53 research outputs found
Suppression of electron spin decoherence of the diamond NV center by a transverse magnetic field
We demonstrate that the spin decoherence of nitrogen vacancy (NV) centers in
diamond can be suppressed by a transverse magnetic field if the electron spin
bath is the primary decoherence source. The NV spin coherence, created in "a
decoherence-free subspace" is protected by the transverse component of the
zero-field splitting, increasing the spin-coherence time about twofold. The
decoherence due to the electron spin bath is also suppressed at magnetic fields
stronger than ~25 gauss when applied parallel to the NV symmetry axis. Our
method can be used to extend the spin-coherence time of similar spin systems
for applications in quantum computing, field sensing, and other metrologies.Comment: 20 pages, 4 figure
Optically detected nuclear quadrupolar interaction of 14N in nitrogen-vacancy centers in diamond
We report sensitive detection of the nuclear quadrupolar interaction of the
14N nuclear spin of the nitrogen-vacancy (NV) center using the electron spin
echo envelope modulation technique. We applied a weak transverse magnetic field
to the spin system so that certain forbidden transitions became weakly allowed
due to second-order effects involving the nonsecular terms of the hyperfine
interaction. The weak transitions cause modulation of the electron spin-echo
signal, and a theoretical analysis suggests that the modulation frequency is
primarily determined by the nuclear quadrupolar frequency; numerical
simulations confirm the analytical results and show excellent quantitative
agreement with experiments. This is an experimentally simple method of
detecting quadrupolar interactions, and it can be used to study spin systems
with an energy structure similar to that of the nitrogen vacancy center.Comment: 18 pages, 4 figure
Systematic Review: microRNAs as Potential Biomarkers in Mild Cognitive Impairment Diagnosis
The rate of progression from Mild Cognitive Impairment (MCI) to Alzheimer's disease (AD) is estimated at >10% per year, reaching up to 80–90% after 6 years. MCI is considered an indicator of early-stage AD. In this context, the diagnostic screening of MCI is crucial for detecting individuals at high risk of AD before they progress and manifest further severe symptoms. Typically, MCI has been determined using neuropsychological assessment tools such as the Montreal Cognitive Assessment (MoCA) or Mini-Mental Status Examination (MMSE). Unfortunately, other diagnostic methods are not available or are unable to identify MCI in its early stages. Therefore, identifying new biomarkers for MCI diagnosis and prognosis is a significant challenge. In this framework, miRNAs in serum, plasma, and other body fluids have emerged as a promising source of biomarkers for MCI and AD-related cognitive impairments. Interestingly, miRNAs can regulate several signaling pathways via multiple and diverse targets in response to pathophysiological stimuli. This systematic review aims to describe the current state of the art regarding AD-related target genes modulated by differentially expressed miRNAs in peripheral fluids samples in MCI subjects to identify potential miRNA biomarkers in the early stages of AD. We found 30 articles that described five miRNA expression profiles from peripheral fluid in MCI subjects, showing possible candidates for miRNA biomarkers that may be followed up as fluid biomarkers or therapeutic targets of early-stage AD. However, additional research is needed to validate these miRNAs and characterize the precise neuropathological mechanisms.Fil: Ogonowski, Natalia Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencia Cognitiva. Fundación Favaloro. Instituto de Neurociencia Cognitiva; Argentina. Universidad Adolfo Ibañez; ChileFil: Salcidua, Stefanny. Universidad Adolfo Ibañez; ChileFil: Leon, Tomas. Universidad de Chile; Chile. Trinity College; IrlandaFil: Chamorro Veloso, Nayaret. Neurognos Spa; ChileFil: Valls, Cristian. Neurognos Spa; ChileFil: Avalos, Constanza. Universidad Adolfo Ibañez; ChileFil: Bisquertt, Alejandro. Neurognos Spa; ChileFil: Rentería, Miguel E.. Berghofer Medical Research Institute; AustraliaFil: Orellana, Paulina. Universidad Adolfo Ibañez; ChileFil: Duran Aniotz, Claudia. Universidad Adolfo Ibañez; Chil
The Rapid Antigen Detection Test for SARS-CoV-2 Underestimates the Identification of COVID-19 Positive Cases and Compromises the Diagnosis of the SARS-CoV-2 (K417N/T, E484K, and N501Y) Variants
Timely detection of severe acute respiratory syndrome due to coronavirus 2 (SARS-CoV-2) by reverse transcription quantitative polymerase chain reaction (RT-qPCR) has been the gold- strategy for identifying positive cases during the current pandemic. However, faster and less expensive methodologies are also applied for the massive diagnosis of COVID-19. In this way, the rapid antigen test (RAT) is widely used. However, it is necessary to evaluate its detection efficiency considering the current pandemic context with the circulation of new viral variants. In this study, we evaluated the sensitivity and specificity of RAT (SD BIOSENSOR, South Korea), widely used for testing and SARS-CoV-2 diagnosis in Santiago of Chile. The RAT showed a 90% (amplification range of 20 ≤ Cq 30. In SARS-CoV-2 variant detection, RAT had a 42.8% detection sensitivity in samples with RT-qPCR amplification range 20 ≤ Cq <25 containing the single nucleotide polymorphisms (SNP) K417N/T, N501Y and E484K, associated with beta or gamma SARS-CoV-2 variants. This study alerts for the special attention that must be paid for the use of RAT at a massive diagnosis level, especially in the current scenario of appearance of several new SARS-CoV-2 variants which could generate false negatives and the compromise of possible viral outbreaks
Room Temperature Operation of a Radiofrequency Diamond Magnetometer near the Shot Noise Limit
We operate a nitrogen vacancy (NV-) diamond magnetometer at ambient
temperatures and study the dependence of its bandwidth on experimental
parameters including optical and microwave excitation powers. We introduce an
analytical theory that yields an explicit formula for the response of an
ensemble of NV- spins to an oscillating magnetic field, such as in NMR
applications. We measure a detection bandwidth of 1.6 MHz and a sensitivity of
4.6 nT/Hz^(1/2), unprecedented in a detector with this active volume and close
to the photon shot noise limit of our experiment.Comment: 4 pages; 4 figures; supporting informatio
Optically Enhanced Solid-State <sup>1</sup>H NMR Spectroscopy
International audienceLow sensitivity is the primary limitation toextending nuclear magnetic resonance (NMR) techniques tomore advanced chemical and structural studies. Photochemicallyinduced dynamic nuclear polarization (photo-CIDNP) is an NMRhyperpolarization technique where light is used to excite a suitabledonor−acceptor system, creating a spin-correlated radical pairwhose evolution drives nuclear hyperpolarization. Systems thatexhibit photo-CIDNP in solids are not common, and this effecthas, up to now, only been observed for 13C and 15N nuclei.However, the low gyromagnetic ratio and natural abundance ofthese nuclei trap the local hyperpolarization in the vicinity of thechromophore and limit the utility for bulk hyperpolarization. Here,we report the first example of optically enhanced solid-state 1HNMR spectroscopy in the high-field regime. This is achieved viaphoto-CIDNP of a donor−chromophore−acceptor molecule in a frozen solution at 0.3 T and 85 K, where spontaneous spindiffusion among the abundant strongly coupled 1H nuclei relays polarization through the whole sample, yielding a 16-fold bulk 1Hsignal enhancement under continuous laser irradiation at 450 nm. These findings enable a new strategy for hyperpolarized NMRbeyond the current limits of conventional microwave-driven DNP
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