COWpads: Sharing iPads in a range of secondary school classrooms

This article outlines a mid-point snapshot of the progress of a small teaching-as-inquiry project at Hillcrest High School in 2013. Three teachers (music, mathematics, French) volunteered to focus on using iPads in a COW (computers on wheels, hence the term COWPads) configuration with a junior class during 2013. Each teacher created their own teaching-as-inquiry question focused on specific aspects of their practice. A University of Waikato researcher supported the teachers by observing classes and meeting regularly for feedback, reflection and discussion. Halfway through the year the following themes have emerged: the technical challenges to using a device designed for personal use as a shared device; a positive impact on students’ concentration levels and spans when using iPads, and shifts in teachers’ pedagogical design and practice. The teachers individually contribute their voices to this article, describing their initial experiences of using iPads on a regular basis and what they concentrated on most during the first few months of the project

Rural vs. Urban Health Disparities

Introduction and Background Individuals in rural areas do not have the same access to health care as individuals who live in urban areas. Individuals who live in rural areas tend to not get the care that they need due to income and location. Purpose Statement Healthcare differs for those who live in rural versus urban populations. How can the intervention of telehealth help to decrease the health disparities for individuals who live in rural communities? Literature Review We searched the phrases “rural and urban” and “health disparities” in google scholar and restricted the search to articles that were published from 2018 to now and we narrowed it down to 3 articles. For the two articles that included our intervention of telehealth we did a Google Scholar advanced search and used the keywords “telehealth” and “health disparities” and filtered the search to where the most recent would be shown and we narrowed it down to 2 articles. Findings The research that we collected strongly suggests that there are health disparities among rural areas compared to urban areas, meaning that rural areas do not have as good of access to adequate health care. The intervention of telehealth however could help improve the health disparities for those in rural areas. Conclusions Rural areas do not have as good of access to healthcare as those who live in urban areas. Our research gave a variety of different examples of how rural areas have a disadvantage when it comes to the quality of healthcare individuals receive. Telehealth can help to decrease these health disparities and improve the quality of care that individuals in rural areas receive

AI and Gender: Four Proposals for Future Research

This report outlines four of the weightiest challenges to gender equality presented by recent developments in artificial intelligence (AI). In tandem, it outlines four research proposals which would effectively tackle these issues. These four research proposals are the direct result of the ‘AI and Gender’ workshop held by the Leverhulme Centre for the Future of Intelligence on 20th February 2019. This was convened with the Ada Lovelace Institute, and supported by PwC. In particular, this report draws on the final activity of the day, the collective intelligence activity. During this activity, participants were invited to identify areas and methods for future research. The report develops and augments the ideas shared during this exercise by drawing on content from the workshop presentations, questions, and discussions, as well as from a broad range of wider literature and research.We are grateful to the Ada Lovelace Institute which provided sponsorship for the Leverhulme Centre for the Future of Intelligence ‘AI and Gender’ workshop. The Ada Lovelace Institute is an independent research and deliberative body – established by the Nuffield Foundation – with a mission to ensure data and AI work for people and society. The views expressed in this report are those of the authors and not necessarily of the Ada Lovelace Institute or the Nuffield Foundation. We are grateful to PwC, who also generously supported the Leverhulme Centre for Future of Intelligence ‘AI and Gender’ workshop. The Leverhulme Centre for the Future of Intelligence is grateful to the Leverhulme Trust for their generous support. Research Centre Grant No. RC-2015-06

Incidence of adult Huntington's disease in the UK: a UK-based primary care study and a systematic review.

OBJECTIVES: The prevalence of Huntington's disease (HD) recorded in the UK primary care records has increased twofold between 1990 and 2010. This investigation was undertaken to assess whether this might be due to an increased incidence. We have also undertaken a systematic review of published estimates of the incidence of HD. SETTING: Incident patients with a new diagnosis of HD were identified from the primary care records of the Clinical Practice Research Datalink (CPRD). The systematic review included all published estimates of the incidence of HD in defined populations. PARTICIPANTS: A total of 393 incident cases of HD were identified from the CPRD database between 1990 and 2010 from a total population of 9,282,126 persons. PRIMARY AND SECONDARY OUTCOME MEASURES: The incidence of HD per million person-years was estimated. From the systematic review, the extent of heterogeneity of published estimates of the incidence of HD was examined using the I(2) statistic. RESULTS: The data showed that the incidence of HD has remained constant between 1990 and 2010 with an overall rate of 7.2 (95% CI 6.5 to 7.9) per million person-years. The systematic review identified 14 independent estimates of incidence with substantial heterogeneity and consistently lower rates reported in studies from East Asia compared with those from Australia, North America and some--though not all--those from Europe. Differences in incidence estimates did not appear to be explained solely by differences in case ascertainment or diagnostic methods. CONCLUSIONS: The rise in the prevalence of diagnosed HD in the UK, between 1990 and 2010, cannot be attributed to an increase in incidence. Globally, estimates of the incidence of HD show evidence of substantial heterogeneity with consistently lower rates in East Asia and parts of Europe. Modifiers may play an important role in determining the vulnerability of different populations to expansions of the HD allele

