LIF measurement of the diluting effect of surface waves on turbulent buoyant plumes.

In this paper, the diluting effect of surface waves on a buoyant plume has been measured using a Laser Induced Fluorescence (LIF) technique. The resulting time-averaged, full field concentration maps have allowed quantification of enhanced mixing due to surface waves as well as measurement of other plume parameters

Crisis intervention for people with severe mental illnesses

Background A particularly difficult challenge for community treatment of people with serious mental illnesses is the delivery of an acceptable level of care during the acute phases of severe mental illness. Crisis-intervention models of care were developed as a possible solution. Objectives To review the effects of crisis-intervention models for anyone with serious mental illness experiencing an acute episode compared to the standard care they would normally receive. If possible, to compare the effects of mobile crisis teams visiting patients' homes with crisis units based in home-like residential houses. Search methods We searched the Cochrane Schizophrenia Group’s Study-Based Register of Trials. There is no language, time, document type, or publication status limitations for inclusion of records in the register. This search was undertaken in 1998 and then updated 2003, 2006, 2010 and September 29, 2014. Selection criteria We included all randomised controlled trials of crisis-intervention models versus standard care for people with severe mental illnesses that met our inclusion criteria. Data collection and analysis We independently extracted data from these trials and we estimated risk ratios (RR) or mean differences (MD), with 95% confidence intervals (CI). We assessed risk of bias for included studies and used GRADE to create a 'Summary of findings' table. Main results The update search September 2014 found no further new studies for inclusion, the number of studies included in this review remains eight with a total of 1144 participants. Our main outcomes of interest are hospital use, global state, mental state, quality of life, participant satisfaction and family burden. With the exception of mental state, it was not possible to pool data for these outcomes. Crisis intervention may reduce repeat admissions to hospital (excluding index admissions) at six months (1 RCT, n = 369, RR 0.75 CI 0.50 to 1.13, high quality evidence), but does appear to reduce family burden (at six months: 1 RCT, n = 120, RR 0.34 CI 0.20 to 0.59, low quality evidence), improve mental state (Brief Psychiatric Rating Scale (BPRS) three months: 2 RCTs, n = 248, MD -4.03 CI -8.18 to 0.12, low quality evidence), and improve global state (Global Assessment Scale (GAS) 20 months; 1 RCT, n = 142, MD 5.70, -0.26 to 11.66, moderate quality evidence). Participants in the crisis-intervention group were more satisfied with their care 20 months after crisis (Client Satisfaction Questionnaire (CSQ-8): 1 RCT, n = 137, MD 5.40 CI 3.91 to 6.89, moderate quality evidence). However, quality of life scores at six months were similar between treatment groups (Manchester Short Assessment of quality of life (MANSA); 1 RCT, n = 226, MD -1.50 CI -5.15 to 2.15, low quality evidence). Favourable results for crisis intervention were also found for leaving the study early and family satisfaction. No differences in death rates were found. Some studies suggested crisis intervention to be more cost-effective than hospital care but all numerical data were either skewed or unusable. We identified no data on staff satisfaction, carer input, complications with medication or number of relapses. Authors' conclusions Care based on crisis-intervention principles, with or without an ongoing homecare package, appears to be a viable and acceptable way of treating people with serious mental illnesses. However only eight small studies with unclear blinding, reporting and attrition bias could be included and evidence for the main outcomes of interest is low to moderate quality. If this approach is to be widely implemented it would seem that more evaluative studies are still neede

Dark states in the magnetotransport through triple quantum dots

We consider the transport through a system of three coupled quantum dots in a perpendicular magnetic field. At zero field, destructive interference can trap an electron in a dark state -- a coherent superposition of dot states that completely blocks current flow. The magnetic field can disrupt this interference giving rise to oscillations in the current and its higher-order statistics as the field is increased. These oscillations have a period of either the flux-quantum or half the flux-quantum, depending on the dot geometry. We give results for the stationary current and for the shotnoise and skewness at zero and finite frequency.Comment: 7 pages, 7 figure

A laminar flow model of aerosol survival of epidemic and non-epidemic strains of Pseudomonas aeruginosa isolated from people with cystic fibrosis

Cystic fibrosis (CF) is an inherited multi-system disorder characterised by chronic airway infection with pathogens such as Pseudomonas aeruginosa. Acquisition of P. aeruginosa by patients with CF is usually from the environment, but recent studies have demonstrated patient to patient transmission of certain epidemic strains, possibly via an airborne route. This study was designed to examine the survival of P. aeruginosa within artificially generated aerosols. Survival was effected by the solution used for aerosol generation. Within the aerosols it was adversely affected by an increase in air temperature. Both epidemic and non-epidemic strains of P. aeruginosa were able to survive within the aerosols, but strains expressing a mucoid phenotype had a survival advantage. This would suggest that segregating individuals free of P. aeruginosa from those with chronic P. aeruginosa infection who are more likely to be infected with mucoid strains may help reduce the risk of cross-infection. Environmental factors also appear to influence bacterial survival. Warming and drying the air within clinical areas and avoidance of humidification devices may also be beneficial in reducing the risk of cross-infection

