OTFS vs. OFDM in the Presence of Sparsity: A Fair Comparison

Many recent works in the literature declare that Orthogonal Time-Frequency-Space (OTFS) modulation is a promising candidate technology for high mobility communication scenarios. However, a truly fair comparison with its direct concurrent and widely used Orthogonal Frequency-Division Multiplexing (OFDM) modulation has not yet been provided. In this paper, we present such a fair comparison between the two digital modulation formats in terms of achievable communication rate. In this context, we explicitly address the problem of channel estimation by considering, for each modulation, a pilot scheme and the associated channel estimation algorithm specifically adapted to sparse channels in the Doppler-delay domain, targeting the optimization of the pilot overhead to maximize the overall achievable rate. In our achievable rate analysis we consider also the presence of a guard interval or cyclic prefix. The results are supported by numerical simulations, for different time-frequency selective channels including multiple scattering components and under non-perfect channel state information resulting from the considered pilot schemes. This work does not claim to establish in a fully definitive way which is the best modulation format, since such choice depends on many other features which are outside the scope of this work (e.g., legacy, intellectual property, ease and know-how for implementation, and many other criteria). Nevertheless, we provide the foundations to properly compare multi-carrier communication systems in terms of their information theoretic achievable rate potential, within meaningful and sensible assumptions on the channel models and on the receiver complexity (both in terms of channel estimation and in terms of soft-output symbol detection)

On the Effectiveness of OTFS for Joint Radar Parameter Estimation and Communication

We consider a joint radar parameter estimation and communication system using orthogonal time frequency space (OTFS) modulation. The scenario is motivated by vehicular applications where a vehicle (or the infrastructure) equipped with a mono-static radar wishes to communicate data to its target receiver, while estimating parameters of interest related to this receiver. Provided that the radar-equipped transmitter is ready to send data to its target receiver, this setting naturally assumes that the receiver has been already detected. In a point-to-point communication setting over multipath time-frequency selective channels, we study the joint radar and communication system from two perspectives, i.e., the radar parameter estimation at the transmitter as well as the data detection at the receiver. For the radar parameter estimation part, we derive an efficient approximated Maximum Likelihood algorithm and the corresponding Cramér-Rao lower bound for range and velocity estimation. Numerical examples demonstrate that multi-carrier digital formats such as OTFS can achieve as accurate radar estimation as state-of-the-art radar waveforms such as frequency-modulated continuous wave (FMCW). For the data detection part, we focus on separate detection and decoding and consider a soft-output detector that exploits efficiently the channel sparsity in the Doppler-delay domain. We quantify the detector performance in terms of its pragmatic capacity, i.e., the achievable rate of the channel induced by the signal constellation and the detector soft-output. Simulations show that the proposed scheme outperforms concurrent state-of-the-art solutions. Overall, our work shows that a suitable digitally modulated waveform enables to efficiently operate joint radar parameter estimation and communication by achieving full information rate of the modulation and near-optimal radar estimation performance. Furthermore, OTFS appears to be particularly suited to the scope

Screening of some Ascomycetes and Basidiomycetes species for the production of 1- phenylethanol enantiomerically pure

Fil: Decarlini, M. Universidad Católica de Córdoba. Facultad de Ciencias Químicas; Argentina.Fil: Colavolpe, B. Instituto Tecnológico de Chascomús. Instituto de Investigaciones Biotecnológicas. Laboratorio de Micología y Cultivo de Hongos Comestibles; Argentina.Fil: Albertó, E. Instituto Tecnológico de Chascomús. Instituto de Investigaciones Biotecnológicas. Laboratorio de Micología y Cultivo de Hongos Comestibles; Argentina.Fil: Vázquez, A. Universidad Católica de Córdoba. Facultad de Ciencias Químicas; Argentina.Fil: Aimar, L. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Departamento de Química. Cátedra de Química Aplicada; Argentina.The asymmetric reduction of prochiral ketones represents a pivotal transformation for the production of chiral alcohols. Several of them are considered as key starting materials in obtaining pharmaceuticals.Fil: Decarlini, M. Universidad Católica de Córdoba. Facultad de Ciencias Químicas; Argentina.Fil: Colavolpe, B. Instituto Tecnológico de Chascomús. Instituto de Investigaciones Biotecnológicas. Laboratorio de Micología y Cultivo de Hongos Comestibles; Argentina.Fil: Albertó, E. Instituto Tecnológico de Chascomús. Instituto de Investigaciones Biotecnológicas. Laboratorio de Micología y Cultivo de Hongos Comestibles; Argentina.Fil: Vázquez, A. Universidad Católica de Córdoba. Facultad de Ciencias Químicas; Argentina.Fil: Aimar, L. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Departamento de Química. Cátedra de Química Aplicada; Argentina.Otras Ciencias Química

