Business-driven IT Management

Business-driven IT management (BDIM) aims at ensuring successful alignment of business and IT through thorough understanding of the impact of IT on business results, and vice versa. In this dissertation, we review the state of the art of BDIM research and we position our intended contribution within the BDIM research space along the dimensions of decision support (as opposed of automation) and its application to IT service management processes. Within these research dimensions, we advance the state of the art by 1) contributing a decision theoretical framework for BDIM and 2) presenting two novel BDIM solutions in the IT service management space. First we present a simpler BDIM solution for prioritizing incidents, which can be used as a template for creating BDIM solutions in other IT service management processes. Then, we present a more comprehensive solution for optimizing the business-related performance of an IT support organization in dealing with incidents. Our decision theoretical framework and models for BDIM bring the concepts of business impact and risk to the fore, and are able to cope with both monetizable and intangible aspects of business impact. We start from a constructive and quantitative re-definition of some terms that are widely used in IT service management but for which was never given a rigorous decision: business impact, cost, benefit, risk and urgency. On top of that, we build a coherent methodology for linking IT-level metrics with business level metrics and make progress toward solving the business-IT alignment problem. Our methodology uses a constructive and quantitative definition of alignment with business objectives, taken as the likelihood – to the best of one’s knowledge – that such objectives will be met. That is used as the basis for building an engine for business impact calculation that is in fact an alignment computation engine. We show a sample BDIM solution for incident prioritization that is built using the decision theoretical framework, the methodology and the tools developed. We show how the sample BDIM solution could be used as a blueprint to build BDIM solutions for decision support in other IT service management processes, such as change management for example. However, the full power of BDIM can be best understood by studying the second fully fledged BDIM application that we present in this thesis. While incident management is used as a scenario for this second application as well, the main contribution that it brings about is really to provide a solution for business-driven organizational redesign to optimize the performance of an IT support organization. The solution is quite rich, and features components that orchestrate together advanced techniques in visualization, simulation, data mining and operations research. We show that the techniques we use - in particular the simulation of an IT organization enacting the incident management process – bring considerable benefits both when the performance is measured in terms of traditional IT metrics (mean time to resolution of incidents), and even more so when business impact metrics are brought into the picture, thereby providing a justification for investing time and effort in creating BDIM solutions. In terms of impact, the work presented in this thesis produced about twenty conference and journal publications, and resulted so far in three patent applications. Moreover this work has greatly influenced the design and implementation of Business Impact Optimization module of HP DecisionCenter™: a leading commercial software product for IT optimization, whose core has been re-designed to work as described here

Business-driven IT Management

Business-driven IT management (BDIM) aims at ensuring successful alignment of business and IT through thorough understanding of the impact of IT on business results, and vice versa. In this dissertation, we review the state of the art of BDIM research and we position our intended contribution within the BDIM research space along the dimensions of decision support (as opposed of automation) and its application to IT service management processes. Within these research dimensions, we advance the state of the art by 1) contributing a decision theoretical framework for BDIM and 2) presenting two novel BDIM solutions in the IT service management space. First we present a simpler BDIM solution for prioritizing incidents, which can be used as a template for creating BDIM solutions in other IT service management processes. Then, we present a more comprehensive solution for optimizing the business-related performance of an IT support organization in dealing with incidents. Our decision theoretical framework and models for BDIM bring the concepts of business impact and risk to the fore, and are able to cope with both monetizable and intangible aspects of business impact. We start from a constructive and quantitative re-definition of some terms that are widely used in IT service management but for which was never given a rigorous decision: business impact, cost, benefit, risk and urgency. On top of that, we build a coherent methodology for linking IT-level metrics with business level metrics and make progress toward solving the business-IT alignment problem. Our methodology uses a constructive and quantitative definition of alignment with business objectives, taken as the likelihood – to the best of one’s knowledge – that such objectives will be met. That is used as the basis for building an engine for business impact calculation that is in fact an alignment computation engine. We show a sample BDIM solution for incident prioritization that is built using the decision theoretical framework, the methodology and the tools developed. We show how the sample BDIM solution could be used as a blueprint to build BDIM solutions for decision support in other IT service management processes, such as change management for example. However, the full power of BDIM can be best understood by studying the second fully fledged BDIM application that we present in this thesis. While incident management is used as a scenario for this second application as well, the main contribution that it brings about is really to provide a solution for business-driven organizational redesign to optimize the performance of an IT support organization. The solution is quite rich, and features components that orchestrate together advanced techniques in visualization, simulation, data mining and operations research. We show that the techniques we use - in particular the simulation of an IT organization enacting the incident management process – bring considerable benefits both when the performance is measured in terms of traditional IT metrics (mean time to resolution of incidents), and even more so when business impact metrics are brought into the picture, thereby providing a justification for investing time and effort in creating BDIM solutions. In terms of impact, the work presented in this thesis produced about twenty conference and journal publications, and resulted so far in three patent applications. Moreover this work has greatly influenced the design and implementation of Business Impact Optimization module of HP DecisionCenter™: a leading commercial software product for IT optimization, whose core has been re-designed to work as described here

