On-line analysis of random vibrations

Measuring device, Randomdec, provides continuous on-line signatures representative of system free vibration curve. Selected points on curve are used in control and failure detection systems. Apparatus applied to both linear and nonlinear systems under nonstationary vibratory states

Operation of solar cell arrays in dilute streaming plasmas

Operation of solar cell arrays in dilute streaming plasma

The Effects of Infections by \u3ci\u3ePyrenophora Teres\u3c/i\u3e and Barley Yellow Dwarf Virus on the Freezing Hardiness of Winter Barley

Single and mixed infections by Pyrenophora teres and two isolates of barley yellow dwarf virus (BYDV) were evaluated for their effects on the resistance to freezing stress of crowns of the winter barley cultivar Pennrad. Plants received one of several treatments: P. teres; either the RMV-NY or PAV-NY isolate of BYDV; RMV + P. teres; PAV + P. teres; or infestation with either nonviruliferous Rhopalosiphum maidis or R. padi. After the treatments, foliage and roots were harvested from 4-wk-old plants to evaluate the effects of infection(s) on top and root growth before freezing. The crowns were subjected to a controlled freezing regime, and resistance to freezing stress was evaluated by assessing retardation of shoot and root regrowth after freezing (crown injury). The treatment combinations resulted in decreased plant growth before freezing and in increased crown injury, relative to control plants. Infection by P. teres did not reduce top and root growth, or lead to crown injury, to the extent of the other treatments. Feeding by viruliferous aphid species, in comparison to feeding by nonviruliferous aphid species, led to decreased top and root growth and to further crown injury. Infections by PAV + P. teres or R MV + P. teres did not reduce top and root growth, but led to increased crown injury relative to plants exposed only to viruliferous aphids

Advanced Scanning Electron Microscopy Methods and Applications to Integrated Circuit Failure Analysis

Semiconductor device failure analysis using the scanning electron microscope (SEM) has become a standard component of integrated circuit fabrication. Improvements in SEM capabilities and in digital imaging and processing have advanced standard acquisition modes and have promoted new failure analysis methods. The physical basis of various data acquisition modes, both standard and new, and their implementation on a computer controlled SEM image acquisition/processing system are discussed, emphasizing the advantages of each method. Design considerations for an integrated, online failure analysis system are also described. Recent developments in the integration of the information provided by electron beam analysis, conventional integrated circuit (IC) testing, computer-aided design (CAD), and device parameter testing into a single system promise to provide powerful future tools for failure analysis

Nondestructive SEM for surface and subsurface wafer imaging

The scanning electron microscope (SEM) is considered as a tool for both failure analysis as well as device characterization. A survey is made of various operational SEM modes and their applicability to image processing methods on semiconductor devices

Aeroservoelastic wind-tunnel investigations using the Active Flexible Wing Model: Status and recent accomplishments

The status of the joint NASA/Rockwell Active Flexible Wing Wind-Tunnel Test Program is described. The objectives are to develop and validate the analysis, design, and test methodologies required to apply multifunction active control technology for improving aircraft performance and stability. Major tasks include designing digital multi-input/multi-output flutter-suppression and rolling-maneuver-load alleviation concepts for a flexible full-span wind-tunnel model, obtaining an experimental data base for the basic model and each control concept and providing comparisons between experimental and analytical results to validate the methodologies. The opportunity is provided to improve real-time simulation techniques and to gain practical experience with digital control law implementation procedures

Parametric flutter studies of an arrow-wing configuration: Some early results

Some early experimental results from a combined experimental and analytical study being conducted at NASA-Langley of the transonic flutter characterisitics of a generic arrow wing configuration are presented. The planned study includes the parametric variation of a variety of structural and geometric characteristics. Presented here are flutter results of the basic arrow wing, for the basic wing with the addition of two simulated lower-surface-mounted engine nacelles, and for the basic wing with the addition of both the fin and the engine nacelles

Calcium Homeostasis in Myogenic Differentiation Factor 1 (MyoD)-Transformed, Virally-Transduced, Skin-Derived Equine Myotubes

Dysfunctional skeletal muscle calcium homeostasis plays a central role in the pathophysiology of several human and animal skeletal muscle disorders, in particular, genetic disorders associated with ryanodine receptor 1 (RYR1) mutations, such as malignant hyperthermia, central core disease, multiminicore disease and certain centronuclear myopathies. In addition, aberrant skeletal muscle calcium handling is believed to play a pivotal role in the highly prevalent disorder of Thoroughbred racehorses, known as Recurrent Exertional Rhabdomyolysis. Traditionally, such defects were studied in human and equine subjects by examining the contractile responses of biopsied muscle strips exposed to caffeine, a potent RYR1 agonist. However, this test is not widely available and, due to its invasive nature, is potentially less suitable for valuable animals in training or in the human paediatric setting. Furthermore, increasingly, RYR1 gene polymorphisms (of unknown pathogenicity and significance) are being identified through next generation sequencing projects. Consequently, we have investigated a less invasive test that can be used to study calcium homeostasis in cultured, skin-derived fibroblasts that are converted to the muscle lineage by viral transduction with a MyoD (myogenic differentiation 1) transgene. Similar models have been utilised to examine calcium homeostasis in human patient cells, however, to date, there has been no detailed assessment of the cells’ calcium homeostasis, and in particular, the responses to agonists and antagonists of RYR1. Here we describe experiments conducted to assess calcium handling of the cells and examine responses to treatment with dantrolene, a drug commonly used for prophylaxis of recurrent exertional rhabdomyolysis in horses and malignant hyperthermia in humans