Iterative receiver design for the estimation of Gaussian samples in impulsive noise

Impulsive noise is the main limiting factor for transmission over channels affected by elec-tromagnetic interference. We study the estimation of (correlated) Gaussian signals in an impulsive noise scenario. In this work, we analyze some of the existing, as well as some novel estimation algorithms. Their performance is compared, for the first time, for different channel conditions, including the Markov–Middleton scenario, where the impulsive noise switches between different noise states. Following a modern approach in digital communications, the receiver design is based on a factor graph model and implements a message passing algorithm. The correlation among signal samples, as well as among noise states brings about a loopy factor graph, where an iterative message passing scheme should be employed. As is well known, approximate variational inference techniques are necessary in these cases. We propose and analyze different algorithms and provide a complete performance comparison among them, showing that the expectation propagation, transparent propa-gation, and parallel iterative schedule approaches reach a performance close to optimal, at different channel conditions

Factor graph based detection approach for high-mobility OFDM systems with large FFT modes

In this article, a novel detector design is proposed for orthogonal frequency division multiplexing (OFDM) systems over frequency selective and time varying channels. Namely, we focus on systems with large OFDM symbol lengths where design and complexity constraints have to be taken into account and many of the existing ICI reduction techniques can not be applied. We propose a factor graph (FG) based approach for maximum a posteriori (MAP) symbol detection which exploits the frequency diversity introduced by the ICI in the OFDM symbol. The proposed algorithm provides high diversity orders allowing to outperform the free-ICI performance in high-mobility scenarios with an inherent parallel structure suitable for large OFDM block sizes. The performance of the mentioned near-optimal detection strategy is analyzed over a general bit-interleaved coded modulation (BICM) system applying low-density parity-check (LDPC) codes. The inclusion of pilot symbols is also considered in order to analyze how they assist the detection process

ITALIAN CANCER FIGURES - REPORT 2015: The burden of rare cancers in Italy = I TUMORI IN ITALIA - RAPPORTO 2015: I tumori rari in Italia

