A Cognitive Look at the "Invisibility" of Older Gay Men Within the Categories 'Gay Man' and 'Elderly Man'

Two studies analyzed whether, at the cognitive level, 'Elderly gay man' is "invisible" both when processing the labels 'Gay man' and 'Elderly man'. We suggest that 'Gay man' is conflated with 'Young man', and that 'Elderly man' is conflated with 'Heterosexual man'. Contact with elderly gay men did not alter the perception of 'Gay man' as prevalently young but weakened the perception of 'Elderly man' as heterosexual by default

Mirrored images but not silicone models trigger aggressive responses in male common wall lizards

Disentangling the effects of single releasers in animal communication is a demanding task because a releaser often consists of a combination of different key stimuli. Territorial communication in reptiles usually depends on visual, chemical, and acoustic stimuli, but the role of each of them depends on phylogeny. Lacertids are modern lizards that rely mainly on chemical cues for their communication, but they also use aggressive displays based on visual recognition. We experimentally tested the visual stimuli that release an aggressive response in the males of a typical lacertid, the common wall lizard (Podarcis muralis), testing the effects of silicone models and mirrored images in captivity. The response to models and control (a blank sheet) was not significantly different and these stimuli did not release any aggressive behaviour. On the contrary, the reflected image in a mirror caused overt aggression (i.e., bites against it) in 63% of tested individuals. The results clearly demonstrate the role of visual stimuli in territorial communication, but only as a combined effect of shape and motion, differently from other lizard families for which shape is enough to stimulate aggre sive responses. Mirrors can be useful tools to investigate aggression related to physiological and morphological aspects in lacertid lizards

NUTRITIONAL AND DIGESTIVE EFFECTS OF GASTRECTOMY FOR GASTRIC CANCER

Background: Gastrectomy often leads to malnutrition. Objective: The aim of this study was to analyze nutritional and digestive effects of gastrectomy for cancer. Patients and methods: Gastrectomized patients were studied by nutritional assessment including a weekly nutritional diary exploring digestive symptoms. Results: Thirty-two patients were analyzed after a mean follow-up of 41.8 months. The mean percentage of weight loss was 12.9% \ub1 13.5%. After total gastrectomy, mean weight loss was 22% \ub1 1.2%, against 7.4% \ub111.9% for subtotal gastrectomy (p = 0.002). Moreover, advancing age was related to weight loss (p = 0.02), with a peak around 70 years. The most frequent postprandial symptoms were abdominal swelling (62%) and early satiety (59%). Finally, findings of the present study imply that overm a long follow-up, there are no specific intolerances related to gastrectomy. Conclusions: Patients who have undergone a total gastrectomy and elderly gastrectomized patients are at risk of malnutrition and need postoperative nutritional support

Development and validation of a prediction score for failure to casirivimab/imdevimab in hospitalized patients with COVID-19 pneumonia

Introduction: Casirivimab and imdevimab (CAS/IMV) are two non-competing, high-affinity human IgG1 anti-SARS-CoV-2 monoclonal antibodies, that showed a survival benefit in seronegative hospitalized patients with COVID-19. This study aimed to estimate the day-28 risk of mechanical ventilation (MV) and death in individuals hospitalized for severe COVID-19 pneumonia and receiving CAS/IMV. Additionally, it aimed to identify variables measured at the time of hospital admission that could predict these outcomes and derive a prediction algorithm. Methods: This is a retrospective, observational cohort study conducted in 12 hospitals in Italy. Adult patients who were consecutively hospitalized from November 2021 to February 2022 receiving CAS/IMV were included. A multivariable logistic regression model was used to identify predictors of MV or death by day 28 from treatment initiation, and β-coefficients from the model were used to develop a risk score that was derived by means of leave-one-out internal cross-validation (CV), external CV, and calibration. Secondary outcome was mortality. Results: A total of 480 hospitalized patients in the training set and 157 patients in the test set were included. By day 28, 36 participants (8%) underwent MV and 28 died (6%) for a total of 58 participants (12%) experiencing the composite primary endpoint. In multivariable analysis, four factors [age, PaO2/FiO2 ratio, lactate dehydrogenase (LDH), and platelets] were independently associated with the risk of MV/death and were used to generate the proposed risk score. The accuracy of the score in the area under the curve (AUC) was 0.80 and 0.77 in internal validation and test for the composite endpoint and 0.87 and 0.86 for death, respectively. The model also appeared to be well calibrated with the raw data. Conclusion: The mortality risk reported in our study was lower than that previously reported. Although CAS/IMV is no longer used, our score might help in identifying which patients are not likely to benefit from monoclonal antibodies and may require alternative interventions

