64 research outputs found
189 HYPEROSMOTIC STIMULATION OF CHONDROCYTES LEADS TO DIFFERENTIAL POST-TRANSCRIPTIONAL REGULATION OF SOX9 AND COL2A1 mRNA
A57 CHONDROGENESIS OF INFRAPATELLAR FAT PAD AND SYNOVIAL MEMBRANE CELLS IN COMPARISON TO ARTICULAR CARTILAGE CHONDROCYTES
Carriage of antimicrobial resistant Escherichia coli in dogs: prevalence, associated risk factors and molecular characteristics
Resistance to antimicrobials, in particular that mediated by extended spectrum β-lactamases (ESBL) and AmpC β-lactamases are frequently reported in bacteria causing canine disease as well as in commensal bacteria, which could be a potential health risk for humans they come into contact with. This cross-sectional study aimed to estimate the prevalence and investigate the molecular characteristics of ESBL and plasmid encoded AmpC (pAmpC)-producing E. coli in the mainland UK vet-visiting canine population and, using responses from detailed questionnaires identify factors associated with their carriage. Faecal samples were cultured for antimicrobial resistant (AMR), ESBL and pAmpC-producing E. coli. A subset of ESBL and pAmpC-producing isolates were subjected to multi-locus sequence typing and DNA microarray analyses. Multivariable logistic regression analysis was used to construct models to identify risk factors associated with multidrug resistant (MDR, resistance to three or more antimicrobial classes), fluoroquinolone resistant, ESBL and AmpC-producing E. coli. AMR E.coli were isolated from 44.8% (n = 260) of samples, with 1.9% and 7.1% of samples carrying ESBL and pAmpC-producing E. coli, respectively. MDR E. coli were identified in 18.3% of samples. Recent use of antimicrobials and being fed raw poultry were both identified as risk factors in the outcomes investigated. A number of virulence and resistance genes were identified, including genes associated with extra-intestinal and enteropathogenic E. coli genotypes. Considering the close contact that people have with dogs, the high levels of AMR E. coli in canine faeces may be a potential reservoir of AMR bacteria or resistance determinants
Observation of a 1750 MeV/c^2 Enhancement in the Diffractive Photoproduction of K^+K^-
Using the FOCUS spectrometer with photon beam energies between 20 and 160
\gev, we confirm the existence of a diffractively photoproduced enhancement in
at 1750 \mevcc with nearly 100 times the statistics of previous
experiments. Assuming this enhancement to be a single resonance with a
Breit-Wigner mass shape, we determine its mass to be
\mevcc and its width to be \mevcc. We find no
corresponding enhancement at 1750 \mevcc in , and again neglecting any
possible interference effects we place limits on the ratio . Our results are consistent with previous
photoproduction experiments, but, because of the much greater statistics,
challenge the common interpretation of this enhancement as the
seen in annihilation experiments.Comment: 10 pages, 5 figure
Evidence for a narrow dip structure at 1.9 GeV/c in diffractive photoproduction
A narrow dip structure has been observed at 1.9 GeV/c in a study of
diffractive photoproduction of the final state performed by the
Fermilab experiment E687.Comment: The data of Figure 6 can be obtained by downloading the raw data file
e687_6pi.txt. v5 (2nov2018): added Fig. 7, the 6 pion energy distribution as
requested by a reade
Matrix metalloproteinase-2 and -9 and their inhibitors in equine joint disease
SIGLEAvailable from British Library Document Supply Centre-DSC:DXN021281 / BLDSC - British Library Document Supply CentreGBUnited Kingdo
210 IDENTIFICATION OF POST-TRANSCRIPTIONALLY REGULATED GENES FOLLOWING EXPOSURE OF HUMAN ARTICULAR CHONDROCYTES TO HYPEROSMOTIC CONDITIONS
189 HYPEROSMOTIC STIMULATION OF CHONDROCYTES LEADS TO DIFFERENTIAL POST-TRANSCRIPTIONAL REGULATION OF SOX9 AND COL2A1 mRNA
Mapping novel protein interactions in the 3’utr of the master chondrocyte regulatory factor SOX9
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