The stress-responsive alternative sigma factor SigB plays a positive role in the antifungal proficiency of Bacillus subtilis

Different Bacillus species with PGPR (plant growth-promoting rhizobacterium) activity produce potent biofungicides and stimulate plant defense responses against phytopathogenic fungi. However, very little is known about how these PGPRs recognize phytopathogens and exhibit the antifungal response. Here, we report the antagonistic interaction between Bacillus subtilis and the phytopathogenic fungus Fusarium verticillioides. We demonstrate that this bacterial-fungal interaction triggers the induction of the SigB transcription factor, the master regulator of B. subtilis stress adaptation. Dual-growth experiments performed with live or dead mycelia or culture supernatants of F. verticillioides showed that SigB was activated and required for the biocontrol of fungal growth. Mutations in the different regulatory pathways of SigB activation in the isogenic background revealed that only the energy-related RsbP-dependent arm of SigB activation was responsible for specific fungal detection and triggering the antagonistic response. The activation of SigB increased the expression of the operon responsible for the production of the antimicrobial cyclic lipopeptide surfactin (the srfA operon). SigB-deficient B. subtilis cultures produced decreased amounts of surfactin, and B. subtilis cultures defective in surfactin production (ΔsrfA) were unable to control the growth of F. verticillioides. In vivo experiments of seed germination efficiency and early plant growth inhibition in the presence of F. verticillioides confirmed the physiological importance of SigB activity for plant bioprotection.Fil: Bartolini, Marco. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento de Microbiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; ArgentinaFil: Cogliati, Sebastian Claudio. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento de Microbiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; ArgentinaFil: Vileta, Dario German. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento de Microbiología; ArgentinaFil: Bauman, Carlos. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento de Microbiología; ArgentinaFil: Ramirez, Walter Joel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; Argentina. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento de Microbiología; ArgentinaFil: Grau, Roberto Ricardo. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento de Microbiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; Argentin

Rendimientos para cuatro líneas endocriadas y seis F1 híbridas de gusano de seda en la Argentina

p.61-65La utilización del vigor híbrido en la producción comercial de seda comenzó a principios del siglo pasado. La calidad del hilo, así como los mayores niveles de productividad son atribuidas al uso de híbridos. En la Argentina la actividad sericícola es incipiente y escasa la oferta de huevos de calidad y productividad comprobada. En el presente trabajo se evaluaron algunas características productivas de híbridos F1 obtenidos de líneas endocriadas. Se midieron 3 variables cuantitativas: peso del capullo entero y de corteza y el largo de capullos. También se determinaron el porcentaje de corteza y el peso equivalente de capullo fresco por 20.000 huevos. Se encontraron diferencias significativas para las características analizadas. Se encontró heterosis sobredominante para todos los cruzamientos, excepto en los híbridos FJ x EO y EO x FJ, que tuvieron heterosis dominante. La productividad, expresada como rendimiento en capullos frescos, resultó mayor para los híbridos que para las líneas endocriadas

