Importance of the Danube in the Development of the European inland transport. Inland and Port Infrastructure Development in Romania

Europe currently has an extensive network of inland waterways components of the PanEuropean Transport Network. The Danube River with Sulina and Danube-Black Sea is part of panEuropean transport corridor VII. European policy in the transport sector, is subject to joint decisions inthe Council of the European Union. A current priority is to balance the use of different types oftransportation alternation and making connections between transport modes. Currently it acts tostimulate the development of a balance between rail sectors, maritime, river and waterways of Europe.Romania is implementing several European and national programs to upgrade its infrastructure on theDanube waterwa

INFLUENCE FACTORS AND MANIFESTATIONS OF PRODUCTIVITY

Notion almost unknown before 1950, labor productivity is now commonly used by economists, engineers, sociologists and politicians alike, influencing all the important issues of the time. Under these circumstances, if it is accepted that labor productivity is the driving variable that generates economic progress, it is justified that people need to increase their efforts to enhance, its value through various means. This article presents the findings of a theoretical research literature regarding landmarks in the evolution of labor productivity. Arguments justifying such an approach have been given by the fact that the labor issue presents an interest not only at the micro level, individual (the consequences it has on the individual work), but also at the macro level, societal (employment relations on the market labor, insurance systems and the offer educational services on the market today).

Strategic Research of the Maritime Market

At the beginning of the 21st century, the research and the knowledge of the maritime market prove to be as important as the other elements of the Marketing from the maritime domain. The research of the maritime market can be considered as the first step in tackling the research problems in the Marketing from this domain, which cannot be avoided or ignored. This thing is necessary due to the permanent increase of the competition on the maritime market, to the permanent entrance of new ships and shipping companies, to the development of new transport routes

The Life Cycle of a Maritime Ship between “Product” and “Service”

The life cycle of a ship represents an issue which the ship owner must take into consideration because he must know a series of aspects connected to the exploitation period until the moment of the current and capital repairs, the degree of use of the ship and separately for each installation, the moment of its taking out from service and especially how it can be extended its duration of exploitation. These aspects are not easy to be calculated because there appear a series of aspects connected to the shipping zone, the type of the transported goods, the way of exploitation and maintenance performed by the crews, the number of the exploitation days and many more others. The life cycle of the service performed by the ship, in fact the type of the transported goods is very important taking into account the changes on the maritime market, the competition between shipping companies, the development of the international economy and the requests of the customers of the shipping companies. In this paper, there are analysed the two aspects which a ship represents, as ”a product” and as a performed ”service” and it is presented a type of analyse for a maritime ship

The decisional process of proper selection of managers from railway transport

The current economic context as led to a significant drop of open positions on the workforce market at the same time with the reorganization that many organisations had to accomplish. The consequences haven’t stopped appearing in the way in which, today there are many candidates with working experience who have occupied management positions in other companies and are now in search of new jobs. Some organizations have stopped hiring, as it happened in the case of The National Company CFR S.S., and those that still have open positions for recruitment are focusing on skills, multiple competences and proven expertise in a certain field. On the workforce market this thing means that those candidates who have skills and proven expertise are the most demanded ones. The purpose of this paper has been the identification of an adequate methodology of selection regarding railway staff, needed in the main activities of human resources management. The study is based on using the method of global utility and ranking individuals based on the order of skills in order to choose the most suitable manager so that he can take part in  a training course organized by the European organism with responsibilities in the field of professional development. The research hypothesis has been as it follows: A proper assessment of human resources in order to choose, following MRU new demands regarding railway transport, causes the growth in efficiency in railway management

The Life Cycle of a Maritime Ship between “Product” and “Service”