Use of the Capability, Opportunity and Motivation Behaviour model (COM-B) to understand interventions to support physical activity behaviour in people with stroke : an overview of reviews

Objective. Physical activity in people with stroke remains low despite considerable research. This overview aimed to provide high-level synthesis and aid clinical decision-making. The Capability, Opportunity, Motivation-Behaviour (COM-B) model was used to classify interventions to understand which components improve physical activity behaviour in people with stroke. Data Sources. CINAHL, Cochrane Database, MEDLINE, PEDro, PsychINFO, SPORTDiscus Review. MethodsA systematic search was conducted (November 2023) to identify reviews of interventions to improve physical activity in people with stroke. Results were screened and assessed for eligibility. Participant characteristics, intervention classification using COM-B, and effect of intervention were extracted. Quality was assessed using AMSTAR2, and Corrected Cover Analysis for study overlap. Narrative synthesis was used to understand components of interventions to improve physical activity behaviour. Results. 1801 references were screened and 29 full-text references assessed for eligibility. Twenty reviews were included. Quality ranged from critically low (n = 3) to high (n = 10). Study overlap calculated using corrected cover area indicated slight overlap (0.028) and minimal reporting bias. The majority of participants were mobile with mild stroke and community dwelling. Twenty-three interventions were classified using COM-B. Three of twelve interventions classified to one aspect of the COM-B were effective. Fourteen of sixteen effective interventions combined at least two COM-B elements, ten of these combined capability and motivation. Conclusion. Interventions including at least two elements of the COM-B are most likely to improve physical activity in mobile stroke survivors. Further research is needed to understand physical activity behaviour in those with moderate to severe stroke

River patterns reveal two stages of landscape evolution at an oblique convergent margin, Marlborough Fault System, New Zealand

Here we examine the landscape of New Zealand's Marlborough Fault System (MFS), where the Australian and Pacific plates obliquely collide, in order to study landscape evolution and the controls on fluvial patterns at a long-lived plate boundary. We present maps of drainage anomalies and channel steepness, as well as an analysis of the plan-view orientations of rivers and faults, and we find abundant evidence of structurally controlled drainage that we relate to a history of drainage capture and rearrangement in response to mountain-building and strike-slip faulting. Despite clear evidence of recent rearrangement of the western MFS drainage network, rivers in this region still flow parallel to older faults, rather than along orthogonal traces of younger, active strike-slip faults. Such drainage patterns emphasize the importance of river entrenchment, showing that once rivers establish themselves along a structural grain, their capture or avulsion becomes difficult, even when exposed to new weakening and tectonic strain. Continued flow along older faults may also indicate that the younger faults have not yet generated a fault damage zone with the material weakening needed to focus erosion and reorient rivers. Channel steepness is highest in the eastern MFS, in a zone centered on the Kaikōura ranges, including within the low-elevation valleys of main stem rivers and at tributaries near the coast. This pattern is consistent with an increase in rock uplift rate toward a subduction front that is locked on its southern end. Based on these results and a wealth of previous geologic studies, we propose two broad stages of landscape evolution over the last 25 million years of orogenesis. In the eastern MFS, Miocene folding above blind thrust faults generated prominent mountain peaks and formed major transverse rivers early in the plate collision history. A transition to Pliocene dextral strike-slip faulting and widespread uplift led to cycles of river channel offset, deflection and capture of tributaries draining across active faults, and headward erosion and captures by major transverse rivers within the western MFS. We predict a similar landscape will evolve south of the Hope Fault, as the locus of plate boundary deformation migrates southward into this region with time.</p

Visualising harms in publications of randomised controlled trials: consensus and recommendations

