641 research outputs found

    New Results on Non-Abelian Vortices - further insights into monopole, vortex and confinement

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    We discuss some of the latest results concerning the non-Abelian vortices. The first concerns the construction of non-Abelian BPS vortices based on general gauge groups of the form G= G' x U(1). In particular detailed results about the vortex moduli space have been obtained for G'=SO(N) or USp(2N). The second result is about the "fractional vortices", i.e., vortices of the minimum winding but having substructures in the tension (or flux) density in the transverse plane. Thirdly, we discuss briefly the monopole-vortex complex.Comment: Latex 20 page

    Optimal Conditions for Kinetic Study of Succinate Dehydrogenase in Rat Liver

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    Succinate dehydrogenase (SDH) commonly is assayed as a marker enzyme for mitochondrial activity. The literature presents numerous conditions for conducting this assay due to the fact that, it has been difficult to get sufficient reduction of the acceptor dye, 2,3,5-triphenyl-2H-tetrazolium chloride (TTC). This study was undertaken to optimize the SDH-catalyzed reduction of TTC dye by evaluation of a greater range of molor ratios of TTC to succinate and by further evaluation of additives reported as beneficial. Improvement in enzyme specific activity was achieved by liver perfusion via the left cardiac ventricle with homogenizing solution. Increase in TTC from 1 to 10 mM and further increase to 20 mM resulted in major improvement in color production. The greatest improvement in apparent activity was achieved by addition of 1 mM phenozine methosulfate, a hydrogen transfer mediator. Use of CaCI₂. EDTA, Triton X-100, NaN₃ and KCN was not beneficial. The above modifications of the SDH assay resulted in greater sensitivity, the conduct of a greater number of assays with less tissue and the sacrifice of fewer animals

    Evaluation and management implications of uncertainty in a multispecies size-structured model of population and community responses to fishing

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    1. Implementation of an ecosystem approach to fisheries requires advice on trade-offs among fished species and between fisheries yields and biodiversity or food web properties. However, the lack of explicit representation, analysis and consideration of uncertainty in most multispecies models has limited their application in analyses that could support management advice. 2. We assessed the consequences of parameter uncertainty by developing 78 125 multispecies size-structured fish community models, with all combinations of parameters drawn from ranges that spanned parameter values estimated from data and literature. This unfiltered ensemble was reduced to 188 plausible models, the filtered ensemble (FE), by screening outputs against fish abundance data and ecological principles such as requiring species' persistence. 3. Effects of parameter uncertainty on estimates of single-species management reference points for fishing mortality (FMSY, fishing mortality rate providing MSY, the maximum sustainable yield) and biomass (BMSY, biomass at MSY) were evaluated by calculating probability distributions of estimated reference points with the FE. There was a 50% probability that multispecies FMSY could be estimated to within ±25% of its actual value, and a 50% probability that BMSY could be estimated to within ±40% of its actual value. 4. Signal-to-noise ratio was assessed for four community indicators when mortality rates were reduced from current rates to FMSY. The slope of the community size spectrum showed the greatest signal-to-noise ratio, indicating that it would be the most responsive indicator to the change in fishing mortality F. Further, the power of an ongoing international monitoring survey to detect predicted responses of size spectrum slope was higher than for other size-based metrics. 5. Synthesis and applications: Application of the ensemble model approach allows explicit representation of parameter uncertainty and supports advice and management by (i) providing uncertainty intervals for management reference points, (ii) estimating working values of reference points that achieve a defined reduction in risk of not breaching the true reference point, (iii) estimating the responsiveness of population, community, food web and biodiversity indicators to changes in F, (iv) assessing the performance of indicators and monitoring programmes and (v) identifying priorities for data collection and changes to model structure to reduce uncertainty

    BrdU Pulse Labelling In Vivo to Characterise Cell Proliferation during Regeneration and Repair following Injury to the Airway Wall in Sheep

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    The response of S-phase cells labelled with bromodeoxyuridine (BrdU) in sheep airways undergoing repair in response to endobronchial brush biopsy was investigated in this study. Separate sites within the airway tree of anaesthetised sheep were biopsied at intervals prior to pulse labelling with BrdU, which was administered one hour prior to euthanasia. Both brushed and spatially disparate unbrushed (control) sites were carefully mapped, dissected, and processed to facilitate histological analysis of BrdU labelling. Our study indicated that the number and location of BrdU-labelled cells varied according to the age of the repairing injury. There was little evidence of cell proliferation in either control airway tissues or airway tissues examined six hours after injury. However, by days 1 and 3, BrdU-labelled cells were increased in number in the airway wall, both at the damaged site and in the regions flanking either side of the injury. Thereafter, cell proliferative activity largely declined by day 7 after injury, when consistent evidence of remodelling in the airway wall could be appreciated. This study successfully demonstrated the effectiveness of in vivo pulse labelling in tracking cell proliferation during repair which has a potential value in exploring the therapeutic utility of stem cell approaches in relevant lung disease models