Evaluation of a quality improvement intervention to reduce anastomotic leak following right colectomy (EAGLE): pragmatic, batched stepped-wedge, cluster-randomized trial in 64 countries

Background: Anastomotic leak affects 8 per cent of patients after right colectomy with a 10-fold increased risk of postoperative death. The EAGLE study aimed to develop and test whether an international, standardized quality improvement intervention could reduce anastomotic leaks. Methods: The internationally intended protocol, iteratively co-developed by a multistage Delphi process, comprised an online educational module introducing risk stratification, an intraoperative checklist, and harmonized surgical techniques. Clusters (hospital teams) were randomized to one of three arms with varied sequences of intervention/data collection by a derived stepped-wedge batch design (at least 18 hospital teams per batch). Patients were blinded to the study allocation. Low- and middle-income country enrolment was encouraged. The primary outcome (assessed by intention to treat) was anastomotic leak rate, and subgroup analyses by module completion (at least 80 per cent of surgeons, high engagement; less than 50 per cent, low engagement) were preplanned. Results: A total 355 hospital teams registered, with 332 from 64 countries (39.2 per cent low and middle income) included in the final analysis. The online modules were completed by half of the surgeons (2143 of 4411). The primary analysis included 3039 of the 3268 patients recruited (206 patients had no anastomosis and 23 were lost to follow-up), with anastomotic leaks arising before and after the intervention in 10.1 and 9.6 per cent respectively (adjusted OR 0.87, 95 per cent c.i. 0.59 to 1.30; P = 0.498). The proportion of surgeons completing the educational modules was an influence: the leak rate decreased from 12.2 per cent (61 of 500) before intervention to 5.1 per cent (24 of 473) after intervention in high-engagement centres (adjusted OR 0.36, 0.20 to 0.64; P < 0.001), but this was not observed in low-engagement hospitals (8.3 per cent (59 of 714) and 13.8 per cent (61 of 443) respectively; adjusted OR 2.09, 1.31 to 3.31). Conclusion: Completion of globally available digital training by engaged teams can alter anastomotic leak rates. Registration number: NCT04270721 (http://www.clinicaltrials.gov)

Extrapolating Stereotypical Information on Sexual Orientation From Race Categories: The Case of Black and Asian Men

The current research analyzed whether race categories concerning Black and Asian men could lead to extrapolative inferences concerning the sexual orientation (i.e., extrapolative sexual orientation stereotyping [ESOS]) of these category members. Study 1 assessed perceived culturally based ESOS and showed that Black men, compared with Asian men, were thought to be more heterosexual than gay men. Study 2 assessed participants' own ESOS and showed that Black men were conflated with heterosexual men to a greater extent than were Asian men, although Asian men were not assimilated to gay men. Black and White men were equally stereotyped as heterosexual men, thus suggesting a drop in the perceived heterosexuality of Asian men rather than an enhancement of the perceived heterosexuality of Black men. Study 3 confirmed that Black men were perceived as more masculine, less feminine, and more heterosexual than Asian men, although no difference was found between the two racial categories in the perceived homosexuality. The enhanced perception of femininity of Asian compared with Black men was associated with a decreased perception of Asian compared with Black men as heterosexual. Together, results suggest that the category of Asian and Black men worked as the basis for inferring the sexual orientation of these group members. These racial categories affected the inferred heterosexuality and less, if not somewhat elusively, the inferred homosexuality of Asian and Black men. Results were discussed with respect to research concerning the extrapolative stereotyping and gender-inversion stereotypes of gay men