On ramsey properties, function spaces, and topological games

An open question of Gruenhage asks if all strategically selectively separable spaces are Markov selectively separable, a game-theoretic statement known to hold for countable spaces. As a corollary of a result by Berner and Juhász, we note that the “strong” version of this statement, where the second player is restricted to selecting single points rather than finite subsets, holds for all T3 spaces without isolated points. Continuing this investigation, we also consider games related to selective sequential separability, and demonstrate results analogous to those for selective separability. In particular, strong selective sequential separability in the presence of the Ramsey property may be reduced to a weaker condition on a countable sequentially dense subset. Additionally, γ-and ω-covering properties on X are shown to be equivalent to corresponding sequential properties on Cp (X). A strengthening of the Ramsey property is also introduced, which is still equivalent to α2 and α4 in the context of Cp (X). © 2010 Mathematics Subject Classification

Clinical trial-identified inflammatory biomarkers in breast and pancreatic cancers

Breast cancer and pancreatic cancer are two common cancer types characterized by high prevalence and high mortality rates, respectively. However, breast cancer has been more well-studied than pancreatic cancer. This narrative review curated inflammation-associated biomarkers from clinical studies that were systematically selected for both breast and pancreatic cancers and discusses some of the common and unique elements between the two endocrine-regulated malignant diseases. Finding common ground between the two cancer types and specifically analyzing breast cancer study results, we hoped to explore potential feasible methods and biomarkers that may be useful also in diagnosing and treating pancreatic cancer. A PubMed MEDLINE search was used to identify articles that were published between 2015-2022 of different kinds of clinical trials that measured immune-modulatory biomarkers and biomarker changes of inflammation defined in diagnosis and treatment of breast cancer and pancreatic cancer patients. A total of 105 papers (pancreatic cancer 23, breast cancer 82) were input into Covidence for the title and abstract screening. The final number of articles included in this review was 73 (pancreatic cancer 19, breast cancer 54). The results showed some of the frequently cited inflammatory biomarkers for breast and pancreatic cancers included IL-6, IL-8, CCL2, CD8+ T cells and VEGF. Regarding unique markers, CA15-3 and TNF-alpha were two of several breast cancer-specific, and CA19 and IL-18 were pancreatic cancer-specific. Moreover, we discussed leptin and MMPs as emerging biomarker targets with potential use for managing pancreatic cancer based on breast cancer studies in the future, based on inflammatory mechanisms. Overall, the similarity in how both types of cancers respond to or result in further disruptive inflammatory signaling, and that point to a list of markers that have been shown useful in diagnosis and/or treatment method response or efficacy in managing breast cancer could potentially provide insights into developing the same or more useful diagnostic and treatment measurement inflammatory biomarkers for pancreatic cancer. More research is needed to investigate the relationship and associated inflammatory markers between the similar immune-associated biological mechanisms that contribute to breast and pancreatic cancer etiology, drive disease progression or that impact treatment response and reflect survival outcomes

The Role of the United Nations in the Maintenance of Peace before and after the Year Two Thousand

Two-day conference on United Nations held at the University of Georgia School of Law on March 3 and 4, 1995. The conference consisted of three panels ( United States attitudes on the role of the United Nations regarding the maintenance and the restoration of peace, Global attitudes on the role of the United Nations on the maintenance and restoration of peace, and The role of the United Nations with respect to the means for accomplishing the maintenance and restoration of peace ). Included dinner remarks by Louis B. Sohn

oMEGACat I: MUSE spectroscopy of 300,000 stars within the half-light radius of ω\omega Centauri

Omega Centauri ($\omega$ Cen) is the most massive globular cluster of the Milky Way and has been the focus of many studies that reveal the complexity of its stellar populations and kinematics. However, most previous studies have used photometric and spectroscopic datasets with limited spatial or magnitude coverage, while we aim to investigate it having full spatial coverage out to its half-light radius and stars ranging from the main sequence to the tip of the red giant branch. This is the first paper in a new survey of $\omega$ Cen that combines uniform imaging and spectroscopic data out to its half-light radius to study its stellar populations, kinematics, and formation history. In this paper, we present an unprecedented MUSE spectroscopic dataset combining 87 new MUSE pointings with previous observations collected from guaranteed time observations. We extract spectra of more than 300,000 stars reaching more than two magnitudes below the main sequence turn-off. We use these spectra to derive metallicity and line-of-sight velocity measurements and determine robust uncertainties on these quantities using repeat measurements. Applying quality cuts we achieve signal-to-noise ratios of 16.47/73.51 and mean metallicity errors of 0.174/0.031 dex for the main sequence stars (18 mag $\rm < mag_{F625W}<$22 mag) and red giant branch stars (16 mag $<\rm mag_{F625W}<$10 mag), respectively. We correct the metallicities for atomic diffusion and identify foreground stars. This massive spectroscopic dataset will enable future studies that will transform our understanding of $\omega$ Cen, allowing us to investigate the stellar populations, ages, and kinematics in great detail.Comment: 27 pages, 18 figures, 3 tables, accepted for publication in ApJ, the catalog will be available in the online material of the published articl

oMEGACat I: MUSE spectroscopy of 300,000 stars within the half-light radius of ω Centauri

