A question of scale

If you search for 'collective behaviour' with your web browser most of the texts popping up will be about group activities of humans, including riots, fashion and mass panic. Nevertheless, collective behaviour is also considered to be an important aspect of observed phenomena in atoms and molecules, for example, during spontaneous magnetization. In your web search, you might also find articles on collectively migrating bacteria, insects or birds; or phenomena where groups of organisms or non- living objects synchronize their signals or motion (think of fireflies flashing in unison or people clapping in phase during rhythmic applause).Comment: Concepts essay, published in Nature http://www.nature.com/nature/journal/v411/n6836/full/411421a0.htm

Gaussian tree constraints applied to acoustic linguistic functional data

Evolutionary models of languages are usually considered to take the form of trees. With the development of so-called tree constraints the plausibility of the tree model assumptions can be addressed by checking whether the moments of observed variables lie within regions consistent with trees. In our linguistic application, the data set comprises acoustic samples (audio recordings) from speakers of five Romance languages or dialects. We wish to assess these functional data for compatibility with a hereditary tree model at the language level. A novel combination of canonical function analysis (CFA) with a separable covariance structure provides a method for generating a representative basis for the data. This resulting basis is formed of components which emphasize language differences whilst maintaining the integrity of the observational language-groupings. A previously unexploited Gaussian tree constraint is then applied to component-by-component projections of the data to investigate adherence to an evolutionary tree. The results indicate that while a tree model is unlikely to be suitable for modeling all aspects of the acoustic linguistic data, certain features of the spoken Romance languages highlighted by the separable-CFA basis may indeed be suitably modeled as a tree.NS acknowledges the support of Economics and Social Science Research Council grant ES/I90427/1. JADA acknowledges the support of UK Engineering and Physical Sciences Research Council grant EP/K021672/2. JSC acknowledges the support of UK Arts and Humanities Research Council grant AH/M002993/1.This is the final version of the article. It first appeared from Elsevier via https://doi.org/10.1016/j.jmva.2016.09.01

Trends in socioeconomic inequalities in behavioural non-communicable disease risk factors: analysis of repeated cross-sectional health surveys in England between 2003 and 2019

Background: Previous studies have shown that those in lower socioeconomic positions (SEPs) generally have higher levels of behavioural non-communicable disease (NCD) risk factors. However, there are limited studies examining recent trends in inequalities. This study examined trends in socioeconomic inequalities in NCD behavioural risk factors and their co-occurrence in England from 2003–19. Methods: This time-trend analysis of repeated cross-sectional data from the Health Survey for England examined the relative index of inequalities (RII) and slope index of inequalities (SII) in four NCD behavioural risk factors: smoking; drinking above recommended limits; insufficient fruit and vegetables consumption; and physical inactivity. Findings: Prevalence of risk factors has reduced over time, however, this has not been consistent across SEPs. Absolute and relative inequalities increased for physical inactivity; relative inequalities also increased for smoking; for insufficient fruit and vegetable consumption, the trends in inequalities depended on SEPs measure. Those in lower SEPs experienced persistent socioeconomic inequalities and clustering of behavioural risk factors. In contrast, those in higher SEPs had higher prevalence of excessive alcohol consumption; this inequality widened over the study period. Interpretation: Inequalities in smoking and physical inactivity are persisting or widening. The pattern of higher drinking in higher SEPs obscure the fact that the greatest burden of alcohol-related harm falls on lower SEPs. Policy attention is required to tackle increasing inequalities in smoking prevalence, low fruit and vegetable consumption and physical inactivity, and to reduce alcohol harm

Minority Becomes Majority in Social Networks

It is often observed that agents tend to imitate the behavior of their neighbors in a social network. This imitating behavior might lead to the strategic decision of adopting a public behavior that differs from what the agent believes is the right one and this can subvert the behavior of the population as a whole. In this paper, we consider the case in which agents express preferences over two alternatives and model social pressure with the majority dynamics: at each step an agent is selected and its preference is replaced by the majority of the preferences of her neighbors. In case of a tie, the agent does not change her current preference. A profile of the agents' preferences is stable if the preference of each agent coincides with the preference of at least half of the neighbors (thus, the system is in equilibrium). We ask whether there are network topologies that are robust to social pressure. That is, we ask if there are graphs in which the majority of preferences in an initial profile always coincides with the majority of the preference in all stable profiles reachable from that profile. We completely characterize the graphs with this robustness property by showing that this is possible only if the graph has no edge or is a clique or very close to a clique. In other words, except for this handful of graphs, every graph admits at least one initial profile of preferences in which the majority dynamics can subvert the initial majority. We also show that deciding whether a graph admits a minority that becomes majority is NP-hard when the minority size is at most 1/4-th of the social network size.Comment: To appear in WINE 201

Flux Discharge Cascades in Various Dimensions

We study the dynamics of electric flux discharge by charged particle pair or spherical string or membrane production in various dimensions. When electric flux wraps at least one compact cycle, we find that a single "pair" production event can initiate a cascading decay in real time that "shorts out" the flux and discharges many units of it. This process arises from local dynamics in the compact space, and so is invisible in the dimensionally-reduced truncation. It occurs in theories as simple as the Schwinger model on a circle, and has implications for any theory with compact dimensions and electric flux, including string theories and the string landscape.Comment: 19+8 pages, 3 figures, 3 appendice

