Prognostic indicators in patients presenting with the nephrotic syndrome

Prognostic indicators in patients presenting with the nephrotic syndrome. Clinical data from 246 patients presenting with a nephrotic syndrome and biopsy-proven glomerular disorder were analyzed, using statistical survival techniques, to determine which of several variables (sex, age, plasma creatinine, diastolic blood pressure and 24-hour urinary protein loss) were associated with subsequent end-stage renal failure. The best prediction of outcome could be made at one year (N = 121); then plasma creatinine (P < 0.001) and heavy proteinuria (P = 0.049) were the best determinants. For a given plasma creatinine level, heavy urinary protein was associated with a worse outcome. The incidence of end-stage renal failure was greatest three to four years from the date edema first developed. Plasma creatinine and urinary protein values, collected four-monthly throughout the study period, were analyzed as time-dependent covariates. A relationship was found between the prevailing risk of renal failure and earlier heavy proteinuria (P < 0.001). Spontaneous complete remission of proteinuria was associated with a highly favorable outcome (P = 0.001) and normal, or impaired but stable, renal function

The Grizzly, November 22, 1994

Pew Roundtable Discusses Priorities at Ursinus • Clinton Wavers on School Prayer • Letters to the Editor: Parent Shows Concern Over Alcohol • Man Arrested for Threatening Children • Class of \u2798 Update • Iraq Recognizes Kuwait • Final Exam Schedule • Berman Features Watercolor Exhibit • Lady Bears Preseason Outlook • Ursinus\u27 All-Centennial Conference Performershttps://digitalcommons.ursinus.edu/grizzlynews/1348/thumbnail.jp

Mycoplasma genitalium: An Emerging Cause of Sexually Transmitted Disease in Women

Mycoplasma genitalium is an emerging sexually transmitted pathogen implicated in urethritis in men and several inflammatory reproductive tract syndromes in women including cervicitis, pelvic inflammatory disease (PID), and infertility. This comprehensive review critically examines epidemiologic studies of M. genitalium infections in women with the goal of assessing the associations with reproductive tract disease and enhancing awareness of this emerging pathogen. Over 27,000 women from 48 published reports have been screened for M. genitalium urogenital infection in high- or low-risk populations worldwide with an overall prevalence of 7.3% and 2.0%, respectively. M. genitalium was present in the general population at rates between those of Chlamydia trachomatis and Neisseria gonorrhoeae. Considering more than 20 studies of lower tract inflammation, M. genitalium has been positively associated with urethritis, vaginal discharge, and microscopic signs of cervicitis and/or mucopurulent cervical discharge in seven of 14 studies. A consistent case definition of cervicitis is lacking and will be required for comprehensive understanding of these associations. Importantly, evidence for M. genitalium PID and infertility are quite convincing and indicate that a significant proportion of upper tract inflammation may be attributed to this elusive pathogen. Collectively, M. genitalium is highly prevalent in high- and low-risk populations, and should be considered an etiologic agent of select reproductive tract disease syndromes in women

Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samples

Funder: NCI U24CA211006Abstract: The Cancer Genome Atlas (TCGA) and International Cancer Genome Consortium (ICGC) curated consensus somatic mutation calls using whole exome sequencing (WES) and whole genome sequencing (WGS), respectively. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, which aggregated whole genome sequencing data from 2,658 cancers across 38 tumour types, we compare WES and WGS side-by-side from 746 TCGA samples, finding that ~80% of mutations overlap in covered exonic regions. We estimate that low variant allele fraction (VAF < 15%) and clonal heterogeneity contribute up to 68% of private WGS mutations and 71% of private WES mutations. We observe that ~30% of private WGS mutations trace to mutations identified by a single variant caller in WES consensus efforts. WGS captures both ~50% more variation in exonic regions and un-observed mutations in loci with variable GC-content. Together, our analysis highlights technological divergences between two reproducible somatic variant detection efforts

Interdecadal foredune changes along the Southeast Australian coastline: 1942-2014