Omega Centauri (ω Cen) is the most massive globular cluster of the Milky Way and has been the focus of many studies that reveal the complexity of its stellar populations and kinematics. However, most previous studies have used photometric and spectroscopic datasets with limited spatial or magnitude coverage, while we aim to investigate it having full spatial coverage out to its half-light radius and stars ranging from the main sequence to the tip of the red giant branch. This is the first paper in a new survey of ω Cen that combines uniform imaging and spectroscopic data out to its half-light radius to study its stellar populations, kinematics, and formation history. In this paper, we present an unprecedented MUSE spectroscopic dataset combining 87 new MUSE pointings with previous observations collected from guaranteed time observations. We extract spectra of more than 300,000 stars reaching more than two magnitudes below the main sequence turn-off. We use these spectra to derive metallicity and line-of-sight velocity measurements and determine robust uncertainties on these quantities using repeat measurements. Applying quality cuts we achieve signal-to-noise ratios of 16.47/73.51 and mean metallicity errors of 0.174/0.031 dex for the main sequence stars (18 mag < magF625W < 22 mag) and red giant branch stars (16 mag < magF625W <10 mag), respectively. We correct the metallicities for atomic diffusion and identify foreground stars. This massive spectroscopic dataset will enable future studies that will transform our understanding of ω Cen, allowing us to investigate the stellar populations, ages, and kinematics in great detail

Atezolizumab-induced Autoimmune Diabetes in a Patient with Metastatic Breast Cancer: A Case Report

Introduction: Immune checkpoint inhibitors (ICI) are a class of immunotherapy drugs used increasingly in the treatment of multiple types of cancer. Major side effects include immune-related adverse effects, potentially resulting in damage to normal tissue across multiple different organ systems.Case Report: A 74-year-old woman with a history of triple negative metastatic breast cancer treated with the ICI atezolizumab presented with new-onset autoimmune diabetes in diabetic ketoacidosis.&nbsp; She required fluid resuscitation, insulin infusion, vasopressors, and initial hospitalization in the intensive care unit. The patient was subsequently discharged on bolus dose insulin and remained an insulin-dependent diabetic at three-month follow-up.Conclusion: Autoimmune diabetes is a rare, but life-threatening, adverse event associated with ICIs such as atezolizumab. To our knowledge this is the only case report of atezolizumab causing autoimmune diabetes in the setting of metastatic breast cancer. As ICIs become more common in the treatment of cancer, emergency physicians should remain vigilant for the various immune-mediated complications associated with this class of immunotherapy drugs

Atezolizumab-induced Autoimmune Diabetes in a Patient with Metastatic Breast Cancer: A Case Report

Introduction: Immune checkpoint inhibitors (ICI) are a class of immunotherapy drugs used increasingly in the treatment of multiple types of cancer. Major side effects include immune-related adverse effects, potentially resulting in damage to normal tissue across multiple different organ systems.Case Report: A 74-year-old woman with a history of triple negative metastatic breast cancer treated with the ICI atezolizumab presented with new-onset autoimmune diabetes in diabetic ketoacidosis.&nbsp; She required fluid resuscitation, insulin infusion, vasopressors, and initial hospitalization in the intensive care unit. The patient was subsequently discharged on bolus dose insulin and remained an insulin-dependent diabetic at three-month follow-up.Conclusion: Autoimmune diabetes is a rare, but life-threatening, adverse event associated with ICIs such as atezolizumab. To our knowledge this is the only case report of atezolizumab causing autoimmune diabetes in the setting of metastatic breast cancer. As ICIs become more common in the treatment of cancer, emergency physicians should remain vigilant for the various immune-mediated complications associated with this class of immunotherapy drugs

Defining the incidence of cardiorespiratory instability in patients in step-down units using an electronic integrated monitoring system

Background: To our knowledge, detection of cardiorespiratory instability using noninvasive monitoring via electronic integrated monitoring systems (IMSs) in intermediate or step-down units (SDUs) has not been described. We undertook this study to characterize respiratory status in an SDU population, to define features of cardiorespiratory instability, and to evaluate an IMS index value that should trigger medical emergency team (MET) activation. Methods: This descriptive, prospective, single-blinded, observational study evaluated all patients in a 24-bed SDU in a university medical center during 8 weeks from November 16, 2006, to January 11, 2007. An IMS (BioSign; OBS Medical, Carmel, Indiana) was inserted into the standard noninvasive hardwired monitoring system and used heart rate, blood pressure, respiratory rate, and peripheral oxygen saturation by pulse oximetry to develop a single neural networked signal, or BioSign Index (BSI). Data were analyzed for cardiorespiratory instability according to BSI trigger value and local MET activation criteria. Staff were blinded to BSI data collected in 326 patients (total census). Results: Data for 18 248 hours of continuous monitoring were captured. Data for peripheral oxygen saturation by pulse oximetry were absent in 30% of monitored hours despite being a standard of care. Cardiorespiratory status in most patients (243 of 326 [74.5%]) was stable throughout their SDU stay, and instability in the remaining patients (83 of 326 [25%]) was exhibited infrequently. We recorded 111 MET activation criteria events caused by cardiorespiratory instability in 59 patients, but MET activation for this cause occurred in only 7 patients. All MET events were detected by BSI in advance (mean, 6.3 hours) in a bimodal distribution (>6 hours and ≤45 minutes). Conclusions: Cardiorespiratory instability, while uncommon and often unrecognized, was preceded by elevation of the IMS index. Continuous noninvasive monitoring augmented by IMS provides sensitive detection of early instability in patients in SDUs. ©2008 American Medical Association. All rights reserved