OBJECTIVE: To improve communication of harm in publications of randomised controlled trials via the development of recommendations for visually presenting harm outcomes. DESIGN: Consensus study. SETTING: 15 clinical trials units registered with the UK Clinical Research Collaboration, an academic population health department, Roche Products, and The BMJ. PARTICIPANTS: Experts in clinical trials: 20 academic statisticians, one industry statistician, one academic health economist, one data graphics designer, and two clinicians. MAIN OUTCOME: measures A methodological review of statistical methods identified visualisations along with those recommended by consensus group members. Consensus on visual recommendations was achieved (at least 60% of the available votes) over a series of three meetings with participants. The participants reviewed and critically appraised candidate visualisations against an agreed framework and voted on whether to endorse each visualisation. Scores marginally below this threshold (50-60%) were revisited for further discussions and votes retaken until consensus was reached. RESULTS: 28 visualisations were considered, of which 10 are recommended for researchers to consider in publications of main research findings. The choice of visualisations to present will depend on outcome type (eg, binary, count, time-to-event, or continuous), and the scenario (eg, summarising multiple emerging events or one event of interest). A decision tree is presented to assist trialists in deciding which visualisations to use. Examples are provided of each endorsed visualisation, along with an example interpretation, potential limitations, and signposting to code for implementation across a range of standard statistical software. Clinician feedback was incorporated into the explanatory information provided in the recommendations to aid understanding and interpretation. CONCLUSIONS: Visualisations provide a powerful tool to communicate harms in clinical trials, offering an alternative perspective to the traditional frequency tables. Increasing the use of visualisations for harm outcomes in clinical trial manuscripts and reports will provide clearer presentation of information and enable more informative interpretations. The limitations of each visualisation are discussed and examples of where their use would be inappropriate are given. Although the decision tree aids the choice of visualisation, the statistician and clinical trial team must ultimately decide the most appropriate visualisations for their data and objectives. Trialists should continue to examine crude numbers alongside visualisations to fully understand harm profiles

The N2-Src neuronal splice variant of C-Src has altered SH3 domain ligand specificity and a higher constitutive activity than N1-Src

N2-Src is a poorly understood neuronal splice variant of the ubiquitous C-Src tyrosine kinase, containing a 17 amino acid insert in its Src homology 3 (SH3) domain. To characterise the properties of N2-Src we directly compared its SH3 domain specificity and kinase activity with C- and N1-Src in vitro. N2- and N1-Src had a similar low affinity for the phosphorylation of substrates containing canonical C-Src SH3 ligands and synaptophysin, an established neuronal substrate for C-Src. N2-Src also had a higher basal kinase activity than N1- and C-Src in vitro and in cells, which could be explained by weakened intramolecular interactions. Therefore, N2-Src is a highly active kinase that is likely to phosphorylate alternative substrates to C-Src in the brain

Efficacy, Safety, and Tolerability of Three Regimens for Prevention of Malaria: A Randomized, Placebo-Controlled Trial in Ugandan Schoolchildren

BACKGROUND: Intermittent preventive treatment (IPT) is a promising malaria control strategy; however, the optimal regimen remains unclear. We conducted a randomized, single-blinded, placebo-controlled trial to evaluate the efficacy, safety, and tolerability of a single course of sulfadoxine-pyrimethamine (SP), amodiaquine + SP (AQ+SP) or dihydroartemisinin-piperaquine (DP) among schoolchildren to inform IPT. METHODS: Asymptomatic girls aged 8 to 12 years and boys aged 8 to 14 years enrolled in two primary schools in Tororo, Uganda were randomized to receive one of the study regimens or placebo, regardless of presence of parasitemia at enrollment, and followed for 42 days. The primary outcome was risk of parasitemia at 42 days. Survival analysis was used to assess differences between regimens. RESULTS: Of 780 enrolled participants, 769 (98.6%) completed follow-up and were assigned a treatment outcome. The risk of parasitemia at 42 days varied significantly between DP (11.7% [95% confidence interval (CI): 7.9, 17.1]), AQ+SP (44.3% [37.6, 51.5]), and SP (79.7% [95% CI: 73.6, 85.2], p<0.001). The risk of parasitemia in SP-treated children was no different than in those receiving placebo (84.6% [95% CI: 79.1, 89.3], p = 0.22). No serious adverse events occurred, but AQ+SP was associated with increased risk of vomiting compared to placebo (13.0% [95% CI: 9.1, 18.5] vs. 4.7% [95% CI: 2.5, 8.8], respectively, p = 0.003). CONCLUSIONS: DP was the most efficacious and well-tolerated regimen tested, although AQ+SP appears to be a suitable alternative for IPT in schoolchildren. Use of SP for IPT may not be appropriate in areas with high-level SP resistance in Africa. TRIAL REGISTRATION: ClinicalTrials.gov NCT00852371