Catechol-O-Methyltransferase (COMT) Val(108/158 )Met polymorphism does not modulate executive function in children with ADHD

BACKGROUND: An association has been observed between the catechol-O-methyltransferase (COMT) gene, the predominant means of catecholamine catabolism within the prefrontal cortex (PFC), and neuropsychological task performance in healthy and schizophrenic adults. Since several of the cognitive functions typically deficient in children with Attention Deficit Hyperactivity Disorder (ADHD) are mediated by prefrontal dopamine (DA) mechanisms, we investigated the relationship between a functional polymorphism of the COMT gene and neuropsychological task performance in these children. METHODS: The Val(108/158 )Met polymorphism of the COMT gene was genotyped in 118 children with ADHD (DSM-IV). The Wisconsin Card Sorting Test (WCST), Tower of London (TOL), and Self-Ordered Pointing Task (SOPT) were employed to evaluate executive functions. Neuropsychological task performance was compared across genotype groups using analysis of variance. RESULTS: ADHD children with the Val/Val, Val/Met and Met/Met genotypes were similar with regard to demographic and clinical characteristics. No genotype effects were observed for WCST standardized perseverative error scores [F(2,97 )= 0.67; p > 0.05], TOL standardized scores [F(2,99 )= 0.97; p > 0.05], and SOPT error scores [F(2,108 )= 0.62; p > 0.05]. CONCLUSIONS: Contrary to the observed association between WCST performance and the Val(108/158 )Met polymorphism of the COMT gene in both healthy and schizophrenic adults, this polymorphism does not appear to modulate executive functions in children with ADHD

Low-frequency variability and zonal contrast in Sahel rainfall and Atlantic sea surface temperature teleconnections during the last century

This study systematically examines teleconnections between Atlantic sea surface temperature (SST) and the west-east distribution of Sahel rainfall throughout the twentieth century, taking nonstationarity into account. Sahel rainfall variability of six selected rain gauges displays three dominant time scales: multi-decadal (> 20 years), quasi-decadal (8-18 years) and interannual (2-8 years). Regarding their patterns of low-frequency scales, three coherent Sahelian subregions can be identified: the Atlantic Coast (Dakar), western-central Sahel (Nioro and Mopti) and eastern Sahel (Niamey, Maradi, Maine-Soroa). Cross-analyses combining spectral and multivariate analyses of 20 station-based data and West-African gridded rainfall data statistically confirm dissimilarities between the western and eastern Sahel. Western and eastern Sahel rainfall data are correlated with SSTs from different regions of the Atlantic Ocean, especially in the North and tropical South Atlantic. As determined by wavelet coherence and phase, in-phase relationship with North Atlantic SSTs only occurs in wet periods and at the multi- and quasi-decadal scales. This teleconnection depends on the time period and the time scale, displaying a NW-SE pattern, which suggests nonuniform modulations of meridional displacements of the Intertropical Convergence Zone (ITCZ). Tropical South Atlantic SST variability is often related to opposite patterns between the Gulf of Guinean Coast (in phase) and Sahel region (out of phase)