Le ?Imagini de gli dei de gli antichi? di Vincenzo Cartari: problemi di attribuzione.

Il presente studio si propone di far luce sulla paternità delle illustrazioni di un importante e celebre trattato mitografico di metà ‘500, le Imagini de gli dèi de gli antichi di Vincenzo Cartari, del 1571. Scopo della trattazione è quello di capire se sia possibile accettare o meno l’ipotesi recentemente avanzata dallo studioso Stefano Pierguidi, dell’ideazione delle immagini del manuale all’artista Giuseppe Porta detto ‘Salviati’. Pertanto si è deciso di procedere in questo modo: innanzi tutto analizzando a fondo la posizione di Pierguidi e cercando riscontro in quanto afferma, quindi cercando altri punti di vista a lui divergenti e mettendoli a confronto. Per poi passare allo studio diretto del trattato e delle sue immagini, la storia ed evoluzione del celebre manuale. Una parte è stata in fine dedicata allo studio della vita e dell’attività dell’artista Giuseppe Porta, così da poter mettere a confronto le sue opere con certezza autografe con le illustrazioni del trattato e giungere in tal modo ad una conclusione

Paleoarte : Un proyecto educativo que vincula el arte y la ciencia

El proyecto se propuso con el objetivo de articular las clases de arte con las de ciencias y tecnología, promoviendo la importancia de las producciones artísticas en la divulgación de la Paleontología. Se planteó considerando los aspectos que involucran el trabajo de un artista plástico que colabora con la ciencia, buscando que los alumnos descubran durante el proceso de realización de las reconstrucciones artísticas, su significancia y relevancia para dicha disciplina. Se estudiaron los mamíferos extintos que habitaron el actual territorio de la Ciudad de Buenos Aires. Para ello se investigaron diversas temáticas: anatomía comparada, diversidad, adaptaciones y rastros fósiles, considerando como eje fundamental la labor del paleoartista. En cada curso se seleccionó una de estas temáticas para modelar, esculpir, dibujar y realizar producciones audiovisuales, habiéndose efectuado diversos relieves escultóricos, una maqueta topográfica de la CABA, documentación video-fotográfica y un libro para niños. Llevar a los alumnos a experimentar el paleoarte, implicó la interpretación y el análisis exhaustivo de los conocimientos, el empleo de variadas técnicas, el desarrollo de la creatividad para plasmarla en diversas expresiones artísticas-tecnológicas, la exploración de un ámbito laboral acorde a la formación del Diseñador en Artes Visuales y la valoración del Patrimonio Paleontológico Nacional.Facultad de Humanidades y Ciencias de la Educació

O trabalho em equipe na estratégia saúde da família.

Backgound and Objectives: The healthcare evaluation aims to improve the capacity to provide adequate assistance and better healthcare to the population. Through an evaluation process, one can rethink the practices that are being offered and subsidize managers for adequacy of services. The aim of this study is to evaluate teamwork, from the perspective of professionals who work in the family health strategy. Method: a descriptive cross-sectional study was performed. The population comprised healthcare professionals working with the family health strategy in the municipalities of the state of Espirito Santo with more than 50,000 inhabitants. Data collection was performed through a semi-structured questionnaire between July 2012 and August 2013. Results: there was a positive evaluation of the professionals regarding teamwork, with most considering the professional relationship always or most of the time good and respectful; the relationships were rarely considered to be confrontational; the organization of the activities was performed jointly, with rare occurrence of difficulties regarding domestic work and the community; the work was always or most of the time based on pre-established routines, as well as the capacity to review routines and procedures and the encouragement for community participation. Conclusion: One can observe the challenge and responsibility of healthcare professionals in acknowledging teamwork and its relevance to changes in the practices of care and management of the Brazilian Unified Health System. KEYWORDS: Health Evaluation; Primary Health care; Family Health; Working Environment.Justificativa e Objetivos: a avaliação em saúde tem como finalidade aprimorar a capacidade de oferecer adequada atenção e melhor condição de saúde à população. Por meio de um processo avaliativo, podemos repensar as práticas que vem sendo ofertadas e subsidiar gestores para adequação dos serviços. O objetivo do estudo é avaliar o trabalho em equipe, na perspectiva dos profissionais que atuam na estratégia da saúde da família. Métodos: trata-se de um estudo descritivo com abordagem quantitativa. A população foi constituída pelos profissionais de saúde atuantes nas estratégias saúde da família nos municípios do estado do Espírito Santo com população superior a 50 mil habitantes. A coleta foi realizada por meio de um questionário semiestruturado entre julho de 2012 e agosto de 2013. Resultados: Observou-se uma avaliação positiva dos profissionais em relação ao trabalho em equipe, a maioria considerando o relacionamento bom e respeitoso; e poucas vezes conflituoso; a organização das atividades realizada de forma conjunta; pouca ocorrência de dificuldades no trabalho interno e com a comunidade; o trabalho sempre ou na maioria das vezes baseado em rotina pré-estabelecida, assim como a capacidade de rever rotinas e procedimento e o estímulo à participação da comunidade. Conclusão: nota-se o desafio e a responsabilidade dos profissionais de saúde no reconhecimento do trabalho em equipe e sua relevância para a mudança das práticas de atenção e gestão do SUS. DESCRITORES: Avaliação em saúde; Atenção Primária à saúde; Saúde da Família; Ambiente de trabalho

