Using individual growth model to analyze the change in quality of life from adolescence to adulthood

BACKGROUND: The individual growth model is a relatively new statistical technique now widely used to examine the unique trajectories of individuals and groups in repeated measures data. This technique is increasingly used to analyze the changes over time in quality of life (QOL) data. This study examines the change from adolescence to adulthood in physical health as an aspect of QOL as an illustration of the use of this analytic method. METHODS: Employing data from the Children in the Community (CIC) study, a prospective longitudinal investigation, physical health was assessed at mean ages 16, 22, and 33 in 752 persons born between 1965 and 1975. RESULTS: The analyses using individual growth models show a linear decline in average physical health from age 10 to age 40. Males reported better physical health and declined less per year on average. Time-varying psychiatric disorders accounted for 8.6% of the explained variation in mean physical health, and 6.7% of the explained variation in linear change in physical health. Those with such a disorder reported lower mean physical health and a more rapid decline with age than those without a current psychiatric disorder. The use of SAS PROC MIXED, including syntax and interpretation of output are provided. Applications of these models including statistical assumptions, centering issues and cohort effects are discussed. CONCLUSION: This paper highlights the usefulness of the individual growth model in modeling longitudinal change in QOL variables

Socioeconomic status and anxiety as predictors of antidepressant treatment response and suicidal ideation in older adults.

BACKGROUND: Separate reports from the maintenance treatment for late-life depression (MTLD) trials have shown that low socioeconomic status (SES) and anxiety symptoms at the time of treatment initiation predict lower levels of response to antidepressant treatment and higher levels of suicidal ideation in older adults. AIM: To determine whether SES and anxiety independently contribute to worse treatment outcomes, as indicated by persistence of depressive symptoms during treatment and the persistence of suicidal ideation. Consistent with prior evidence that sociodemographic factors and clinical history are both prognostic of depression treatment efficacy, we hypothesized that SES and pre-existing anxiety symptoms will both predict lower levels of response to treatment and higher levels of suicidal ideation. METHOD: Secondary analyses of data from the MTLD trials. RESULTS: Regression analyses which controlled for comorbid anxiety indicated that residents of middle- and high-income census tracts were more likely to respond to treatment (HR, 1.63; 95%CI, 1.08-2.46) and less likely to report suicidal ideation during treatment (OR, 0.51; 95%CI, 0.28-0.90) than residents of low income census tracts. The same regression models indicated that pre-existing anxiety symptoms were independently related to lower treatment response (HR, 0.73; 95%CI, 0.60-0.89) and higher risk of suicidal ideation (OR, 1.45; 95%CI, 0.98-2.14). CONCLUSION: These findings demonstrate the importance of treating anxiety symptoms during the course of treatment for late-life depression and, at the same time, addressing barriers to treatment response related to low SES

Putting GM technologies to work: public research pipelines in selected African countries

Can public policies and research institutions in African countries provide safe and useful genetically modified (GM) food crops? This is an urgent question, recognizing that advancing GM food crops can be difficult, affected by global debate, and various regulatory protocols. Reaching farmers has been achieved in several countries only for GM cotton for insect resistant while approvals for food and feed crops lag behind. To address this question, we identified and examined public research pipelines for GM crops in Egypt, Kenya, South Africa and Zimbabwe. Genetic transformation events are reported for 21 crops. Findings are presented for events nearing final stages of development, analysis of the crops, traits and genes involved, and details regarding biosafety. The paper concludes with a summary offering various policies, institutional and regulatory suggestions. Key Words: Africa, biosafety, biotechnology, genetic modification, public research African Journal of Biotechnology Vol.3(11) 2004: 564-57

Protein phosphatase 4 – from obscurity to vital functions

AbstractProtein phosphatase 4 (Ppp4) is a ubiquitous serine/threonine phosphatase in the PPP family that is now recognised to regulate a variety of cellular functions independently of protein phosphatase 2A (PP2A). Regulatory subunits (R1 and R2) have been identified in mammals that interact with the catalytic subunit of Ppp4 (Ppp4c) and control its activity. Ppp4c–R2 complexes play roles in organelle assembly; not only are they essential for maturation of the centrosome, but they are also involved in spliceosomal assembly via interaction with the survival of motor neurons (SMNs) complex. Several cellular signalling routes, including NF-κB and the target of rapamycin (TOR) pathways appear to be regulated by Ppp4. Emerging evidence indicates that Ppp4 may play a role in the DNA damage response and that Ppp4c–R1 complexes decrease the activity of a histone deacetylase, implicating Ppp4 in the regulation of chromatin activities. Antitumour agents, cantharidin and fostriecin, potently inhibit the activity of Ppp4. Orthologues of mammalian Ppp4 subunits in Saccharomyces cerevisiae confer resistance to the anticancer, DNA-binding drugs, cisplatin and oxaliplatin

Mindfully Teaching in the Classroom: a Literature Review

The practice of mindfulness is being used with increased frequency in schools around the world. In the current literature review we outline some of the core concepts and practices associated with mindfulness and discuss studies analysing the process of mindfulness teacher training. Preliminary research in this emerging field suggests that mindfulness has the potential to improve classroom management, teacher-student relationships and instructional strategies. Mindfulness instructors recommend that before teachers can feel comfortable and effectively teach mindfulness in the classroom they need to embody and practice mindfulness in their own lives. It is proposed that in order to improve our knowledge base in this area a critical synthesis and analysis of school-based mindfulness programs is required

Obsidian in the Late-Inka Period of Antofagasta de la Sierra (Southern Argentinean Puna): basin bottom versus intermediate sectors?

