Peer coaching through mHealth targeting physical activity in people with Parkinson disease: feasibility study

BACKGROUND: Long-term engagement in exercise and physical activity mitigates the progression of disability and increases quality of life in people with Parkinson disease (PD). Despite this, the vast majority of individuals with PD are sedentary. There is a critical need for a feasible, safe, acceptable, and effective method to assist those with PD to engage in active lifestyles. Peer coaching through mobile health (mHealth) may be a viable approach. OBJECTIVE: The purpose of this study was to develop a PD-specific peer coach training program and a remote peer-mentored walking program using mHealth technology with the goal of increasing physical activity in persons with PD. We set out to examine the feasibility, safety, and acceptability of the programs along with preliminary evidence of individual-level changes in walking activity, self-efficacy, and disability in the peer mentees. METHODS: A peer coach training program and a remote peer-mentored walking program using mHealth was developed and tested in 10 individuals with PD. We matched physically active persons with PD (peer coaches) with sedentary persons with PD (peer mentees), resulting in 5 dyads. Using both Web-based and in-person delivery methods, we trained the peer coaches in basic knowledge of PD, exercise, active listening, and motivational interviewing. Peer coaches and mentees wore FitBit Zip activity trackers and participated in daily walking over 8 weeks. Peer dyads interacted daily via the FitBit friends mobile app and weekly via telephone calls. Feasibility was determined by examining recruitment, participation, and retention rates. Safety was assessed by monitoring adverse events during the study period. Acceptability was assessed via satisfaction surveys. Individual-level changes in physical activity were examined relative to clinically important differences. RESULTS: Four out of the 5 peer pairs used the FitBit activity tracker and friends function without difficulty. A total of 4 of the 5 pairs completed the 8 weekly phone conversations. There were no adverse events over the course of the study. All peer coaches were "satisfied" or "very satisfied" with the training program, and all participants were "satisfied" or "very satisfied" with the peer-mentored walking program. All participants would recommend this program to others with PD. Increases in average steps per day exceeding the clinically important difference occurred in 4 out of the 5 mentees. CONCLUSIONS: Remote peer coaching using mHealth is feasible, safe, and acceptable for persons with PD. Peer coaching using mHealth technology may be a viable method to increase physical activity in individuals with PD. Larger controlled trials are necessary to examine the effectiveness of this approach.This study is supported by Boston Roybal Center for Active Lifestyle Interventions (RALI Boston), Grant #P30 AG048785, and the American Parkinson Disease Association, Massachusetts chapter. The authors would like to thank Nicole Sullivan, SOT, for her assistance with data management and data collection and Nick Wendel, DPT, for his assistance with data collection. Additionally, the authors would like to thank the participants in this study for their time, effort, and insights. (P30 AG048785 - Boston Roybal Center for Active Lifestyle Interventions (RALI Boston); American Parkinson Disease Association, Massachusetts chapter)Accepted manuscrip

SensiCut: Material-Aware Laser Cutting Using Speckle Sensing and Deep Learning

Laser cutter users face difficulties distinguishing between visually similar materials. This can lead to problems, such as using the wrong power/speed settings or accidentally cutting hazardous materials. To support users, we present SensiCut, an integrated material sensing platform for laser cutters. SensiCut enables material awareness beyond what users are able to see and reliably differentiates among similar-looking types. It achieves this by detecting materials' surface structures using speckle sensing and deep learning. SensiCut consists of a compact hardware add-on for laser cutters and a user interface that integrates material sensing into the laser cutting workflow. In addition to improving the traditional workflow and its safety1, SensiCut enables new applications, such as automatically partitioning designs when engraving on multi-material objects or adjusting their geometry based on the kerf of the identified material. We evaluate SensiCut's accuracy for different types of materials under different sheet orientations and illumination conditions