The Impact of Lifestyle Interventions in High-Risk Early Breast Cancer Patients: A Modeling Approach from a Single Institution Experience

none21noA healthy lifestyle plays a strategic role in the prevention of BC. The aim of our prospective study is to evaluate the effects of a lifestyle interventions program based on special exercise and nutrition education on weight, psycho-physical well-being, blood lipid and hormonal profile among BC patients who underwent primary surgery. From January 2014 to March 2017, a multidisciplinary group of oncologists, dieticians, physiatrists and an exercise specialist evaluated 98 adult BC female patients at baseline and at different time points. The patients had at least one of the following risk factors: BMI ≥ 25 Kg/m2, high testosterone levels, high serum insulin levels or diagnosis of MS. Statistically significant differences are shown in terms of BMI variation with the lifestyle interventions program, as well as in waist circumference and blood glucose, insulin and testosterone levels. Moreover, a statistically significant difference was reported in variations of total Hospital Anxiety and Depression Scale (HADS) score, in the anxiety HADS score and improvement in joint pain. Our results suggested that promoting a healthy lifestyle in clinical practice reduces risk factors involved in BC recurrence and ensures psycho-physical well-being.openMirco Pistelli, Valentina Natalucci, Laura Scortichini, Veronica Agostinelli, Edoardo Lenci, Sonia Crocetti, Filippo Merloni, Lucia Bastianelli, Marina Taus, Daniele Fumelli, Gloria Giulietti, Claudia Cola, Marianna Capecci, Roberta Serrani, Maria Gabriella Ceravolo, Maurizio Ricci, Albano Nicolai, Elena Barbieri, Giulia Nicolai, Zelmira Ballatore, Agnese Savini and Rossana BerardiPistelli, Mirco; Natalucci, Valentina; Scortichini, Laura; Agostinelli, Veronica; Lenci, Edoardo; Crocetti, Sonia; Merloni, Filippo; Bastianelli, Lucia; Taus, Marina; Fumelli, Daniele; Giulietti, Gloria; Cola, Claudia; Capecci, Marianna; Serrani, Roberta; Gabriella Ceravolo, Maria; Ricci, Maurizio; Nicolai, Albano; Barbieri, Elena; Nicolai, Giulia; Ballatore, Zelmira; Savini and Rossana Berardi, Agnes

Development and Implementation of the AIDA International Registry for Patients With Still's Disease