Este trabajo pretende aportar información acerca de la circulación de distintas variedades de obsidiana en la microrregión de Antofagasta de la Sierra con el objetivo de comenzar a evaluar algunas propuestas sobre aspectos de la organización político-social de las sociedades que la habitaron durante el Tardío-Inka. Para ello se recurrió a análisis geoquímicos sobre muestras de obsidiana procedentes de sitios arqueológicos emplazados en distintos microambientes de la cuenca, específicamente, fondo de cuenca y sectores intermedios. Los resultados alcanzados no son concluyentes acerca de la existencia o no de un posible control en la circulación de este recurso por parte de las elites emplazadas en el fondo de cuenca. Sin embargo, a la luz de numerosos antecedentes, es posible sugerir que las sociedades antofagasteñas tardías, incluidas las unidades familiares pastoriles de los sectores intermedios, hayan mantenido vigentes mecanismos y criterios de intercambio de larga distancia los que tenían ya una larga trayectoria histórica. Este primer abordaje plantea la necesidad de seguir profundizando no sólo en los aspectos geoquímicos, sino también en los tecnológicos, a los fines de avanzar en la comprensión de las diversas prácticas implicadas en la circulación de obsidianas en el entramado político-social de la cuenca posterior a ca. 1100 años AP.This paper provides information about the circulation of different varieties of obsidian in the Antofagasta de la Sierra micro-region in order to begin to evaluate some proposals about Late-Inka societies social and political organization aspects. In order to do this, geochemical analysis on obsidian samples from archaeological sites located in different microenvironments of the basin, specifically its bottom and intermediate sectors, were carried out. The results obtained are not conclusive about the existence or not of any control over the circulation of this resource by the elites located on the bottom of basin. However, in light of numerous precedents, it is possible to suggest that late local societies of Antofagasta, including the pastoral families of the intermediate sectors, kept in use long distance trade mechanisms and criteria that had a long historical trajectory. This first approach raises the need to further deepen not only in the geochemical aspects, but also in the technological ones, in order to advance in the understanding of the various practices involved in obsidian circulation in the basin’s socio-political network post ca. 1100 years BP.Fil: Escola, Patricia Susana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigaciones y Transferencia de Catamarca. Universidad Nacional de Catamarca. Centro de Investigaciones y Transferencia de Catamarca; ArgentinaFil: Elias, Alejandra Mercedes. Secretaría de Cultura de la Nación. Dirección Nacional de Cultura y Museos. Instituto Nacional de Antropología y Pensamiento Latinoamericano; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Cohen, Maria Lorena. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Estudios Sociales. Universidad Nacional de Tucumán. Instituto Superior de Estudios Sociales; Argentin

Participation of epididymal cysteine-rich secretory proteins in sperm egg fusion and their potential use for male fertility regulation

Rat protein DE is an androgen-dependent cysteine-rich secretory protein (CRISP) synthesized by proximal epididymal regions. DE, also known as CRISP-1, is localized on the equatorial segment of acrosome-reacted spermatozoa and participates in gamete fusion through binding to egg complementary sites. Immunization of rats with DE inhibits fertility and sperm fusion ability, suggesting that DE represents a good epididymal contraceptive target. Recombinant DE fragments and synthetic peptides revealed that DE binds to the egg via a 12-amino acid region of an evolutionarily conserved motif, Signature 2 (S2). The ability of other CRISP to bind to the rat egg was correlated with their S2 amino acid sequences. Although testicular protein Tpx-1 (CRISP-2) was capable of binding to rodent eggs, human epididymal AEG-related protein (ARP) and helothermine (from lizard saliva) were not. The S2 region presented only two substitutions in Tpx-1 and four in ARP and helothermine, compared with the DE S2, suggesting that this amino acid sequence was relevant for egg interaction. Studies with Tpx-1 and anti-Tpx-1 revealed the participation of this protein in gamete fusion through binding to complementary sites in the egg. In competition studies, DE reduced binding of Tpx-1 dose-dependently, indicating that both CRISP share the egg complementary sites. That anti-DE and anti-Tpx-1 inhibit sperm-egg fusion while recognizing only the corresponding proteins, suggests functional cooperation between these homologous CRISP to ensure fertilization success. These results increase our understanding of the molecular mechanisms of gamete fusion and contribute to the development of new and safer fertility regulating methods.Fil: Cohen, Debora Juana. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Da Ros, Vanina Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Busso. Dolores. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Ellerman, Diego Andrés. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Maldera, Julieta Antonella. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Goldweic, Nadia Micaela. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Cuasnicu, Patricia Sara. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentin