(Dimethyl sulfoxide-κO)di­phenyl­(3-thioxo-3H-1,2-dithiole-4,5-dithiol­ato-κ2 S 4,S 5)tin(IV)

The Sn atom in the title compound, [Sn(C6H5)2(C3S5)(C2H6OS)], exists within a distorted trigonal-bipyramidal geometry defined by two S atoms of the 1,2-dithiole-3-thione-4,5-dithiol­ate dianion, two ipso-C atoms from the phenyl groups, and the O atom of the dimethyl sulfoxide mol­ecule. In this description, one of the S atoms and the O occupy axial positions. In the crystal, centrosymmetrically related mol­ecules associate via pairs of C—H⋯S contacts, forming dimeric aggregates

Transmissão de doença de Chagas por transplante renal

Our objective is to report the case of a male patient submitted to kidney transplant from a living donor infected with Trypanosoma cruzi. The patient developed clinical manifestations of acute Chagas disease in the second post-transplant month and was successfully treated with benzonidazole. We discuss the possible means of transmission of Trypanosoma cruzi, the importance of its transmission to transplantation of solid organs, and the approach to this situation.Paciente submetido a transplante renal com órgão de doador vivo infectado pelo Tripanossoma cruzi e que desenvolve manifestações clínicas de doença de Chagas aguda no segundo mês pós- transplante, sendo tratado com sucesso com benzonidazol. Discutem-se as vias de transmissão e relevância clínica na transplantação de órgãos sólidos assim como as atitudes a serem tomadas diante desta situação

Identifying the research, advocacy, policy and implementation needs for the prevention and management of respiratory syncytial virus lower respiratory tract infection in low- and middle-income countries

Introduction: The high burden of respiratory syncytial virus (RSV) infection in young children disproportionately occurs in low- and middle-income countries (LMICs). The PROUD (Preventing RespiratOry syncytial virUs in unDerdeveloped countries) Taskforce of 24 RSV worldwide experts assessed key needs for RSV prevention in LMICs, including vaccine and newer preventive measures. Methods: A global, survey-based study was undertaken in 2021. An online questionnaire was developed following three meetings of the Taskforce panellists wherein factors related to RSV infection, its prevention and management were identified using iterative questioning. Each factor was scored, by non-panellists interested in RSV, on a scale of zero (very-low-relevance) to 100 (very-high-relevance) within two scenarios: (1) Current and (2) Future expectations for RSV management. Results: Ninety questionnaires were completed: 70 by respondents (71.4% physicians; 27.1% researchers/scientists) from 16 LMICs and 20 from nine high-income (HI) countries (90.0% physicians; 5.0% researchers/scientists), as a reference group. Within LMICs, RSV awareness was perceived to be low, and management was not prioritised. Of the 100 factors scored, those related to improved diagnosis particularly access to affordable point-of-care diagnostics, disease burden data generation, clinical and general education, prompt access to new interventions, and engagement with policymakers/payers were identified of paramount importance. There was a strong need for clinical education and local data generation in the lowest economies, whereas upper-middle income countries were more closely aligned with HI countries in terms of current RSV service provision. Conclusion: Seven key actions for improving RSV prevention and management in LMICs are proposed

Enterovirus infections and type 1 diabetes mellitus: is there any relationship?

Several health organizations have classified diabetes mellitus, a metabolic syndrome, as the epidemic of the century, since it affects millions of people worldwide and is one of the top ten causes of death. Type 1 diabetes is considered to be an autoimmune disease, in which autoaggressive T cells infiltrate the islets of Langerhans in the pancreas, leading to the destruction of insulin producing beta cells. The risk of the disease is modulated by genetic factors, mainly genes coding for human leukocyte antigens (HLA). However, the incidence of this disease has increased significantly during the recent decades, which cannot be explained only by genetic factors. Environmental perturbations have also been associated to the development of diabetes. Among these factors, viral triggers have been implicated; particularly enteroviruses, which have been associated to the induction of the disease. Supporting the hypothesis, numerous lines of evidence coming from mouse models and patients with this type of diabetes have shown the association. The present review aims to provide some understanding of how type 1 diabetes occurs and the possible role of enterovirus in this pathology

Transmissão de doença de Chagas por transplante renal

Our objective is to report the case of a male patient submitted to kidney transplant from a living donor infected with Trypanosoma cruzi. The patient developed clinical manifestations of acute Chagas disease in the second post-transplant month and was successfully treated with benzonidazole. We discuss the possible means of transmission of Trypanosoma cruzi, the importance of its transmission to transplantation of solid organs, and the approach to this situation.Paciente submetido a transplante renal com órgão de doador vivo infectado pelo Tripanossoma cruzi e que desenvolve manifestações clínicas de doença de Chagas aguda no segundo mês pós- transplante, sendo tratado com sucesso com benzonidazol. Discutem-se as vias de transmissão e relevância clínica na transplantação de órgãos sólidos assim como as atitudes a serem tomadas diante desta situação

Distribution and genetic diversity of the human polyomaviruses JC and BK in surface water and sewage treatment plant during 2009 in Porto Alegre, Southern Brazil

Abstract The human polyomaviruses JC and BK (JCPyV and BKPyV) are ubiquitous, species-specific viruses that belong to the family Polyomaviridae. These viruses are known to be excreted in human urine, and they are potential indicators of human wastewater contamination. In order to assess the distribution of both JCPyV and BKPyV in urban water samples collected from a sewage treatment plant (STP) and from a canalized water stream of Porto Alegre, Brazil, two nested-PCR assays were optimized and applied to the samples collected. The amplicons obtained were submitted to sequencing, and the sequences were analyzed with sequences of human polyomaviruses previously deposited in GenBank. Twelve out of 30 water samples (40%) were JCPyV positive, whereas six samples (20%) were BKPyV positive. The sequencing results confirmed the presence of JCPyV subtypes 1 and 3, whereas only BKPyV Ia and Ib were found. This study shows for the first time the presence of human polyomaviruses in surface water and in samples collected in a sewage treatment plant in southern Brazil