The fast molecular outflow in the Seyfert galaxy IC5063 as seen by ALMA

We use high-resolution (0.5 arcsec) CO(2-1) observations performed with ALMA to trace the kinematics of the molecular gas in the Seyfert 2 galaxy IC5063. A fast outflow of molecular gas extends along the entire radio jet, with the highest outflow velocities about 0.5kpc from the nucleus, at the location of the brighter hot-spot in the W lobe. The data show that a massive, fast outflow with velocities up to 650 km/s of cold molecular gas is present, in addition to one detected earlier in warm H2, HI and ionised gas. Both the central AGN and the radio jet could energetically drive the outflow. However, the characteristics of the outflowing gas point to the radio jet being the main driver. This is important, because IC5063, although one of the most powerful Seyfert galaxies, is a relatively weak radio source (P = 3x10^23 W/Hz). All the observed characteristics can be described by a scenario of a radio plasma jet expanding into a clumpy medium, interacting directly with the clouds and inflating a cocoon that drives a lateral outflow into the interstellar medium. This model is consistent with results obtained by recent simulations such as those of Wagner et al.. A stronger, direct interaction between the jet and a gas cloud is present at the location of the brighter W lobe. Even assuming the most conservative values for the conversion factor CO-to-H2, the mass of the outflowing gas is between 1.9 and 4.8x10^7 Msun. These amounts are much larger than those of the outflow of warm gas (molecular and ionized) and somewhat larger than of the HI outflow. This suggests that most of the observed cold molecular outflow is due to fast cooling after being shocked. This gas is the end product of the cooling process. Our CO observations demonstrate that fast outflows of molecular gas can be driven by relativistic jets.Comment: Accepted for publication in A&A. 11 pages, 8 figure

Bactericidal action of positive and negative ions in air

In recent years there has been renewed interest in the use of air ionisers to control of the spread of airborne infection. One characteristic of air ions which has been widely reported is their apparent biocidal action. However, whilst the body of evidence suggests a biocidal effect in the presence of air ions the physical and biological mechanisms involved remain unclear. In particular, it is not clear which of several possible mechanisms of electrical origin (i.e. the action of the ions, the production of ozone, or the action of the electric field) are responsible for cell death. A study was therefore undertaken to clarify this issue and to determine the physical mechanisms associated with microbial cell death. In the study seven bacterial species (Staphylococcus aureus, Mycobacterium parafortuitum, Pseudomonas aeruginosa, Acinetobacter baumanii, Burkholderia cenocepacia, Bacillus subtilis and Serratia marcescens) were exposed to both positive and negative ions in the presence of air. In order to distinguish between effects arising from: (i) the action of the air ions; (ii) the action of the electric field, and (iii) the action of ozone, two interventions were made. The first intervention involved placing a thin mica sheet between the ionisation source and the bacteria, directly over the agar plates. This intervention, while leaving the electric field unaltered, prevented the air ions from reaching the microbial samples. In addition, the mica plate prevented ozone produced from reaching the bacteria. The second intervention involved placing an earthed wire mesh directly above the agar plates. This prevented both the electric field and the air ions from impacting on the bacteria, while allowing any ozone present to reach the agar plate. With the exception of Mycobacterium parafortuitum, the principal cause of cell death amongst the bacteria studied was exposure to ozone, with electroporation playing a secondary role. However in the case of Mycobacterium parafortuitum, electroporation resulting from exposure to the electric field appears to have been the principal cause of cell inactivation. The results of the study suggest that the bactericidal action attributed to negative air ions by previous researchers may have been overestimated

Clear detection of dusty torus signatures in a Weak-Line Radio Galaxy: the case of PKS 0043-42

We report the clearest detection to date of dusty torus signatures in a Weak-Line Radio Galaxy (WLRG). The deep Spitzer InfraRed Spectrograph (IRS) rest-frame mid-infrared (MIR) spectrum of the WLRG PKS 0043-42 (z=0.116) shows a clear spectral turnover at wavelengths longer than ~20 micron suggestive of warm dust, as well as a 9.7 micron silicate absorption feature. In addition, the hard X-ray results, based on Chandra data, strongly support a picture in which PKS 0043-42 has a torus and accretion disc more typical of Strong-Line Radio Galaxies (SLRGs). The MIR and X-ray spectra are markedly different from those of other WLRGs at similar redshifts, and here we show that the former can be successfully fitted with clumpy torus models with parameters characteristic of Type-2 AGN tori: close to edge-on (i=74 deg) and relatively broad (torus angular width=60 deg), with an outer radius of 2 pc, hydrogen column density ~1.6x10^(23) cm^(-2), and AGN bolometric luminosity ~1.6x10^(44) erg s^(-1). The presence of a compact torus in PKS 0043-42 provides evidence that this WLRG is fuelled by cold, rather than hot, gas accretion. We suggest that WLRGs are a diverse population, and PKS 0043-42 may represent a type of radio galaxy in which the AGN activity has been recently re-triggered as a consequence of intermittent gas supply, or in which the covering factor of the Narrow-Line Region (NLR) clouds is relatively low.Comment: 7 pages, 6 figures, 1 table. Accepted by MNRA

The potential impact of the fetal genotype on maternal blood pressure during pregnancy.

The heritability of pregnancy-induced hypertension (encompassing both gestational hypertension and preeclampsia) is around 0.47, suggesting that there is a genetic component to its development. However, the maternal genetic risk variants discovered so far only account for a small proportion of the heritability. Other genetic variants that may affect maternal blood pressure in pregnancy arise from the fetal genome, for example wild-type pregnant mice carrying offspring with Cdkn1c or Stox1 disrupted develop hypertension and proteinuria. In humans, there is a higher risk for preeclampsia in women carrying fetuses with Beckwith-Wiedemann syndrome (including those fetuses with CDKN1C mutations) and a lower risk for women carrying babies with trisomy 21. Other risk may be associated with imprinted fetal growth genes and genes that are highly expressed in the placenta such as GCM1. This article reviews the current state of knowledge linking the fetal genotype with maternal blood pressure in pregnancy.MRCThis is the Author Accepted Manuscript of Petry CJ, Beardsall K, Dunger DB. "The potential impact of the fetal genotype on maternal blood pressure during pregnancy". published in the Journal of Hypertension. The published version is available at http://dx.doi.org/10.1097/HJH.000000000000021