Letter from Katherine Cobb, 1906-05-24, Boston, Mass., to Anne Whitney, Boston, Mass.

https://repository.wellesley.edu/whitney_correspondence/2539/thumbnail.jp

Trans-disciplinary responses to climate change: lessons from rice-based systems in Asia

Climate change will continue to have a largely detrimental impact on the agricultural sector worldwide because of predicted rising temperatures, variable rainfall, and an increase in extreme weather events. Reduced crop yields will lead to higher food prices and increased hardship for low income populations, especially in urban areas. Action on climate change is one of the Sustainable Development Goals (SDG 13) and is linked to the Paris Climate Agreement. The research challenge posed by climate change is so complex that a trans-disciplinary response is required, one that brings together researchers, practitioners, and policy-makers in networks where the lines between “research” and “development” become deliberately blurred. Fostering such networks will require researchers, throughout the world, not only to work across disciplines but also to pursue new South–North and South–South partnerships incorporating policy-makers and practitioners. We use our diverse research experiences to describe the emergence of such networks, such as the Direct Seeded Rice Consortium (DSRC) in South and Southeast Asia, and to identify lessons on how to facilitate and strengthen the development of trans-disciplinary responses to climate change

Calcification of Rat Valve Allografts

Scanning electron microscopy (SEM) and energy dispersive X-ray microanalysis (EDS) have been used to quantify calcium deposition in bioprosthetic valves. To further characterize the calcification process as it pertains to allograft valve tissue, two models of tissue valve implantation were used. The first model used subcutaneous implantation of glutaraldehyde-preserved allogeneic aortic and pulmonary valve leaflets. The second model used syngeneic or allogeneic fresh aortic valve grafts implanted heterotopically into the abdominal aorta of recipient rats. Reference light microscopy was used to select sections for SEM and EDS. In the subcutaneous model, calcium content in both the pulmonary and aortic valves increased up to three weeks, followed by a plateau. The pulmonary leaflets showed greater calcium content than aortic leaflets. In the heterotopic implantation study, calcification occurred to a significantly greater degree in the allogeneic than in the syngeneic valves. This technique may be useful in analyzing the factors that contribute to deterioration of bioprosthetic and allograft valves

Lineage-specific compaction of Tcrb requires a chromatin barrier to protect the function of a long-range tethering element

Gene regulation relies on dynamic changes in three-dimensional chromatin conformation, which are shaped by composite regulatory and architectural elements. However, mechanisms that govern such conformational switches within chromosomal domains remain unknown. We identify a novel mechanism by which cis-elements promote long-range interactions, inducing conformational changes critical for diversification of the TCRβ antigen receptor locus (Tcrb). Association between distal Vβ gene segments and the highly expressed DβJβ clusters, termed the recombination center (RC), is independent of enhancer function and recruitment of V(D)J recombinase. Instead, we find that tissue-specific folding of Tcrb relies on two distinct architectural elements located upstream of the RC. The first, a CTCF-containing element, directly tethers distal portions of the Vβ array to the RC. The second element is a chromatin barrier that protects the tether from hyperactive RC chromatin. When the second element is removed, active RC chromatin spreads upstream, forcing the tether to serve as a new barrier. Acquisition of barrier function by the CTCF element disrupts contacts between distal Vβ gene segments and significantly alters Tcrb repertoires. Our findings reveal a separation of function for RC-flanking regions, in which anchors for long-range recombination must be cordoned off from hyperactive RC landscapes by chromatin barriers

Continuing medical education challenges in chronic fatigue syndrome

<p>Abstract</p> <p>Background</p> <p>Chronic fatigue syndrome (CFS) affects at least 4 million people in the United States, yet only 16% of people with CFS have received a diagnosis or medical care for their illness. Educating health care professionals about the diagnosis and management of CFS may help to reduce population morbidity associated with CFS.</p> <p>Methods</p> <p>This report presents findings over a 5-year period from May 2000 to June 2006 during which we developed and implemented a health care professional educational program. The objective of the program was to distribute CFS continuing education materials to providers at professional conferences, offer online continuing education credits in different formats (e.g., print, video, and online), and evaluate the number of accreditation certificates awarded.</p> <p>Results</p> <p>We found that smaller conference size (OR = 80.17; 95% CI 8.80, 730.25), CFS illness related target audiences (OR = 36.0; 95% CI 2.94, 436.34), and conferences in which CFS research was highlighted (OR = 4.15; 95% CI 1.16, 14.83) significantly contributed to higher dissemination levels, as measured by visit rates to the education booth. While print and online courses were equally requested for continuing education credit opportunities, the online course resulted in 84% of the overall award certificates, compared to 14% for the print course. This remained consistent across all provider occupations: physicians, nurses, physician assistants, and allied health professionals.</p> <p>Conclusion</p> <p>These findings suggest that educational programs promoting materials at conferences may increase dissemination efforts by targeting audiences, examining conference characteristics, and promoting online continuing education forums.</p