Methods For Evaluating The Performance Of Small Acoustic Filters

Experimental methods are needed for determining the characteristics of small acoustic filters used in systems with pulsating gas flows. These characteristics could then be used to predict the performance of proposed filter designs in a particular system, according to plane wave acoustic theory. Dependence on trial-and-error experimentation in solving noise control problems would thus be minimized. A literature survey revealed only a few earlier attempts to evaluate the acoustic performance of small filters and filter elements. Three methods for determining reflection and transmission factors are described, evaluated, and compared. A method employing a standing wave tube of unique design is recommended for determination of reflection factors. Transmission factors are obtained from reflection factors and pressure measurements at the filter inlet and outlet. Use of an anechoic termination simplifies the calculations and increases accuracy; design and evaluation of such a termination is described. © 1969, Acoustical Society of America. All rights reserved

Interview with Bill Cohen by Brien Williams

Biographical NoteWilliam S. Cohen was born on August 28, 1940, in Bangor, Maine, to Reuben and Clara Cohen. He attended Bangor High School and was graduated from Bowdoin College in 1962 with a major in Latin. He earned his law degree at Boston University School of Law in 1965. He worked at a law firm in Bangor, eventually becoming a partner. He served on the Bangor City Council and was mayor of Bangor from 1961 to 1962. In 1972, Cohen was elected to the U.S. House of Representatives, where he was a member of the House Judiciary Committee during the Watergate hearings. He was elected to the Senate in 1978 after serving as a representative for three terms. He was reelected in 1984 and 1990. He served on the Iran-Contra Committee. After retiring from the Senate in 1997, he was appointed to serve as secretary of defense by President Clinton, a position he held until 2001. In 2001 he founded the Cohen Group, a consulting firm specializing in East Asian affairs. He has authored several books, both fiction and nonfiction, including Men of Zeal, which he co-authored with George J. Mitchell about the Iran-Contra affair. SummaryInterview includes discussions of: Bowdoin College; Mitchell’s entry into politics; qualities that made Mitchell a successful senator; the working relationship between Cohen and Mitchell; Cohen’s and Muskie’s relationship; Muskie’s temper; Zen and the Art of Motorcycle Maintenance; the cooperation among members of the Maine delegation in Congress; the Dickey-Lincoln Project; the Maine Indian Land Claims issue; the Maine Republican Party; cross-party values in Maine; the walk; Iran-Contra; Mitchell’s questioning of Oliver North; writing Men of Zeal and how the book tour upset Cohen’s Republican colleagues; the job of majority leader; how Senate Republicans viewed Mitchell; policies on which Cohen and Mitchell worked together; Mitchell’s decision to step down; Cohen’s decision to retire; becoming secretary of defense; the Cohen Group; Roll Call; The Singularity is Near and the health issues that interest Cohen today

Fogler Library: William S. Cohen Lecture with Bob Woodward

Video recording of the 2007 conversation between William S. Cohen and Bob Woodward about the Watergate Investigations. The Cohen Lecture Series began in 1997 with the deposit of 1300 boxes of Cohen\u27s papers to Raymond H. Fogler Library Special Collections. The Cohen collection documents over 25 years of Mr. Cohen\u27s service to Maine and the United States. The Bob Woodward and Carl Bernstein Watergate Papers are held at the Harry Ransom Center at the University of Texas.https://digitalcommons.library.umaine.edu/umaine_video/1024/thumbnail.jp

Letter from William S. Cohen, U.S. Senator

Letter from William S. Cohen, U.S. Senator for Maine, congratulating her on her honorary doctorate in humane letters from the Rhode Island College.https://digitalcommons.usm.maine.edu/giguere-awards/1023/thumbnail.jp

Impact of early-stage HIV transmission on treatment as prevention

Timely HIV treatment improves health (1) and reduces transmission (2). These individual- level benefits of HIV treatment for both clinical and preventive purposes are well established, but several questions remain about the population-level impact of HIV treatment as prevention (3). In PNAS, Eaton and Hallett (4) use a mathematical model to address one such question: Does the proportion of transmission during early HIV infection affect the impact of HIV treatment on HIV incidence

A Method for Individualizing the Prediction of Immunogenicity of Protein Vaccines and Biologic Therapeutics: Individualized T Cell Epitope Measure (iTEM)

The promise of pharmacogenomics depends on advancing predictive medicine. To address this need in the area of immunology, we developed the individualized T cell epitope measure (iTEM) tool to estimate an individual's T cell response to a protein antigen based on HLA binding predictions. In this study, we validated prospective iTEM predictions using data from in vitro and in vivo studies. We used a mathematical formula that converts DRB1* allele binding predictions generated by EpiMatrix, an epitope-mapping tool, into an allele-specific scoring system. We then demonstrated that iTEM can be used to define an HLA binding threshold above which immune response is likely and below which immune response is likely to be absent. iTEM's predictive power was strongest when the immune response is focused, such as in subunit vaccination and administration of protein therapeutics. iTEM may be a useful tool for clinical trial design and preclinical evaluation of vaccines and protein therapeutics

Two frameworks for integrating knowledge in induction

The use of knowledge in inductive learning is critical for improving the quality of the concept definitions generated, reducing the number of examples required in order to learn effective concept definitions, and reducing the computation needed to find good concept definitions. Relevant knowledge may come in many forms (such as examples, descriptions, advice, and constraints) and from many sources (such as books, teachers, databases, and scientific instruments). How to extract the relevant knowledge from this plethora of possibilities, and then to integrate it together so as to appropriately affect the induction process is perhaps the key issue at this point in inductive learning. Here the focus is on the integration part of this problem; that is, how induction algorithms can, and do, utilize a range of extracted knowledge. Preliminary work on a transformational framework for defining knowledge-intensive inductive algorithms out of relatively knowledge-free algorithms is described, as is a more tentative problems-space framework that attempts to cover all induction algorithms within a single general approach. These frameworks help to organize what is known about current knowledge-intensive induction algorithms, and to point towards new algorithms