Objective: Aim of this paper is to present the design, construction, and modalities of dissemination of the AutoInflammatory Disease Alliance (AIDA) International Registry for patients with systemic juvenile idiopathic arthritis (sJIA) and adult-onset Still's disease (AOSD), which are the pediatric and adult forms of the same autoinflammatory disorder. Methods: This Registry is a clinical, physician-driven, population- and electronic-based instrument implemented for the retrospective and prospective collection of real-world data. The collection of data is based on the Research Electronic Data Capture (REDCap) tool and is intended to obtain evidence drawn from routine patients' management. The collection of standardized data is thought to bring knowledge about real-life clinical research and potentially communicate with other existing and future Registries dedicated to Still's disease. Moreover, it has been conceived to be flexible enough to easily change according to future scientific acquisitions. Results: Starting from June 30th to February 7th, 2022, 110 Centers from 23 Countries in 4 continents have been involved. Fifty-four of these have already obtained the approval from their local Ethics Committees. Currently, the platform counts 290 users (111 Principal Investigators, 175 Site Investigators, 2 Lead Investigators, and 2 data managers). The Registry collects baseline and follow-up data using 4449 fields organized into 14 instruments, including patient's demographics, history, clinical manifestations and symptoms, trigger/risk factors, therapies and healthcare access. Conclusions: This international Registry for patients with Still's disease will allow a robust clinical research through collection of standardized data, international consultation, dissemination of knowledge, and implementation of observational studies based on wide cohorts of patients followed-up for very long periods. Solid evidence drawn from "real-life " data represents the ultimate goal of this Registry, which has been implemented to significantly improve the overall management of patients with Still's disease. NCT 05200715 available at

Development and Implementation of the AIDA International Registry for Patients With Undifferentiated Systemic AutoInflammatory Diseases

Objective: This paper points out the design, development and deployment of the AutoInflammatory Disease Alliance (AIDA) International Registry dedicated to pediatric and adult patients affected by Undifferentiated Systemic AutoInflammatory Diseases (USAIDs). Methods: This is an electronic registry employed for real-world data collection about demographics, clinical, laboratory, instrumental and socioeconomic data of USAIDs patients. Data recruitment, based on the Research Electronic Data Capture (REDCap) tool, is designed to obtain standardized information for real-life research. The instrument is endowed with flexibility, and it could change over time according to the scientific acquisitions and potentially communicate with other similar tools; this platform ensures security, data quality and data governance. Results: The focus of the AIDA project is connecting physicians and researchers from all over the world to shed a new light on heterogeneous rare diseases. Since its birth, 110 centers from 23 countries and 4 continents have joined the AIDA project. Fifty-four centers have already obtained the approval from their local Ethics Committees. Currently, the platform counts 290 users (111 Principal Investigators, 179 Site Investigators, 2 Lead Investigators, and 2 data managers). The Registry is collecting baseline and follow-up data using 3,769 fields organized into 23 instruments, which include demographics, history, symptoms, trigger/risk factors, therapies, and healthcare information access for USAIDs patients. Conclusions: The development of the AIDA International Registry for USAIDs patients will facilitate the online collection of real standardized data, connecting a worldwide group of researchers: the Registry constitutes an international multicentre observational groundwork aimed at increasing the patient cohort of USAIDs in order to improve our knowledge of this peculiar cluster of autoinflammatory diseases

Efficacy of canakinumab in patients with Still's disease across different lines of biologic therapy: real-life data from the International AIDA Network Registry for Still's Disease

Introduction: The effectiveness of canakinumab may change according to the different times it is used after Still's disease onset. This study aimed to investigate whether canakinumab (CAN) shows differences in short- and long-term therapeutic outcomes, according to its use as different lines of biologic treatment.Methods: Patients included in this study were retrospectively enrolled from the AutoInflammatory Disease Alliance (AIDA) International Registry dedicated to Still's disease. Seventy-seven (51 females and 26 males) patients with Still's disease were included in the present study. In total, 39 (50.6%) patients underwent CAN as a first-line biologic agent, and the remaining 38 (49.4%) patients were treated with CAN as a second-line biologic agent or subsequent biologic agent.Results: No statistically significant differences were found between patients treated with CAN as a first-line biologic agent and those previously treated with other biologic agents in terms of the frequency of complete response (p =0.62), partial response (p =0.61), treatment failure (p >0.99), and frequency of patients discontinuing CAN due to lack or loss of efficacy (p =0.2). Of all the patients, 18 (23.4%) patients experienced disease relapse during canakinumab treatment, 9 patients were treated with canakinumab as a first-line biologic agent, and nine patients were treated with a second-line or subsequent biologic agent. No differences were found in the frequency of glucocorticoid use (p =0.34), daily glucocorticoid dosage (p =0.47), or concomitant methotrexate dosage (p =0.43) at the last assessment during CAN treatment.Conclusion: Canakinumab has proved to be effective in patients with Still's disease, regardless of its line of biologic treatment