The life cycle of a ship represents an issue which the ship owner must take into consideration because he must know a series of aspects connected to the exploitation period until the moment of the current and capital repairs, the degree of use of the ship and separately for each installation, the moment of its taking out from service and especially how it can be extended its duration of exploitation. These aspects are not easy to be calculated because there appear a series of aspects connected to the shipping zone, the type of the transported goods, the way of exploitation and maintenance performed by the crews, the number of the exploitation days and many more others. The life cycle of the service performed by the ship, in fact the type of the transported goods is very important taking into account the changes on the maritime market, the competition between shipping companies, the development of the international economy and the requests of the customers of the shipping companies. In this paper, there are analysed the two aspects which a ship represents, as ”a product” and as a performed ”service” and it is presented a type of analyse for a maritime ship

A nonsynonymous FCER1B SNP is associated with risk of developing allergic rhinitis and with IgE levels

Allergic rhinitis is associated with elevated serum IgE levels. IgE response is mediated by the highaffinity IgE receptor (FcεRI), which is polymorphic. Studies analyzing the association between allergic rhinitis and FcεRI variants have been conducted with controversial results. The objective of this study is to analyze, in 1,041 individuals, the putative clinical association of allergic rhinitis with common polymorphisms in FcεRI subunits genes. These SNPs included FECR1A rs2494262, rs2427837 and rs2251746; FECR1B rs1441586, rs569108 and rs512555; FCER1G rs11587213, rs2070901 and rs11421. Statistically significant differences were observed for the FCER1B rs569108 and rs512555 polymorphisms frequencies when comparing patients with allergic rhinitis without asthma and controls. The OR (95% CI) value for the 237Gly allele (rs569108) is equal to 0.26 (0.08–0.86, P = 0.017) and for the G allele (rs512555) it is equal to 0.27 (0.08–0.88, P = 0.020). These two SNPs are linked (D’ = 1.0, LOD = 56.05). Also observed was a statistically significant trend towards lower IgE values among allergic rhinitis patients with variant alleles for both SNPs. In conclusion, in patients with allergic rhinitis without asthma, the FCER1B rs569108 and rs512555 polymorphisms are associated with increased risk of developing allergic rhinitis and with lower IgE levels.Trabajo financiado por: Instituto de Salud Carlos III. Fondo de Investigación Sanitaria. Becas PI12/00241, PI12/00324 y RETICS RD12/0013/0002 Junta de Extremadura y Fondos FEDER. Ayuda GR15026peerReviewe

Heme oxygenase 1 and 2 common genetic variants and risk for essential tremor

Varios informes sugirieren que una función hemo oxigenasa 1 y 2 de los genes HMOX HMOX1 y 2 modifican el riesgo de desarrollar la enfermedad de Parkinson (EP). Porque el temblor esencial (ET) y PD comparten fenotipo y, probablemente, unos factores etiológicos semejantes, analizamos si tales genes están relacionados con el riesgo de desarrollar ET. Se analizó la distribución de las frecuencias genotípicas y alélicas de los HMOX1 rs2071746, HMOX1 rs2071747, HMOX2 rs2270363 y rs1051308 HMOX2 polimorfismos de nucleótido único, así como la presencia de variaciones de número de copias de estos genes en 202 sujetos con ET familiar y 747 controles sanos. Las frecuencias alélicas de rs2071746T y R1051308G ET fueron significativamente menores en los pacientes que en los controles. Ninguno de los polimorfismos estudiados influyeron en el comienzo de la enfermedad. El presente estudio sugiere una débil asociación entre HMOX1 rs2071746 y rs1051308 HMOX2 polimorfismo y el riesgo de desarrollar ET en la población española.Several reports suggested a role of heme oxygenase genes 1 and 2 (HMOX1 and HMOX2) in modifying the risk to develop Parkinson disease (PD). Because essential tremor (ET) and PD share phenotypical and, probably, etiologic factors of the similarities, we analyzed whether such genes are related with the risk to develop ET. We analyzed the distribution of allelic and genotype frequencies of the HMOX1 rs2071746, HMOX1 rs2071747, HMOX2 rs2270363, and HMOX2 rs1051308 single nucleotide polymorphisms, as well as the presence of copy number variations of these genes in 202 subjects with familial ET and 747 healthy controls. Allelic frequencies of rs2071746T and rs1051308G were significantly lower in ET patients than in controls. None of the studied polymorphisms influenced the disease onset. The present study suggests a weak association between HMOX1 rs2071746 and HMOX2 rs1051308 polymorphisms and the risk to develop ET in the Spanish population.T• Instituto de Salud Carlos III, Fondo de Investigación Sanitaria: Ayudas PI12/00241, PI12/00324 y RETICS RD12/0013/0002 • Junta de Extremadura: Ayuda GR10068 • Ministerio de Ciencia e Innovación: Ayudas SAF2006-10126 (2006–2009) y SAF2010-22329-C02-01 (2011–2013) • Parcialmente financiado Fondos FEDER – Fondo Europeo de Desarrollo RegionalpeerReviewe

