Long-lived Five-Coordinate Platinum(IV) Intermediates : regiospecific C-C coupling

Three different phosphine derivatives of doubly cyclometallated diphenypyridine complexes of Pt(II), 1, were reacted with methyliodide to give octahedral Pt(IV) complexes, 2, as two isomers. Treatment of either isomer of complexes 2 with AgBF4, to abstract iodide, gave long-lived five-coordinate complexes 3, which could be trapped as pyridine adducts. Complexes 3 underwent a C-C coupling reaction, at a rate that depended on phosphine size, to give a methyl group attached to the original diphenylpyridine. Recylometallation was then performed and the cycle of reactions was repeated to give a diphenylpyridine doubly methylated on only one phenyl, with complete regiospecificity. NMR was used to demonstrate the geometry of all complexes in solution, with multiple Xray crystal structures confirming these assignments

Poll Tax photograph © Garry Clarkson/Alamy used in 'Society Now', the journal of The Economic and Social Research Council (ESRC). Summer 2013. Nick Stevens, Editor - [email protected]

Poll Tax photograph from 1990, used in 'Society Now', the journal of The Economic and Social Research Council (ESRC). Summer 2013. Used to illustrate, 'The Blunders of Our Governments, by Anthony King and Ivor Crewe (Oneworld Publications September 2013. Contact Professor Anthony King, University of Essex Email [email protected] Telephone 01206 873393 ESRC Grant Number RES-062-23-2036 Nick Stevens, Editor - [email protected]. Photograph licensed through Alamy photo agency, © Garry Clarkson worldwide rights

Characterising encapsulated nuclear waste using cosmic-ray muon tomography

Tomographic imaging techniques using the Coulomb scattering of cosmic-ray muons have been shown previously to successfully identify and characterise low- and high-Z materials within an air matrix using a prototype scintillating-fibre tracker system. Those studies were performed as the first in a series to assess the feasibility of this technology and image reconstruction techniques in characterising the potential high-Z contents of legacy nuclear waste containers for the UK Nuclear Industry. The present work continues the feasibility study and presents the first images reconstructed from experimental data collected using this small-scale prototype system of low- and high-Z materials encapsulated within a concrete-filled stainless-steel container. Clear discrimination is observed between the thick steel casing, the concrete matrix and the sample materials assayed. These reconstructed objects are presented and discussed in detail alongside the implications for future industrial scenarios.Comment: 6 pages, 4 figure

Effective public involvement in the HoST-D Programme for dementia home care support: From proposal and design to methods of data collection (innovative practice)

Public involvement is an important element in health and social care research. However, it is little evaluated in research. This paper discusses the utility and impact of public involvement of carers and people with dementia in a five-year programme on effective home support in dementia, from proposal and design to methods of data collection, and provides a useful guide for future research on how to effectively involve the public. The Home SupporT in Dementia (HoST-D) Programme comprises two elements of public involvement, a small reference group and a virtual lay advisory group. Involving carers and people with dementia is based on the six key values of involvement – respect, support, transparency, responsiveness, fairness of opportunity, and accountability. Carers and people with dementia gave opinions on study information, methods of data collection, an economic model, case vignettes, and a memory aid booklet, which were all taken into account. Public involvement has provided benefits to the programme whilst being considerate of the time constraints and geographical locations of members

Chronic Blood Flow Restriction Exercise Improves Objective Physical Function: A Systematic Review

Background: Blood flow restriction or KAATSU exercise training is associated with greater muscle mass and strength increases than non-blood flow restriction equivalent exercise. Blood flow restriction exercise has been proposed as a possible alternative to more physically demanding exercise prescriptions (such as high-load/high-intensity resistance training) in a range of clinical and chronic disease populations. While the maintenance of muscle mass and size with reduced musculoskeletal tissue loading appeals in many of these physically impaired populations, there remains a disconnect between some of the desired clinical measures for chronic disease populations and those commonly measured in the literature examining blood flow restriction exercise. While strength does play a vital role in physical function, task-specific objective measures of physical function indicative of activities of daily living are often more clinically relevant and applicable for evaluating the success of medical and surgical interventions or monitoring age- and disease-related physical decline. Objective: To determine whether exercise interventions utilizing blood flow restriction are able to improve objective measures of physical function indicative of activities of daily living. Methods: A systematic search of Medline, Embase, CINAHL, SPORTDiscus, and Springer identified 13 randomized control trials utilizing an exercise intervention combined with blood flow restriction, while measuring at least one objective measure of physical function. Participants were ≥18 years of age. Systematic review of the literature and quality assessment of the included studies used the Cochrane Collaboration's tool for assessing risk bias. Results: Data from 13 studies with a total of 332 participants showed blood flow restriction exercise, regardless of modality, most notably increased performance on the 30 s sit-to-stand and timed up and go tests, and generally improved physical function on other tests including walking tests, variations of sit-to-stand tests, and balance, jumping, and stepping tests. Conclusions: From the evidence available, blood flow restriction exercise of multiple modalities improved objective measures of physical function indicative of activities of daily living

Prospectus, January 18, 2006

https://spark.parkland.edu/prospectus_2006/1000/thumbnail.jp