Seafloor Control on Sea Ice

The seafloor has a profound role in Arctic sea ice formation and seasonal evolution. Ocean bathymetry controls the distribution and mixing of warm and cold waters, which may originate from different sources, thereby dictating the pattern of sea ice on the ocean surface. Sea ice dynamics, forced by surface winds, are also guided by seafloor features in preferential directions. Here, satellite mapping of sea ice together with buoy measurements are used to reveal the bathymetric control on sea ice growth and dynamics. Bathymetric effects on sea ice formation are clearly observed in the conformation between sea ice patterns and bathymetric characteristics in the peripheral seas. Beyond local features, bathymetric control appears over extensive ice-prone regions across the Arctic Ocean. The large-scale conformation between bathymetry and patterns of different synoptic sea ice classes, including seasonal and perennial sea ice, is identified. An implication of the bathymetric influence is that the maximum extent of the total sea ice cover is relatively stable, as observed by scatterometer data in the decade of the 2000s, while the minimum ice extent has decreased drastically. Because of the geologic control, the sea ice cover can expand only as far as it reaches the seashore, the continental shelf break, or other pronounced bathymetric features in the peripheral seas. Since the seafloor does not change significantly for decades or centuries, sea ice patterns can be recurrent around certain bathymetric features, which, once identified, may help improve short-term forecast and seasonal outlook of the sea ice cover. Moreover, the seafloor can indirectly influence cloud cover by its control on sea ice distribution, which differentially modulates the latent heat flux through ice covered and open water areas

The Recent High State of the BL Lacertae Object AO 0235 and Cross-Correlations Between Optical and Radio Bands

We present new optical (B, V , R, I) and radio (at 14.5, 8.5, and 4.8 GHz) observations of the γ-ray- loud blazar AO 0235+164 obtained during the high state of 1997 December-1998 January. The data were combined with historical light curves from the literature to study correlated optical and radio variations over a time span of more than 20 years. Flux variability with large and energy-dependent amplitude is observed at both wave bands, with the source varying over all timescales sampled (years-months- days), in agreement with previous reports. We have performed a cross-correlation analysis of optical and radio light curves applying various detailed statistical methods. The principal results of our analysis can be summarized as follows : (1) we find that the optical and radio variations exhibit correlated flux changes at their average level , stressing the conclusion that the same emission mechanism is responsible for the radiation in the two bands (i.e., synchrotron emission from shocked plasma in the jet). However, as previously reported, a few strong flares at optical do not have obvious counterparts at longer wavelengths, possibly indicating that an additional component is present in the optical (e.g., microlensing), or, alternatively, rapid cooling of the synchrotron particles in a radiative shock. (2) Periodic variations are observed at radio frequencies (14.5 and 8.0 GHz) with a pattern repeating every ~5.8 years, as indicated by the Lomb-Scargle periodogram. This is the first report for periodicity at radio wavelengths for this source; future continuous monitoring is needed to confirm this result. (3) Through the analysis of B-V and R-I slopes, we observe large spectral variations, with a bimodal behavior. In the first state, the emission is consistent with a variable power law all across the sampled optical region (from R to V bands); in the second state, the R-I slope is constant while the B-V slope varies, i.e., the continuum has various degrees of curvature at the shorter wavelengths. In general, the power-law slope is not correlated with the f;ux of the source. However, there is an indication that when the source is in the first state, the spectrum becomes softer as the source brightens

High levels of childhood obesity observed among 3- to 7-year-old New Zealand Pacific children is a public health concern.