Heme oxygenase-1 and 2 common genetic variants and risk for restless legs syndrome

Varios neurotransmisores, neuropatológicos, neuroimagen, y los datos experimentales, sugieren que la deficiencia de hierro juega un papel importante en la fisiopatología del síndrome de piernas inquietas (RLS). HMOX (Hemeoxygenases) es un importante mecanismo de defensa contra el estrés oxidativo, principalmente a través de la degradación del hemo a biliverdin, libre de hierro, y monóxido de carbono. Hemos analizado si los genes HMOX1 y HMOX2 están relacionados con el riesgo de desarrollar el síndrome de piernas inquietas. Se analizó la distribución de genotipos y las frecuencias alélicas de los HMOX1 rs2071746, HMOX1 rs2071747, HMOX2 rs2270363 y rs1051308 HMOX2 SNPs, así como la presencia de variaciones de número de copia (CNVs) de estos genes en 205 sujetos RLS y 445 controles sanos. Las frecuencias de rs2071746 genotipo TT y R2071746T variante alélica fueron significativamente inferiores en los pacientes de SPI que en controles, aunque los otros 3 SNPs estudiados RLS no difirió entre pacientes y controles. Ninguno de los polimorfismos estudiados influyeron en el inicio de la enfermedad, la gravedad de la RLS, historia familiar de SPI, la ferritina sérica, o respuesta a agonistas dopaminérgicos, clonazepam o GABAergic drogas. El presente estudio sugiere una débil asociación entre el polimorfismo rs2071746 HMOX1 y el riesgo de desarrollar el SPI en la población española.Several neurochemical, neuropathological, neuroimaging, and experimental data, suggest that iron deficiency plays an important role in the pathophysiology of restless legs syndrome (RLS). Hemeoxygenases (HMOX) are an important defensive mechanism against oxidative stress, mainly through the degradation of heme to biliverdin, free iron, and carbon monoxide. We analyzed whether HMOX1 and HMOX2 genes are related with the risk to develop RLS. We analyzed the distribution of genotypes and allelic frequencies of the HMOX1 rs2071746, HMOX1 rs2071747, HMOX2 rs2270363, and HMOX2 rs1051308 SNPs, as well as the presence of Copy number variations (CNVs) of these genes in 205 subjects RLS and 445 healthy controls. The frequencies of rs2071746TT genotype and rs2071746T allelic variant were significantly lower in RLS patients than that in controls, although the other 3 studied SNPs did not differ between RLS patients and controls. None of the studied polymorphisms influenced the disease onset, severity of RLS, family history of RLS, serum ferritin levels, or response to dopaminergic agonist, clonazepam or GABAergic drugs. The present study suggests a weak association between HMOX1 rs2071746 polymorphism and the risk to develop RLS in the Spanish population.• Instituto de Salud Carlos III, Fondo de Investigación Sanitaria: Ayudas PI12/00241, PI12/00324 y RETICS RD12/0013/0002 • Junta de Extremadura: Ayuda GR10068 GR10068 y PRIS10016 (Fundesalud,Mérida, Spain) • Ministerio de Ciencia e Innovación: Ayudas SAF2006-10126 (2006–2009) y SAF2010-22329-C02-01 (2011–2013) • Parcialmente financiado Fondos FEDER – Fondo Europeo de Desarrollo RegionalpeerReviewe