EGFR and HER2 Gene Copy Number and Response to First-Line Chemotherapy in Patients with Advanced Non-small Cell Lung Cancer (NSCLC)

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A Remote Monitoring System to Optimize the Home Management of Oral Anticancer Therapies (ONCO-TreC): Prospective Training-Validation Trial

Background: A platform designed to support the home management of oral anticancer treatments and provide a secure web-based patient–health care professional communication modality, ONCO-TreC, was tested in 3 cancer centers in Italy. Objective: The overall aims of the trial are to customize the platform; assess the system’s ability to facilitate the shared management of oral anticancer therapies by patients and health professionals; and evaluate system usability and acceptability by patients, caregivers, and health care professionals. Methods: Patients aged ≥18 years who were candidates for oral anticancer treatment as monotherapy with an Eastern Cooperative Oncology Group performance status score of 0 to 1 and a sufficient level of familiarity with mobile devices were eligible. ONCO-TreC consisted of a mobile app for patients and a web-based dashboard for health care professionals. Adherence to treatment (pill count) and toxicities reported by patients through the app were compared with those reported by physicians in medical records. Usability and acceptability were evaluated using questionnaires. Results: A total of 40 patients were enrolled, 38 (95%) of whom were evaluable for adherence to treatment. The ability of the system to measure adherence to treatment was high, with a concordance of 97.3% (95% CI 86.1%-99.9%) between the investigator and system pill count. Only 60% (3/5) of grade 3, 54% (13/24) of grade 2, and 19% (7/36) of grade 1 adverse events reported by physicians in the case report forms were also reported in the app directly by patients. In total, 94% (33/35) of patients had ≥1 app launch each week, and the median number of daily accesses per patient was 2. Approximately 71% (27/38) and 68% (26/38) of patients used the app for messages and vital sign entering, respectively, at least once during the study period. Conclusions: ONCO-TreC is an important tool for measuring and monitoring adherence to oral anticancer drugs. System usability and acceptability were very high, whereas its reliability in registering toxicity could be improved

Use of the ONCO-TreC electronic diary compared with a standard paper diary to improve adherence to oral cancer therapy in patients with solid and haematological tumours: protocol for a randomised controlled trial

Introduction ONCO-TreC platform consists of a mobile application delivered to patients as electronic diary and a web-based dashboard managed by healthcare professionals. We aim to compare the effectiveness of ONCO-TreC electronic diary with a standard paper diary, in improving adherence to oral cancer therapy in patients with solid and haematological tumours. Methods and analysis This is an open label, superiority, randomised controlled trial conducted in two Italian oncology units. Patients will be randomised with a 1:1 ratio to electronic or paper diary. For both groups a counsellor will be responsible for drug and diary delivery. The evaluation period will end after six cycles of therapy. The primary aim is to compare the proportion of non-adherent patients in the two arms. Adherence will be measured through pill count; anyone who takes less than 90% of the total prescribed drug dose will be considered non-adherent. Assuming a percentage of non-adherent patients to oral therapy of 40% in arm B, and a 60% reduction in this percentage in arm A, a sample of 124 patients will provide 80% power to identify an absolute difference greater than 24 percentage points using a bilateral Fisher’s exact test with a significance level of 0.05. Considering a dropout rate of 10%, approximately 136 patients will have to be enrolled. The primary analysis will be performed on the intention-to-treat population. Secondary aims are to describe the reasons for non-adherence, the level of satisfaction of patients and healthcare professionals with the paper and electronic diary, and the impact of non-adherence in terms of healthcare costs. Ethics and dissemination Ethical approval was obtained from Romagna Ethics Committee (CEROM), study ID 2108, prot. n. IRST 100.28 of 10/04/2020. Informed consent will be obtained from all study participants. Findings will be disseminated through peer-reviewed journals, conferences and event presentations