The SARS-CoV-2 Alpha variant was associated with increased clinical severity of COVID-19 in Scotland: A genomics-based retrospective cohort analysis

Objectives The SARS-CoV-2 Alpha variant was associated with increased transmission relative to other variants present at the time of its emergence and several studies have shown an association between Alpha variant infection and increased hospitalisation and 28-day mortality. However, none have addressed the impact on maximum severity of illness in the general population classified by the level of respiratory support required, or death. We aimed to do this. Methods In this retrospective multi-centre clinical cohort sub-study of the COG-UK consortium, 1475 samples from Scottish hospitalised and community cases collected between 1st November 2020 and 30th January 2021 were sequenced. We matched sequence data to clinical outcomes as the Alpha variant became dominant in Scotland and modelled the association between Alpha variant infection and severe disease using a 4-point scale of maximum severity by 28 days: 1. no respiratory support, 2. supplemental oxygen, 3. ventilation and 4. death. Results Our cumulative generalised linear mixed model analyses found evidence (cumulative odds ratio: 1.40, 95% CI: 1.02, 1.93) of a positive association between increased clinical severity and lineage (Alpha variant versus pre-Alpha variants). Conclusions The Alpha variant was associated with more severe clinical disease in the Scottish population than co-circulating lineages

As representações sociais e a experiência da doença Social representations and the experience of illness

O artigo objetiva analisar as relações entre representações sociais e a experiência da doença. O estudo é uma revisão crítica sobre a discussão da doença. O trabalho é constituído de: (a) resgate da utilização do conceito de representações sociais da doença; (b) aspectos sobre a experiência da doença; e (c) princípios para a compreensão do processo do adoecer. Como conclusão, os autores destacam a necessária articulação entre a experiência da doença e seu contexto de produção material e simbólica.<br>This article analyzes the relationship between social representations and the experience of illness. The study is a critical review of the debate on illness. The work focuses on (a) a review of the concept of "social representations of illness"; (b) key aspects of the experience of illness and; (c) principles for understanding the illness process. The authors also emphasize the necessary link between the experience of illness and the context of its material and symbolic production