The southern regional conference on technology assessment: Summary

The proceedings of a conference on technology assessment are presented. A survey of recent Federal activity in technology assessment was discussed initially. Emphasis was placed on state and local activities with respect to technology assessment to include the following subjects: (1) the technology assessment desired by states, (2) organization of technology assessment activities, (3) how to perform technology assessments for less than $5,000, and (4) the preparation of environmental impact statements. Specific application of technology assessment to solid waste management in Connecticut is reported

SuperNeurons: Dynamic GPU Memory Management for Training Deep Neural Networks

Going deeper and wider in neural architectures improves the accuracy, while the limited GPU DRAM places an undesired restriction on the network design domain. Deep Learning (DL) practitioners either need change to less desired network architectures, or nontrivially dissect a network across multiGPUs. These distract DL practitioners from concentrating on their original machine learning tasks. We present SuperNeurons: a dynamic GPU memory scheduling runtime to enable the network training far beyond the GPU DRAM capacity. SuperNeurons features 3 memory optimizations, \textit{Liveness Analysis}, \textit{Unified Tensor Pool}, and \textit{Cost-Aware Recomputation}, all together they effectively reduce the network-wide peak memory usage down to the maximal memory usage among layers. We also address the performance issues in those memory saving techniques. Given the limited GPU DRAM, SuperNeurons not only provisions the necessary memory for the training, but also dynamically allocates the memory for convolution workspaces to achieve the high performance. Evaluations against Caffe, Torch, MXNet and TensorFlow have demonstrated that SuperNeurons trains at least 3.2432 deeper network than current ones with the leading performance. Particularly, SuperNeurons can train ResNet2500 that has $10^4$ basic network layers on a 12GB K40c.Comment: PPoPP '2018: 23nd ACM SIGPLAN Symposium on Principles and Practice of Parallel Programmin

Multilingual gendered identities: female undergraduate students in London talk about heritage languages

In this paper I explore how a group of female university students, mostly British Asian and in their late teens and early twenties, perform femininities in talk about heritage languages. I argue that analysis of this talk reveals ways in which the participants enact ‘culturally intelligible’ gendered subject positions. This frequently involves negotiating the norms of ‘heteronormativity’, constituting femininity in terms of marriage, motherhood and maintenance of heritage culture and language, and ‘girl power’, constituting femininity in terms of youth, sassiness, glamour and individualism. For these young women, I ask whether higher education can become a site in which they have the opportunities to explore these identifications and examine other ways of imagining the self and what their stories suggest about ‘doing being’ a young British Asian woman in London

Computations in non-commutative Iwasawa theory

We study special values of L-functions of elliptic curves over Q twisted by Artin representations that factor through a false Tate curve extension $Q(\mu_p^\infty,\sqrt[p^\infty]{m})/Q$. In this setting, we explain how to compute L-functions and the corresponding Iwasawa-theoretic invariants of non-abelian twists of elliptic curves. Our results provide both theoretical and computational evidence for the main conjecture of non-commutative Iwasawa theory.Comment: 60 pages; with appendix by John Coates and Ramdorai Sujath

Decision-making: initiating insulin therapy for adults with diabetes

<b>AIM:</b> This paper is a report of a study to describe nurses' perceptions of decision-making and the evidence base for the initiation of insulin therapy. <b>BACKGROUND:</b> Several theoretical perspectives and professional's attributes underpin decision-making to commence insulin therapy. The management of type 2 diabetes is moving from secondary to primary care and this affects how clinical decisions are made, by whom and the evidence base for these decisions. <b>METHOD:</b> A postal survey was conducted with a stratified sample of 3478 Diabetes Specialist Nurses and Practice Nurses with a special interest in diabetes across the four countries of the United Kingdom. A total of 1310 valid responses were returned, giving a response rate of 37.7%. The questionnaire was designed for the study and pilot-tested before use. Responses were given using Likert-type scales. Data were collected during 2005 and 2006, and one reminder was sent. <b>RESULTS:</b> People with diabetes are seen as having little influence in decision-making. Consultant physicians appear to be influential in most decisions, and the nursing groups held varying perceptions of who made clinical decisions. Nurses' identified different responsibilities for those working solely in secondary care from those working in both community and secondary care. Practice nurses were not as involved as anticipated. <b>CONCLUSION:</b> Nurses working with people with diabetes need to encourage them to become more active partners in care. Clinical guidelines can assist in decision-making where nurses are least experienced in initiating insulin therapy