Foredunes are important features within coastal landscapes, yet there are relatively few medium to long-term studies on how they evolve and change over time. This study of Australia\u27s New SouthWales (NSW) foredunes has used 70 years of aerial photographs (or photogrammetry) and recent Light Detection and Ranging (LiDAR) datasets to assess multi-decadal fluctuations in foredune morphology. It was shown that over the past 70 years NSW foredunes have exhibited considerable spatial variation, ranging from accretion/aggradation to recession. Those sites that accreted predominantly extended seaward as new incipient dunes, gaining a maximum of 235 m3 m-1 in sand volume over the study period (for the entire dune system). These sites were commonly found in the north of the state, within closed sediment compartments, and with strong onshore (and alongshore) wind climates present (increasing the potential for aeolian sand transport). Stable foredunes were those that remained within +/- 50 m3 m-1 of their initial volume and managed to recover from the various storm impacts over the study period. The majority of these sites were found within the central to southern half of the state, behind embayed beaches, and within leaky sediment compartments, or those that have estuarine sinks. Finally, those foredunes in recession have retreated landwards and/or have reduced in height or width, and lost up to 437 m3 m-1 of sand volume over the study period. There was no clear spatial trend for these sites; however, generally they were found in compartments that had unusual orientations, had disruptions in longshore drift/cross shore sand delivery (i.e., rocky reefs), or were being impacted by humans (i.e., the installation of river training walls, sand bypassing systems, or coastal management programs). This study has shown that NSW foredunes have undergone substantial recent changes and, by understanding their past history, will provide better insight into how they can be managed into the future

Rapid shoreline progradation followed by vertical foredune building at Pedro Beach, southeastern Australia

At Pedro Beach on the southeastern coast of Australia a series of foredune ridges provides an opportunity to explore the morphodynamic paradigm as it applies to coastal barrier systems using optically stimulated luminescence (OSL) dating, ground penetrating radar (GPR) and airborne LiDAR topography. A series of sandy dune-capped ridges, increasing in height seawards, formed from c. 7000 years ago to c. 3900 years ago. During this time the shoreline straightened as the embayment filled and accommodation space for Holocene sediments diminished. Calculation of Holocene sediment accumulation above mean sea level utilising airborne LiDAR topography shows a decline in average sediment supply over this time period coupled with a decrease in shoreline progradation rate from 1.2 m/yr to 0.38 m/yr. The average ridge \u27exposure lifetime\u27 during this period increases resulting in higher ridges as dune-forming processes have longer to operate. Increasing exposure to wave and wind energy also appears to have resulted in higher ridges as the sheltering effect of marginal headlands was diminished. An inherited disequilibrium shoreface profile will drive onshore accumulation of sandy sediments forming a prograded barrier; however, if there is no longer \u27accommodation space\u27 for sediment, this will be an overriding factor causing the cessation of progradation, as occurred c. 3900 years ago at Pedro Beach. Excess sediment in the nearshore zone after 3900 years ago may have been moved northward to nourish downdrift beaches in the compartment. A high outer foredune has formed through vertical accretion after 500 years ago, evidenced by GPR subsurface structures and OSL ages, with a distinct period of vertical and lee slope accretion and dated to the period 1890-1930 AD. The increased dune sediment transport resulting in foredune building is attributed to recent human disturbance. 2018 John Wiley & Sons, Ltd

The coast of Australia

Australia has one of the longest, most diverse and pristine coastlines in the world. From the oldest rocks on the planet to those that are still evolving, the Australian coast is a dynamic, ever-changing suite of dramatic landforms and productive ecosystems. From iconic beaches such as Bondi and long unbroken sands of the Coorong to the endless curtain of the Nullarbor cliffs along the Great Australian Bight, this illuminating book explores these magnificent landforms, revealing how they formed and continue to change. It details the various coastal systems that operate, including beaches, dunes, estuaries, deltas, rocky coast and coral reefs. Written by two of Australia\u27s leading coastal experts, Andrew Short and Colin Woodroffe, The Coast of Australia provides the first comprehensive account of the Australian coast. Covering 36,000 km of shoreline, The Coast of Australia is an engaging exploration of this massive, largely undeveloped and highly variable coastline