y/o serotonina, antioxidantes y/o colinérgicas. También se refiere a los procedimientos para la preparación de estos nuevos compuestos, a las composiciones farmacéuticas que los contienen y a su uso para la fabricación de un medicamento para el tratamiento de enfermedades del sistema nervioso relacionadas con degeneración neuronal, depresión, trastornos psiquiátricos y cognitivos, trauma o lesión celular, u otro trastorno neurológico relacionado, tratamiento de fatiga diurna, trastornos del sueño, pérdida de eficacia mental, debilidad e irritabilidad y síntomas relacionados con la descompensación horaria (efecto jet-lag o síndrome transoceánico).Peer reviewedConsejo Superior de Investigaciones Científicas, Universidad Autónoma de MadridB1 Patente sin examen previ

Impact of Exposome Factors on Epidermal Barrier Function in Patients with Obstructive Sleep Apnea Syndrome

Exposome factors, such as sleep deprivation and diet, could affect skin barrier function. The objectives of this study are to compare skin barrier function between patients with Obstructive Sleep Apnea Syndrome (OSAS) and healthy individuals, and to evaluate the effect of other exposome factors on skin. A cross-sectional study was conducted. Patients with OSAS and healthy volunteers matched by age and sex were included. OSAS severity was assessed by the Apnea-Hypopnea Index (AHI). Validated questionnaires were used to assess diet, anxiety, depression, and psychological stress. Skin barrier function parameters including temperature, erythema, melanin, pH, transepidermal water loss (TEWL), and stratum corneum hydration (SCH) were measured on the volar forearm. A total of 86 participants were included, 56 patients with OSAS and 30 healthy volunteers. TEWL was higher in OSAS patients than in healthy individuals (8.01 vs. 8.68 g center dot m(-2)center dot h(-1)). Regarding disease severity, severe patients had higher TEWL values (9.31 vs. 8.46 vs. 7.08 g center dot m(-2)center dot h(-1)) compared to moderate and mild patients. Patients with OSAS had significantly lower sleep quality (11.89 vs. 6.47 Pittsburgh Sleep Quality Index score; p < 0.001), poor adherence to the Mediterranean Diet (8.46 vs. 9.77; p = 0.005), and significantly higher anxiety and depression levels than healthy individuals. In conclusion, patients with OSAS may have skin barrier impairment, reflected in higher TEWL values. These patients also have higher levels of anxiety, depression, stress, and a lower adherence to a Mediterranean Diet, all exposome factors that might impact on skin barrier function