Gravitational Higgs mechanism in neutron star interiors

We suggest that nonminimally coupled scalar fields can lead to modifications of the microphysics in the interiors of relativistic stars. As a concrete example, we consider the generation of a non-zero photon mass in such high-density environments. This is achieved by means of a light gravitational scalar, and the scalarization phase transition in scalar-tensor theories of gravitation. Two distinct models are presented, and phenomenological implications are briefly discussed

Proposal of an FTIR Methodology to Monitor Oxidation Level in Used Engine Oils: Effects of Thermal Degradation and Fuel Dilution

This article describes a procedure, based on ASTM standards D7214 and E2412, that has been defined to improve quantification of oil oxidation in used engine oils. Taking into account typical problems that can be found in this type of sample, including thermal oxidation and fuel dilution, Fourier transform infrared (FTIR) spectra were analyzed also considering the effect of the oil formulation. Two zones were considered inside the typical wave number range for quantification of oxidation, where those problems can be detected and assessed more easily: zone A between 1725 and 1650 cm-1, where the main oxidation products, such as aldehydes, carboxylic acids, and ketones, occur due to thermal degradation of the oil; and zone B between 1770 and 1725 cm-1, where esters due to potential biodiesel dilution problems are detected. Copyright © Society of Tribologists and Lubrication Engineers.The authors are grateful for Spanish Grant TRA2008-06508 (GLAUTO) from the Ministerio de Ciencia e Innovacion-Direccion General de Investigacion for supporting this work.Macian Martinez, V.; Tormos, B.; Gomez Estrada, YA.; Salavert Fernández, JM. (2012). Proposal of an FTIR Methodology to Monitor Oxidation Level in Used Engine Oils: Effects of Thermal Degradation and Fuel Dilution. Tribology Transactions. 55(6):872-882. https://doi.org/10.1080/10402004.2012.721921S87288255

Oral ferroportin inhibitor vamifeport for improving iron homeostasis and erythropoiesis in β-thalassemia: current evidence and future clinical development

Introduction: In β-thalassemia, imbalanced globin synthesis causes reduced red blood cell survival and ineffective erythropoiesis. Suppressed hepcidin levels increase ferroportin-mediated iron transport in enterocytes, causing increased iron absorption and potentially iron overload. Low hepcidin also stimulates ferroportin-mediated iron release from macrophages, increasing transferrin saturation (TSAT), potentially forming non-transferrin-bound iron, which can be toxic. Modulating the hepcidin–ferroportin axis is an attractive strategy to improve ineffective erythropoiesis and limit the potential tissue damage resulting from iron overload. There are no oral β-thalassemia treatments that consistently ameliorate anemia and prevent iron overload. / Areas covered: The preclinical and clinical development of vamifeport (VIT-2763), a novel ferroportin inhibitor, was reviewed. PubMed, EMBASE and ClinicalTrials.gov were searched using the search term ‘VIT-2763ʹ. / Expert opinion: Vamifeport is the first oral ferroportin inhibitor in clinical development. In healthy volunteers, vamifeport had comparable safety to placebo, was well tolerated and rapidly decreased iron levels and reduced TSAT, consistent with observations in preclinical models. Data from ongoing/planned Phase II studies are critical to define its potential in β-thalassemia and other conditions associated with iron overabsorption and/or ineffective erythropoiesis. If vamifeport potentially increases hemoglobin and reduces iron-related parameters, it could be a suitable treatment for non-transfusion-dependent and transfusion-dependent β-thalassemia

Negative ion chemistry in Titan's upper atmosphere

International audienceThe Electron Spectrometer (ELS), one of the sensors making up the Cassini Plasma Spectrometer (CAPS) revealed the existence of numerous negative ions in Titan's upper atmosphere. The observations at closest approach (not, vert, similar1000 km) show evidence for negatively charged ions up to not, vert, similar10,000 amu/q, as well as two distinct peaks at 22±4 and 44±8 amu/q, and maybe a third one at 82±14 amu/q. We present the first ionospheric model of Titan including negative ion chemistry. We find that dissociative electron attachment to neutral molecules (mostly HCN) initiates the formation of negative ions. The negative charge is then transferred to more acidic molecules such as HC3N, HC5N or C4H2. Loss occurs through associative detachment with radicals (H and CH3). We attribute the three low mass peaks observed by ELS to CN−, C3N−/C4H− and C5N−. These species are the first intermediates in the formation of the even larger negative ions observed by ELS, which are most likely the precursors to the aerosols observed at lower altitudes