OBJECTIVES: This collaborative study, based on data collected by the network of Italian Cancer Registries (AIRTUM), describes the burden of rare cancers in Italy. Estimated number of new rare cancer cases yearly diagnosed (incidence), proportion of patients alive after diagnosis (survival), and estimated number of people still alive after a new cancer diagnosis (prevalence) are provided for about 200 different cancer entities. MATERIALS AND METHODS: Data herein presented were provided by AIRTUM population- based cancer registries (CRs), covering nowadays 52% of the Italian population. This monograph uses the AIRTUM database (January 2015), which includes all malignant cancer cases diagnosed between 1976 and 2010. All cases are coded according to the International Classification of Diseases for Oncology (ICD-O-3). Data underwent standard quality checks (described in the AIRTUM data management protocol) and were checked against rare-cancer specific quality indicators proposed and published by RARECARE and HAEMACARE (www.rarecarenet.eu; www.haemacare.eu). The definition and list of rare cancers proposed by the RARECAREnet "Information Network on Rare Cancers" project were adopted: rare cancers are entities (defined as a combination of topographical and morphological codes of the ICD-O-3) having an incidence rate of less than 6 per 100,000 per year in the European population. This monograph presents 198 rare cancers grouped in 14 major groups. Crude incidence rates were estimated as the number of all new cancers occurring in 2000-2010 divided by the overall population at risk, for males and females (also for gender-specific tumours).The proportion of rare cancers out of the total cancers (rare and common) by site was also calculated. Incidence rates by sex and age are reported. The expected number of new cases in 2015 in Italy was estimated assuming the incidence in Italy to be the same as in the AIRTUM area. One- and 5-year relative survival estimates of cases aged 0-99 years diagnosed between 2000 and 2008 in the AIRTUM database, and followed up to 31 December 2009, were calculated using complete cohort survival analysis. To estimate the observed prevalence in Italy, incidence and follow-up data from 11 CRs for the period 1992-2006 were used, with a prevalence index date of 1 January 2007. Observed prevalence in the general population was disentangled by time prior to the reference date (≤2 years, 2-5 years, ≤15 years). To calculate the complete prevalence proportion at 1 January 2007 in Italy, the 15-year observed prevalence was corrected by the completeness index, in order to account for those cancer survivors diagnosed before the cancer registry activity started. The completeness index by cancer and age was obtained by means of statistical regression models, using incidence and survival data available in the European RARECAREnet data. RESULTS: In total, 339,403 tumours were included in the incidence analysis. The annual incidence rate (IR) of all 198 rare cancers in the period 2000-2010 was 147 per 100,000 per year, corresponding to about 89,000 new diagnoses in Italy each year, accounting for 25% of all cancer. Five cancers, rare at European level, were not rare in Italy because their IR was higher than 6 per 100,000; these tumours were: diffuse large B-cell lymphoma and squamous cell carcinoma of larynx (whose IRs in Italy were 7 per 100,000), multiple myeloma (IR: 8 per 100,000), hepatocellular carcinoma (IR: 9 per 100,000) and carcinoma of thyroid gland (IR: 14 per 100,000). Among the remaining 193 rare cancers, more than two thirds (No. 139) had an annual IR <0.5 per 100,000, accounting for about 7,100 new cancers cases; for 25 cancer types, the IR ranged between 0.5 and 1 per 100,000, accounting for about 10,000 new diagnoses; while for 29 cancer types the IR was between 1 and 6 per 100,000, accounting for about 41,000 new cancer cases. Among all rare cancers diagnosed in Italy, 7% were rare haematological diseases (IR: 41 per 100,000), 18% were solid rare cancers. Among the latter, the rare epithelial tumours of the digestive system were the most common (23%, IR: 26 per 100,000), followed by epithelial tumours of head and neck (17%, IR: 19) and rare cancers of the female genital system (17%, IR: 17), endocrine tumours (13% including thyroid carcinomas and less than 1% with an IR of 0.4 excluding thyroid carcinomas), sarcomas (8%, IR: 9 per 100,000), central nervous system tumours and rare epithelial tumours of the thoracic cavity (5%with an IR equal to 6 and 5 per 100,000, respectively). The remaining (rare male genital tumours, IR: 4 per 100,000; tumours of eye, IR: 0.7 per 100,000; neuroendocrine tumours, IR: 4 per 100,000; embryonal tumours, IR: 0.4 per 100,000; rare skin tumours and malignant melanoma of mucosae, IR: 0.8 per 100,000) each constituted <4% of all solid rare cancers. Patients with rare cancers were on average younger than those with common cancers. Essentially, all childhood cancers were rare, while after age 40 years, the common cancers (breast, prostate, colon, rectum, and lung) became increasingly more frequent. For 254,821 rare cancers diagnosed in 2000-2008, 5-year RS was on average 55%, lower than the corresponding figures for patients with common cancers (68%). RS was lower for rare cancers than for common cancers at 1 year and continued to diverge up to 3 years, while the gap remained constant from 3 to 5 years after diagnosis. For rare and common cancers, survival decreased with increasing age. Five-year RS was similar and high for both rare and common cancers up to 54 years; it decreased with age, especially after 54 years, with the elderly (75+ years) having a 37% and 20% lower survival than those aged 55-64 years for rare and common cancers, respectively. We estimated that about 900,000 people were alive in Italy with a previous diagnosis of a rare cancer in 2010 (prevalence). The highest prevalence was observed for rare haematological diseases (278 per 100,000) and rare tumours of the female genital system (265 per 100,000). Very low prevalence (<10 prt 100,000) was observed for rare epithelial skin cancers, for rare epithelial tumours of the digestive system and rare epithelial tumours of the thoracic cavity. COMMENTS: One in four cancers cases diagnosed in Italy is a rare cancer, in agreement with estimates of 24% calculated in Europe overall. In Italy, the group of all rare cancers combined, include 5 cancer types with an IR>6 per 100,000 in Italy, in particular thyroid cancer (IR: 14 per 100,000).The exclusion of thyroid carcinoma from rare cancers reduces the proportion of them in Italy in 2010 to 22%. Differences in incidence across population can be due to the different distribution of risk factors (whether environmental, lifestyle, occupational, or genetic), heterogeneous diagnostic intensity activity, as well as different diagnostic capacity; moreover heterogeneity in accuracy of registration may determine some minor differences in the account of rare cancers. Rare cancers had worse prognosis than common cancers at 1, 3, and 5 years from diagnosis. Differences between rare and common cancers were small 1 year after diagnosis, but survival for rare cancers declined more markedly thereafter, consistent with the idea that treatments for rare cancers are less effective than those for common cancers. However, differences in stage at diagnosis could not be excluded, as 1- and 3-year RS for rare cancers was lower than the corresponding figures for common cancers. Moreover, rare cancers include many cancer entities with a bad prognosis (5-year RS <50%): cancer of head and neck, oesophagus, small intestine, ovary, brain, biliary tract, liver, pleura, multiple myeloma, acute myeloid and lymphatic leukaemia; in contrast, most common cancer cases are breast, prostate, and colorectal cancers, which have a good prognosis. The high prevalence observed for rare haematological diseases and rare tumours of the female genital system is due to their high incidence (the majority of haematological diseases are rare and gynaecological cancers added up to fairly high incidence rates) and relatively good prognosis. The low prevalence of rare epithelial tumours of the digestive system was due to the low survival rates of the majority of tumours included in this group (oesophagus, stomach, small intestine, pancreas, and liver), regardless of the high incidence rate of rare epithelial cancers of these sites. This AIRTUM study confirms that rare cancers are a major public health problem in Italy and provides quantitative estimations, for the first time in Italy, to a problem long known to exist. This monograph provides detailed epidemiologic indicators for almost 200 rare cancers, the majority of which (72%) are very rare (IR<0.5 per 100,000). These data are of major interest for different stakeholders. Health care planners can find useful information herein to properly plan and think of how to reorganise health care services. Researchers now have numbers to design clinical trials considering alternative study designs and statistical approaches. Population-based cancer registries with good quality data are the best source of information to describe the rare cancer burden in a population

