Exact correlations in a single file system with a driven tracer

We study the effect of a single driven tracer particle in a bath of other particles performing the random average process on an infinite line using a stochastic hydrodynamics approach. We consider arbitrary fixed as well as random initial conditions and compute the two-point correlations. For quenched uniform and annealed steady state initial conditions we show that in the large time $T$ limit the fluctuations and the correlations of the positions of the particles grow subdiffusively as $\sqrt{T}$ and have well defined scaling forms under proper rescaling of the labels. We compute the corresponding scaling functions exactly for these specific initial configurations and verify them numerically. We also consider a non translationally invariant initial condition with linearly increasing gaps where we show that the fluctuations and correlations grow superdiffusively as $T^{3/2}$ at large times.Comment: 7 pages, 4 figures, supplementary material appended. To appear in EP

An Embankment on Soft Clays with Sand Drains Numerical Characterization of the Parameters from In-situ Measurements

The deformation parameters of a soft lacustrine deposit, with vertical sand drains, are evaluated by means of field measurements obtained during and after the construction of a railway embankment. The geotechnical system, modelled as linearly elastic and in plane strain, is analyzed by means of the finite element method and the estimation problem is solved adopting a Bayesian approach. The experimental data, the a priori estimation of the parameters and their uncertainties are considered in the back-analysis. The results provide the optimal values of the parameters, a measure of their uncertainties and, consequently, an index of the effectiveness of the field measurement program

Frozen shuffle update for an asymmetric exclusion process on a ring

We introduce a new rule of motion for a totally asymmetric exclusion process (TASEP) representing pedestrian traffic on a lattice. Its characteristic feature is that the positions of the pedestrians, modeled as hard-core particles, are updated in a fixed predefined order, determined by a phase attached to each of them. We investigate this model analytically and by Monte Carlo simulation on a one-dimensional lattice with periodic boundary conditions. At a critical value of the particle density a transition occurs from a phase with `free flow' to one with `jammed flow'. We are able to analytically predict the current-density diagram for the infinite system and to find the scaling function that describes the finite size rounding at the transition point.Comment: 16 page

Cytosolic 5'-Nucleotidase II Interacts with the Leucin Rich Repeat of NLR Family Member Ipaf

IMP/GMP preferring cytosolic 5'-nucleotidase II (cN-II) is a bifunctional enzyme whose activities and expression play crucial roles in nucleotide pool maintenance, nucleotide-dependent pathways and programmed cell death. Alignment of primary amino acid sequences of cN-II from human and other organisms show a strong conservation throughout the entire vertebrata taxon suggesting a fundamental role in eukaryotic cells. With the aim to investigate the potential role of this homology in protein-protein interactions, a two hybrid system screening of cN-II interactors was performed in S. cerevisiae. Among the X positive hits, the Leucin Rich Repeat (LRR) domain of Ipaf was found to interact with cN-II. Recombinant Ipaf isoform B (lacking the Nucleotide Binding Domain) was used in an in vitro affinity chromatography assay confirming the interaction obtained in the screening. Moreover, co-immunoprecipitation with proteins from wild type Human Embryonic Kidney 293 T cells demonstrated that endogenous cN-II co-immunoprecipitated both with wild type Ipaf and its LRR domain after transfection with corresponding expression vectors, but not with Ipaf lacking the LRR domain. These results suggest that the interaction takes place through the LRR domain of Ipaf. In addition, a proximity ligation assay was performed in A549 lung carcinoma cells and in MDA-MB-231 breast cancer cells and showed a positive cytosolic signal, confirming that this interaction occurs in human cells. This is the first report of a protein-protein interaction involving cN-II, suggesting either novel functions or an additional level of regulation of this complex enzym

The collagenic architecture of human dura mater: Laboratory investigation

Object. Human dura mater is the most external meningeal sheet surrounding the CNS. It provides an efficient protection to intracranial structures and represents the most important site for CSF turnover. Its intrinsic architecture is made up of fibrous tissue including collagenic and elastic fibers that guarantee the maintenance of its biophysical features. The recent technical advances in the repair of dural defects have allowed for the creation of many synthetic and biological grafts. However, no detailed studies on the 3D microscopic disposition of collagenic fibers in dura mater are available. The authors report on the collagenic 3D architecture of normal dura mater highlighting the orientation, disposition in 3 dimensions, and shape of the collagen fibers with respect to the observed layer. Methods. Thirty-two dura mater specimens were collected during cranial decompressive surgical procedures, fixed in 2.5% Karnovsky solution, and digested in 1 N NaOH solution. After a routine procedure, the specimens were observed using a scanning electron microscope. Results. The authors distinguished the following 5 layers in the fibrous dura mater of varying thicknesses, orientation, and structures: bone surface, external median, vascular, internal median, and arachnoid layers. Conclusions. The description of the ultrastructural 3D organization of the different layers of dura mater will give us more information for the creation of synthetic grafts that are as similar as possible to normal dura mater. This description will be also related to the study of the neoplastic invasion

