5,495 research outputs found
The Time of Flight System of the AMS-02 Space Experiment
The Time-of-Flight (TOF) system of the AMS detector gives the fast trigger to
the read out electronics and measures velocity, direction and charge of the
crossing particles. The new version of the detector (called AMS-02) will be
installed on the International Space Station on March 2004. The fringing field
of the AMS-02 superconducting magnet is kG where the
photomultiplers (PM) are installed. In order to be able to operate with this
residual field, a new type of PM was chosen and the mechanical design was
constrained by requiring to minimize the angle between the magnetic field
vector and the PM axis. Due to strong field and to the curved light guides, the
time resolution will be ps, while the new electronics will allow
for a better charge measurement.Comment: 5 pages, 4 figures. Proc. of 7th Int. Conf. on Adv. Tech. and Part.
Phys., 15-19 October 2001,Como (Italy
The AMS-02 Time of Flight System. Final Design
The AMS-02 detector is a superconducting magnetic spectrometer that will
operate on the International Space Station. The time of flight (TOF) system of
AMS-02 is composed by four scintillator planes with 8, 8, 10, 8 counters each,
read at both ends by a total of 144 phototubes. This paper describes the new
design, the expected performances, and shows preliminary results of the ion
beam test carried on at CERN on October 2002.Comment: 4 pages, 6 EPS figures. Proc. of the 28th ICRC (2003
The EEE Project
The new experiment ``Extreme Energy Events'' (EEE) to detect extensive air
showers through muon detection is starting in Italy. The use of particle
detectors based on Multigap Resistive Plate Chambers (MRPC) will allow to
determine with a very high accuracy the direction of the axis of cosmic ray
showers initiated by primaries of ultra-high energy, together with a high
temporal resolution. The installation of many of such 'telescopes' in numerous
High Schools scattered all over the Italian territory will also allow to
investigate coincidences between multiple primaries producing distant showers.
Here we present the experimental apparatus and its tasks.Comment: 4 pages, 29th ICRC 2005, Pune, Indi
A compact light readout system for longitudinally segmented shashlik calorimeters
The longitudinal segmentation of shashlik calorimeters is challenged by dead
zones and non-uniformities introduced by the light collection and readout
system. This limitation can be overcome by direct fiber-photosensor coupling,
avoiding routing and bundling of the wavelength shifter fibers and embedding
ultra-compact photosensors (SiPMs) in the bulk of the calorimeter. We present
the first experimental test of this readout scheme performed at the CERN PS-T9
beamline in 2015 with negative particles in the 1-5~GeV energy range. In this
paper, we demonstrate that the scheme does not compromise the energy resolution
and linearity compared with standard light collection and readout systems. In
addition, we study the performance of the calorimeter for partially contained
charged hadrons to assess the separation capability and the response of
the photosensors to direct ionization.Comment: To appear in Nuclear Instruments and Methods in Physics Research,
A drug safety evaluation of abiraterone acetate in the treatment of prostate cancer
Introduction: To evaluate the safety profile characteristics of abiraterone acetate (AA) in the treatment of metastatic prostate cancer (mPCa). Areas covered: In this literature review the authors evaluate safety data from phase III trials investigating the combination of abiraterone acetate plus prednisone (AAP) in patients with metastatic prostate cancer. In particular, the aim was to clarify its toxicity profile, long-term exposure impact, and the correlation with general health-related quality of life (HRQoL). Expert opinion: Based on the studies reviewed, it appears that abiraterone acetate has favourable outcomes, is effective and well tolerated, mostly in asymptomatic or slightly symptomatic patients, and has recognised toxicity profile characteristics. Incidence of adverse events (AEs), such as mineralocorticoid- and corticosteroid-releated AEs, and hepatotoxicity is well known and widely described. Understanding the toxicity profile of AA could assist decision-making in clinical practice
Features, risk factors and clinical outcome of {"}very late{"} recurrences after surgery for localized renal carcinoma: A retrospective evaluation of a cohort with a minimum of 10 years of follow up
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TESTING THE AGILE DATABASE FOR AN EXTERNAL VALIDATION OF A NOMOGRAM TO PREDICT MALIGNANCY OR AGGRESSIVENESS OF RENAL MASSES, BASED ON R.E.N.A.L. SCORE
Defoliation, Recovery and Increasing Mortality in Italian Forests: Levels, Patterns and Possible Consequences for Forest Multifunctionality
Forest health and multifunctionality are threatened by global challenges such as climate change. Forest health is currently assessed within the pan-European ICP Forests (International Co-operative Programme on Assessment and Monitoring of Air Pollution Effects on Forests) programme through the evaluation of tree crown conditions (defoliation). This paper analyses the results of a 24-year assessment carried out in Italy on 253 permanent plots distributed across the whole forested area. The results evidenced a substantial stability of crown conditions at the national level, according to the usual defoliation thresholds Defoliation > 25% and Defoliation > 60%, albeit with species-specific patterns. Within this apparent temporal stability, an increased fraction of extremely defoliated and dead trees was observed. Extreme defoliation mostly occurred in years with severe summer drought, whereas mortality was higher in the years after the drought. The results for singular species evidenced critical conditions for Castanea sativa Mill. and Pinus species, whereas Quercus species showed a progressive decrease in defoliation. Deciduous species, such as Fagus sylvatica L., Ostrya carpinifolia Scop. and Quercus pubescens Willd. suffer the loss of leaves in dry years as a strategy to limit water loss by transpiration but recover their crown in the following years. The recurrence of extreme heat waves and drought from the beginning of the XXI century may increase the vulnerability of forests, and increased tree mortality can be expected in the future
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