4,000 research outputs found
Indications of a sub-linear and non-universal Kennicutt-Schmidt relationship
We estimate the parameters of the Kennicutt-Schmidt (KS) relationship,
linking the star formation rate (Sigma_SFR) to the molecular gas surface
density (Sigma_mol), in the STING sample of nearby disk galaxies using a
hierarchical Bayesian method. This method rigorously treats measurement
uncertainties, and provides accurate parameter estimates for both individual
galaxies and the entire population. Assuming standard conversion factors to
estimate Sigma_SFR and Sigma_mol from the observations, we find that the KS
parameters vary between galaxies, indicating that no universal relationship
holds for all galaxies. The KS slope of the whole population is 0.76, with the
2sigma range extending from 0.58 to 0.94. These results imply that the
molecular gas depletion time is not constant, but varies from galaxy to galaxy,
and increases with the molecular gas surface density. Therefore, other galactic
properties besides just Sigma_mol affect Sigma_SFR, such as the gas fraction or
stellar mass. The non-universality of the KS relationship indicates that a
comprehensive theory of star formation must take into account additional
physical processes that may vary from galaxy to galaxy.Comment: 7 pages, 2 figures, 1 table. Updated to match MNRAS accepted versio
Age-related changes to macrophages are detrimental to fracture healing in mice.
The elderly population suffers from higher rates of complications during fracture healing that result in increased morbidity and mortality. Inflammatory dysregulation is associated with increased age and is a contributing factor to the myriad of age-related diseases. Therefore, we investigated age-related changes to an important cellular regulator of inflammation, the macrophage, and the impact on fracture healing outcomes. We demonstrated that old mice (24Â months) have delayed fracture healing with significantly less bone and more cartilage compared to young mice (3Â months). The quantity of infiltrating macrophages into the fracture callus was similar in old and young mice. However, RNA-seq analysis demonstrated distinct differences in the transcriptomes of macrophages derived from the fracture callus of old and young mice, with an up-regulation of M1/pro-inflammatory genes in macrophages from old mice as well as dysregulation of other immune-related genes. Preventing infiltration of the fracture site by macrophages in old mice improved healing outcomes, with significantly more bone in the calluses of treated mice compared to age-matched controls. After preventing infiltration by macrophages, the macrophages remaining within the fracture callus were collected and examined via RNA-seq analysis, and their transcriptome resembled macrophages from young calluses. Taken together, infiltrating macrophages from old mice demonstrate detrimental age-related changes, and depleting infiltrating macrophages can improve fracture healing in old mice
The role of intermolecular coupling in the photophysics of disordered organic semiconductors: Aggregate emission in regioregular polythiophene
We address the role of excitonic coulping on the nature of photoexcitations
in the conjugated polymer regioregular poly(3-hexylthiophene). By means of
temperature-dependent absorption and photoluminescence spectroscopy, we show
that optical emission is overwhelmingly dominated by weakly coupled
H-aggregates. The relative absorbance of the 0-0 and 0-1 vibronic peaks
provides a powerfully simple means to extract the magnitude of the
intermolecular coupling energy, approximately 5 and 30 meV for films spun from
isodurene and chloroform solutions respectively.Comment: 10 pages, 4 figures, published in Phys. Rev. Let
Determining exciton bandwidth and film microstructure in polythiophene films using linear absorption spectroscopy
We analyze the linear absorption spectrum of regioregular
poly(3-hexylthiophene) films spun from a variety of solvents to probe directly
the film microstructure and how it depends on processing conditions. We
estimate the exciton bandwidth and the percentage of the film composed of
aggregates quantitatively using a weakly interacting H-aggregate model. This
provides a description of the degree and quality of crystallites within the
film and is in turn correlated with thin-film field-effect transistor
characteristics.Comment: Applied Physics Letters (in press); 9 pages, three figure
The use of intravascular ultrasound imaging to improve use of inferior vena cava filters in a high-risk bariatric population
ObjectivePulmonary embolism is the leading cause of death after gastric bypass procedures for obesity, approximating 0.5% to 4%. All bariatric patients, but especially the super-obese, which have a body mass index (BMI) >50 kg/m2, are at significant risk for postoperative venous thromboembolism (VTE). Visualization and weight limitations of fluoroscopy tables exclude most bariatric and all super-obese patients from inferior vena cava (IVC) filter placement using fluoroscopy. Intravascular ultrasound (IVUS)-guided IVC filter placement is the only modality that allows these high-risk patients to have an IVC filter placed.MethodsHospital and outpatient records of the 494 patients who underwent gastric bypass procedures from January 1, 2004, to May 31, 2006, were reviewed. All patients who had concurrent IVC filter placement with the use of IVUS guidance were selected. Comorbidities, outcomes, and complications were recorded.ResultsWe identified 27 patients with mean BMI of 70 ± 3 kg/m2; of these, 25 were super-obese (BMI >50 kg/m2). Procedures included five laparoscopic and 22 open gastric bypass operations. All patients underwent concurrent IVC filter placement using IVUS guidance. In addition to super-obesity, indications for IVC filter placement included history of VTE (n = 4), known hypercoagulable state (n = 2), and profound immobility (n = 21). Mean follow up was 293 ± 40 days. Technical success rate was 96.3%. There were no catheter site complications. In one surviving patient, a nonfatal pulmonary embolism was detected by computed tomography 2 months postoperatively. Two patients died, and autopsy excluded VTE as the cause of death in both.ConclusionThis study suggests efficacy of IVUS-guided IVC filter placement in preventing mortality from pulmonary embolism in high-risk bariatric patients, including the super-obese. IVUS-guided IVC filter placement can be safely performed with an excellent success rate in all bariatric patients, including the super-obese, who otherwise would not be candidates for IVC filter placement due to the limitations imposed by their large body habitus
RNA-binding protein CPEB1 remodels host and viral RNA landscapes.
