12,444 research outputs found

    Friction measuring apparatus Patent

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    Kinetic and static friction force measurement between magnetic tape and magnetic head surface

    Metabolomic profiling of macrophages determines the discrete metabolomic signature and metabolomic interactome triggered by polarising immune stimuli

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    Priming and activating immune stimuli have profound effects on macrophages, however, studies generally evaluate stimuli in isolation rather than in combination. In this study we have investigated the effects of pro-inflammatory and anti-inflammatory stimuli either alone or in combination on macrophage metabolism. These stimuli include host factors such as IFNγ and ovalbumin-immunoglobulin immune complexes, or pathogen factors such as LPS. Untargeted LC-MS based metabolomics provided an in-depth profile of the macrophage metabolome, and revealed specific changes in metabolite abundance upon either individual stimuli or combined stimuli. Here, by factoring in an interaction term in the linear model, we define the metabolome interactome. This approach allowed us to determine whether stimuli interact in a synergistic or antagonistic manner. In conclusion this study demonstrates a robust approach to interrogate immune-metabolism, especially systems that model host-pathogen interactions

    The Distance of the First Overtone RR Lyrae Variables in the MACHO LMC Database: A New Method to Correct for the Effects of Crowding

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    Previous studies have indicated that many of the RR Lyrae variables in the LMC have properties similar to the ones in the Galactic globular cluster M3. Assuming that the M3 RR Lyrae variables follow the same relationships among period, temperature, amplitude and Fourier phase parameter phi31 as their LMC counterparts, we have used the M3 phi31-logP relation to identify the M3-like unevolved first overtone RR Lyrae variables in 16 fields near the LMC bar. The temperatures of these variables were calculated from the M3 logP-logTe relation so that the extinction could be derived for each star separately. Since blended stars have lower amplitudes for a given period, the period amplitude relation should be a useful tool for identifying which stars are affected by crowding. We find that the low amplitude stars are brighter. We remove them from the sample and derive an LMC distance modulus 18.49+/-0.11.Comment: 30 pages, 7 figures, accepted for publication in the Astronomical Journa

    Fermi-Walker gauge in 2+1 dimensional gravity.

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    It is shown that the Fermi-Walker gauge allows the general solution of determining the metric given the sources, in terms of simple quadratures. We treat the general stationary problem providing explicit solving formulas for the metric and explicit support conditions for the energy momentum tensor. The same type of solution is obtained for the time dependent problem with circular symmetry. In both cases the solutions are classified in terms of the invariants of the Wilson loops outside the sources. The Fermi-Walker gauge, due to its physical nature, allows to exploit the weak energy condition and in this connection it is proved that, both for open and closed universes with rotational invariance, the energy condition imply the total absence of closed time like curves. The extension of this theorem to the general stationary problem, in absence of rotational symmetry is considered. At present such extension is subject to some assumptions on the behavior of the determinant of the dreibein in this gauge. PACS number: 0420Comment: 28 pages, RevTex, no figure

    Extracting the depolarization coefficient D_NN from data measured with a full acceptance detector

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    The spin transfer from vertically polarized beam protons to Lambda or Sigma hyperons of the associated strangeness production pp -> pK Lambda (Sigma) is described with the depolarization coefficient D_NN. As the polarization of the hyperons is determined by their weak decays, detectors, which have a large acceptance for the decay particles, are needed. In this paper a formula is derived, which describes the depolarization coefficient D_NN by count rates of a 4 pi detector. It is shown, that formulas, which are given in publications for detectors with restricted acceptance, are specific cases of this formula for a 4 pi detector.Comment: Accepted for publication by Nuclear Instruments and Methods in Physics Research Section

    Mesoscopic order and the dimentionality of long-range resonance energy transfer in supramolecular semiconductors

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    We present time-resolved photoluminescence measurements on two series of oligo-p-phenylenevinylene materials that self-assemble into supramolecular nanostructures with thermotropic reversibility in dodecane. One set of derivatives form chiral, helical stacks while the second set form less organised, frustrated stacks. Here we study the effects of supramolecular organisation on the resonance energy transfer rates. We measure these rates in nanoassemblies formed with mixed blends of oligomers and compare them with the rates predicted by Foerster theory. Our results and analysis show that control of supramolecular order in the nanometre lengthscale has a dominant effect on the efficiency and dimentionality of resonance energy transfer.Comment: 17 Pages, 5 Figures, Submitted to J. Chem. Phy

    Generalized Massive Gravity and Galilean Conformal Algebra in two dimensions

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    Galilean conformal algebra (GCA) in two dimensions arises as contraction of two copies of the centrally extended Virasoro algebra (tt,xϵxt\rightarrow t, x\rightarrow\epsilon x with ϵ0\epsilon\rightarrow 0). The central charges of GCA can be expressed in term of Virasoro central charges. For finite and non-zero GCA central charges, the Virasoro central charges must behave as asymmetric form O(1)±O(1ϵ)O(1)\pm O(\frac{1}{\epsilon}). We propose that, the bulk description for 2d GCA with asymmetric central charges is given by general massive gravity (GMG) in three dimensions. It can be seen that, if the gravitational Chern-Simons coupling 1μ\frac{1}{\mu} behaves as of order O(1ϵ\frac{1}{\epsilon}) or (μϵμ\mu\rightarrow\epsilon\mu), the central charges of GMG have the above ϵ\epsilon dependence. So, in non-relativistic scaling limit μϵμ\mu\rightarrow\epsilon\mu, we calculated GCA parameters and finite entropy in term of gravity parameters mass and angular momentum of GMG.Comment: 9 page

    High precision measurement of the associated strangeness production in proton proton interactions

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    A new high precision measurement of the reaction pp -> pK+Lambda at a beam momentum of 2.95 GeV/c with more than 200,000 analyzed events allows a detailed analysis of differential observables and their inter-dependencies. Correlations of the angular distributions with momenta are examined. The invariant mass distributions are compared for different regions in the Dalitz plots. The cusp structure at the N Sigma threshold is described with the Flatt\'e formalism and its variation in the Dalitz plot is analyzed.Comment: accepted for publication in Eur. Phys. J.
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