Follow-up practices for high-grade extremity Osteosarcoma

BACKGROUND: The optimal conduct of follow-up (FU) of patients with osteosarcoma is uncertain. In the absence of any formal validation of optimal timing and method of surveillance, guidance is provided by oncology societies' recommendations. FU is designed to detect either local recurrence or metastatic disease at a time when early treatment is still possible and might be effective. METHODS: We performed a retrospective analysis of 101 patients with high-grade extremity osteosarcoma in a single centre. Chest x-ray (CXR) was used as routine surveillance method; however patients with initial lung metastases or previous suspicious findings had computed tomography (CT) scans. RESULTS: With a median FU time of 30.7 months 34 patients relapsed. Relapse-free survival after 5 years was 61% (CI 52%; 73%), late relapses occurred in only two patients between 2 and 5 years of FU. Twenty-five of the 34 relapses were detected at routine FU appointments. All 8 local recurrences were noted clinically. Twenty-two patients had metastases confined to the lungs, either detected on CXR or CT. Thirty-two percent of patients with lung metastases only were salvaged successfully. CONCLUSIONS: Routine FU in high-grade osteosarcoma results in clinical detection of local relapse, and detection of lung metastases by CXR at a time when metastatectomy is possible. The optimal time interval for FU appointments is not known, however we recommend more frequent surveillance visits during the two years after treatment. We hypothesize that routine CT scans are not required and propose CXR for detection of lung metastases

Catastrophic senescence and semelparity in the Penna aging model

The catastrophic senescence of the Pacific salmon is among the initial tests used to validate the Penna aging model. Based on the mutation accumulation theory, the sudden decrease in fitness following reproduction may be solely attributed to the semelparity of the species. In this work, we report other consequences of mutation accumulation. Contrary to earlier findings, such dramatic manifestation of aging depends not only on the choice of breeding strategy but also on the value of the reproduction age, R, and the mutation threshold, T. Senescence is catastrophic when $T \leq R$. As the organism's tolerance for harmful genetic mutations increases, the aging process becomes more gradual. We observe senescence that is threshold dependent whenever T>R. That is, the sudden drop in survival rate occurs at age equal to the mutation threshold value

Behavioural homogenisation with spillovers in a normative domain

The importance of culture for human social evolution hinges largely on the extent to which culture supports outcomes that would not otherwise occur. An especially controversial claim is that social learning leads groups to coalesce around group-typical behaviours and associated social norms that spill over to shape choices in asocial settings. To test this, we conducted an experiment with 878 groups of participants in 116 communities in Sudan. Participants watched a short film and evaluated the appropriate way to behave in the situation dramatized in the film. Each session consisted of an asocial condition in which participants provided private evaluations and a social condition in which they provided public evaluations. Public evaluations allowed for social learning. Across sessions, we randomized the order of the two conditions. Public choices dramatically increased the homogeneity of normative evaluations. When the social condition was first, this homogenizing effect spilled over to subsequent asocial conditions. The asocial condition when first was thus alone in producing distinctly heterogeneous groups. Altogether, information about the choices of others led participants to converge rapidly on similar normative evaluations that continued to hold sway in subsequent asocial settings. These spillovers were at least partly owing to the combined effects of conformity and self-consistency. Conformity dominated self-consistency when the two mechanisms were in conflict, but self-consistency otherwise produced choices that persisted through time. Additionally, the tendency to conform was heterogeneous. Females conformed more than males, and conformity increased with the number of other people a decision-maker observed before making her own choice

Mitigating agency risk between investors and ventures’ managers

The general management literature has long focused on the agency risks involved in the relationship between general managers and shareholders. Shareholders can deploy contractual and non-contractual mechanisms to reduce these inefficiencies. This study examines - based on a broad international sample of investment contracts - how the use of contractual and non-contractual mechanisms is related to the degree of risks associated with the venture’s development stage as well as how these practices differ across countries. Hypotheses are tested using a proprietary dataset of 265 hand-collected investment contracts associated with ventures in the U.S., Israel and nine European countries. Findings suggest that the use of mitigating contractual and non-contractual mechanisms is related to the degree of agency risks, and that these practices vary across countries. This study draws implications for how investors can best deploy their capital in different institutional settings whilst nurturing their relationships with managers and entrepreneurs

Local Scale Thermal Environment and Limited Gene Flow Indicates Vulnerability of Warm Edge Populations in a Habitat Forming Macroalga

© Copyright © 2020 Clark, Poore, Coleman and Doblin. Species inhabiting warm-edge populations of their distribution are suggested to be at the forefront of global warming due to reduced fitness, limited gene flow and living close to their physiological thermal limits. Determining the scale that governs thermal niche and the functional responses of habitat-forming species to environmental stressors is critical for successful conservation efforts, particularly as coastal ecosystems are impacted by global change. Here, we examine the susceptibility of warm-edge populations to warming, in the habitat-forming macroalga, Hormosira banksii, from south-eastern Australia. We use a quantitative breeding design to quantify intraspecific variation in thermal performance (growth, ontogenic development and photosynthetic efficiency) of different genotypes sourced from sites at the equatorward distributional edge (warm-edge) and those toward the center of its distribution (non-edge). The genetic diversity and structure of H. banksii was also examined using microsatellite markers amongst the same sites. Our results found variable responses in thermal performance for growth and development. Warm-edge germlings grew optimally in lower temperatures tested and had narrower thermal breadth compared to non-edge germlings which grew in higher and more broader temperatures. Warm-edge germlings however, showed greater plasticity to tolerate high light indicated by a greater proportion of energy being dissipated as regulated non-photochemical quenching [Y(NPQ)] than non-regulated non-photochemical quenching [Y(NO)]. Overall genetic diversity was lower at the warm-edge location with evidence of increased structuring and reduced gene flow in comparison to the non-edge location. Evidence of genetic structuring was not found locally between high and low shore within sites. Together, these data suggest that non-edge populations may be “thermally buffered” from increased temperatures associated with ocean warming. Warm-edge populations of H. banksii, however, may be vulnerable to warming, due to narrower thermal breadth and sensitivity to higher temperatures, with genetic impoverishment through loss of individuals likely to further reduce population viability