    Metamemory in a familiar place: the effects of environmental context on feeling of knowing

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    Feeling-of-knowing (FOK) judgments are judgments of future recognizability of currently inaccessible information. They are known to depend both on the access to partial information about a target of retrieval and on the familiarity of the cue that is used as a memory probe. In the present study we assessed whether FOK judgments could also be shaped by incidental environmental context in which these judgments are made. To this end, we investigated 2 phenomena previously documented in studies on recognition memory—a context familiarity effect and a context reinstatement effect—in the procedure used to investigate FOK judgments. In 2 experiments, we found that FOK judgments increase in the presence of a familiar environmental context. The results of both experiments further revealed still higher FOK judgments when made in the presence of environmental context matching the encoding context of both cue and its associated target. The effect of context familiarity on FOK judgment was paralleled by an effect on the latencies of an unsuccessful memory search, but the effect of context reinstatement was not. Importantly, the elevated feeling of knowing in reinstated and familiar contexts was not accompanied by an increase in the accuracy of those judgments. Together, these results demonstrate that metacognitive processes are shaped by the overall volume of memory information accessed at retrieval, independently of whether this memory information is related to a cue, a target, or a context in which remembering takes place

    A 5d/3d duality from relativistic integrable system

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    We propose and prove a new exact duality between the F-terms of supersymmetric gauge theories in five and three dimensions with adjoint matter fields. The theories are compactified on a circle and are subject to the Omega deformation. In the limit proposed by Nekrasov and Shatashvili, the supersymmetric vacua become isolated and are identified with the eigenstates of a quantum integrable system. The effective twisted superpotentials are the Yang-Yang functional of the relativistic elliptic Calogero-Moser model. We show that they match on-shell by deriving the Bethe ansatz equation from the saddle point of the five-dimensional partition function. We also show that the Chern-Simons terms match and extend our proposal to the elliptic quiver generalizations.Comment: 30 pages, 4 figures. v2: typo corrected, references adde

    Measuring Community Programs and Policies in the Healthy Communities Study

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    Childhood obesity is a challenging public health issue facing communities throughout the U.S. Local efforts are believed to be essential to assuring environments that support physical activity and healthy food/beverage consumption among children and their families. However, little is known about how broadly and intensively communities are implementing combinations of programs and policies that address childhood nutrition, physical activity, and weight control. The Healthy Communities Study is a nationwide scientific study in diverse communities to identify characteristics of communities and programs that may be associated with childhood obesity. Data collection occurred in 2013–2015; data analysis will be completed in 2016. As part of the Healthy Communities Study, researchers designed a measurement system to assess the number and scope of community programs and policies and to examine possible associations between calculated “intensity” scores for these programs and policies and behavioral and outcome measures related to healthy weight among children. This report describes the protocol used to capture and code instances of community programs and policies, to characterize attributes of community programs and policies related to study hypotheses, and to calculate the intensity of combinations of community programs and policies (i.e., using the attributes of change strategy, duration, and reach)

    Experimental implications of mirror matter-type dark matter

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    Mirror matter-type dark matter is one dark matter candidate which is particularly well motivated from high energy physics. The theoretical motivation and experimental evidence are pedagogically reviewed, with emphasis on the implications of recent orthopositronium experiments, the DAMA/NaI dark matter search, anomalous meteorite events etc.Comment: about 12 pages lon

    Adaptability and Social Support: Examining Links with Psychological Wellbeing Among UK Students and Non-students

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    The purpose of this multi-study article was to investigate the roles of adaptability and social support in predicting a variety of psychological outcomes. Data were collected from Year 12 college students (N = 73; Study 1), university students (N = 102; Study 2), and non-studying members of the general public (N = 141; Study 3). Findings showed that, beyond variance attributable to social support, adaptability made a significant independent contribution to psychological wellbeing (life satisfaction, psychological wellbeing, flourishing, and general affect) and psychological distress across all studies. Beyond the effects of adaptability, social support was found to make a significant independent contribution to most wellbeing outcomes (but not psychological distress in university students). In a multi-group analysis comparing predictors of psychological wellbeing in university students and non-studying adults, where the same outcome measures were used (Study 4; N = 243), it was found that adaptability played a stronger role (relative to social support) for university students, whereas social support played a stronger role for non-studying adults. Finally, (contrary to expectations) there was no evidence of an interaction between adaptability and social support predicting psychological outcomes—adaptability and social support operated as independent main effects. These findings demonstrate the importance of adaptability and social support in uniquely predicting psychological wellbeing in different sample groups. It is argued here that these two factors, should be given greater consideration in discussions of psychological wellbeing, and are relevant to psychological wellbeing at different major developmental life stages
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