Clinical and laboratory features associated with macrophage activation syndrome in Still's disease: data from the international AIDA Network Still's Disease Registry

: To characterize clinical and laboratory signs of patients with still's disease experiencing macrophage activation syndrome (MAS) and identify factors associated with MAS development. patients with still's disease classified according to internationally accepted criteria were enrolled in the autoInflammatory disease alliance (AIDA) still's disease registry. clinical and laboratory features observed during the inflammatory attack complicated by MAS were included in univariate and multivariate logistic regression analysis to identify factors associated to MAS development. A total of 414 patients with Still's disease were included; 39 (9.4%) of them developed MAS during clinical history. At univariate analyses, the following variables were significantly associated with MAS: classification of arthritis based on the number of joints involved (p = 0.003), liver involvement (p = 0.04), hepatomegaly (p = 0.02), hepatic failure (p = 0.01), axillary lymphadenopathy (p = 0.04), pneumonia (p = 0.03), acute respiratory distress syndrome (p < 0.001), platelet abnormalities (p < 0.001), high serum ferritin levels (p = 0.009), abnormal liver function tests (p = 0.009), hypoalbuminemia (p = 0.002), increased LDH (p = 0.001), and LDH serum levels (p < 0.001). at multivariate analysis, hepatomegaly (OR 8.7, 95% CI 1.9-52.6, p = 0.007) and monoarthritis (OR 15.8, 95% CI 2.9-97.1, p = 0.001), were directly associated with MAS, while the decade of life at Still's disease onset (OR 0.6, 95% CI 0.4-0.9, p = 0.045), a normal platelet count (OR 0.1, 95% CI 0.01-0.8, p = 0.034) or thrombocytosis (OR 0.01, 95% CI 0.0-0.2, p = 0.008) resulted to be protective. clinical and laboratory factors associated with MAS development have been identified in a large cohort of patients based on real-life data

Análisis de los niveles de rentabilidad generados durante la experiencia asociativa de los centros de acopio y enfriamiento de leche en las comunidades de Pesillo, Paquiestancia y Santo Domingo 1, del cantón Cayambe en el periodo 2004-2011.

CILEC The proposal is to maintain a comprehensive , integrated and multidisciplinary science in each of the projects you work, these topics cover the entire value chain of milk, from production to when they reach the final consumer products . Research lines CILEC , transversely issues will affect the value chain of milk above , their relationship will allow analysis encompassing different social, environmental , technical and productive. The Salesian University called to work with people who have not been seen at their needs , creates the Research Center of the Milk - CILEC , which aims to contribute effectively to the knowledge and solve the problems of cattle and the value chain of milk through research and liaison with producers.La propuesta del CILEC es mantener una visión integral, integrada y multidisciplinaria de las ciencias en cada uno de los proyectos que trabaje, estos abarcarán temas de toda la cadena de valor de la leche, desde la producción hasta cuando llegan los productos al consumidor final. Las líneas de investigación del CILEC, de forma transversal incidirán en los temas de la cadena de valor de la Leche antes mencionados, su interrelación permitirá su análisis englobando los diferentes problemas sociales, ambientales, técnicos y productivos. La Universidad Politécnica Salesiana llamada a trabajar con la gente que no ha sido atendida en sus necesidades, crea el Centro de Investigación de la Leche-CILEC, cuyo objetivo es contribuir en forma efectiva al conocimiento y solución de los problemas de la ganadería bovina y de la cadena de valor de la leche a través de la investigación y vinculación con productores