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Global chronostratigraphical correlation table for the last 2.7 million years, version 2019 QI-500
A substantially updated version of the correlation table showing chronostratigraphical subdivisions of late Cenozoic geological time, spanning the last 2.7 million years is presented. It provides scientists, students, professionals and the general public with a ready reference to stratigraphical terms and schemes in use in different areas for similar periods. The updates comprised the status of Quaternary chronostratigraphic subdivision, the combined age-modelled geomagnetic and isotope records from ocean drilling records, and revised regional correlation schemes, notably for eastern Europe. The paper describes the chart in its 2019 QI-500 form and contains sections on its types of usage and formal subdivision status, besides reference and description of the contents of the various columns. The paper also describes and discusses the resolution of correlations in younger and older parts of the last 2.7 Ma.n/
IL-17A induces Pendrin expression and chloride-bicarbonate exchange in human bronchial epithelial cells
The epithelium plays an active role in the response to inhaled pathogens in part by responding to signals from the immune system. Epithelial responses may include changes in chemokine expression, increased mucin production and antimicrobial peptide secretion, and changes in ion transport. We previously demonstrated that interleukin-17A (IL-17A), which is critical for lung host defense against extracellular bacteria, significantly raised airway surface pH in vitro, a finding that is common to a number of inflammatory diseases. Using microarray analysis of normal human bronchial epithelial (HBE) cells treated with IL-17A, we identified the electroneutral chloride-bicarbonate exchanger Pendrin (SLC26A4) as a potential mediator of this effect. These data were verified by real-time, quantitative PCR that demonstrated a time-dependent increase in Pendrin mRNA expression in HBE cells treated with IL-17A up to 48 h. Using immunoblotting and immunofluorescence, we confirmed that Pendrin protein expression is increased in IL-17 treated HBE cells and that it is primarily localized to the mucosal surface of the cells. Functional studies using live-cell fluorescence to measure intracellular pH demonstrated that IL-17A induced chloride-bicarbonate exchange in HBE cells that was not present in the absence of IL-17A. Furthermore, HBE cells treated with short interfering RNA against Pendrin showed substantially reduced chloride-bicarbonate exchange. These data suggest that Pendrin is part of IL-17A-dependent epithelial changes and that Pendrin may therefore be a therapeutic target in IL-17A-dependent lung disease. © 2014 Adams et al
Engaging with community researchers for exposure science: lessons learned from a pesticide biomonitoring study
A major challenge in biomonitoring studies with members of the general public is ensuring their continued involvement throughout the necessary length of the research. The paper presents evidence on the use of community researchers, recruited from local study areas, as a mechanism for ensuring effective recruitment and retention of farmer and resident participants for a pesticides biomonitoring study. The evidence presented suggests that community researchers' abilities to build and sustain trusting relationships with participants enhanced the rigour of the study as a result of their on-the-ground responsiveness and flexibility resulting in data collection beyond targets expected
A Sparse Stress Model
Force-directed layout methods constitute the most common approach to draw
general graphs. Among them, stress minimization produces layouts of
comparatively high quality but also imposes comparatively high computational
demands. We propose a speed-up method based on the aggregation of terms in the
objective function. It is akin to aggregate repulsion from far-away nodes
during spring embedding but transfers the idea from the layout space into a
preprocessing phase. An initial experimental study informs a method to select
representatives, and subsequent more extensive experiments indicate that our
method yields better approximations of minimum-stress layouts in less time than
related methods.Comment: Appears in the Proceedings of the 24th International Symposium on
Graph Drawing and Network Visualization (GD 2016
Neuromodulation and the role of electrodiagnostic techniques
Electrodiagnostic techniques have been utilized in surgery since the early 1960s. These techniques have been primarily used in neurosurgery; however, with the introduction of neuromodulation for voiding dysfunction, these techniques have now found their way into the field of female pelvic medicine. This article will review techniques applicable to evaluate pelvic floor function as it relates to neuromodulation. It will also review the literature describing how these techniques are used to help determine appropriate candidates as well as improve surgical outcomes. A PubMed search was conducted using the terms neuromodulation, Interstim, electrodiagnosis, electrodiagnostic techniques, electromyography with limits to the pelvic floor, and voiding dysfunction. Eight articles and three abstracts were found that directly related to the use of electrodiagnostic techniques as they apply to neuromodulation. Electrodiagnostic techniques may play a role in helping predict appropriate candidates for neuromodulation as well as improve surgical outcomes
A theoretical framework for the regulation of Shh morphogen-controlled gene expression.
How morphogen gradients govern the pattern of gene expression in developing tissues is not well understood. Here, we describe a statistical thermodynamic model of gene regulation that combines the activity of a morphogen with the transcriptional network it controls. Using Sonic hedgehog (Shh) patterning of the ventral neural tube as an example, we show that the framework can be used together with the principled parameter selection technique of approximate Bayesian computation to obtain a dynamical model that accurately predicts tissue patterning. The analysis indicates that, for each target gene regulated by Gli, which is the transcriptional effector of Shh signalling, there is a neutral point in the gradient, either side of which altering the Gli binding affinity has opposite effects on gene expression. This explains recent counterintuitive experimental observations. The approach is broadly applicable and provides a unifying framework to explain the temporospatial pattern of morphogen-regulated gene expression
The Maximal Inverse Seesaw from Operator and Oscillating Asymmetric Sneutrino Dark Matter
The maximal supersymmetric inverse seesaw mechanism (MSIS)
provides a natural way to relate asymmetric dark matter (ADM) with neutrino
physics. In this paper we point out that, MSIS is a natural outcome if one
dynamically realizes the inverse seesaw mechanism in the next-to minimal
supersymmetric standard model (NMSSM) via the dimension-five operator
, with the NMSSM singlet developing TeV scale VEV; it
slightly violates lepton number due to the suppression by the fundamental scale
, thus preserving maximally. The resulting sneutrino is a
distinguishable ADM candidate, oscillating and favored to have weak scale mass.
A fairly large annihilating cross section of such a heavy ADM is available due
to the presence of singlet.Comment: journal versio
The Dark Side of the Electroweak Phase Transition
Recent data from cosmic ray experiments may be explained by a new GeV scale
of physics. In addition the fine-tuning of supersymmetric models may be
alleviated by new O(GeV) states into which the Higgs boson could decay. The
presence of these new, light states can affect early universe cosmology. We
explore the consequences of a light (~ GeV) scalar on the electroweak phase
transition. We find that trilinear interactions between the light state and the
Higgs can allow a first order electroweak phase transition and a Higgs mass
consistent with experimental bounds, which may allow electroweak baryogenesis
to explain the cosmological baryon asymmetry. We show, within the context of a
specific supersymmetric model, how the physics responsible for the first order
phase transition may also be responsible for the recent cosmic ray excesses of
PAMELA, FERMI etc. We consider the production of gravity waves from this
transition and the possible detectability at LISA and BBO
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