This cross-sectional, community-based survey was designed to assess attained growth and body composition of 3- to 7-y-old Pacific children (n = 21 boys and 20 girls) living in Dunedin, New Zealand, and to examine nondietary factors associated with the percentage of body fat. Fat mass, lean tissue mass and the percentage of body fat were measured using dual energy X-ray absorptiometry. One trained anthropometrist also measured height, weight, skinfolds (triceps, subscapular) and circumferences (mid-upper arm, chest, waist, calf). Compared with the National Center for Health Statistics and National Health and Examination Surveys I and II reference data, these Pacific children were tall and heavy for their age with high arm-muscle-area-for-height. Median (quartiles) Z-scores for height and BMI-for-age and arm-muscle-area-for-height were 1.33 (0.60, 2.15), 1.20 (0.74, 4.43) and 1.09 (0.63, 1.85), respectively. Their median (quartile) percentage of body fat was 21.8% (15.0, 35.5) of which 38.5% was located in the trunk. The estimated percentage of children classified as obese ranged from 34 to 49% depending on the criterion used. Over 60% of the children had levels of trunk fat above 1 SD of reported age- and sex-specific Z-scores for New Zealand children. The nondietary factors examined (hours of television viewing and hours playing organized sports, as reported by parents) were not associated with variations in the percentage of body fat, after adjusting for age, sex and birth weight. These extremely high levels of obesity and truncal fat among very young New Zealand children will have major public health implications as these children age

GJ 1252 b: A 1.2 R\u3csub\u3e⊕\u3c/sub\u3e Planet Transiting An M3 Dwarf At 20.4 pc

We report the discovery of GJ 1252 b, a planet with a radius of 1.193 ± 0.074 R⊕ and an orbital period of 0.52 days around an M3-type star (0.381 ± 0.019 M⊕, 0.391 ± 0.020 R⊕) located 20.385 ± 0.019 pc away. We use Transiting Exoplanet Survey Satellite (TESS) data, ground-based photometry and spectroscopy, Gaia astrometry, and high angular resolution imaging to show that the transit signal seen in the TESS data must originate from a transiting planet. We do so by ruling out all false-positive scenarios that attempt to explain the transit signal as originating from an eclipsing stellar binary. Precise Doppler monitoring also leads to a tentative mass measurement of 2.09 ± 0.56 M⊕. The host star proximity, brightness (V = 12.19 mag, K = 7.92 mag), low stellar activity, and the system\u27s short orbital period make this planet an attractive target for detailed characterization, including precise mass measurement, looking for other objects in the system, and planet atmosphere characterization

Higgs-Boson Mass Limits and Precise Measurements beyond the Standard Model

The triviality and vacuum stability bounds on the Higgs-boson mass (\mh) were revisited in presence of weakly-coupled new interactions parameterized in a model-independent way by effective operators of dimension 6. The constraints from precision tests of the Standard Model were taken into account. It was shown that for the scale of new physics in the region \Lambda \simeq 2 \div 50 \tev the Standard Model triviality upper bound remains unmodified whereas it is natural to expect that the lower bound derived from the requirement of vacuum stability is substantially modified depending on the scale \La and strength of coefficients of effective operators. A natural generalization of the standard triviality condition leads also to a substantial reduction of the allowed region in the (\Lambda,\mh) space.Comment: 18 pages 3 eps figures. The discussion in the appendix was modified slightly and some typographical errors were correcte

No Evidence of a Drug-Drug Interaction Between Letermovir (MK-8228) and Mycophenolate Mofetil

Introduction: Letermovir (MK-8228) is a potent, oncedaily inhibitor of the cytomegalovirus (CMV) terminase complex that is being developed for the prophylaxis of CMV infection in transplant patients. This study evaluated the pharmacokinetic interactions, safety, and tolerability of letermovir when coadministered in healthy subjects with mycophenolate mofetil (MMF), which is the morpholinoethyl ester prodrug of mycophenolic acid (MPA). Methods: This was an open-label trial in 14 healthy female subjects that explored the pharmacokinetic parameters of a single 1 g oral dose of MMF administered alone on Day 1 and coadministered on Day 12 with 480 mg oral once-daily letermovir given on Day 5 and from Day 8 continued through Day 16. Letermovir PK was assessed at single dose (Day 5) and at steady state on Day 12 (with MMF) and Day 16 (alone following MMF washout). Results: Coadministration of 480 mg qd letermovir at steady state with a single dose of 1 g of MMF had no effect on the pharmacokinetics of MPA. The MPA AUC0-inf and Cmax geometric mean ratios (GMRs) [90% confidence interval] for the comparison (MMF with letermovir/ MMF alone) were 1.08 [0.96, 1.21] and 0.96 [0.81, 1.13], respectively. Coadministration of a single dose of 1 g MMF with 480 mg qd letermovir at steady state had no clinically meaningful effect on the pharmacokinetics of letermovir, with AUC0-24 and Cmax GMR of 1.18 [1.04, 1.32] and 1.11 [0.93, 1.34], respectively. The letermovir geometric mean accumulation ratio (Day 16/Day 5) and 95% CI were 1.13 [0.90, 1.42] for AUC0-24 and 1.01 [ 0.79, 1.28] f or Cmax, indicating that accumulation of letermovir when administered as daily doses is minimal. All related AEs were reported as mild in severity and resolved. Conclusions: Multiple-dose administration of 480 mg letermovir daily with a single dose of 1 g MMF was generally well tolerated by the healthy subjects in this study. Coadministration of letermovir and MMF had no clinically meaningful effect on the PK of letermovir or MPA. Letermovir and MMF may be coadministered without dose adjustment

Limits on a Composite Higgs Boson

Precision electroweak data are generally believed to constrain the Higgs boson mass to lie below approximately 190 GeV at 95% confidence level. The standard Higgs model is, however, trivial and can only be an effective field theory valid below some high energy scale characteristic of the underlying non-trivial physics. Corrections to the custodial isospin violating parameter T arising from interactions at this higher energy scale dramatically enlarge the allowed range of Higgs mass. We perform a fit to precision electroweak data and determine the region in the (m_H, Delta T) plane that is consistent with experimental results. Overlaying the estimated size of corrections to T arising from the underlying dynamics, we find that a Higgs mass up to 500 GeV is allowed. We review two composite Higgs models which can realize the possibility of a phenomenologically acceptable heavy Higgs boson. We comment on the potential of improvements in the measurements of m_t and M_W to improve constraints on composite Higgs models.Comment: 9 pages, 2 eps figures. Shortened for PRL; some references elminate

Hit-and-run transcriptional control by bZIP1 mediates rapid nutrient signaling in Arabidopsis

The dynamic nature of gene regulatory networks allows cells to rapidly respond to environmental change. However, the underlying temporal connections are missed, even in kinetic studies, as transcription factor (TF) binding within at least one time point is required to identify primary targets. The TF-regulated but unbound genes are dismissed as secondary targets. Instead, we report that these genes comprise transient TF-target interactions most relevant to rapid signal transduction. We temporally perturbed a master TF (Basic Leucine Zipper 1, bZIP1) and the nitrogen (N) signal it transduces and integrated TF regulation and binding data from the same cell samples. Our enabling approach could identify primary TF targets based solely on gene regulation, in the absence of TF binding. We uncovered three classes of primary TF targets: (i) poised (TF-bound but not TF-regulated), (ii) stable (TF-bound and TF-regulated), and (iii) transient (TF-regulated but not TF-bound), the largest class. Unexpectedly, the transient bZIP1 targets are uniquely relevant to rapid N signaling in planta, enriched in dynamic N-responsive genes, and regulated by TF and N signal interactions. These transient targets include early N responders nitrate transporter 2.1 and NIN-like protein 3, bound by bZIP1 at 1-5 min, but not at later time points following TF perturbation. Moreover, promoters of these transient targets are uniquely enriched with cis-regulatory motifs coinherited with bZIP1 binding sites, suggesting a recruitment role for bZIP1. This transient mode of TF action supports a classic, but forgotten, "hit-and-run" transcription model, which enables a "catalyst TF" to activate a large set of targets within minutes of signal perturbation