Host and virus interactions occurring at the post-transcriptional level are critical for infection but remain poorly understood. Here, we performed comprehensive transcriptome-wide analyses revealing that human cytomegalovirus (HCMV) infection results in widespread alternative splicing (AS), shortening of 3' untranslated regions (3' UTRs) and lengthening of poly(A)-tails in host gene transcripts. We found that the host RNA-binding protein CPEB1 was highly induced after infection, and ectopic expression of CPEB1 in noninfected cells recapitulated infection-related post-transcriptional changes. CPEB1 was also required for poly(A)-tail lengthening of viral RNAs important for productive infection. Strikingly, depletion of CPEB1 reversed infection-related cytopathology and post-transcriptional changes, and decreased productive HCMV titers. Host RNA processing was also altered in herpes simplex virus-2 (HSV-2)-infected cells, thereby indicating that this phenomenon might be a common occurrence during herpesvirus infections. We anticipate that our work may serve as a starting point for therapeutic targeting of host RNA-binding proteins in herpesvirus infections
Overcoming status quo bias in the human brain
Humans often accept the status quo when faced with conflicting choice alternatives. However, it is unknown how neural pathways connecting cognition with action modulate this status quo acceptance. Here we developed a visual detection task in which subjects tended to favor the default when making difficult, but not easy, decisions. This bias was suboptimal in that more errors were made when the default was accepted. A selective increase in subthalamic nucleus (STN) activity was found when the status quo was rejected in the face of heightened decision difficulty. Analysis of effective connectivity showed that inferior frontal cortex, a region more active for difficult decisions, exerted an enhanced modulatory influence on the STN during switches away from the status quo. These data suggest that the neural circuits required to initiate controlled, nondefault actions are similar to those previously shown to mediate outright response suppression. We conclude that specific prefrontal-basal ganglia dynamics are involved in rejecting the default, a mechanism that may be important in a range of difficult choice scenarios
Three-Dimensional Shapes of Spinning Helium Nanodroplets
A significant fraction of superfluid helium nanodroplets produced in a
free-jet expansion have been observed to gain high angular momentum resulting
in large centrifugal deformation. We measured single-shot diffraction patterns
of individual rotating helium nanodroplets up to large scattering angles using
intense extreme ultraviolet light pulses from the FERMI free-electron laser.
Distinct asymmetric features in the wide-angle diffraction patterns enable the
unique and systematic identification of the three-dimensional droplet shapes.
The analysis of a large dataset allows us to follow the evolution from
axisymmetric oblate to triaxial prolate and two-lobed droplets. We find that
the shapes of spinning superfluid helium droplets exhibit the same stages as
classical rotating droplets while the previously reported metastable, oblate
shapes of quantum droplets are not observed. Our three-dimensional analysis
represents a valuable landmark for clarifying the interrelation between
morphology and superfluidity on the nanometer scale
Association of Long-Term Exposure to Transportation Noise and Traffic-Related Air Pollution with the Incidence of Diabetes: A Prospective Cohort Study.
BACKGROUND: Evidence for an association between transportation noise and cardiovascular disease has increased; however, few studies have examined metabolic outcomes such as diabetes or accounted for environmental coexposures such as air pollution, greenness, or walkability. OBJECTIVES: Because diabetes prevalence is increasing and may be on the causal pathway between noise and cardiovascular disease, we examined the influence of long-term residential transportation noise exposure and traffic-related air pollution on the incidence of diabetes using a population-based cohort in British Columbia, Canada. METHODS: We examined the influence of transportation noise exposure over a 5-y period (1994-1998) on incident diabetes cases in a population-based prospective cohort study (n=380,738) of metropolitan Vancouver (BC) residents who were 45-85 y old, with 4-y of follow-up (1999-2002). Annual average transportation noise (Lden), air pollution [black carbon, particulate matter with aerodynamic diameter <2.5ÎŒm (PM2.5), nitrogen oxides], greenness [Normalized Difference Vegetation Index (NDVI)], and neighborhood walkability at each participant's residence were modeled. Incident diabetes cases were identified using administrative health records. RESULTS: Transportation noise was associated with the incidence of diabetes [interquartile range (IQR) increase, 6.8 A-weighted decibels (dBA); OR=1.08 (95% CI: 1.05, 1.10)]. This association remained after adjustment for environmental coexposures including traffic-related air pollutants, greenness, and neighborhood walkability. After adjustment for coexposure to noise, traffic-related air pollutants were not associated with the incidence of diabetes, whereas greenness was protective. CONCLUSION: We found a positive association between residential transportation noise and diabetes, adding to the growing body of evidence that noise pollution exposure may be independently linked to metabolic health and should be considered when developing public health interventions. https://doi.org/10.1289/EHP1279
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