QED representation for the net of causal loops

The present work tackles the existence of local gauge symmetries in the setting of Algebraic Quantum Field Theory (AQFT). The net of causal loops, previously introduced by the authors, is a model independent construction of a covariant net of local C*-algebras on any 4-dimensional globally hyperbolic space-time, aimed to capture structural properties of any reasonable quantum gauge theory. Representations of this net can be described by causal and covariant connection systems, and local gauge transformations arise as maps between equivalent connection systems. The present paper completes these abstract results, realizing QED as a representation of the net of causal loops in Minkowski space-time. More precisely, we map the quantum electromagnetic field Fμν, not free in general, into a representation of the net of causal loops and show that the corresponding connection system and the local gauge transformations find a counterpart in terms of Fμν

The universal algebra of the electromagnetic field III. Static charges and emergence of gauge fields

A universal C*-algebra of gauge invariant operators is presented, describing the electromagnetic field as well as operations creating pairs of static electric charges having opposite signs. Making use of Gauss’ law, it is shown that the string-localized operators, which necessarily connect the charges, induce outer automorphisms of the algebra of the electromagnetic field. Thus they carry additional degrees of freedom which cannot be created by the field. It reveals the fact that gauge invariant operators encode information about the presence of non-observable gauge fields underlying the theory. Using the Gupta-Bleuler formalism, concrete implementations of the outer automorphisms by exponential functions of the gauge fields are presented. These fields also appear in unitary operators inducing the time translations in the resulting representations of the universal algebra

Effects of mixed of a ketogenic diet in overweight and obese women with polycystic ovary syndrome

Polycystic ovary syndrome (PCOS) is a commonly occurring endocrine disorder characterized by hirsutism, anovulation, and polycystic ovaries. Often comorbid with insulin resistance, dyslipidemia, and obesity, it also carries significant risk for the development of cardiovascular and metabolic sequelae, including diabetes and metabolic syndrome. The relationship between central obesity and the development of insulin resistance is widely verified. Adipose tissue excess and the coexistent dysregulation of adipocyte functions directly contribute to the pathogenesis of the metabolic complications observed in women with PCOS. In the light of these evidence, the most therapeutic option prescribed to obese women with PCOS, regardless of the phenotype e from the severity of clinical expression, is lifestyle correction by diet and physical activity. The aim of this study is to evaluate the beneficial effects of ketogenic diet in 17 obese women with PCOS. Our results showed that the ketogenic diet inducing therapeutic ketosis, improves the anthropometric and many biochemical parameters such as LH, FSH, SHBG, insulin sensitivity and HOMA index. In addition, it induces a reduction in androgenic production, whereas the contextual reduction of fat mass reduced the acyclic production of estrogens deriving from the aromatization in the adipose tissue of the androgenic excess, with an improvement of the LH/FSH ratio. This is the first study on the effects of the ketogenic diet on PCOS, however, further studies are needed to elucidate the mechanism underlying ketogenic diet effects

Trade-off between photovoltaic systems installation and agricultural practices on arable lands: An environmental and socio-economic impact analysis for Italy

The paper introduces and discusses an open-source spatial-based model (called r.green.solar) able to quantify the energy production from solar photovoltaic (PV) ground-mounted panels. Socio-economic and environmental impacts can be evaluated by the model. The model starts from the theoretical quantity of solar PV potential energy and estimates a reduction of total amount of energy based on legal, technical, recommended and economic constraints. Model outputs were used for a trade-off analysis between energy production and traditional crops for food/feed cultivation on not irrigated arable land. The model was tested at regional level for a Mediterranean context (Italy). The results confirm that the economic profitability of PV systems follows a north-south gradient, but the main impacts are related to local peculiarities – such as the disposal of not irrigated arable land and the presence of constraints, in particular the landscape maintenance, the morphological variables and the specialization index – and crop yields. © 2016 Elsevier Ltd. All rightsreserved

Chronic post-traumatic volar plate avulsions of the finger proximal interphalangeal joint: A literature review of different surgical techniques

Avulsions of the volar plate of the finger proximal interphalangeal joint (PIPJ) following sprains are often undiagnosed in the acute setting. Therefore, the chronic outcomes of this injury are most frequently the object of study and treatment. Different techniques for volar plate chronic avulsion repair are described in the literature. The most used among these are mainly two: the direct suturing with or without the use of bone anchors and the tenodesis techniques with flexor digitalis superficialis (FDS). The aim of this systematic review is to determine outcomes and complications associated with these surgical treatments of post-traumatic volar plate avulsions without phalangeal fractures. An electronic literature research was carried out and pertinent articles were selected. Surgical techniques details, outcomes and complications for direct sutures and tenodesis technique are discussed. Outcomes (Range of motion and pain) seem to be comparable, whereas authors that use the direct suture technique describe more frequently PIPJ flexion contracture complication. From this review of the literature, authors believe that both techniques are available for the repair of chronic injuries of the volar plate of the PIPJ, although direct suturing can be considered as less reproducible

