215 research outputs found
When is policing fair? Groups, identity and judgements of the procedural justice of coercive crowd policing
Procedural justice theory (PJT) is now a widely utilised theoretical perspective in policing research that acknowledges the centrality of police ‘fairness’. Despite its widespread acceptance this paper asserts that there are conceptual limitations that emerge when applying the theory to the policing of crowd events. This paper contends that this problem with PJT is a result of specific assumptions that are highlighted by two studies using a novel experimental approach. Study 1 systematically manipulated the social categories used to describe crowd participants subjected to police coercion. The experiment demonstrates how these social categories dramatically affected participants’ perceptions of the same police action and that it was participants’ relational identification with the police, rather than a superordinate category, that mediated the association between judgements of procedural fairness and intentions to cooperate. In Study 2, using a quasi-experimental design, we then replicated and extended these findings by demonstrating how perceptions of procedural fairness are also influenced by levels of in-group identification. The paper concludes by exploring the implications of the data for reconceptualising the social psychological processes mediating these judgements and impacts of police legitimacy
Application of an electrospray-interface as a new nebulizer for inductively coupled plasma atomic emission spectrometry
Opinion dynamics: models, extensions and external effects
Recently, social phenomena have received a lot of attention not only from
social scientists, but also from physicists, mathematicians and computer
scientists, in the emerging interdisciplinary field of complex system science.
Opinion dynamics is one of the processes studied, since opinions are the
drivers of human behaviour, and play a crucial role in many global challenges
that our complex world and societies are facing: global financial crises,
global pandemics, growth of cities, urbanisation and migration patterns, and
last but not least important, climate change and environmental sustainability
and protection. Opinion formation is a complex process affected by the
interplay of different elements, including the individual predisposition, the
influence of positive and negative peer interaction (social networks playing a
crucial role in this respect), the information each individual is exposed to,
and many others. Several models inspired from those in use in physics have been
developed to encompass many of these elements, and to allow for the
identification of the mechanisms involved in the opinion formation process and
the understanding of their role, with the practical aim of simulating opinion
formation and spreading under various conditions. These modelling schemes range
from binary simple models such as the voter model, to multi-dimensional
continuous approaches. Here, we provide a review of recent methods, focusing on
models employing both peer interaction and external information, and
emphasising the role that less studied mechanisms, such as disagreement, has in
driving the opinion dynamics. [...]Comment: 42 pages, 6 figure
Advanced molecular pathology for rare tumours: a national feasibility study and model for centralised medulloblastoma diagnostics
Aims
Application of advanced molecular pathology in rare tumours is hindered by low sample numbers, access to specialised expertise/technologies and tissue/assay QC and rapid reporting requirements. We assessed the feasibility of co-ordinated real-time centralised pathology review (CPR), encompassing molecular diagnostics and contemporary genomics (RNA-seq/DNA methylation-array).
Methods
This nationwide trial in medulloblastoma (<80 UK diagnoses/year) introduced a national reference centre (NRC) and assessed its performance and reporting to World Health Organisation standards. Paired frozen/formalin-fixed, paraffin-embedded tumour material were co-submitted from 135 patients (16 referral centres).
Results
Complete CPR diagnostics were successful for 88% (120/135). Inadequate sampling was the most common cause of failure; biomaterials were typically suitable for methylation-array (129/135, 94%), but frozen tissues commonly fell below RNA-seq QC requirements (53/135, 39%). Late reporting was most often due to delayed submission. CPR assigned or altered histological variant (vs local diagnosis) for 40/135 tumours (30%). Benchmarking/QC of specific biomarker assays impacted test results; fluorescent in-situ hybridisation most accurately identified high-risk MYC/MYCN amplification (20/135, 15%), while combined methods (CTNNB1/chr6 status, methylation-array subgrouping) best defined favourable-risk WNT tumours (14/135; 10%). Engagement of a specialist pathologist panel was essential for consensus assessment of histological variants and immunohistochemistry. Overall, CPR altered clinical risk-status for 29% of patients.