Intersection of two TASEP traffic lanes with frozen shuffle update

Motivated by interest in pedestrian traffic we study two lanes (one-dimensional lattices) of length $L$ that intersect at a single site. Each lane is modeled by a TASEP (Totally Asymmetric Exclusion Process). The particles enter and leave lane $\sigma$ (where $\sigma=1,2$) with probabilities $\alpha_\sigma$ and $\beta_\sigma$, respectively. We employ the `frozen shuffle' update introduced in earlier work [C. Appert-Rolland et al, J. Stat. Mech. (2011) P07009], in which the particle positions are updated in a fixed random order. We find analytically that each lane may be in a `free flow' or in a `jammed' state. Hence the phase diagram in the domain $0\leq\alpha_1,\alpha_2\leq 1$ consists of four regions with boundaries depending on $\beta_1$ and $\beta_2$. The regions meet in a single point on the diagonal of the domain. Our analytical predictions for the phase boundaries as well as for the currents and densities in each phase are confirmed by Monte Carlo simulations.Comment: 7 figure

Measurement of pi^0 photoproduction on the proton at MAMI C

Differential cross sections for the gamma p -> pi^0 p reaction have been measured with the A2 tagged-photon facilities at the Mainz Microtron, MAMI C, up to the center-of-mass energy W=1.9 GeV. The new results, obtained with a fine energy and angular binning, increase the existing quantity of pi^0 photoproduction data by ~47%. Owing to the unprecedented statistical accuracy and the full angular coverage, the results are sensitive to high partial-wave amplitudes. This is demonstrated by the decomposition of the differential cross sections in terms of Legendre polynomials and by further comparison to model predictions. A new solution of the SAID partial-wave analysis obtained after adding the new data into the fit is presented.Comment: 13 pages, 12 figures, 1 tabl

Determination of the scalar polarizabilities of the proton using beam asymmetry Σ3\Sigma_{3} in Compton scattering

The scalar dipole polarizabilities, $\alpha_{E1}$ and $\beta_{M1}$, are fundamental properties related to the internal dynamics of the nucleon. The currently accepted values of the proton polarizabilities were determined by fitting to unpolarized proton Compton scattering cross section data. The measurement of the beam asymmetry $\Sigma_{3}$ in a certain kinematical range provides an alternative approach to the extraction of the scalar polarizabilities. At the Mainz Microtron (MAMI) the beam asymmetry was measured for Compton scattering below pion photoproduction threshold for the first time. The results are compared with model calculations and the influence of the experimental data on the extraction of the scalar polarizabilities is determined.Comment: 6 pages, 5 figure

Helicity-dependent cross sections and double-polarization observable E in η photoproduction from quasifree protons and neutrons

Precise helicity-dependent cross sections and the double-polarization observable E were measured for η photoproduction from quasifree protons and neutrons bound in the deuteron. The η → 2γ and η → 3π0 → 6γ decay modes were used to optimize the statistical quality of the data and to estimate systematic uncertainties. The measurement used the A2 detector setup at the tagged photon beam of the electron accelerator MAMI in Mainz. A longitudinally polarized deuterated butanol target was used in combination with a circularly polarized photon beam from bremsstrahlung of a longitudinally polarized electron beam. The reaction products were detected with the electromagnetic calorimeters Crystal Ball and TAPS, which covered 98% of the full solid angle. The results show that the narrow structure observed earlier in the unpolarized excitation function of η photoproduction off the neutron appears only in reactions with antiparallel photon and nucleon spin (σ1/2). It is absent for reactions with parallel spin orientation (σ3/2) and thus very probably related to partial waves with total spin 1/2. The behavior of the angular distributions of the helicity-dependent cross sections was analyzed by fitting them with Legendre polynomials. The results are in good agreement with a model from the Bonn-Gatchina group, which uses an interference of P11 and S11 partial waves to explain the narrow structure