Modeling of forest landscape evolution at regional level: a FOSS4G approach

In the last decades the Alpine landscape has dramatically changed due to social and economic factors. The most visible impact has been the reduction of the population for mid and high altitude villages and the shrinking of the part of the land used for agriculture and grazing, with a progressive reduction of pastures and meadows and the expansion of the forested areas. For these reasons, a dataset describing the forest, meadows and pasture coverage for the Trentino region, in the eastern Italian Alps, has been created. A set of heterogeneous sources has been selected so that maps and images cover the longest possible time span on the whole Trentino region with comparable quality, creating a Land Use/Land Cover (LULC) map based on historical maps from 1859 to 1936 and aerial images from 1954 to 2015. The achieved accuracy ranges from 98% for historical maps to 94% for aereal imagery. The analysis of selected landscape metrics provided preliminary results about the forest distribution and patterns of recolonization during the last 155 years. It has been possible to create future scenarios for the forest evolution for the next 85 years. Given the large number of maps involved, the great flexibility provided by FOSS for spatial analysis, such as GRASS, R, QGIS and GAMA and the possibility of scripting all the operations have played a pivotal role in the success both in the creation of the dataset and in the extraction and modeling of land use change

Why Me? To Be an Ultra-Responder to Antiplatelet Therapy: A Case Report

Background: Platelet function testing is a valid tool to investigate the clinical response to antiplatelet therapy in different clinical settings; in particular, it might supply helpful information in patients with cerebrovascular disease. Oral antiplatelet treatment, such as Aspirin (ASA) and Clopidogrel, is the gold standard in secondary stroke prevention of non-cardiogenic ischemic stroke; conversely, its application as a primary prevention therapy is not routinely recommended in patients with vascular risk factors. Multiple electrode platelet aggregometry (MEA) impedance aggregometer is a validated device to test platelet inhibition induced by ASA or Clopidogrel. Case Report: We report the case of a 78-year-old patient without relevant clinical history, taking ASA as primary prevention strategy, who was admitted for sudden onset of dysarthria and left facial hyposthenia during physical effort. Brain CT revealed two small subcortical bilateral spontaneous intracranial hemorrhages. Platelet aggregometry with MEA performed upon admission revealed a very strong platelet inhibition induced by ASA (result of the ASPI Test was 5 U, consistent with an ultra-responsiveness to ASA, and the cutoff value of correct responsiveness is <40 U). MRI at longitudinal follow-up revealed the presence of two small cavernous angioma underlying hemorrhagic spots. Conclusion: The evaluation of platelet reactivity in stroke patients undergoing antiplatelet therapies, not commonly performed in clinical practice, could be useful to optimize prevention strategies; the verification of the biological effectiveness of ASA or Clopidogrel could be a valid tool in the definition of each patient's risk profile, particularly in patients with cerebrovascular disease known to be at increased risk for both hemorrhagic and thrombotic complications

Middle cerebral artery ischemic stroke and COVID-19: a case report

We present a clinical case of a patient with SARS-CoV-2 infection and respiratory symptoms, complicated with a pro-thrombotic state involving multiple vascular territories and concomitant interleukin-6 increase. This case underlines the possibility to develop a COVID-19-related coagulopathy

Alternative 3' UTRs direct localization of functionally diverse protein isoforms in neuronal compartments

The proper subcellular localization of RNAs and local translational regulation is crucial in highly compartmentalized cells, such as neurons. RNA localization is mediated by specific cis-regulatory elements usually found in mRNA 3'UTRs. Therefore, processes that generate alternative 3'UTRs-alternative splicing and polyadenylation-have the potential to diversify mRNA localization patterns in neurons. Here, we performed mapping of alternative 3'UTRs in neurites and soma isolated from mESC-derived neurons. Our analysis identified 593 genes with differentially localized 3'UTR isoforms. In particular, we have shown that two isoforms of Cdc42 gene with distinct functions in neuronal polarity are differentially localized between neurites and soma of mESC-derived and mouse primary cortical neurons, at both mRNA and protein level. Using reporter assays and 3'UTR swapping experiments, we have identified the role of alternative 3'UTRs and mRNA transport in differential localization of alternative CDC42 protein isoforms. Moreover, we used SILAC to identify isoform-specific Cdc42 3'UTR-bound proteome with potential role in Cdc42 localization and translation. Our analysis points to usage of alternative 3'UTR isoforms as a novel mechanism to provide for differential localization of functionally diverse alternative protein isoforms