Contribution of recent transgenic models and transcriptional profiling studies to our understanding of the mechanisms by which androgens control spermatogenesis

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Coenzyme Q10 dose-escalation study in hemodialysis patients: safety, tolerability, and effect on oxidative stress.

BackgroundCoenzyme Q10 (CoQ10) supplementation improves mitochondrial coupling of respiration to oxidative phosphorylation, decreases superoxide production in endothelial cells, and may improve functional cardiac capacity in patients with congestive heart failure. There are no studies evaluating the safety, tolerability and efficacy of varying doses of CoQ10 in chronic hemodialysis patients, a population subject to increased oxidative stress.MethodsWe performed a dose escalation study to test the hypothesis that CoQ10 therapy is safe, well-tolerated, and improves biomarkers of oxidative stress in patients receiving hemodialysis therapy. Plasma concentrations of F2-isoprostanes and isofurans were measured to assess systemic oxidative stress and plasma CoQ10 concentrations were measured to determine dose, concentration and response relationships.ResultsFifteen of the 20 subjects completed the entire dose escalation sequence. Mean CoQ10 levels increased in a linear fashion from 704 ± 286 ng/mL at baseline to 4033 ± 1637 ng/mL, and plasma isofuran concentrations decreased from 141 ± 67.5 pg/mL at baseline to 72.2 ± 37.5 pg/mL at the completion of the study (P = 0.003 vs. baseline and P < 0.001 for the effect of dose escalation on isofurans). Plasma F2-isoprostane concentrations did not change during the study.ConclusionsCoQ10 supplementation at doses as high as 1800 mg per day was safe in all subjects and well-tolerated in most. Short-term daily CoQ10 supplementation decreased plasma isofuran concentrations in a dose dependent manner. CoQ10 supplementation may improve mitochondrial function and decrease oxidative stress in patients receiving hemodialysis.Trial registrationThis clinical trial was registered on clinicaltrials.gov [NCT00908297] on May 21, 2009

Fusies in alle lagen van het onderwijs: praktische en juridische handvatten bij de toepassing van de fusietoets

Trias Europea: de verhoudingen tussen de overheidsmachten in de EU en de lidstaten in een bewegend constitutioneel landscha

Bestuursrecht en faillissementsrecht: een ongemakkelijke relatie

FdR – Publicaties niet-programma gebonde

Study of the Earth’s short-scale gravity field using the ERTM2160 gravity model

This paper describes the computation and analysis of the Earth’s short-scale gravity field through high-resolution gravity forward modelling using the Shuttle Radar Topography Mission (SRTM) global topography model. We use the established residual terrain modelling technique along with advanced computational resources and massive parallelisation to convert the high-pass filtered SRTM topography – complemented with bathymetric information in coastal zones – to implied short-scale gravity effects. The result is the ERTM2160 model (Earth Residual Terrain Modelled-gravity field with the spatial scales equivalent to spherical-harmonic coefficients up to degree 2160 removed). ERTM2160, used successfully for the construction of the GGMplus gravity maps, approximates the short-scale (i.e., ~10 km down to ~250 m) gravity field in terms of gravity disturbances, quasi/geoid heights and vertical deflections at ~3 billion gridded points within ±60 latitude. ERTM2160 reaches maximum values for the quasi/geoid height of ~30 cm, gravity disturbance in excess of 100 mGal, and vertical deflections of ~30 arc-seconds over the Himalaya mountains.Analysis of the ERTM2160 field as a function of terrain roughness shows in good approximation a linear relationship between terrain roughness and gravity effects, with values of ~1.7 cm (quasi/geoid heights), ~11 mGal (gravity disturbances) and 1.5 arc-seconds (vertical deflections) signal strength per 100 m standard deviation of the terrain. These statistics can be used to assess the magnitude of omitted gravity signals over various types of terrain when using degree-2160 gravity models such as EGM2008. Applications for ERTM2160 are outlined including its use in gravity smoothing procedures, augmentation of EGM2008, fill-in for future ultra-high resolution gravity models in spherical harmonics, or calculation of localised or global power spectra of Earth’s short-scale gravity field. ERTM2160 is freely available via http://ddfe.curtin.edu.au/gravitymodels/ERTM2160

Can Europe recover without credit?

Data from 135 countries covering five decades suggests that creditless recoveries, in which the stock of real credit does not return to the pre-crisis level for three years after the GDP trough, are not rare and are characterised by remarkable real GDP growth rates: 4.7 percent per year in middle-income countries and 3.2 percent per year in high-income countries. However, the implications of these historical episodes for the current European situation are limited, for two main reasons. First, creditless recoveries are much less common in highincome countries, than in low-income countries which are financially undeveloped. European economies heavily depend on bank loans and research suggests that loan supply played a major role in the recent weak credit performance of Europe. There are reasons to believe that, despite various efforts, normal lending has not yet been restored. Limited loan supply could be disruptive for the European economic recovery and there has been only a minor substitution of bank loans with debt securities. Second, creditless recoveries were associated with significant real exchange rate depreciation, which has hardly occurred so far in most of Europe. This stylised fact suggests that it might be difficult to re-establish economic growth in the absence of sizeable real exchange rate depreciation, if credit growth does not return

Nonaffine rubber elasticity for stiff polymer networks

We present a theory for the elasticity of cross-linked stiff polymer networks. Stiff polymers, unlike their flexible counterparts, are highly anisotropic elastic objects. Similar to mechanical beams stiff polymers easily deform in bending, while they are much stiffer with respect to tensile forces (``stretching''). Unlike in previous approaches, where network elasticity is derived from the stretching mode, our theory properly accounts for the soft bending response. A self-consistent effective medium approach is used to calculate the macroscopic elastic moduli starting from a microscopic characterization of the deformation field in terms of ``floppy modes'' -- low-energy bending excitations that retain a high degree of non-affinity. The length-scale characterizing the emergent non-affinity is given by the ``fiber length'' $l_f$, defined as the scale over which the polymers remain straight. The calculated scaling properties for the shear modulus are in excellent agreement with the results of recent simulations obtained in two-dimensional model networks. Furthermore, our theory can be applied to rationalize bulk rheological data in reconstituted actin networks.Comment: 12 pages, 10 figures, revised Section II