Pair Production of Fourth Family Charged Sleptons at e+e−e^{+}e^{-} Colliders

We study the pair production of $\tilde{l}_{4}$, which is the supersymmetric partner of the fourth family charged lepton, at the $e^{+}e^{-}$ colliders. It is shown that the investigation of this process at ILC/CLIC will give opportunity to differentiate the MSSM with three and four families.Comment: 6 pages, 2 figure

Impact of the relatively light fourth family neutrino on the Higgs boson search

The existence of a fourth fermion generation has mostly been considered as a source of enhanced Higgs signals with respect to the 3 family Standard Model predictions. However, a fourth Standard Model family neutrino could cause the opposite situation. It is shown that relatively light fourth family neutrino (2m_(nu_(4))<m_(H)) could drastically change the interpretation of the search results for the Higgs boson, especially if m_(H)<170 GeV.Comment: 5 pages, 9 figure

The impact of technology in hotels: A case study of Istanbul and Ankara hotels

[No abstract available

An analog of glibenclamide selectively enhances autophagic degradation of misfolded α1-antitrypsin Z

The classical form of α1-antitrypsin deficiency (ATD) is characterized by intracellular accumulation of the misfolded variant α1-antitrypsin Z (ATZ) and severe liver disease in some of the affected individuals. In this study, we investigated the possibility of discovering novel therapeutic agents that would reduce ATZ accumulation by interrogating a C. elegans model of ATD with high-content genome-wide RNAi screening and computational systems pharmacology strategies. The RNAi screening was utilized to identify genes that modify the intracellular accumulation of ATZ and a novel computational pipeline was developed to make high confidence predictions on repurposable drugs. This approach identified glibenclamide (GLB), a sulfonylurea drug that has been used broadly in clinical medicine as an oral hypoglycemic agent. Here we show that GLB promotes autophagic degradation of misfolded ATZ in mammalian cell line models of ATD. Furthermore, an analog of GLB reduces hepatic ATZ accumulation and hepatic fibrosis in a mouse model in vivo without affecting blood glucose or insulin levels. These results provide support for a drug discovery strategy using simple organisms as human disease models combined with genetic and computational screening methods. They also show that GLB and/or at least one of its analogs can be immediately tested to arrest the progression of human ATD liver disease.</div

A Search for leptophilic Z_(l) boson at future linear colliders

We study the possible dynamics associated with leptonic charge in future linear colliders. Leptophilic massive vector boson, Z_(l), have been investigated through the process e^(+)e^(-) -> mu^(+)mu^(-). We have shown that ILC and CLIC will give opportunity to observe Z_(l) with masses up to the center of mass energy if the corresponding coupling constant g_(l) exceeds 10^(-3).Comment: 12 pages, 10 figure

The GBT Project

The GigaBit Transceiver (GBT) architecture and transmission protocol has been proposed for data transmission in the physics experiments of the future upgrade of the LHC accelerator, the SLHC. Due to the high beam luminosity planned for the SLHC, the experiments will require high data rate links and electronic components capable of sustaining high radiation doses. The GBT ASICs address this issue implementing a radiation-hard bi-directional 4.8 Gb/s optical fibre link between the counting room and the experiments. The paper describes in detail the GBT-SERDES architecture and presents an overview of the various components that constitute the GBT chipset

Giant cervicothoracic extradural arachnoid cyst: case report

The pathogenesis, etiology, and treatment of the spinal arachnoid cyst have not been well established because of its rarity. A 57-year-old male was presented with spastic quadriparesis predominantly on the left side. His radiological examination showed widening of the cervical spinal canal and left neural foramina due to a cerebrospinal fluid - filled extradural cyst that extended from C2 to T2 level. The cyst was located left anterolaterally, compressing the spinal cord. Through a C4–T2 laminotomy, the cyst was excised totally and the dural defect was repaired. Several features of the reported case, such as cyst size, location, and clinical features make it extremely unusual. The case is discussed in light of the relevant literature