On Achievable Rate of OFDM and OTFS in the Presence of Sparsity

Orthogonal time frequency space (OTFS) modulation is often declared to be superior to its direct concurrent, i.e., orthogonal frequency division multiplexing (OFDM) modulation. However, the comparison is often performed under favorable conditions for OTFS as, for instance, the assumption of extremely high Doppler shifts and/or the approximation of delay and Doppler shifts to be integer multiples of the Doppler-delay resolution of OTFS modulation. In order to provide a fair comparison, this paper addresses a comparison in terms of the information-theoretic achievable rate under practical separate detection and decoding, explicitly considering the pilot overhead necessary to acquire the channel state information, the accuracy of the channel estimation, and any other possible additional loss. We do not claim to establish in a definitive way which is the best modulation format, since the choice thereof depends on many other features which are outside the scope of this work (e.g., legacy, intellectual property, ease and know-how for implementation, and many other criteria). Nevertheless, we provide the foundations to properly compare multi-carrier communication systems in terms of their information theoretic achievable rate potential, within meaningful and sensible assumptions on the channel models and on the receiver complexity (both in terms of channel estimation and in terms of soft-output symbol detection)

A Parallel VLSI Architecture for 1-Gb/s, 2048-b, Rate-1/2 Turbo Gallager Code Decoder

This paper presents a 2048 bit, rate 1/2 soft decision decoder for a new class of codes known as Turbo Gallager Codes. The decoder can support up to 1 Gbit/s code rate and performs up to 48 decoding iteration ensuring at the same time high throughput and good coding gain. In order to evaluate the performance and the gate complexity of the decoder VLSI architecture, it has been synthesized in a 0.18 μm standard-cell CMOS technology

Estimation of Correlated Gaussian Samples in Impulsive Noise

We consider the estimation of correlated Gaussian samples in (correlated) impulsive noise, through message-passing algorithms. The factor graph includes cycles and, due to the mixture of Gaussian (samples and noise) and Bernoulli variables (the impulsive noise switches), the complexity of messages increases exponentially. We first analyze a simple but suboptimal solution, called Parallel Iterative Scheduling. Then we implement both Expectation Propagation — for which numerical stability must be addressed — and a simple variation thereof (called Transparent Propagation) that is inherently stable and simplifies the overall computation. Both algorithms reach a performance close to ideal, practically coinciding with the lower bound on the mean square estimation error