Conclusion
National real-time CPR is feasible, delivering robust diagnostics to WHO criteria and assignment of clinical risk-status, significantly altering clinical management. Recommendations and experience from our study are applicable to advanced molecular diagnostics systems, both local and centralised, across rare tumour types, enabling their application in biomarker-driven routine diagnostics and clinical/research studies
Emergence and maintenance of actionable genetic drivers at medulloblastoma relapse
Background
Less than 5% of medulloblastoma (MB) patients survive following failure of contemporary radiation-based therapies. Understanding the molecular drivers of medulloblastoma relapse (rMB) will be essential to improve outcomes. Initial genome-wide investigations have suggested significant genetic divergence of the relapsed disease.
Methods
We undertook large-scale integrated characterization of the molecular features of rMB—molecular subgroup, novel subtypes, copy number variation (CNV), and driver gene mutation. 119 rMBs were assessed in comparison with their paired diagnostic samples (n = 107), alongside an independent reference cohort sampled at diagnosis (n = 282). rMB events were investigated for association with outcome post-relapse in clinically annotated patients (n = 54).
Results
Significant genetic evolution occurred over disease-course; 40% of putative rMB drivers emerged at relapse and differed significantly between molecular subgroups. Non-infant MBSHH displayed significantly more chromosomal CNVs at relapse (TP53 mutation-associated). Relapsed MBGroup4 demonstrated the greatest genetic divergence, enriched for targetable (eg, CDK amplifications) and novel (eg, USH2A mutations) events. Importantly, many hallmark features of MB were stable over time; novel subtypes (>90% of tumors) and established genetic drivers (eg, SHH/WNT/P53 mutations; 60% of rMB events) were maintained from diagnosis. Critically, acquired and maintained rMB events converged on targetable pathways which were significantly enriched at relapse (eg, DNA damage signaling) and specific events (eg, 3p loss) predicted survival post-relapse.
Conclusions
rMB is characterised by the emergence of novel events and pathways, in concert with selective maintenance of established genetic drivers. Together, these define the actionable genetic landscape of rMB and provide a basis for improved clinical management and development of stratified therapeutics, across disease-course
Introduction to representations of the canonical commutation and anticommutation relations
Lecture notes of a minicourse given at the Summer School on Large Coulomb
Systems - QED in Nordfjordeid, 2003, devoted to representations of the CCR and
CAR. Quasifree states, the Araki-Woods and Araki-Wyss representations, and the
lattice of von Neumenn algebras in a bosonic/fermionic Fock space are discussed
in detail
Coaches' learning and sustainability in high performance sport
In undertaking their complicated and multi-faceted work, high performance coaches have previously been shown to be influential in the performance of athletes. It has also been noted that high performance coaches are learners by necessity. However, what remains unclear is how coaches' learning influences their engagement in sustainable practice. This study draws on three cohorts of full-time high performance coaches employed in Olympic and professional sports throughout Australia. Semi-structured interviews were conducted face-to-face and were inductively analysed. The results revealed that the coaches were presented with a variety of opportunities to learn, with the most valued sources being 'learning on the job', 'discussions with others' and 'experience as athletes'. These unmediated learning opportunities are critiqued along with other mediated opportunities in relation to notions of sustainability. The dominance of unmediated sources of learning meant that sustainable practice was present but was not assured. Sustainable practice is also discussed in relation to the dominant models of high performance athlete development and the demands of coaching work
The Sudbury Neutrino Observatory
The Sudbury Neutrino Observatory is a second generation water Cherenkov
detector designed to determine whether the currently observed solar neutrino
deficit is a result of neutrino oscillations. The detector is unique in its use
of D2O as a detection medium, permitting it to make a solar model-independent
test of the neutrino oscillation hypothesis by comparison of the charged- and
neutral-current interaction rates. In this paper the physical properties,
construction, and preliminary operation of the Sudbury Neutrino Observatory are
described. Data and predicted operating parameters are provided whenever
possible.Comment: 58 pages, 12 figures, submitted to Nucl. Inst. Meth. Uses elsart and
epsf style files. For additional information about SNO see
http://www.sno.phy.queensu.ca . This version has some new reference
Silagem de capim-elefante (Pennisetum purpureum, Schum) com e sem acipin, associada a duas fontes protéicas na alimentação de bovinos em confinamento
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